A multi-color quantitative magnetic nanoparticle imaging method and system based on trapezoidal wave excitation solves the problem that the existing technology cannot implement multi-color quantitative magnetic particle imaging. The method includes: constructing, based on hysteresis effect and hysteresis inertial growth differences of n superparamagnetic iron oxide nanoparticles (SPIOs) under trapezoidal wave excitation, an equation set of quality of n SPIOs in a to-be-tested sample formed by any composition of n SPIO standard products; solving the equation set to obtain the quality distribution of the to-be-tested sample at position r; and performing rearrangement, color assignment, and image merging on the quality distribution to implement multi-color quantitative imaging of various particles in magnetic particle imaging (MPI). The method broadens the functions of MPI to realize multi-color quantitative imaging, such that MPI has greater potential for application in the medical field.

There is provided a method and system for identifying the location of an obstruction in a pipeline comprising: sensing the magnetic field generated by a pipeline at an initial pressure from a first location along the length of the pipeline to obtain a baseline reading; altering the pressure from a first end until a maximum pressure or minimum pressure is attained; sensing the magnetic field at the maximum or minimum pressure from the first location to obtain a stress reading; and identifying the location of the obstruction as a) being between a second end and the first location when there is a deviation between the stress reading and the baseline reading at the first location or as b) being between the first end and the first location when there is an absence of a deviation between the stress reading and the baseline reading at the first location.

A system for detecting analytes in a test sample, and a method for processing the same, is provided. The system includes a cartridge reader unit that has a control unit and a pneumatic system, and a cartridge assembly that prepares the samples with mixing material(s) through communication channels. The assembly has a memory chip with parameters for preparing the sample and at least one sensor (GMR sensor) for detecting analytes in the sample. The assembly is pneumatically and electronically mated with the reader unit via a pneumatic interface and an electronic interface such that the parameters may be implemented via the control unit. The pneumatic system is contained within the unit and has pump(s) and valve(s) for selectively applying fluid pressure to the pneumatic interface of the assembly, and thus through the communication channels, to move the sample and mixing material(s) through and to sensor. The control unit activates the pneumatic system to prepare the sample and provide it to the sensor for detecting analytes, and also processes measurements from the sensor to generate test results.

A sample analyzer according to an embodiment includes a magnetic field applier configured to apply a magnetic field to a cartridge containing a sample and magnetic particles which bond an object to be detected in the sample; a measurer configured to measure the magnetic particles in the cartridge; and an analyzing processor configured to analyze and process a result of a measurement by the measurer. In addition, the magnetic field applier includes an electromagnet disposed on a first side of the cartridge; a magnetic member configured to be magnetized by the electromagnet; and a moving actuator configured to move the magnetic member.

Devices and methods for molecule detection using such devices are disclosed herein. A molecule detection device comprises at least one fluidic channel configured to receive molecules to be detected, a sensor comprising a spin torque oscillator (STO) and encapsulated by a material separating the sensor from the at least one fluidic channel, and detection circuitry coupled to the sensor. At least some of the molecules to be detected are labeled by magnetic nanoparticles (HNPs). A surface of the material provides binding sites for the molecules to be detected. The detection circuitry is configured to detect a frequency or frequency noise of a radio-frequency (RF) signal generated by the STO in response to presence or absence of at least one MNP coupled to one or more binding sites associated with the sensor.

The present invention relates to a magnetometric device that measures the magnetic properties of a sample and whose most notable characteristic lies in that it is portable and highly precise, and can be used for the detection of a magnetic signal from nanostructures exposed to a fixed external magnetic field of excitation, of a unique value, it not being possible to alter the external magnetic field. The fixed external field can only be altered by modifying the device by means of exchanging the permanent magnets; however, once the device is sealed, this field does not vary. Different quantities of the same magnetic material may be placed in the sample holder, increasing the measurement signal; the present device can therefore determine the magnetic mass being measured following calibration of the magnetic material employed.

A measurement apparatus includes: a memory; and a processor coupled to the memory and configured to: acquire, for each of two samples which are objects made of a same material, have different sizes, and have similar shapes, magnetization curve data measured for the sample and a shape parameter including a dimension of the sample; calculate magnetization of an inner part of each of the samples based on the acquired magnetization curve data and shape parameter of the sample by using a model representing magnetization of the object by separating the magnetization of the object into a magnetization component of a surface part and a magnetization component of an inner part of the object in accordance with a volume ratio between the surface part and the inner part of the object; and output the calculated result.

A machine learning system and method. The machine learning system includes at least one computation circuit that performs a weighted summation of incoming signals and provides a resulting signal. The weighted summation is carried out at least in part by a magnetic element in which weights are adjusted based on changes in effective magnetic susceptibility of the magnetic element.

A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a computer in electrical communication with the power module and the sense module. The computer generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10.sup.−6/° C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles are injected into a breast and the lymph nodes collecting the particles are detected with the probe and deemed sentinel nodes.

Disclosed is a power calculation method of a magnetic circuit. In view of the power problem of a magnetic circuit and the phase problem of a magnetomotive force (MMF) and a magnetic flux in the magnetic circuit, the present disclosure draws a magnetic circuit vector diagram based on an equivalent magnetic circuit vector model, and provides a method for calculating virtual magnetic active power, virtual magnetic reactive power, and virtual magnetic complex power of the magnetic circuit by analyzing the MMF, the magnetic flux, the reluctance, and the magnetic reactance in the magnetic circuit by using the magnetic circuit vector diagram. A mathematical relationship between the virtual magnetic power of the magnetic circuit and the electric power of the corresponding equivalent electric circuit is derived according to a conversion factor between the virtual magnetic power and the electric power, so that the electric power can be directly calculated according to magnetic parameters such as the MMF and the magnetic flux in the magnetic circuit. The power calculation method of the magnetic circuit provided in the present disclosure can calculate and analyze the virtual magnetic power of the magnetic circuit according to the magnetic circuit vectors, so as to calculate the electric power from the magnetic circuit through conversion. The electric power can be solved according to the magnetic circuit vectors directly when the electric vectors are not available to calculate electric power in electromagnetic components.