A method of extracting complex impedance from selected volumes of the material under test (MUT) combined with various embodiments of electrode sensor arrays. Configurations of linear and planar electrode arrays provide measured data of complex impedance of selected volumes, or voxels, of the MUT, which then can be used to extract the impedance of selected sub-volumes or sub-voxels of the MUT through application of circuit theory. The complex impedance characteristics of the sub-voxels may be used to identify variations in the properties of the various sub-voxels of the MUT, or be correlated to physical properties of the MUT using electromagnetic impedance tomography and/or spectroscopy.

The invention pertains to advances in real-time methods in nuclear magnetic resonance by offering a new dual-frequency dynamic nuclear polarization (DNP) method that uses a microwave beam to polarize the spins of electrons and concomitantly act as a NMR transmitter.

The invention pertains to advances in real-time methods in nuclear magnetic resonance by offering a new dual-frequency dynamic nuclear polarization (DNP) method that uses a microwave beam to polarize the spins of electrons and concomitantly act as a NMR transmitter.

Apparatus and methods for the detection of proteins in biological fluids such as urine using a label-free assay is described. Specific proteins are detected by their binding to highly specific capture reagents such as SOMAmers that are attached to the surface of a substrate. Changes to these capture reagents and their local environment upon protein binding modify the behavior of color centers (e.g., fluorescence, ionization state, spin state, etc.) embedded in the substrate beneath the bound capture reagents. These changes can be read out, for example, optically or electrically, for an individual color center or as an average response of many color centers.

The invention is related to a sample holder for measurements of optically detected magnetic resonance, including a bottom plate, a top plate and a middle plate, wherein all the plates are made of a dielectric material. The top plate is provided with at least one top opening, enabling continuous optical access to the studied sample during measurements. The sample is placed in the central opening provided in the middle plate. The non-magnetic conductive strips provided on the surfaces of the bottom plate, the middle plate and the top plate ensure formation of an electrical circuit, which allows coupling of the studied sample with the generated microwave radiation to be achieved once the microwave sources is switched on. The invention also includes a sample holder for measurements of optically detected magnetic resonance, enabling formation of at least one loop of the electrical circuit.

A method for hyperpolarizing spins includes the following steps: a) placing a sample containing spins (s) in a stationary magnetic field; b) magnetically coupling the sample to an electromagnetic resonator having a resonance frequency ω.sub.0 equal to the Larmor frequency of the spins in the stationary magnetic field, such that the coupling with the resonator dominates the relaxation dynamics of the spins; and c) reducing the effective temperature of the electromagnetic field inside the electromagnetic resonator below its physical temperature and that of the sample; whereby the polarization of the spins of the sample is established at a value higher than its thermal equilibrium value. An apparatus for implementing such a method is also provided.

A method for magnetic resonance imaging (MRI) may include obtaining a magnetic resonance (MR) image of a subject, wherein the MR image may be acquired based on a first MRI device and include at least one region of interest (ROI) of the subject. The method may also include selecting, based on the MR image and an ROI determination model, a portion of a main magnetic field generated by the first MRI device. The selected portion of the main magnetic field may correspond to the at least one ROI. The method may also include performing a magnetic field homogenization operation on the selected portion of the main magnetic field.

A method for magnetic resonance imaging (MRI) may include obtaining a magnetic resonance (MR) image of a subject, wherein the MR image may be acquired based on a first MRI device and include at least one region of interest (ROI) of the subject. The method may also include selecting, based on the MR image and an ROI determination model, a portion of a main magnetic field generated by the first MRI device. The selected portion of the main magnetic field may correspond to the at least one ROI. The method may also include performing a magnetic field homogenization operation on the selected portion of the main magnetic field.

According to an example aspect of the present invention, there is provided generating, Low-Field-Magnetic Resonance Imaging, LF-MRI, or Ultra-Low-Field Magnetic Resonance Imaging, ULF-MRI, data with respect to an image frame, determining a sensorwise agreement of the data with determined sensitivity profiles, and determining a mapping between the image frame and a sensor frame, such that the sensorwise agreement has been fulfilled.

According to an example aspect of the present invention, there is provided generating, Low-Field-Magnetic Resonance Imaging, LF-MRI, or Ultra-Low-Field Magnetic Resonance Imaging, ULF-MRI, data with respect to an image frame, determining a sensorwise agreement of the data with determined sensitivity profiles, and determining a mapping between the image frame and a sensor frame, such that the sensorwise agreement has been fulfilled.