Described here are systems and methods for designing and implementing spatially selective, multidimensional adiabatic radio frequency (“RF”) pulses for use in magnetic resonance imaging (“MRI”). Spatially selective inversion can be achieved adiabatically in both two-dimensional (“2D”) and three-dimensional (“3D”) regions-of-interest. The multidimensional adiabatic pulses are generally designed using sub-pulses that are adiabatically driven using a parent adiabatic pulse.

According to one embodiment, a MRI apparatus includes an RF coil apparatus receiving MR signals by coil elements corresponding to channels, modurating the MR signals to have different frequencies for each of the channels, and outputting an analog multiplexed signal in which the MR signals with different frequencies are composited over the channels, and a receiver including ADC circuitry converting the analog multiplexed signal to a digital multiplexed signal, and predetermined number of separation channels separating the digital multiplexed signal, based on the number of the channels relating to composition of the MR signals with the different frequencies. The receiver stops a separation process of the digital multiplexed signal for separation channels not used in the separation process among the predetermined number of separation channels.

Nuclear magnetic resonance (NMR) logging tools may be configured for situation-dependent NMR logging operations by including two dissimilar coils that may function in four different modes of operation based on logging conditions including: a resistivity of the fluid, a diameter of the wellbore, a depth into the subterranean formation of the volume of investigation, or a combination thereof. For example, an NMR logging tool with a z-coil and a transversal coil may be useful in generating in a volume of investigation of a subterranean formation either (1) a transversal radiofrequency (RF) excitation with the transversal coil or (2) a quadrature RF excitation with both the z-coil and the transversal coil, where the choice of transversal or quadrature RF excitation is based on the logging conditions; and detecting an NMR signal from the subterranean formation with one of: (1) the transversal coil or (2) both the z-coil and the transversal coil.

A solid state electronic spin system contains electronic spins disposed within a solid state lattice and coupled to an electronic spin bath and a nuclear spin bath, where the electronic spin bath composed of electronic spin impurities and the nuclear spin bath composed of nuclear spin impurities. The concentration of nuclear spin impurities in the nuclear spin bath is controlled to a value chosen so as to allow the nuclear spin impurities to effect a suppression of spin fluctuations and spin decoherence caused by the electronic spin bath. Sensing devices such as magnetic field detectors can exploit such a spin bath suppression effect, by applying optical radiation to the electronic spins for initialization and readout, and applying RF pulses to dynamically decouple the electronic spins from the electronic spin bath and the nuclear spin bath.

A method to detect transient binding of a substrate molecule of interest in solution to a molecular target includes selecting the substrate molecule of interest and the molecular target such that the substrate molecule of interest can transiently bind to the molecular target; placing one of a sample or a subject of interest in a magnetic resonance (MR) apparatus, the sample or the subject of interest containing the substrate molecule of interest so as to be in contact with the molecular target; providing magnetic labelling of non-exchangeable or slowly exchangeable MR sensitive nuclei of the substrate molecule of interest; receiving an MR signal from the MR sensitive nuclei of the solvent molecules using the MR apparatus; and analyzing the MR signal to obtain a quantity associated with the transient binding of the substrate molecule of interest to the molecular target.

A composite pulse sequence that causes a series of magnetic moment rotations that, in combination, are equivalent to a pulse sequence that would cause a single rotation having a target desired rotation angle α is described. The composite pulse sequence involves a plurality of pulses which each individually have a desired rotation (A°, B° etc) that is less than the target desired rotation α°. The pulses each cause a rotation about respective axes, that may be orthogonal to each other. Slice selection magnetic gradients can be employed to make the component rotations of the composite pulse slice selective.

Methods of fingerprinting a specific molecule in a composition using nuclear magnetic resonance (NMR) is disclosed. The disclosed NMR methods provide several modifications and improvements over existing NMR techniques. In some embodiments, the methods include applying a cycle of signal processing steps, including applying a radio frequency (RF) pulse, applying a gradient pulse having a pulse length less than or equal to 1000 μs, and applying a water suppression technique (WET). In some embodiments, the methods further include repeating the cycle for at least 3 times to acquire an enhanced signal of the composition. In some embodiments, the methods further include fingerprinting the specific molecule based on the enhanced signal of the composition

A method for performing magnetic resonance imaging is provided. The method includes providing a magnetic resonance imaging system comprising: a radio frequency receive system comprising a radio frequency receive coil, and a housing, wherein the housing comprises a permanent magnet for providing an inhomogeneous permanent gradient field, a radio frequency transmit system, and a single-sided gradient coil set. The method also includes placing the receive coil proximate a target subject; applying a sequence of chirped pulses via the transmit system; applying a multi-slice excitation along the inhomogeneous permanent gradient field; applying a plurality of gradient pulses via the gradient coil set orthogonal to the inhomogeneous permanent gradient field; acquiring a signal of the target subject via the receive system, wherein the signal comprises at least two chirped pulses; and forming a magnetic resonance image of the target subject.

According to one embodiment, a data processing apparatus includes processing circuitry. The processing circuitry generates two or more magnetic resonance spectroscopy (MRS) pulse sequences in which different frequency bands are selected as suppression targets. The processing circuitry obtains multiple MRS signals acquired by the two or more MRS pulse sequences. The processing circuitry estimates a relative amount of each molecule included in a measurement target region from the MRS signals, based on a co-occurrence of a frequency profile that depends on a molecule type.

The present invention relate to a system and associate method of MRI and MR spectroscopy which provide stable measurements of the relaxation times, T1 and T2, by using tailored multi-band RF pulses that direct control of the saturation conditions in the background pool of macro-molecular protons, and hence provide a flexible means to induce constant Magnetisation Transfer (MT) effects. In doing this, equal saturation of the background pool is obtained for all measurements independent of the parameters that may be changed, for example, the rotation rate used to obtain a desired flip angle, that is, the degree of change in the magnetisation of the free pool of protons.