A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity.

A magnetic resonance imaging apparatus according to an embodiment includes sequence controlling circuitry and processing circuitry. The sequence controlling circuitry is configured to execute (i) a first pulse sequence in which a spatially selective Inversion recovery (IR) pulse and a spatially non-selective IR pulse are applied, and subsequently an acquisition is performed and (ii) a second pulse sequence in which the spatially non-selective IR pulse is applied without applying the spatially selective IR pulse, and subsequently an acquisition is performed, while varying the first TI period, with respect to a plurality of first TI periods. The processing circuitry is configured to calculate a second TI period to be used in a third pulse sequence and a fourth pulse sequence, based on data obtained from the first pulse sequence and the second pulse sequence. The sequence controlling circuitry executes (iii) the third pulse sequence in which the spatially selective IR pulse and the spatially non-selective IR pulse are applied, and subsequently an acquisition is performed and (iv) the fourth pulse sequence in which the spatially non-selective IR pulse is applied without applying the spatially selective IR pulse, and subsequently an acquisition is performed. The processing circuitry generates a magnetic resonance image of an imaged region based on data obtained from the third pulse sequence and the fourth pulse sequence.

A Computer-implemented method of reconstructing a dynamic series of motion-compensated magnetic resonance images of a patient is provided. Images of a patient are acquired over time, at least partially in free-breathing, at a first image resolution and on a frame-by-frame basis. Each frame of the k-space data includes a first subset of data points having a first sample density and a second subset of data points having a second sample density. For each frame, a sub-group of the first subset and the second subset of the k-space data is selected, and an image is reconstructed at a second image resolution. The motion between the second image resolution images is estimated in the form of motion fields. The motion information is incorporated into a final reconstruction of a dynamic series of motion-compensated magnetic resonance images of the patient at a third image resolution.

Provided is a method for generating MRI data including applying, by an MRI computing device, an RF excitation pulse, and completing, by the MRI computing device, a K-space by acquiring a plurality of phase encoding line groups, in a state in which any other RF excitation pulse is not applied after applying the RF excitation pulse, in which each of the plurality of phase encoding line groups includes a plurality of phase encoding lines, and an absolute value of an average phase encoding size of a phase encoding line group acquired earlier is not greater than an absolute value of an average phase encoding size of a phase encoding line group acquired later, among the plurality of phase encoding line groups.

The disclosure is directed to an Echo-Planar-Imaging (EPI) magnetic resonance imaging techniques combined with a variable-density undersampling scheme. The technique comprises generating an RF pulse, applying a switched frequency-encoding read out gradient in a variable time interval, and applying simultaneously an intermittently blipped low-magnitude phase-encoding gradient with a variable value of an integral of the phase-encoding gradient. The aforementioned steps are carried out such that the k-space is at least partially undersampled and the time interval of one read out gradient is varied depending on the integral of the phase encoding gradient, such that a ratio between the variable time interval of the read out gradient and the integral of the corresponding phase encoding gradient is kept above or at a predetermined constant value, which is related to a predetermined criteria of image quality.

A system and method for denoising experimental data originating from multiple acquisitions by a magnetic resonance imaging device, by analysis of selected principal components, to obtain a better compromise between the efficiency of the denoising and retention of the relevant information in the experimental data under consideration during their reconstruction to produce denoised experimental data. A selection criterion is based on the informative indicators quantifying the spatial information contained in images of scores associated with said principal components. The invention also provides for the capability to apply an adaptive filtering excluding the persistent spatial noise associated with each component selected.

A method for performing magnetic resonance imaging on a subject comprises: injecting a contrast agent into a region of interest of the subject; applying a pulse sequence to the region of interest; collecting auxiliary data for the region of interest, the auxiliary data being related to one or more time-varying parameters of the subject within the region of interest; determining a temporal factor Φ from the auxiliary data; collecting imaging data for the region of interest, the imaging data being related to one or more spatially-varying parameters of the subject within the region of interest; determining a spatial factor Ur from the imaging data; modeling a multi-dimensional image sequence as I=UrΦ; and deriving at least a first metric and a second metric from the multi-dimensional image sequence I, the first metric and the second metric being associated with distinct perfusion-based imaging techniques.

A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity.

A medical image processing apparatus including processing circuitry configured to obtain MR dynamic images acquired by MR imaging on a subject, in which a contrast agent has been injected, in accordance with an examination-time imaging condition including magnetic field information, contrast agent information, and/or tissue information, set a standard imaging condition, and calculate a first index value indicating a temporal change of an MR signal value caused by the contrast agent, the index value being standardized by conversion from the examination-time imaging condition to the standard imaging condition based on the MR dynamic images, the examination-time imaging condition, and the standard imaging condition.

A magnetic resonance imaging apparatus according to an embodiment includes sequence controlling circuitry and processing circuitry. The sequence controlling circuitry is configured to execute (i) a first pulse sequence in which a spatially selective Inversion recovery (IR) pulse and a spatially non-selective IR pulse are applied, and subsequently an acquisition is performed and (ii) a second pulse sequence in which the spatially non-selective IR pulse is applied without applying the spatially selective IR pulse, and subsequently an acquisition is performed, while varying the first TI period, with respect to a plurality of first TI periods. The processing circuitry is configured to calculate a second TI period to be used in a third pulse sequence and a fourth pulse sequence, based on data obtained from the first pulse sequence and the second pulse sequence. The sequence controlling circuitry executes (iii) the third pulse sequence in which the spatially selective IR pulse and the spatially non-selective IR pulse are applied, and subsequently an acquisition is performed and (iv) the fourth pulse sequence in which the spatially non-selective IR pulse is applied without applying the spatially selective IR pulse, and subsequently an acquisition is performed. The processing circuitry generates a magnetic resonance image of an imaged region based on data obtained from the third pulse sequence and the fourth pulse sequence.