Methods and systems for modulation and mapping of brain tissue in a subject using an ultrasound assembly are provided. An exemplary method for modulation uses an ultrasound assembly including a housing and an ultrasound transducer joined to the housing. The method includes securing the housing to the head of the subject with the ultrasound transducer aligned with a region of the brain tissue to target the region of the brain tissue for modulating, and providing focused ultrasound at an acoustic pressure to the targeted region using the ultrasound transducer to induce cavitation proximate the targeted region. The method further includes detecting a cavitation signal magnitude from the induced cavitation corresponding to the acoustic pressure and modulating the targeted region.

A system for characterizing tissue includes a probe that delivers a continuous and periodic mechanical vibration to a tissue of a subject; an ultrasound emitter that emits a sequence of ultrasound shots and an ultrasound receiver that receives corresponding echo signals to track how the tissue is moved by the periodic mechanical vibration delivered to the tissue; and a control module programmed to provide homogeneity information to an operator of the system, the homogeneity information being determined from at least some of the echo signals and being representative of the ability of the tissue to transmit elastic waves and of the homogeneity of the tissue with respect to the propagation of elastic waves.

A system for characterizing tissue includes a probe that delivers a continuous and periodic mechanical vibration to a tissue of a subject; an ultrasound emitter that emits a sequence of ultrasound shots and an ultrasound receiver that receives corresponding echo signals to track how the tissue is moved by the periodic mechanical vibration delivered to the tissue; and a control module programmed to provide homogeneity information to an operator of the system, the homogeneity information being determined from at least some of the echo signals and being representative of the ability of the tissue to transmit elastic waves and of the homogeneity of the tissue with respect to the propagation of elastic waves.

A measurement and imaging instrument capable of beamforming with high speed and high accuracy without approximate calculation. The instrument includes a reception unit which receives a wave arriving from a measurement object to generate a reception signal; and an instrument main body which performs a lateral modulation while superposing two waves in a two-dimensional case and three or four waves in a three-dimensional case in beamforming processing of the reception signal in which at least one wave arriving from the measurement object is processed as being transmitted or received in the axial direction or directions symmetric with respect to the axial direction to generate a multi-dimensional reception signal, performs Hilbert transform with respect to the multi-dimensional reception signal, and performs partial derivative processing or one-dimensional Fourier transform to generate analytic signals of the multi-dimensional reception signals of the two waves or the three or four waves.

Described here are systems and methods for super-resolution imaging with ultrasound in which a Kalman filter-based microvessel inpainting technique is used to facilitate robust super-resolution imaging with limited or otherwise missing microbubble signals. The systems and methods described in the present disclosure can be combined with both local and global microbubble tracking methods.

Certain embodiments pertain to cross-amplitude modulation (xAM) ultrasound imaging methods and systems configured to excite a first subaperture of transducer elements to transmit a first ultrasound plane wave, excite a second subaperture of transducer elements to transmit a second ultrasound plane wave noncollinear to the first ultrasound plane wave, the second ultrasound plane wave axisymmetric to the first ultrasound plane wave about a bisector, and simultaneously excite both first and second subapertures to transmit first and second ultrasound plane waves to cause an acoustic pressure above a threshold along the bisector.

Described here are systems and methods for super-resolution imaging with ultrasound in which a Kalman filter-based microvessel inpainting technique is used to facilitate robust super-resolution imaging with limited or otherwise missing microbubble signals. The systems and methods described in the present disclosure can be combined with both local and global microbubble tracking methods.

Methods and systems for modulation and mapping of brain tissue in a subject using an ultrasound assembly are provided. An exemplary method for modulation uses an ultrasound assembly including a housing and an ultrasound transducer joined to the housing. The method includes securing the housing to the head of the subject with the ultrasound transducer aligned with a region of the brain tissue to target the region of the brain tissue for modulating, and providing focused ultrasound at an acoustic pressure to the targeted region using the ultrasound transducer to induce cavitation proximate the targeted region. The method further includes detecting a cavitation signal magnitude from the induced cavitation corresponding to the acoustic pressure and modulating the targeted region.

An ultrasound imaging apparatus and a method of controlling the same are provided. The ultrasound imaging apparatus includes an ultrasound contrast agent (UCA) sensor configured to determine whether an UCA flows in an object based on an echo signal that is reflected by the object in a mechanical index environment. The ultrasound imaging apparatus further includes a controller configured to obtain at least one among an UCA image and a tissue image of the object in another mechanical index environment lower than the mechanical index environment in response to the UCA sensor determining that the UCA flows in the object.

An ultrasonic diagnostic imaging system and method are presented in which the balance between image resolution and frame rate (Res/Speed) and the balance between image resolution and penetration (Pen/Gen/Res) are automatically adjusted in response to image content. A motion detector analyzes the relative motion between successive images. If the motion content is relatively high, the imaging parameters are changed in favor of relatively greater frame rate and reduced resolution. A low motion content causes the opposite adjustment. The electronic noise between successive images is also computed with a relatively high noise content (low correlation) in the far field resulting in an adjustment to penetration as by lowering the transmit frequency. A relatively low noise content causes an adjustment in favor of increased resolution.