A diagnostic imaging system utilizing a reduced crystal design pattern is utilized to image a subject and collect event data. The reduced crystal design pattern includes filled crystal locations and empty crystal locations. A processor accounts for empty crystal locations by selecting windows that include nearest neighbor filled crystal locations. The nearest neighbor filled crystal locations include event data which is averaged by the processor and assigned to the empty crystal location. A weighted average based on distance or event strength is incorporated.

Disclosed is a novel method of obtaining transmission scan data in a PET scanner by incorporating one or more stationary gamma-ray sources that provide forward scattered gamma-photons that can be used as transmission imaging radiation.

For positron emission tomography (PET) detector gain stabilization despite temperature variation, an open loop gain control based on temperature establishes a baseline gain despite possible temperature variation. The baseline gain is then adjusted with a more sensitive closed-loop (e.g., peak tracking) approach for dealing with temperature. By combining both types of gain control to deal with temperature, the advantages of both are provided while avoiding disadvantages of either approach by itself.

Described is a directional gamma detector including a detection probe and a handgrip, wherein the detection probe includes: a supporting rod and a detection head coupled or integrated with a first end of the supporting rod. The detection head includes a plurality of detection elements distinct from each other for simultaneously detecting gamma rays directed in different directions and including at least one scintillation crystal and a corresponding first electronic conversion circuitry. Each detection element is associated with a respective collimator. The handgrip is equipped internally with a second electronic circuitry for converting the signals. The detection probe, and in particular a second end of the supporting rod, is reversibly connectable to the handgrip by a mechanical connector equipped with electrical contacts for transferring the signals from the first electronic conversion circuitry to the second electronic conversion circuitry.

A system and method for the measurement of radiation emitted from an in-vivo administered radioactive analyte. Gamma radiation sensors may be used to determine the proper or improper administration of a radioactive analyte, and identify patient administration factors that correlate with improper administration over a set of patients so as to identify administration risk factors to improve administration of radioactive analyte. In some cases, the system employs a sensor having a scintillation material to convert gamma radiation to visible light, which enables embodiments of the sensor to be ex vivo. A light detector converts the visible light to an electrical signal. This signal is amplified and is processed to measure the captured radiation. The sensor enables collection of sufficient data to support separate application to predictive models, background comparisons, or change analysis.

Provided are a radiation detector, a radiographic imaging apparatus, and a manufacturing method that include a TFT substrate in which a plurality of pixels that accumulate electric charges generated depending on light converted from radiation are formed in a pixel region of a first surface of a flexible base material and a terminal region of the first surface is provided with a terminal for electrically connecting a flexible cable; a conversion layer that is provided outside the terminal region on the first surface of the base material to convert the radiation into light; a first reinforcing substrate that is provided on a surface of the conversion layer opposite to a surface on a TFT substrate side and has a higher stiffness than the base material; and a second reinforcing substrate that is provided on a second surface of the base material opposite to the first surface to cover a surface larger than the first reinforcing substrate, and that are capable of suppressing that a defect occurs in the substrate and have an excellent peeling property in a reworking process.

Embodiments are directed generally to an ionizing-radiation beamline monitoring system that includes a vacuum chamber structure with vacuum compatible flanges through which an incident ionizing-radiation beam enters the monitoring system. Embodiments further include at least one scintillator within the vacuum chamber structure that can be at least partially translated in the ionizing-radiation beam while oriented at an angle greater than 10 degrees to a normal of the incident ionizing-radiation beam, a machine vision camera coupled to a light-tight structure at atmospheric/ambient pressure that is attached to the vacuum chamber structure by a flange attached to a vacuum-tight viewport window with the camera and lens optical axis oriented at an angle of less than 80 degrees with respect to a normal of the scintillator, and at least one ultraviolet (“UV”) illumination source facing the scintillator in the ionizing-radiation beam for monitoring a scintillator stability comprising scintillator radiation damage.

Apparatus, techniques and systems are described for facilitating identification of a target area during a probe-guided radio-localization surgical procedure. The described apparatus, techniques and systems can be used to implement a nuclear-uptake mode controller integrated into a probe to allow a user to instantly switch between multiple nuclear-uptake modes directly from the probe hand-piece. For example, a nuclear-uptake mode controller integrated into the probe can be used to instantly switch between a high-sensitivity nuclear-up-take mode and a high-resolution nuclear-uptake mode to effectively identify the target area in the presence of interfering nuclear signals by better matching the probe's nuclear detection parameters to a search task for that target area.

Disclosed is a novel method of obtaining transmission scan data in a PET scanner by incorporating one or more stationary gamma-ray sources that provide forward scattered gamma-photons that can be used as transmission imaging radiation.

The invention relates to a combined detector (660) comprising a gamma radiation detector (100) and an X-ray radiation detector (661). The gamma radiation detector (100) comprises a gamma scintillator array (101.sub.x, y), an optical modulator (102) and a first photodetector array (103.sub.a, b) for detecting the first scintillation light generated by the gamma scintillator array (101.sub.x, y). The optical modulator (102) is disposed between the gamma scintillator array (101.sub.x, y) and the first photodetector array (103.sub.a, b) for modulating a transmission of the first scintillation light between the gamma scintillator array (101.sub.x, y) and the first photodetector array (103.sub.a, b). The optical modulator (102) comprises at least one optical modulator pixel having a cross sectional area (102′) in a plane that is perpendicular to the gamma radiation receiving direction (104). The cross sectional area of each optical modulator pixel (102′) is greater than or equal to the cross sectional area of each photodetector pixel (103′.sub.a, b).