Multiple interactions, such as Compton scattering, inside a PET detector are used to predict an incident photon's direction for identifying true coincidence events versus scatter/random coincidence events by creating a cone shaped shell projection defining a range of possible flight directions for the incident photon. The disclosed techniques can be used as prior information to improve the image reconstruction process. The disclosed techniques can be implemented in a LYSO/SiPM-based layer stacked detector, which can precisely register multiple interactions' 3D position.

In general, an X-ray imaging apparatus according to one embodiment includes an X-ray tube, an X-ray detector, and processing circuitry. The processing circuitry is configured to obtain correction-target data that includes component deterioration resulting from a transient response of the X-ray detector, and to output, based on the obtained correction-target and a model that outputs data in which component deterioration resulting from a transient response is reduced based on an input of data that includes component deterioration resulting from a transient response, corrected data in which the component deterioration resulting from the transient response of the X-ray detector is reduced.

Various aspects include methods compensating for Compton scattering effects in pixel radiation detectors. Various aspects may include determining whether gamma ray detection events occurred in two or more detector pixels within an event frame, determining whether the gamma ray detection events occurred in detector pixels within a threshold distance of each other in response to determining that gamma ray detection events occurred in two or more detector pixels within the event frame, and recording the two or more gamma ray detection events as a single gamma ray detection event having an energy equal to the sum of measured energies of the two or more gamma ray detection events located in a detector pixel having a highest measured energy in response to determining that the gamma ray detection events occurred in detector pixels within the threshold distance of each other.

A method and apparatus are provided for nonlinear energy correction of a gamma-ray detector using a calibration spectrum acquired from the background radiation of lutetium isotope 176 (Lu-176) present in scintillators in the gamma-ray detector. Further, by periodically acquiring Lu-176 spectra using the background radiation from the scintillators, the nonlinear energy correction can be monitored to detect when changes in the gamma-ray detector cause the detector to go out of calibration, and then use a newly acquired Lu-176 spectrum to update the calibration of the nonlinear energy correction as needed. The detector calibration is performed by comparing a reference histogram to a calibration histogram generated using the nonlinear energy correction, and adjusting the parameters of the nonlinear energy correction until the two histograms match. Alternatively, the detector calibration is performed by comparing reference and calibration values for specific spectral features, rather than for the whole Lu-176 spectrum.

A data processing apparatus according to an embodiment includes acquisition circuitry and specification circuitry. The acquisition circuitry is configured to acquire a detector signal containing a first component that is based on Cherenkov light and a second component that is based on scintillation light. The specification circuitry is configured to specify timing information about generation of the detector signal by curve fitting to the first component.

Multiple interactions, such as Compton scattering, inside a PET detector are used to predict an incident photon's direction for identifying true coincidence events versus scatter/random coincidence events by creating a cone shaped shell projection defining a range of possible flight directions for the incident photon. The disclosed techniques can be used as prior information to improve the image reconstruction process. The disclosed techniques can be implemented in a LYSO/SiPM-based layer stacked detector, which can precisely register multiple interactions' 3D position.

A positron emission tomography (PET) apparatus and method employs a plurality of radiation detectors (20) disposed around an imaging region (16) and configured to detect 511 keV radiation events emanating from the imaging region. A calibration phantom is disposed in the imaging region. One or more processors are configured to: acquire and store listmode data of the phantom; measure a random rate for each line of response (LOR) from the listmode data using a coincident 511 keV events detector (34) with a time offset (54); determine a singles rate for each detector pixel from the random event rate, for example via a histogram plotting singles rate for each detector pixel; compute a live time factor of each LOR; compute a dead time correction factor as the reciprocal of the live time factor; and correct images according to the dead time correction factor.

A method is provided including, acquiring detection events with a radiation detector including a semiconductor plate and configured to produce electrical signals in response to absorption of ionizing radiation in the semiconductor plate, wherein electrons and holes are generated responsive to absorption of the ionizing radiation. The semiconductor plate includes a first surface opposed to a second surface, with sidewalls interposed between the first surface and the second surface. A cathode electrode is disposed on the first surface and pixelated anode electrodes are disposed on the second surface. The method also includes optically coupling infrared (IR) radiation into a first portion of at least one of the sidewalls of the semiconductor plate of the radiation detector, and not coupling IR radiation into a second portion of the at least one of the sidewalk.

An imaging method and device are described for improving the performance of a gamma camera by optimizing a figure of merit that depends upon cost, efficiency, and spatial resolution. In a modular gamma camera comprising a tiled array of gamma detector modules, the performance figure of merit can be optimized by sparsely placing gamma detector modules within the gamma camera, optimizing collimation, and providing means for detector and/or collimator motion. Sparse gamma cameras can be constructed as flat or curved panels, and elliptical or circular rings.

A detector configuration that combines a plurality of elongated semiconductor photo-multiplier sensor strips coupled to a scintillator crystal block with a differential readout that will enhance the time resolution. This is permitted due to a reduction of electronic noise due to reduced cross talk and noise in the ground. In addition, the dead area is minimized and thus the efficiency of the photodetector is enhanced.