An intraoral scanner comprises a light source, a moveable opto-mechanical module, an axial actuator, and an image sensor. The light source is configured to generate light that is to be output onto an object external to the intraoral scanner. The moveable opto-mechanical module comprises integrated projection/imaging optics and an exit pupil, the projection/imaging optics having an optical axis, wherein the projection/imaging optics are entirely integrated into the moveable opto-mechanical module. The axial actuator is coupled to the projection/imaging optics and configured to move the moveable opto-mechanical module comprising an entirety of the projection/imaging optics in the optical axis to achieve a plurality of focus settings. The image sensor is configured to receive reflected light that has been reflected off of the object external to the intraoral scanner for the plurality of focus settings.

A base assembly includes an imaging sensor having a sensor surface to receive a sample, and a platform connected to the base assembly. The base assembly includes (a) an aperture configured to receive a lid surface of a lid in a position to define an imaging space between the sensor surface and the lid surface and (b) a movement portion movable toward and away from the base assembly. The platform and the base assembly are configured to limit contact between the sample and the base assembly other than at the sensor surface.

An optical device may include an optical fiber having a fixed end and a free end; a first actuator positioned at a actuator position between the fixed end and the free end and configured to apply a first force on the actuator position of the optical fiber such that a movement of the free end of the optical fiber in a first direction is caused, wherein the first direction is orthogonal to a longitudinal axis of the optical fiber; and a deformable rod disposed adjacent to the optical fiber, and having a first end and a second end, wherein the first end is connected to a first rod position of the optical fiber and the second end is connected to a second rod position of the optical fiber.

An optical probe assembly as a confocal endomicroscope includes an optical focusing stage that focuses an output beam onto a sample and a mirror scanning stage that is movable for scanning the output beam in both a lateral two dimensional plane and an axial direction, using a side-view configuration. The side-view configuration allows for output beam illumination and fluorescent imaging of the sample with greater imaging resolution and improved access to hard to reach tissue within a subject.

Apparatus and methods for measuring infrared absorption of a sample that includes delivering a pulse of infrared radiation to a region of the sample, delivering pulses of radiation of a shorter wavelength than infrared radiation to a sub-region within the region, and using one or more properties of the induced photoacoustic signals to create a signal indicative of infrared absorption of the sub-region of the sample.

A common beam scanning retinal imaging system comprises: a light source module (1), an adaptive optics module (2), a beam scanning module (3), a small field-of-view relay module (5), a large field-of-view relay module (6), a sight beacon module (9), a pupil monitoring module (7), a detection module (8), a control module (10) and an output module (11). The system can perform real-time correction of human eye aberration by adaptive optics technology, and realize the confocal scanning imaging function in a large field of view and the adaptive optics high-resolution imaging function in a small field of view simultaneously by the common beam synchronous scanning configuration combined with the two relay optical path structures for both the small field of view and the large field of view. The system can not only observe disease lesions in a wide range on the retina by the large field-of-view imaging, but also observe fine structures of the lesions by the small field-of-view high-resolution imaging. A variety of imaging images are acquired by common path optical beam scanning to meet the needs of different application scenes, which greatly expands the application range of the existing confocal imaging equipment.

An optical device may include an optical fiber having a fixed end and a free end a first actuator positioned at a actuator position between the fixed end and the free end and configured to apply a first force on the actuator position of the optical fiber such that a movement of the free end of the optical fiber in a first direction is caused, wherein the first direction is orthogonal to a longitudinal axis of the optical fiber; and a deformable rod disposed adjacent to the optical fiber, and having a first end and a second end, wherein the first end is connected to a first rod position of the optical fiber and the second end is connected to a second rod position of the optical fiber.

Systems and methods for Broad Line Fundus Imaging (BLFI), an imaging approach that is a hybrid between confocal and widefield imaging systems, are presented. These systems and methods are focused on improving the quality and signal of broad line fundus images or imaging methods to create high contrast and high resolution fundus images. Embodiments related to improved pupil splitting, artifact removal, reflex minimization, adaptable field of view, instrument alignment and illumination details are considered.

A spectral confocal measurement device includes a light source portion, configured to emit a broad-spectrum light beam with a certain wavelength range in a first predetermined path; an optical sampling portion, configured to converge the broad-spectrum light beam emitted from the light source portion on different measurement surfaces of an object to be measured, and output a reflected light in a second predetermined path that is different from a reverse direction of the first predetermined path; and a measurement portion, configured to receive and process the reflected light from the optical sampling portion to obtain a measurement result. The device can improve measurement accuracy and reduce production costs. In addition, a spectral confocal measurement method is also provided.

Systems and methods are provided for label-free, real-time hyperspectral imaging (HSI) endoscopy for molecular-guided surgery of cancers without the need for an exogenous contrast agent. One device is a high-speed image mapping spectrometer integrated with a white-light reflectance fiberoptic bronchoscope. The imaging system has a parallel acquisition instrument that captures a hyperspectral datacube that may be pre-processed and features extracted and a discriminative feature set is selected and used for the classification of cancer and benign tissue. An algorithm that enables fast and accurate tissue classification may also be applied that utilizes a supervised deep-learning-based framework that is trained with the clinically visible tumor and benign tissue during surgery and then applied to identify the residual tumor.