The present invention relates to a coherent detection array and methods of multiplexing for signal readout of the coherent detection array. The coherent detection array may be implemented on a photonic integrated circuit (PIC). It may comprise a plurality of coherent detection units coupling with connecting waveguides and electrical conducting paths, wherein the electrical conducting paths may manifest as readout channels for multiplexing electrical signals. The detection units may be configured to include free-space-to-waveguide couplers, optical couplers, and photodetectors. The coherent detection array enables multiplexing methods that may leverage extra degrees of freedom of the coherent detection array. These methods may include those enabled by the local oscillator and those related to the properties and responses of the components of the PIC-based detection array.

A holographic three-dimensional multi-spot light stimulation device is provided with: a three-dimensional imaging holographic optical system A which employs fluorescent exciting light to acquire three-dimensional fluorescence distribution information resulting from fluorescent signal light from a plurality of stimulation target objects; and a three-dimensional light stimulation holographic optical system B which employs a light stimulation hologram generated on the basis of the acquired three-dimensional fluorescence distribution information to form a plurality of light spots in space, to impart stimulation simultaneously to the plurality of stimulation target objects. Furthermore, the three-dimensional light stimulation holographic optical system B is provided with a spatial light phase modulating element 22 and a control unit 25, wherein the control unit 25 generates the light stimulation hologram by controlling the spatial light phase modulating element 22 on the basis of the three-dimensional fluorescence distribution information.

The present invention relates to a coherent detection array and methods of multiplexing for signal readout of the coherent detection array. The coherent detection array may be implemented on a photonic integrated circuit (PIC). It may comprise a plurality of coherent detection units coupling with connecting waveguides and electrical conducting paths, wherein the electrical conducting paths may manifest as readout channels for multiplexing electrical signals. The detection units may be configured to include free-space-to-waveguide couplers, optical couplers, and photodetectors. The coherent detection array enables multiplexing methods that may leverage extra degrees of freedom of the coherent detection array. These methods may include those enabled by the local oscillator and those related to the properties and responses of the components of the PIC-based detection array.