A manufacturing system for a biopharmaceutical product includes first and second sets of biopharmaceutical manufacturing equipment located at a first and second enterprise sites, and memory configured to store an enterprise configuration and a process specification. The enterprise configuration includes records of one or more equipment parameters of the multiple pieces of equipment of the first and second sets of biopharmaceutical manufacturing equipment. At least one processor is configured to execute instructions determine whether at least one of the first enterprise site and the second enterprise site is capable of manufacturing the biopharmaceutical product, transmit a generated set of instructions to the determined at least one of the first enterprise site and the second enterprise site, and operate the multiple pieces of equipment at the determined at least one of the first enterprise site and the second enterprise site to manufacture the biopharmaceutical product.

A computer implemented method for generating a problem specific representation of a process network to enable controlling or monitoring a process network with at least two interconnected chemical plants, the method comprising the steps of providing a first digital representation of the process network comprising a digital process representation of each plant, its connections to other plants and sensor elements placed in the process network, generating based on the first digital representation a graph structure including vertices representing unit operations, edges linking unit operations representing at least physico-chemical quantities, wherein the edges include edge meta data representing at least physico-chemical quantities, and a measurable tag, generating based on the graph structure a collapsed graph structure including, vertices representing virtual unit operations, edges linking virtual unit operations representing at least physico-chemical quantities, wherein the edges include edge meta data representing observable physico chemical quantities, and their relation to vertices, deriving a set of balance equations from the collapsed graph structure, providing the set of balance equations, and physico- chemical quantities for monitoring and/or controlling operation of a process network is proposed.

A plurality of hierarchy information management devices include a first hierarchy information management unit managing first hierarchy information in which information on instruments is represented in a hierarchy structure, and each hierarchy information management device manages the first hierarchy information of a different one of the instruments. A monitoring device includes: a second hierarchy information management unit generating second hierarchy information based on a plurality of different pieces of the first hierarchy information acquired from the hierarchy information management devices, the second hierarchy information being hierarchy information in which the first hierarchy information is connected in a hierarchy structure; a display unit displaying information; and a display processing unit performing a process of switching between a plurality of different monitoring screens for display on the display unit, the different monitoring screens corresponding to different layers in the second hierarchy information and showing the operating state of the monitoring targets.

A system includes a memory and a processing device, operatively coupled to the memory, to perform operations including receiving, as input to a trained machine learning model for identifying defect impact with respect to at least one type defect type, data associated with a process related to electronic device manufacturing. The data associated with the process comprises at least one of: an input set of recipe settings for processing a component, a set of desired characteristics to be achieved by processing the component, or a set of constraints specifying an allowable range for each setting of the set of recipe settings. The operations further include obtaining an output by applying the data associated with the process to the trained machine learning model. The output is representative of the defect impact with respect to the at least one defect type.

The present disclosure relates to an Industrial Internet of Things (IoT) and a method for controlling a balance rate of a production line. The Industrial IoT includes an user platform, a service platform, a management platform, a sensor network platform, and an object platform interacting in sequence, the service platform adopts a centralized arrangement, the management platform adopts an independent arrangement, and the sensor network platform adopts a rear sub-platform arrangement.

A first valve of a manifold for a fluid distribution system may regulate a fluid flow to a first fluid handling device (“FHD”). A second valve of the manifold may communicate with a second FHD, a reservoir, or a recirculation line. A target flow condition for the manifold may be determined by a manifold control system (“MCS”) based on a device setting received for the first FHD. The MCS may determine a fluid distribution system operation for obtaining the target flow condition based on the target flow condition, a flowrate of the fluid flow, and an operational state of a supply device. The operation may include the MCS controlling at least one of the supply device, the first valve, and the second valve to change the flowrate. The MCS may continuously operate at least one manifold valve to maintain the target flow condition once exhibited by the manifold.

A system and method for controlling operations of a fluid distribution may include a first manifold receiving a next mode of operation for the fluid distribution system. The first manifold may calculate first and second flow requirements for the first and second manifolds that may respectively include a first and second total flowrates from the first and second manifolds. The first manifold may determine required operation states for valves of the first manifold and the second manifold for the next mode based on the first and second flow requirements. The first manifold may be controllably operated to cause the second manifold and a supply device of the fluid distribution system to operate in the required operation states and provide first and second flow requirements. The first manifold may direct the second manifold to independently balance individual outlet flowrates of the second manifold while continuing to provide the second flow requirements.

In order to monitor the operational status of a plant, a plant monitoring apparatus 10 includes: a control program acquisition unit 11 configured to acquire a control program for controlling the plant on the basis of sensor data from a sensor installed in the plant; a causal relationship extraction unit 12 configured to extract, from the control program, causal relationships between a plurality of signals that are used in the plant; a causal relationship specification unit 13 configured to specify the current state of the plurality of signals and compare the specified state and the extracted causal relationships to specify a causal relationship corresponding to the specified state; and a display unit 14 configured to display the specified causal relationship on a screen.

Embodiments of a software defined automation system that provides a reference architecture for designing, managing and maintaining a highly available, scalable and flexible automation system. In some embodiments, an SDA system can include a localized subsystem including a system controller node and multiple compute nodes. The multiple compute nodes can be communicatively coupled to the system controller node via a first communication network. The system controller node can manage the multiple compute nodes and virtualization of a control system on a compute node via the first communication network. The virtualized control system includes virtualized control system elements connected to a virtual network that is connected to a second communication network to enable the virtualized control system elements to control a physical control system element via the second communication network connected to the virtual network.

Transaction-enabled systems and methods for royalty apportionment and stacking are disclosed. An example system may include a plurality of royalty generating elements (a royalty stack) each related to a corresponding one or more of a plurality of intellectual property (IP) assets (an aggregate stack of IP). The system may further include a royalty apportionment wrapper to interpret IP licensing terms and apportion royalties to a plurality of owning entities corresponding to the aggregate stack of IP in response to the IP licensing terms and a smart contract wrapper. The smart contract wrapper is configured to access a distributed ledger, interpret an IP description value and IP addition request, to add an IP asset to the aggregate stack of IP, and to adjust the royalty stack.