The present disclosure relates to manufacturing a pharmaceutical compound according to a manufacturing process. The manufacturing process comprises process parameters and rules that use the process parameters as literals. A control system determines a partition of the rules into subsets of rules, each being independent from the other subsets of rules in relation to the literals used in the rules. The controller creates simplified representations of the manufacturing process, which comprise the literals from a corresponding subset of rules and are created by eliminating literals used by other subsets of rules. The controller checks compliance of the manufacturing process based on the simplified representations of the manufacturing process by comparing values of the literals of a current process execution against literals in the simplified representations and adjusts the manufacturing process where the comparing identifies a difference. The controller repeats the steps of checking and adjusting until no differences are identified.