A system and method for providing automatic setup of a remote patient care environment. Connectivity to a centralized server over a network connection is confirmed. Data reporting for a patient by one or more monitoring devices that are wirelessly connectable is induced through control provided through a user interface. Each of the devices is registered as the device attempts to establish a wireless connection and report the data conditioned on permission for access. Upon granting of the permission for access, the device is wirelessly connected and the data is subsequently received over the wireless connection.

A technique for updating road maps is disclosed. A number of GPS traces can be matched with a number of roads in a map. Matched GPS traces may be processed by a matched segment module to produce proposed changes to the map. The map can be updated using a map updating module based on the proposed changes from the matched segment module. Unmatched GPS traces may be processed by an unmatched segment module to produce proposed changes to the map. The map can be updated using a map updating module based on the proposed changes from the unmatched segment module. The proposed changes to the map may include metadata defining new roads in the map, new intersections in the map, updates to turn restrictions in the map, updates to the allowable directional traffic flow on the roads within the map, updates to road closures in the map.

The present invention relates to a fresh water acute criteria prediction method based on a quantitative structure-activity relationship for metals. An unknown toxic endpoint of a metal is predicted according to a quantitative relationship between structural characteristics of heavy metal ions and acute toxicity effects of aquatic organisms, and hazard concentrations for protecting the aquatic organisms of different proportions are derived from sensitivity distribution analysis on different species. The fresh water acute criteria prediction method is a method for establishing a metal toxicity predictive model by integrating physicochemical structural parameters of heavy metals and toxic mechanisms of different aquatic organisms and applying the metal toxicity predictive model to prediction of an unknown criteria reference value.

A laboratory system is disclosed. The laboratory system comprises a plurality of laboratories comprising one or more analytical instruments for performing a plurality of analytical tests (T1-n) and providing analytical test results (TR1-n) and a remote computer communicatively connected to the laboratories. Each of the laboratories is configured to define test result validation criteria (C1-n) for validating at least one of the analytical test results (TR1-n) associated with the respective analytical tests (T1-n) of one of the plurality of laboratories. The remote computer is configured to define a plurality of profiles (P1-n) of validation criteria, to assign the profiles (P1-n) of test result validation criteria (C1-n) to one or more of the laboratories (102), and to perform an automatic validation of groups (G1-n) of the analytical test results (TR1-n) according to the profiles (P1-n) of test result validation criteria (C1-n).

Measuring of the binding of a transcription factor (using, for example, chromatin immunoprecipitation) according to the present invention is provides an improved marker for a disease. These markers can be used in diagnostics for diseases where a transcription factor binding event plays a role. Additionally, they can be used to adjust disease risk profiles for healthy individuals as with typical genetic variants.

Systems in a flow cytometer having an interrogation zone and illumination impinging the interrogation zone include: a lens subsystem including a collimating element that collimates light from the interrogation zone, a light dispersion element that disperses collimated light into a light spectrum, and a focusing lens that focuses the light spectrum onto an array of adjacent detection points; a detector array, including semiconductor detector devices, that collectively detects a full spectral range of input light signals, in which each detector device detects a subset spectral range of the full spectral range of light signals; and a user interface that enables a user to create a set of virtual detector channels by grouping detectors in the detector array, such that each virtual detector channel corresponds to a detector group and has a virtual detector channel range including the sum of subset spectral ranges of the detectors in the corresponding detector group.

A system includes a processor configured to determine that a first user will transition from a first climate-controllable environment to a second climate-controllable environment within a threshold time. The processor is also configured to compare first and second environment temperatures. The processor is further configured to detect whether a second-user control device is in communication with a second-environment climate control and set the second-environment climate control to a desired temperature, based on the first environment temperature, responsive to an absence of the second-user control device.

Systems and methods are described for controlling acquisition of sensor information, including: one or more physiological sensors and a computing device including a processor programmed to query the physiological sensors to measure one or more physiological parameters of an individual in response to at least one flag indicating a need to measure the one or more physiological parameters; receive a set of sensor values from the physiological sensors; assign a quality value to the set of sensor values received from the physiological sensors; retain the set of sensor values if the assigned quality value of the set of sensor values meets or exceeds a minimum quality value threshold; and update the at least one flag if the assigned quality value of the set of sensor values meets or exceeds the minimum quality value threshold.

The present invention provides methods for optimization of the harvest process by clarification of cell samples using centrifugation and depth filtration. The present invention provides methods for the determination of the optimal ratio of Q/ for the centrifugation step of a harvest process of a cell culture. The present invention provides methods for the determination of the number of particles and the size of the particles in the centrate of a centrifugation step of a harvest process of a cell culture by the use of imaging technology. The present invention provides methods for the scaling of the harvesting process from lab-bench scale to industrial scale.

Disclosed herein are methods of protein quantification and normalization using haloalkylated tryptophan fluorescence. Complex protein samples, i.e., samples that each contain 1,000 or more distinct proteins, from diverse sources that do not have common protein profiles are treated with a halo-substituted organic compound (i.e. haloalkane) that reacts with tryptophan residues to form fluorescent products. Irradiation of the samples with ultraviolet light and the detection and quantification of the resultant fluorescent emissions from all proteins in each sample are then used to obtain comparative values for total protein content among the various samples. The values thus obtained are found to be valid indications of comparative total protein content, despite the fact that the tryptophan levels vary widely among the various proteins in any single sample and the samples, due to the diversity of their origins, tend to differ among themselves in the identities and relative amounts of the proteins that they contain. Protein samples are also normalized to correct for differences in sample dilution, sample loading, and protein transfer inconsistencies, by using stain-free detection of total protein in each of the samples, or detection of subsamples within each sample.