The present invention provides compositions and methods for reducing inflammation in the lungs of a mammal that is afflicted by a condition that leads to inflammation in the lungs. The compositions and methods described herein include agents that inhibit inflammasome signaling in the mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s).

The present invention provides compositions and methods for reducing inflammation in the lungs of a mammal that is afflicted by a condition that leads to inflammation in the lungs. The compositions and methods described herein include agents that inhibit inflammasome signaling in the mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s).

Systems and methods are described to enable the inclusion of customized audio messages into packages for physical items. Specifically, embodiments of the present disclosure enable a user, in connection with an order to physical items, to record an audio message (e.g., a gift message) to be played back on the opening of a package including the physical items. The recorded audio message can be encoded into audio data at a user computing device and transmitted over a network to a fulfillment processing system associated with the order. The fulfillment processing system can encode the audio data into a playback device included within a package of the ordered items. The playback device may include one or more sensors (such as mechanical switches, light sensors, etc.) that notify the playback device when the package is opened. The playback device can then output the audio message to a receiving party.

Systems and methods are described to enable the inclusion of customized audio messages into packages for physical items. Specifically, embodiments of the present disclosure enable a user, in connection with an order to physical items, to record an audio message (e.g., a gift message) to be played back on the opening of a package including the physical items. The recorded audio message can be encoded into audio data at a user computing device and transmitted over a network to a fulfillment processing system associated with the order. The fulfillment processing system can encode the audio data into a playback device included within a package of the ordered items. The playback device may include one or more sensors (such as mechanical switches, light sensors, etc.) that notify the playback device when the package is opened. The playback device can then output the audio message to a receiving party.

The present invention provides compositions and methods for reducing inflammation in the lungs of a mammal that is afflicted by a condition that leads to inflammation in the lungs. The compositions and methods described herein include agents that inhibit inflammasome signaling in the mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s).

A railway crossing programmable device includes a communication module in signal communication with a central server for authentication of a user to use the programmable device to modify the railway system circuit. The programmable device further includes a circuit modification module configured for electrical coupling to a railway system circuit for modifying an electrical connection of the railway system circuit in a programmed manner. The programmable device further includes a user interface configured to receive user data and display output information related to at least one of a user, a device, and a circuit modification.

A railway crossing programmable device includes a communication module in signal communication with a central server for authentication of a user to use the programmable device to modify the railway system circuit. The programmable device further includes a circuit modification module configured for electrical coupling to a railway system circuit for modifying an electrical connection of the railway system circuit in a programmed manner. The programmable device further includes a user interface configured to receive user data and display output information related to at least one of a user, a device, and a circuit modification.

The present invention relates to a record player with a cabinet, a speaker, a movement base-plate, and a movement, wherein the cabinet contains a first opening and a second opening, the first opening being positioned on a side surface, a bottom surface or a top surface of the cabinet, and the second opening being positioned on the top surface of the cabinet; the speaker is positioned at the first opening and is electrically connected to the movement; and the movement base-plate is positioned at the second opening and includes a recessed part in which the movement is placed. The record player of the present invention includes a built-in speaker and a good resonance chamber formed therein, therefore the sound quality played by the record player can be effectively improved.

The present invention relates to a record player with a cabinet, a speaker, a movement base-plate, and a movement, wherein the cabinet contains a first opening and a second opening, the first opening being positioned on a side surface, a bottom surface or a top surface of the cabinet, and the second opening being positioned on the top surface of the cabinet; the speaker is positioned at the first opening and is electrically connected to the movement; and the movement base-plate is positioned at the second opening and includes a recessed part in which the movement is placed. The record player of the present invention includes a built-in speaker and a good resonance chamber formed therein, therefore the sound quality played by the record player can be effectively improved.

The present invention relates to a record player with a cabinet, a speaker, a movement base-plate, and a movement, wherein the cabinet contains a first opening and a second opening, the first opening being positioned on a side surface, a bottom surface or a top surface of the cabinet, and the second opening being positioned on the top surface of the cabinet; the speaker is positioned at the first opening and is electrically connected to the movement; and the movement base-plate is positioned at the second opening and includes a recessed part in which the movement is placed. The record player of the present invention includes a built-in speaker and a good resonance chamber formed therein, therefore the sound quality played by the record player can be effectively improved.