Chromatography columns for the purification of eluates from .sup.68Ge/.sup.68Ga generators comprising silica as stationary phase and purification processes that use said columns are described.

The present disclosure relates in general to nuclear medicine and generators for the production of radiopharmaceuticals for medical use. In particular, present disclosure relates to a generator column that resists high heat such as depyrogenation and sterilization. This allows some steps of the preparation of the column to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present disclosure further describes methods for the preparation of a generator where a parent radioisotope is charged on the column matrix before or after the matrix is loaded in the column.

The present invention relates to assemblies and method for obtaining a container comprising .sup.212Pb on the walls obtained from a .sup.212Pb precursor isotope source. The invention provides an improved system and method for producing .sup.212Pb high purity without the need for processing, with high yields, and which safely and efficiently can be transported to the locations where it is to be used.

Embodiments of the present invention provide for assessing the state of an .sup.82Rb elution system. In certain embodiments, a system begins an assessment that comprises an elution, and a metric may be measured. This metric may be a concentration of .sup.82Rb, .sup.82Sr, or .sup.85Sr in a fluid that is eluted from the generator, the volume of the fluid that is eluted from the generator, or the pressure of the fluid flowing through at least one portion of the system. If the assessment is completed, an output may be generated on a user interface that recommends a course of action, or no course of action, based on a result of the assessment. Should the assessment not complete successfully because it is interrupted, a .sup.82Sr/.sup.82Rb generator of the system may be halted so as to prevent a user from performing an end-run around these quality control mechanisms of the .sup.82Rb elution system.

The present disclosure relates in general to nuclear medicine and generators for the production of radiopharmaceuticals for medical use. In particular, present disclosure relates to a generator column that resists high heat such as depyrogenation and sterilization. This allows some steps of the preparation of the column to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present disclosure further describes methods for the preparation of a generator where a parent radioisotope is charged on the column matrix before or after the matrix is loaded in the column.

The actinium generator described herein is based on peroxide precipitation of thorium from its daughter products radium and actinium. In this system, the “actinium generator” is a quantity of solid thorium peroxide stored under a cover solution. The thorium peroxide is stored as a suspension to allow for the buildup of the decay products radium and actinium in the suspension. The suspension is then treated with a peroxide solution and the solid and liquid phases are separated. The thorium remains in the solid peroxide form while the soluble actinium and radium are removed with the liquid phase in a rinsing step. After rinsing, an amount of the rinsing solution is retained with the thorium peroxide solid as a fresh cover solution to form another suspension for storage. This new suspension is then stored to allow actinium and radium to again build up in the suspension for a subsequent separation cycle.

Provided herein are the safety features for radiopharmaceutical infusion system for treatment or diagnostic purpose, wherein infusion system comprises a controller, a source of radiopharmaceutical including other components. The controller is configured to perform automated quality control steps at the start of the system during daily quality control and ensure that system complies to desired technical attributes prior to administration to patients. The quality control steps comprise calibration, breakthrough testing, checking for unauthorized connection and/or malware in the system, network or other connected devices.

In one aspect, the technology relates to a method of producing Ac, the method including preparing a phosphate-modified titania material to produce an ion-exchange material, contacting a solution including .sup.229Th with the ion-exchange material to produce a Th-loaded titania material, eluting the Th-loaded titania material with a wash solution to produce an eluted solution containing eluted compounds including .sup.225Ac, concentrating the eluted solution to generate eluted compounds including the .sup.225Ac, and separating the .sup.225Ac from the eluted compounds.

An infusion system can include a radioisotope generator that generates a radioactive eluate via an elution, an activity detector configured to measure an activity of the radioactive eluate generated by the radioisotope generator, and a controller. The controller can analyze a radioactivity profile of the radioactive eluate to determine a characteristic of the profile indicative of breakthrough. The controller may issue a user alert, cease elution, or perform yet other actions based on the analysis.

An apparatus for producing Pb-212. The apparatus comprises an emanation box that comprises an emanation source comprising a porous non-reactive material. The emanation box receives at least one of Th-228 and Ra-224, wherein the at least one of Th-228 and Ra-224 decays to Rn-220 within the emanation box. The apparatus further includes a carrier gas feed coupled to the emanation box. The carrier gas feed directs an inert gas into the emanation box and the inert gas carries the Rn-220 out of the emanation box through a carrier gas exit port of the emanation box. The apparatus also includes one or more Rn-220 targets coupled to the carrier gas exit port. The carrier gas carries the Rn-220 from the emanation box to the one or more Rn-220 targets and the Rn-220 decays into Pb-212 within the one or more Rn-220 targets. The Pb-212 is directed into the Pb-212 collection container.