A method for producing a radionuclide comprises irradiating a target material with a linear accelerator to produce a radionuclide, dissolving the irradiated target material comprising the radionuclide, and separating the radionuclide from the irradiated target material. Additional methods are disclosed.

Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.

The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.

A method for producing Pb-212 and Ac-225 isotopes is disclosed. The method comprises irradiating a Ra-226 containing target with charged particles and/or photons for producing at least Ac-225 isotopes and Ac-224 isotopes. The method further comprises after a cooling time, applying chromatography for separating actinium from the remaining fraction containing radium. The method also comprises, after a first further waiting time, applying extraction chromatography using a resin having an 18-crown-6 ether or an equivalent of an 18-crown-6 ether, as extractant in HNO3 and/or HCl for separating Pb from the remaining fraction containing radium.

An irradiation target system having an irradiation target with at least one annular plate defining a central opening and including an elongated body, a flange portion, and a tab portion, wherein the flange portion extends beyond a first end of the plurality of plates, a target debundling tool, having a base plate, a gripper assembly affixed to the base plate, and a twister assembly including a housing defining a target bore configured to receive the target therein, and a slide portion that is slidably and non-rotatably mounted to the housing at a bottom end of the target bore.

The embodiments of the present disclosure provide a method for producing Ac-225 from Ra-226, comprising submitting Ra-226 to a photo-nuclear process, collecting an electrochemical precipitation of an Ac-225 on a cathode in a recipient, removing the cathode from the recipient after the electrochemical precipitation of the Ac-225, transferring the cathode to a hot cell environment, and extracting the Ac-225 from the cathode in the hot cell environment. The Ra-226 may comprise a liquid solution in the recipient, and submitting Ra-226 to the photo-nuclear process may comprise irradiating the Ra-226 to produce Ra-225. The Ra-225 may decay into Ac-225 upon irradiation of the Ra-226.

The actinium generator described herein is based on peroxide precipitation of thorium from its daughter products radium and actinium. In this system, the “actinium generator” is a quantity of solid thorium peroxide stored under a cover solution. The thorium peroxide is stored as a suspension to allow for the buildup of the decay products radium and actinium in the suspension. The suspension is then treated with a peroxide solution and the solid and liquid phases are separated. The thorium remains in the solid peroxide form while the soluble actinium and radium are removed with the liquid phase in a rinsing step. After rinsing, an amount of the rinsing solution is retained with the thorium peroxide solid as a fresh cover solution to form another suspension for storage. This new suspension is then stored to allow actinium and radium to again build up in the suspension for a subsequent separation cycle.

Provided herein are methods of isolating and using radioactive mercury. In particular, provided herein are methods of isolating radioactive mercury including the use of a thiacrown ether, and using the isolated radioactive mercury in therapeutic and/or imaging applications.

In one aspect, the technology relates to a method of producing Ac, the method including preparing a phosphate-modified titania material to produce an ion-exchange material, contacting a solution including .sup.229Th with the ion-exchange material to produce a Th-loaded titania material, eluting the Th-loaded titania material with a wash solution to produce an eluted solution containing eluted compounds including .sup.225Ac, concentrating the eluted solution to generate eluted compounds including the .sup.225Ac, and separating the .sup.225Ac from the eluted compounds.

An apparatus including a heating element and a sublimation vessel disposed adjacent the heating element such that the heating element heats a portion thereof. A collection vessel is removably disposed within the sublimation vessel and is open on an end thereof. A crucible is configured to sealingly position a solid mixture against the collection vessel.