Disclosed are embodiments directed to a multi-ion identification device, a system and method using the same to utilize chemical ionization in multiple adduct formation from the substances in the sampled gas of a gas sample being addressed to be analyzed in a mass analyzer. The multi-ion identification device includes a buffering region to have the sample flow turbulence decayed before the sample flow entrance to the ionization region)) utilizing chemical ionization by reagents from an ensemble of reagent ion towers.

An ion source includes an electron generator, an ionization chamber, and a magnetic field. The electron generator is configured to produce electrons. The ionization chamber has an electron entrance aperture through a first wall, an ion exit aperture through a second wall, and an axis. The ionization chamber is configured to produce ions. The magnetic field is arranged to confine electrons in a beam directed through the electron entrance aperture, in a direction within 45 degrees of parallel to the axis, and towards a location displaced from the ion exit aperture.

Certain configurations of plasma discharge chambers and plasma ionization sources comprising a plasma discharge chamber are described. In some examples, the discharge chamber comprises a conductive area and is configured to sustain a plasma discharge within the discharge chamber. In other examples, the discharge chamber comprises at least one inlet configured to receive a plasma gas and at least one outlet configured to provide ionized analyte from the discharge chamber. Systems and methods using the discharge chambers are also described.

The invention generally relates to systems and methods for conducting reactions and screening for reaction products.

The invention relates to a chemical ionisation method, in particular an adduct ionisation method, for ionising a sample including analytes to be ionised, wherein ligand compound ions formed from reactant ions and a dopant substance are made available in a reaction volume (2), wherein said sample with said analytes is introduced into said reaction volume (2) to react with said ligand compound ions to form adduct ions and a neutral byproduct, said adduct ions including ionised analytes being adducts of said reactant ions and the respective said analytes, wherein said reactant ions and said dopant substance provide a higher binding energy when binding together to said ligand compound ions than a binding energy said reactant ions and a ligand forming substance provide when binding together, wherein said ligand forming substance is present at least in traces in said reaction volume (2) when said sample with said analytes react with said ligand compound ions to form said adduct ions and said neutral byproduct. Furthermore, the invention relates to An ion molecule reactor (1) for ionising a sample including analytes to be ionised with the chemical ionisation method according to one of claims 1 to 11, in particular for use with a mass spectrometer (100), including: a reaction volume (2) adapted for ionising inside said reaction volume (2)said sample including said analytes to be ionised by chemical ionisation, in particular adduct ionisation, wherein inside of said reaction volume (2) ligand compound ions formed from reactant ions and a dopant substance can be made available to react with said sample including said analytes to form adduct ions and a neutral byproduct, said adduct ions including ionised analytes being adducts of said reactant ions and the respective said analytes, at least one sample inlet (4) for introducing said sample including said analytes into said reaction volume (2); at least one reactant inlet (5, 6) for introducing at least one substance into said reaction volume (2) for making said ligand compound ions available inside said reaction volume (2); and an outlet (7) for letting out said adduct ions from said reaction volume (2).

The present invention relates to an interface unit which can be used in a laser ablation-direct analysis in real time-mass spectrometry (LA-DART-MS) system, and more particularly, provides an interface unit which can be disposed between a DART unit and an MS unit to improve detection sensitivity of a sample laser-ablated by a laser beam.

A mass spectrometry device that is provided with an ionization unit and ionizes, by the ionization unit, a sample separated by a separation column, subjects the sample to mass separation and detect ions obtained in the mass separation, includes: a gas introduction unit that introduces a first gas obtained by vaporizing a liquid into the ionization unit using a second gas, wherein: the ionization unit ionizes the sample by reacting ions obtained by ionizing the first gas with the sample.

The invention generally relates to systems and methods for conducting reactions and screening for reaction products.

The present invention relates to a reaction chamber (12) for an IMR-MS apparatus or a PTR-MS apparatus, comprising an essentially gaslight outer housing (14), comprising at least two ion lenses (16) with essentially constant orifice dimensions and/or at least two ion lenses (17) with different orifice dimensions arranged around the reaction region (20), and at least one at least partly gaslight sealing (19), characterized in that the ion lenses (16,17) are placed inside the essentially gaslight outer housing (14), wherein between at least two adjacent ion lenses (16,17) an at least partly gaslight sealing (19) is mounted, wherein the room between at least other two ion lenses (16, 17) is such to allow a gas flow through said room from the reaction region (20) into the outer space (21). The present invention further relates to a method to operate an apparatus according to the invention.

A method for determining in a sample, by mass spectrometry, the amount of one or more analytes selected from the group consisting of N-acetylthreonine, TMAP, phenylacetylglutamine, tryptophan, creatinine, meso-erythritol, arabitol, myo-inositol, N-acetyl serine, N-acetylalanine, 3-methylhistidine, trans-4-hydroxyproline, kynurenine, urea, C-glycosyltryptophan, 3-indoxyl sulfate, pseudouridine, and combinations thereof is described. The method comprises subjecting the sample to an ionization source under conditions suitable to produce one or more ions detectable by mass spectrometry from each of the one or more of the analytes; measuring, by mass spectrometry, the amount of the one or more ions from each of the one or more analytes; and using the measured amount of the one or more ions to determine the amount of each of the one or more analytes in the sample. Also described is a kit comprising one or more isotopically labeled analogues as internal standards for each of the one or more analytes.