The present disclosure relates to an integrated package having an active area, an electrical routing circuit, an optical routing circuit, and a vacuum vessel. Methods of making such a package are also described herein.

The present disclosure relates to an integrated package having an active area, an electrical routing circuit, an optical routing circuit, and a vacuum vessel. Methods of making such a package are also described herein.

The invention relates to a mass spectrometer, comprising an ion guide having a plurality of electrodes that are supplied with a radio frequency voltage to facilitate radial confinement of ions in an internal volume defined by inward facing surfaces of the electrodes, the internal volume including a first section having a variable radial diameter along a longitudinal axis of the ion guide, in which the electrodes are helically wound, and an adjacent second section having a substantially constant radial diameter along the longitudinal axis, wherein the electrodes extend from the first section to the second section continuously. The continuous nature of the ion guide electrodes facilitates in particular unhindered axial propagation of ions through the assembly and prevents ion losses during their transmission through different compartments of the mass spectrometer.

The invention relates to a mass spectrometer, comprising an ion guide having a plurality of electrodes that are supplied with a radio frequency voltage to facilitate radial confinement of ions in an internal volume defined by inward facing surfaces of the electrodes, the internal volume including a first section having a variable radial diameter along a longitudinal axis of the ion guide, in which the electrodes are helically wound, and an adjacent second section having a substantially constant radial diameter along the longitudinal axis, wherein the electrodes extend from the first section to the second section continuously. The continuous nature of the ion guide electrodes facilitates in particular unhindered axial propagation of ions through the assembly and prevents ion losses during their transmission through different compartments of the mass spectrometer.

A system for testing the chemical content of a plurality of plastic containers continuously moving along a test line. The system includes a detector maintained at a first vacuum level for sequentially receiving a sample of air from each of the plurality of plastic containers as they move along the test line and for detecting the chemical content of each of the samples. There is a conduit including a first end proximate the plurality of plastic containers and a second, remote end. There is a sensor module interfacing the conduit between its first end and the second ends. There is also a vacuum pump interconnected to the second end of the conduit to maintain the interior of the conduit at a second, lower vacuum level and to establish an airflow rate to sequentially withdraw and transport air samples from the plastic containers to the sensor module.

A system for testing the chemical content of a plurality of plastic containers continuously moving along a test line. The system includes a detector maintained at a first vacuum level for sequentially receiving a sample of air from each of the plurality of plastic containers as they move along the test line and for detecting the chemical content of each of the samples. There is a conduit including a first end proximate the plurality of plastic containers and a second, remote end. There is a sensor module interfacing the conduit between its first end and the second ends. There is also a vacuum pump interconnected to the second end of the conduit to maintain the interior of the conduit at a second, lower vacuum level and to establish an airflow rate to sequentially withdraw and transport air samples from the plastic containers to the sensor module.

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

A mass spectrometer is disclosed comprising a rotatable isolation valve 1 having a curved, spherical, cylindrical or concave portion. At least a portion of an ion guide 2 is positioned so as to extend within a swept volume of the isolation valve 1 enabling the ion guide 2 to be positioned close to a second downstream ion guide 3 and for ions to be transmitted from the first 2 ion guide to the second ion guide 3 with high ion transmission efficiency.

A mass spectrometer is disclosed comprising a rotatable isolation valve 1 having a curved, spherical, cylindrical or concave portion. At least a portion of an ion guide 2 is positioned so as to extend within a swept volume of the isolation valve 1 enabling the ion guide 2 to be positioned close to a second downstream ion guide 3 and for ions to be transmitted from the first 2 ion guide to the second ion guide 3 with high ion transmission efficiency.