The invention generally relates to logical operations in mass spectrometry. The system comprising a mass spectrometer comprising one or more ion traps; and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply one or more scan functions to the one or more ion traps, the scan functions being combine together.

The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.

A method for multiple transition monitoring of at least one analyte in a sample using a quadrupole mass analyzer is provided and comprises at least one voltage application step, wherein a direct current (DC) voltage and a radio frequency (AC) voltage are applied between two pairs of electrodes of at least one mass filter of the analyzer, wherein the AC voltage has an amplitude V.sub.AC and the DC voltage has an applicable voltage V.sub.DC, wherein a supplementary AC voltage is superimposed on top of the AC and the DC voltage, wherein an amplitude ΔV.sub.DC of the supplementary AC voltage is

[00001]$\le \frac{V_{\mathrm{DC},\max }}{2^{b+1}},$

wherein V.sub.DC,max is a maximum voltage output of the DC voltage and b is a bit size of at least one electronics board of the mass filter of the analyzer; and wherein at least one transition of the analyte is determined with at least one detector of the analyzer.

The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.

There is provided a method of operating a charge detection mass spectrometer (CDMS), the CDMS comprising an electrostatic ion trap, the electrostatic ion trap comprising a plurality of electrodes, the method comprising: a) introducing a first ion into the electrostatic ion trap at a first ion energy, b) setting the voltage of the plurality of electrodes to a first voltage map, c) obtaining first CDMS data indicative of a first ion oscillation frequency, d) obtaining an acceptable range or ranges of ion oscillation frequencies, e) changing the first ion energy to a second ion energy and/or changing the first voltage map to a second voltage map, and f) obtaining second CDMS data indicative of a second ion oscillation frequency.

An analytical device includes: a mass spectrometry unit that separates ions based on flight time and detects the ions having been separated; an analysis unit that creates data corresponding to a spectrum in which an intensity of the ions having been detected and the flight time or m/z corresponding to the flight time are associated; a peak width calculation unit that calculates a first peak width at a first intensity and a second peak width at a second intensity different from the first intensity for at least one peak in the spectrum; and an adjustment unit that performs an adjustment of the mass spectrometry unit based on the first peak width and the second peak width.

A tuning system may acquire, from a mass spectrometer during a batch of one or more analytical runs performed with the mass spectrometer, tune data associated with an operating characteristic of the mass spectrometer. The tuning system may determine, based on the tune data, a value of an operating parameter configured to adjust the operating characteristic of the mass spectrometer and set the operating parameter to the determined value.

A multipole rod set of an ion guide is adapted to receive a radial RF trapping voltage and a radial dipole direct current DC voltage. A lens electrode of the ion guide is positioned at one end of the multipole rod set to extract ions from the multipole rod set and adapted to receive an axial trapping AC voltage and a DC voltage. A radial dipole DC voltage is applied to the multipole rod set and an axial trapping AC voltage is simultaneously applied to a lens electrode in order to extract a bandpass mass range of ions trapped in the multipole rod set. Alternatively, a radial RF trapping voltage amplitude is applied to the multipole rod set and an axial trapping AC voltage is simultaneously applied to the lens electrode in order to extract a bandpass mass range of ions trapped in the multipole rod set.

A method of mass spectrometry is disclosed involving scanning a parameter of a first device through which a mixture of components is passed. Different components are transmitted through or produced in the first device at different values of the parameter and hence scanning the device parameter introduces a temporal modulation or profile to the components. This temporal variation is then removed prior to mass analysing the components through a process of homogenisation.

The present invention discloses a method for authentication of animal species origin of leather products, which includes the following steps: Step 1: Model establishment: (1) Collect leather samples from different animal species origins, set mass spectrometric parameters, cut the surface of leather samples using a preheated electric soldering iron, and detect the resulting sample ions using the mass spectrometer; (2) Create a multivariate statistical model based on principal component analysis and linear discriminant analysis of rapid evaporative ionization mass spectrometric data and evaluate the model with cross-validation tests; Step 2: Analysis of real leather samples: detect and authenticate the identity of real leather samples based on the multivariate statistical model. The authentication method disclosed in present invention is a rapid analytical method that requires no sample pretreatment and can identify the animal species origin of leather products rapidly and accurately.