An amplifying circuit includes a reference voltage generating circuit, a common-mode voltage conversion circuit, a common-mode negative feedback circuit, and an amplifying sub-circuit. The reference voltage generating circuit generates a first reference voltage, a second reference voltage, and a reference common-mode voltage according to a post-stage common-mode voltage. The common-mode voltage conversion circuit converts the pre-stage output differential signal into a differential input signal according to the reference common-mode voltage. The common-mode negative feedback circuit generates a control voltage to quickly establish a common-mode negative feedback of the amplifying sub-circuit, wherein the first reference voltage and the second reference voltage are used to cancel a baseline signal of the pre-stage output differential signal. The amplifying circuit can eliminate the baseline signal, convert the common-mode voltage and quickly establish the common-mode negative feedback.

An operational amplifier with totem pole connected output transistors having inputs coupled to multiplexers for selectable coupling of signals and voltage levels thereto. The high and low output transistors may be forced hard on or hard off in addition to normal coupling of signals thereto. The operation of the output transistors may be dynamically changed to pass only positive going signals, negative going signals, placed in a tristate high impedance state, hard connected to a supply voltage and/or hard connected to supply common return. A core independent peripheral (CIP) may also be coupled to the operational amplifier for dynamically changing the multiplexer inputs in real time, as can external control signals to a control circuit coupled to the multiplexers.

An electronic circuit comprises an input stage, a gain stage operatively coupled to the input stage, a primary output stage operatively coupled to the gain stage, a replica output stage operatively coupled to the gain stage in parallel to the primary output stage, and a clock circuit. The clock circuit operates the electronic circuit in multiple phases including a sampling phase to disconnect the primary output stage and the replica output stage from the gain stage to obtain an offset voltage, an active phase to reconnect the primary output stage to apply the offset voltage to reduce an offset at the primary output stage, and an intermediate phase to first reconnect the replica output stage to the gain stage prior to the active phase.

An electronic circuit comprises an input stage, a gain stage operatively coupled to the input stage, a primary output stage operatively coupled to the gain stage, a replica output stage operatively coupled to the gain stage in parallel to the primary output stage, and a clock circuit. The clock circuit operates the electronic circuit in multiple phases including a sampling phase to disconnect the primary output stage and the replica output stage from the gain stage to obtain an offset voltage, an active phase to reconnect the primary output stage to apply the offset voltage to reduce an offset at the primary output stage, and an intermediate phase to first reconnect the replica output stage to the gain stage prior to the active phase.

A radio frequency receiving circuit, including: a tail current source, configure to be multiplexed to input radio frequency signals and amplify the radio frequency signals for producing a radio frequency current; a clock signal input unit, in connection with the tail current source and configured to input clock signals; a sampling-and-holding unit, in connection with the clock signal input unit and configured to output an orthogonal signal having a frequency of one half of a clock frequency; and a load unit, in connection with the sampling-and-holding unit. The radio frequency current flowing through the load unit is converted into a voltage which is modulated by the orthogonal signal, and a medium frequency signal having a frequency equivalent to a difference between a radio frequency signal frequency and an orthogonal signal frequency is output, whereby achieving the frequency mixing.

A semiconductor amplifier circuit comprising an input block adapted for receiving a voltage signal to be amplified, an integrator circuit having an integrating capacitor providing a continuous-time signal representative for the integral of the voltage signal, a first feedback path comprising: a sample-and-hold block and a first feedback block, the first feedback path providing a proportional feedback signal upstream of the current integrator. The amplification factor is larger than 1 for a predefined frequency range. Charge stored on the integrating capacitor at the beginning of a sample period is linearly removed during one single sampling period in such a way that the absolute value of the charge is smaller at the end of the sampling period than at the beginning of the sample period when the voltage signal to be amplified is equal to zero.

The present invention provides monoclonal antibodies that bind to the Factor XII (FXII) protein, and methods of use thereof. In various embodiments of the invention, the antibodies are fully human antibodies that bind to FXII and to the activated form of FXII (FXIIa). In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing FXII activity, thus providing a means of treating or preventing a disease, disorder or condition associated with thrombosis in humans.

An amplifying circuit includes a reference voltage generating circuit, a common-mode voltage conversion circuit, a common-mode negative feedback circuit, and an amplifying sub-circuit. The reference voltage generating circuit generates a first reference voltage, a second reference voltage, and a reference common-mode voltage according to a post-stage common-mode voltage. The common-mode voltage conversion circuit converts the pre-stage output differential signal into a differential input signal according to the reference common-mode voltage. The common-mode negative feedback circuit generates a control voltage to quickly establish a common-mode negative feedback of the amplifying sub-circuit, wherein the first reference voltage and the second reference voltage are used to cancel a baseline signal of the pre-stage output differential signal. The amplifying circuit can eliminate the baseline signal, convert the common-mode voltage and quickly establish the common-mode negative feedback.

A main amplifier generates an output signal S.sub.OUT according to a difference between first and second voltages VP and VN. A first gm amplifier is arranged as a differential input stage. A second, fully differential, gm amplifier amplifies a voltage difference between its non-inverting and inverting input terminals, and outputs a differential current signal I.sub.3N/I.sub.3P via its inverting and non-inverting output terminals. An integrator integrates a differential input current I.sub.4P/I.sub.4N input via its non-inverting and inverting input terminals, and samples and holds the signal every predetermined period, to generate a differential voltage signal. A first selector is arranged as an upstream stage of the second gm amplifier, and outputs the differential input signal without change or otherwise after swapping. A second selector is arranged as a downstream stage of the second gm amplifier, and outputs the signal I.sub.3N/I.sub.3P output from the second gm amplifier without change or otherwise after swapping.

A sample and hold amplifier includes an input node for receiving an input current signal, a non-linear sampling capacitor circuit having an input coupled to the input node, an operational amplifier having a negative input coupled to an output of the non-linear sampling capacitor circuit, a positive input coupled to ground, and an output for providing a sample and hold voltage signal, and a linear capacitor coupled between the negative input and the output of the operational amplifier. The non-linear sampling capacitor includes a non-linear capacitor coupled between an intermediate node and ground, a first switch coupled between the input and the intermediate node configured to switch according to a first phase signal, and a second switch coupled between the output and the intermediate node configured to switch according to a second phase signal.