Systems and methods for detection of interconnected outputs of a power supply are provided. A first channel of a power supply is activated, such that power is supplied to a first load connected to the first channel. A first load voltage is measured for the first load. A second load voltage is measured for a second load connected to a second channel of the power supply. The second load voltage is compared to the first load voltage to generate an interconnection result. The power supply is shut down when the interconnection result indicates that the second load voltage matches the first load voltage, such that all channels of the power supply do not supply power to any load connected thereto.