Mycobacterial antigens, such as MAP and M. bovis antigens, are described. The antigens can be used in subunit compositions to elicit immune responses in order to prevent and/or control mycobacterial infections, as well as in diagnostics in order to detect mammals infected with mycobacteria.

The present invention provides isolated proteins isolatable from a Pasteurella spp. such as P. multocida. Also provided by the present invention are compositions that include one or more of the proteins, and methods for making and methods for using the proteins.

An antibacterial protein against Bacillus with the amino acid sequence as set forth in SEQ ID NO: 1 is disclosed. Also disclosed is a method of preparing an antibacterial protein against Bacillus. The method includes: culturing BL21-pBAD-BAL200 cells, the BL21-pBAD-BAL200 cells including a plasmid that comprising a sequence as set forth in SEQ ID NO: 2; inducing the expression of the antibacterial protein; and purifying the antibacterial protein.

The invention provides novel quinoline sulfonamide compounds of Formula I: ##STR00001##
and their use for the treatment or prevention of bacterial infections caused by both Gram positive and Gram negative bacteria such as, for example, infections caused by one or more bacteria from the Enterobactericeae, Staphylococcaceae, or Streptococcaceae families. The compounds described and claimed herein may be formulated in one or more pharmaceutical or veterinary compositions for use in animal husbandry, and in particular in relation to the treatment of mastitis by directly targeting mastitis causing bacteria in a bovine herd. In certain embodiments described herein the pharmaceutical or veterinary compositions are formulated as a spray for direct administration to the udder of the bovine animal such as a cow.

A guardian information-based animal integrated management server is proposed. The server may include a guardian information receiver receiving guardian information including at least one of a name, address, birth date, and sex of a guardian, and an animal receiver receiving animal information including at least one of a type, sex, photograph, and birth date of an animal corresponding to the guardian. The server may also include an electronic gift certificate providing processor providing an electronic gift certificate including at least one of a medical treatment and vaccination for the animal. The server may further include a medical treatment information receiver receiving medical treatment information regarding at least one of a medical treatment, surgery, vaccination, and prescription for the animal, and a medical treatment history managing processor matching a medical treatment history of the animal with the guardian information according to the received medical treatment information, and managing same.

Nanoparticles and formulations for non-surgical sterilization are disclosed herein. The nanoparticles for non-surgical sterilization contains a cage, such as a zeolitic imidazolate framework (“ZIF”), a surface modifying agent, a targeting ligand, and an active agent. The surface modifying agent is attached to the outer surface of the cage and the targeting ligand is exposed to the surrounding environment. The active agent is encapsulated in the cage. The targeting ligand binds to a reproductive hormone or a receptor of a reproductive hormone. The active agents can be a ribosome inactivating protein, an apoptosis inducer, a hormone, a receptor ligand, or a nucleic acid, or a combination thereof, that inactivates the ovaries or testes. Uses for the nanoparticles and formulations incorporating the nanoparticles for sterilizing a subject in need thereof are also disclosed.

Systems and methods are provided for controlling heat stress and accumulations in livestock using the application of water sprays onto the animal in conjunction with fan induced airflow. The system has a controller with sensor inputs of the ambient environment including temperature, humidity, wind speed, and surrounding surface temperature sensors and fan and spray control outputs. To achieve savings in water and electricity, a transient, one-dimensional simultaneous heat and mass transfer model of evaporation within the wetted fur layer of a dairy cow is used to estimate drying time and heat rejection rate based on ambient conditions along with a control algorithm to predict the fan speed and sprinkler operation frequency needed to meet specified cooling load thresholds given the outdoor conditions. Estimated savings demonstrated that the model-based controller could reduce annual electricity and water consumption by 20% and 40%, respectively.

The present invention refers to a system of environmental data collection, monitoring and behavioral analysis of animals on pasture, in a georeferenced environment using agrometeorological sensors, with the objective of spreading precision farming. The data generated is collected over a wireless network and stored in a database. The system is capable of analyzing the data of the various sensors to generate information on the cattle's behavior, and can also correlate them with environmental characteristics and data of the management area.

A structure for sheltering and cooling livestock may include a concrete floored barn having an improved evaporative cooling system. The cooling system may include a misting stack having air inlets, a mixing chamber, and three cooling zones wherein the cooling zones correspond to three different temperature ranges. Each of the cooling zones may include a plurality of nozzles which produce a mist. As air passes through the mixing chamber, the mist may evaporate and cool the air. The cooling system may further include a plurality of large exhaust fans located at an end of the barn distal from the misting stack. The fans may draw the cool air through the barn, over and around the livestock, and out of the barn.

Implantable devices, methods, and systems for using the implanted devices to monitor cattle are described herein.