A chemical modification process for a polymer component comprising at least one polymer comprising, as reactive groups, amine groups and/or hydroxyl groups, the process comprising a step of covalent reaction between some or all of the reactive groups and at least one functional compound comprising at least one group able to react in a covalent manner with said reactive groups, the functional compound(s) being selected from epoxide compounds, anhydride compounds, acyl halide compounds, silyl ether compounds and mixtures thereof, characterised in that the covalent reaction step is carried out in the presence of at least one supercritical fluid.

Proposed is a novel method for preparing liraglutide by means of an ionic liquid and a eutectic solvent, which are environment-friendly solvents. More specifically, the method is characterized in that fractionated peptide 1 represented by the following formula (1) and fractionated peptide 2 represented by the following formula (2) are subjected to a coupling reaction in the presence of an ionic liquid or a eutectic solvent. In preparing GLP-1 analogues such as liraglutide, the present method increases reactivity when producing liraglutide, which is an unprocessed reactant, by using an ionic liquid and a eutectic solvent as environment-friendly solvents instead of using organic solvents. Accordingly, through a relatively short and simple purification process, the present method has advantages of reducing the formation of related substances, improving purity, improving yields, shortening reaction times, reducing production cost, and lowering the manufacturing cost.

The invention relates to method for preparing a high-purity regenerated polysaccharide by precipitating a dissolved polysaccharide due to a reaction of the solvent with an organic carbonate, which is much more health-friendly, environmentally friendly and safer than conventional methods. Materials from the produced regenerated polysaccharide are also provided.

A method for reducing water production from a hydrocarbon bearing subterranean formation includes identifying a high permeability zone in the formation and injecting a dense CO.sub.2 composition from a production well into the high permeability zone. The dense CO.sub.2 composition includes dense CO.sub.2 and a thickener soluble in the dense CO.sub.2. The thickener includes a copolymer that is the polymerized reaction product of monomers that include at least one alkenyl ether or dialkenyl ether monomer, at least one acrylate or methacrylate monomer, at least one structural monomer, and at least one allyl ester monomer. After injecting the dense CO.sub.2 composition into the high permeability zone, the method includes withdrawing hydrocarbons from the hydrocarbon bearing subterranean formation through the production well. The dense CO.sub.2 composition blocks pores in the high permeability zone to reduce or prevent flow of water from the high permeability zone into the production well.

A Spiro compound serving as an ERK inhibitor, and an application thereof in preparing a drug for treating an ERK-related disease. The present invention specifically relates to a compound represented by formula (III) or a pharmaceutically acceptable salt thereof.

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An extraction system and method of extraction are described herein. The extraction system generally includes an extraction vessel including a vessel body, an extraction solvent inlet, a material inlet, and an outlet, a collection vessel operably connected to the outlet, a dispersion devise disposed proximate the extraction solvent inlet and including a first surface and a second surface, a plurality of openings formed in the dispersion device and extending from the first surface to the second surface, whereby the plurality of openings are adapted for the flow of an extraction solvent therethrough.

The invention relates to a method for producing an extract from cannabis plant matter, containing tetrahydrocannabinol, cannabidiol and optionally the carboxylic acids thereof. According to said method, the dried plant matter is ground and subjected to a CO.sub.2 extraction and the primary extract obtained is separated. The invention method permits Δ.sup.8 or Δ.sup.9 tetrahydrocannabinol to be selectively obtained both from industrial hemp and from drug-producing hemp, optionally after dissolving the primary extract in ethanol, separating undesirable waxes and removing the solvent under reduced pressure.

A process for treatment of nanoparticles of mineral filler for obtaining 5 processed nanoparticles for use in polymerization in the presence of nanopartciles which includes the steps of (a) drying a mineral filler with an inert gas for remove catalyst poisons; (b) mixing the mineral filler dried obtained in step (a) with a swelling agent in a liquid state or near a critical state or in the supercritical state; (c) subjecting the swelling agent of the 10 mixture obtained in step (b) to an endoenthalpic or isoentalphic phase change by altering the conditions of the temperature and/or pressure; (d) subjecting the nanoparticles of the mixture obtained in step (c) to contact of scavenging agent to react with catalyst poisons; then the mixture obtained in step (d) can be dried in a step (e) with an inert gas to remove sub-products 15 from scavenging agent and catalyst poisons to obtain the treated nanoparticles.

Apparatus for salt separation (2) under supercritical water conditions, comprising a heat exchanger (4) and a fluidized bed reactor (6). The fluidized bed reactor comprising a supercritical water pressure containing wall (8) defining therein a fluidized bed chamber (10) connected to an inlet system (16) at one end thereof and an outlet system (18) configured to separate solids from supercritical fluid at another end thereof. The fluidized bed chamber receives a fluidized bed (12) therein and is configured to receive through the inlet system (16) a liquefied aqueous substance (14) for treatment in the fluidized bed chamber. The inlet system (16) comprises an inlet chamber (20) and a fluidization plate (22) positioned between the inlet chamber (20) and the fluidized bed chamber (10). The fluidized bed chamber extends between the inlet system (16) and outlet system (18) and comprises an entry section (10a) adjacent the inlet system (16), an outlet section (10c) adjacent the outlet system (18), and a mid-section (10b) extending between the entry section and the outlet section. The heat exchanger (4) extends along the fluidized bed chamber (10) and is configured to generate a decreasing temperature gradient in the fluidized bed chamber from the outlet section (10c) to the entry section (10a), the temperature gradient in the outlet section and mid-section being supercritical for aqueous substances and being subcritical for aqueous substances in the entry section (10a) adjacent the fluidization plate (22).

Milk fat globule membrane (MFGM) phospholipid compositions, methods of preparing and using the MFGM phospholipid compositions, liposomes comprising the MFGM phospholipid compositions, and methods of preparing and using the liposomes comprising the MFGM phospholipid compositions. In various examples, a MFGM phospholipid composition is formed by sequential supercritical carbon dioxide (SC—CO.sub.2) extraction of a milk product and extraction of the remaining milk product with a polar compound-modified SC—CO.sub.2 extraction, where the extract is the MFGM. In various examples, the MFGM is used to prepare liposomes. In various examples, the liposomes are prepared by expansion of a supercritical solution comprising the MFGM composition. In various examples, the liposomes are used to administer a cargo, such as, for example, hydrophilic compound(s), hydrophobic compound(s), amphiphilic compound(s), or the like, any one or all of which may be therapeutic agent(s), nutrient(s), bioagent(s), or the like, or any combination thereof to a subject.