The protector includes a box-like metal housing formed of first and second housing parts connected by a spring-loaded hinge for movement between an open position, in which a seal associated with the vehicle cargo compartment door handle is exposed, and a closed position, in which the seal cannot be accessed. At least one of the housing parts is hollow and configured to accommodate the handle such that when the housing parts are in the closed position the seal is fully enclosed. A padlock may be used to lock the housing parts in the closed position such that the seal cannot be accidentally broken falsely indicating that the cargo compartment door has been opened during transit.