In accordance with one embodiment, a method for automatically coordinating droplets for optically controlled microfluidic systems, comprising using light to move one or a plurality of droplets simultaneously, applying an algorithm to coordinate droplet motions and avoid droplet collisions, and moving droplets to a layout of droplets. In another embodiment, a system for automatically coordinating droplets for optically controlled microfluidic systems, comprising using a light source to move one or a plurality of droplets simultaneously, using an algorithm to coordinate droplet motions and avoid droplet collisions, and using a microfluidic device to move droplets to a layout of droplets.

A fluidic system having a first volume, a second volume and a membrane geometrically separating the two volumes, which has an open-pore microstructure for the passage of a first medium and a second medium. There is a contact angle (Θ) between the interface of the media and the pore surface. A first electrical field in the region of the membrane and a first electromagnetic radiation and a first heating of the membrane define a first state (Z.sub.1), in which the membrane is not wetted or is less wetted by the first medium and is more heavily wetted by the second medium such that a first contact angle Θ.sub.1>90° is formed between the pore surface and the interface. The first medium and the second medium and the pore surface have a surface energy of which at least one surface energy can be reversibly changed in such a way that a second contact angle Θ.sub.2<Θ.sub.1 occurs between the pore surface and the interface in a second state (Z.sub.2).

A capsule is disclosed which includes a flexible outer shell capable of transforming into an asymmetric shape; an internal medium encapsulated by the outer shell, the medium including a plurality of magnetic particles, wherein the magnetic particles can move in response to an applied magnetic field. A valve system includes an in-line valve sized to fit within a flow channel including a capsule having a flexible outer shell containing an internal medium encapsulated by the outer shell, the medium including a plurality of magnetic particles; and a magnetic field source disposed about the exterior wall of the channel.

An ER fluid valve includes a housing and a plurality of parallel flow passages through the housing each defined by spaced electrodes at least one of which is controllable independently of other flow passages electrodes. A controller is configured to selectively establish electrical fields for all of the independently controllable electrodes to close all of the flow passages to ER fluid flowing through the housing. By removing the fields from all of the independently controllable electrodes, all the flow passages are open to the ER fluid flowing through the housing. By establishing fields for select independently controllable electrodes to close their associated flow passages and by leaving other flow passages open, restricted flow of the ER fluid through the housing is accomplished to vary the flow rate through the housing.

In accordance with one embodiment, a method for automatically coordinating droplets, beads, nanostructures, and/or biological objects for optically controlled microfluidic systems, comprising using light to move one or a plurality of droplets or the like simultaneously, applying an algorithm to coordinate droplet and/or other motions and avoid undesired droplet and/or other collisions, and moving droplets and/or others to a layout of droplets and/or others. In another embodiment, a system for automatically coordinating droplets and/or others for optically controlled microfluidic systems, comprising using a light source to move one or a plurality of droplets and/or others simultaneously, using an algorithm to coordinate droplet and/or other motions and avoid undesired droplet and/or other collisions, and using a microfluidic device to move droplets and/or others to a layout of droplets and/or others.

In accordance with one embodiment, a method for automatically coordinating droplets, beads, nanostructures, and/or biological objects for optically controlled microfluidic systems, comprising using light to move one or a plurality of droplets or the like simultaneously, applying an algorithm to coordinate droplet and/or other motions and avoid undesired droplet and/or other collisions, and moving droplets and/or others to a layout of droplets and/or others. In another embodiment, a system for automatically coordinating droplets and/or others for optically controlled microfluidic systems, comprising using a light source to move one or a plurality of droplets and/or others simultaneously, using an algorithm to coordinate droplet and/or other motions and avoid undesired droplet and/or other collisions, and using a microfluidic device to move droplets and/or others to a layout of droplets and/or others.

An apparatus for generating a pressure wave in a liquid medium is disclosed. The apparatus includes a plurality of pressure wave generators having respective moveable pistons, the pistons having respective control rods connected thereto. The apparatus also includes a plurality of transducers coupled to the liquid medium and means for causing the pistons of respective ones of the plurality of the pressure wave generators to be accelerated toward respective ones of the plurality of transducers. The apparatus further includes means for causing restraining forces to be applied to respective control rods to cause respective pistons to impact respective transducers at respective desired times and with respective desired amounts of kinetic energy such that the respective desired amounts of kinetic energy are converted into a pressure wave in the liquid medium.

A capsule is disclosed which includes a flexible outer shell capable of transforming into an asymmetric shape; an internal medium encapsulated by the outer shell, the medium including a plurality of magnetic particles, wherein the magnetic particles can move in response to an applied magnetic field. A valve system includes an in-line valve sized to fit within a flow channel including a capsule having a flexible outer shell containing an internal medium encapsulated by the outer shell, the medium including a plurality of magnetic particles; and a magnetic field source disposed about the exterior wall of the channel.

A microchip includes a channel permitting a sheath liquid to flow therethrough; and a microtube for introducing a sample liquid into a laminar flow of the sheath liquid flowing through the channel; wherein liquid feeding is performed in the condition where a laminar flow of the sample liquid introduced through the microtube is surrounded by the laminar flow of the sheath liquid.

An ER fluid valve includes a housing and a plurality of parallel flow passages through the housing each defined by spaced electrodes at least one of which is controllable independently of other flow passages electrodes. A controller is configured to selectively establish electrical fields for all of the independently controllable electrodes to close all of the flow passages to ER fluid flowing through the housing. By removing the fields from all of the independently controllable electrodes, all the flow passages are open to the ER fluid flowing through the housing. By establishing fields for select independently controllable electrodes to close their associated flow passages and by leaving other flow passages open, restricted flow of the ER fluid through the housing is accomplished to vary the flow rate through the housing.