Flexible artificial retina device
09731130 · 2017-08-15
Assignee
Inventors
Cpc classification
A61F2/14
HUMAN NECESSITIES
Y10T29/4913
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10T29/49155
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
H01L2924/13091
ELECTRICITY
H01L24/75
ELECTRICITY
H01L2924/00
ELECTRICITY
Y10T29/49144
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10T29/49117
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
H01L2924/00
ELECTRICITY
Y10T29/49126
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
International classification
Abstract
An implant apparatus comprising a plurality of photo sensors, a plurality of micro electrodes, a plurality of guard rings surrounding the micro electrodes and circuitry coupled to the photo sensors and the micro electrodes are described. The photo sensors may receive incoming light. The circuit may drive the micro electrodes to stimulate neuron cells for enabling perception of a vision of the light captured by the photo sensors. The guard rings may confine electric flows from the micro electrodes to the targeted neuron cells. The apparatus may be implemented in a flexible material to conform to a shape of a human eyeball to allow the micro electrodes aligned with the neuron cells for the stimulation.
Claims
1. An implant apparatus comprising: a plurality of photo sensors to receive light; a plurality of micro electrodes to stimulate neuron cells for enabling perception of a vision of the light captured by the photo sensors; a plurality of guard rings, each micro electrode surrounded by one of the guard rings to provide local return paths to confine electric flows from the electrode to targeted neuron cells, wherein the guard ring serves as a local return electrode corresponding to the micro electrode to prevent the electric flows from being toward undesired target directions; and circuitry coupled to the photo sensors and the micro electrodes, the circuitry to drive the micro electrodes for the stimulation of the neuron cells, wherein the apparatus is implemented in an integrated semiconductor device with a bendable flexibility to conform to a shape of a human eyeball and allow the micro electrodes in close proximity to the neuron cells for the stimulation.
2. The apparatus of claim 1, wherein each micro electrode is sized to target a small number of separate neuron cells.
3. The apparatus of claim 1, wherein the micro electrodes are distributed in a quasi-spherical geometry based on the shape of a human eyeball.
4. The apparatus of claim 1, wherein the semiconductor device includes an array of pixel units, and wherein each pixel unit includes one of the micro electrodes, one of the guard rings surrounding the one electrode, one of the photo sensors, and corresponding circuitry.
5. The apparatus of claim 4, wherein the array of pixel units comprises a microelectrode array having a density higher than 250 microelectrodes per square millimeter.
6. The apparatus of claim 4, wherein the device comprises layered structures including a semiconductor layer and metal interconnect layers, wherein the semiconductor layer includes the photo sensors and transistors for the circuitry, the micro electrodes coupled with the circuitry via the metal interconnect layers.
7. The apparatus of claim 6, wherein the semiconductor device has a front side and a back side opposite to the front side, wherein the semiconductor layer is positioned in the layered structure close to the front side of the semiconductor device and wherein the substrate layer is positioned in the layered structure close to a back side of the semiconductor device.
8. The apparatus of claim 7, wherein the semiconductor device allows the light to reach photo sensors in the semiconductor layer from the front side.
9. The apparatus of claim 7, wherein the micro electrodes are in contact with the neuron cells from the front side of the semiconductor device.
10. The apparatus of claim 7, wherein the micro electrodes are in contact with the neuron cells from the back side of the semiconductor device, wherein the layered structures include through-silicon vias to join the metal interconnect layer and the micro electrodes.
11. The apparatus of claim 1, wherein the photo sensors and the micro electrodes are arranged to face opposite sides of the semiconductor device and wherein the semiconductor is configured to allow the light to reach the photo sensors from one of the sides with the micro electrodes.
12. The apparatus of claim 11, wherein the substrate is thinned to allow the photo sensors to absorb the light through the substrate.
13. The apparatus of claim 12, wherein the substrate has a thickness of about less than 20 microns.
14. The apparatus of claim 1, wherein thickness of the semiconductor device is sized to allow the photo sensors to capture the light from either sides of the semiconductor device.
15. The apparatus of claim 1, wherein the stimulation is based on the electric flows from the electrodes to the neuron cells, and wherein the local return paths are provided based on low impedance current path selection.
16. The apparatus of claim 1, wherein the apparatus is suitable of being implanted within living tissues, and wherein the semiconductor device is sealed within biocompatible layers to provide bi-directional protection between the living tissues and the layered structures.
17. The apparatus of claim 16, wherein at least one of the micro electrodes include protruding tips over the biocompatible layer to increase proximity between the at least one electrodes and targeted neuron cells.
18. The apparatus of claim 17, wherein the protruding tips are arranged in one or more protruding layers of different heights above a surface of the semiconductor device to allow micro electrodes of different layers to access different layers of the neuron cells.
19. The apparatus of claim 4, wherein the circuitry includes a plurality of processing circuitry, each pixel unit including one of the plurality of processing circuitry, wherein the pixel units are arranged as a network with interconnects to allow processing circuitry of each pixel unit to derive a stimulus from the light received via the pixel unit and at least one other pixel unit of the network via the interconnects.
20. The apparatus of claim 19, wherein the pixel unit is associated with at least one neighboring pixel units according to the array and wherein the at least one other pixel units include the neighboring pixel units of the pixel unit.
21. An apparatus implementable to tissues including neuron cells, comprising: a plurality pixel units arranged in a two dimensional array to enable perception of a vision of light incoming to the pixel units, each pixel unit comprising a photo sensor to receive the light, a micro electrode to deliver a stimulus to targeted ones of the neuron cells for the perception, a guard ring surrounding the micro electrode to confine electric flows of the stimulus from the electrode to the targeted neuron cells, wherein the guard ring serves as a local return electrode corresponding to the micro electrode to prevent the electric flows from being toward undesired target directions, and circuitry to derive the stimulus from the light and drive the electrode, wherein the two dimensional array is arranged within a semiconductor device having a front surface and a back surface opposite to the front surface; and biocompatible layers wrapping the device to bi-directionally protect the device and the tissues, the biocompatible layers having openings to allow electrodes of the pixel units to stimulate the neuron cells, wherein the device comprises flexible material to allow the device to be bendable in a two dimension manner to conform to a shape of a human eyeball and wherein the flexible material is translucent to enable the device to receive the light from either the front surface or the back surface of the device.
22. The apparatus of claim 21, further comprising: a plurality perforation holes through the device to allow fluidic flow between the front surface and the back surface passing the perforation holes.
23. An integrated semiconductor device for retina prosthesis, the device comprising: an array of pixel units to enable perception of a vision of light, each pixel unit comprising a sensor to sense the light, an electrode to deliver a stimulus to targeted ones of neuron cells for the perception, a guard ring surrounding the electrode to provide local return paths to confine electric flows from the electrode to the targeted neuron cells, wherein the guard ring serves as a local return electrode corresponding to the micro electrode to prevent the electric flows from being toward undesired target directions, and circuitry to derive the stimulus from the light to drive the electrode, wherein the array of pixel units are arranged with a density of higher than 250 electrodes per square millimeter in the device, and wherein the device is bendable to allow the array of pixel units to conform to a radius of curvature of at least 12.5 millimeter according to a shape of a human eyeball.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) The present invention is illustrated by way of example and not limitation in the figures of the accompanying drawings, in which like references indicate similar elements and in which:
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DETAILED DESCRIPTION
(11) Retina chip assembly processes or non-planar (such as quasi-spherical) surface patches of (integrated) semiconductor chips and methods are described herein. In the following description, numerous specific details are set forth to provide thorough explanation of embodiments of the present invention. It will be apparent, however, to one skilled in the art, that embodiments of the present invention may be practiced without these specific details. In other instances, well-known components, structures, and techniques have not been shown in detail in order not to obscure the understanding of this description.
(12) Reference in the specification to “one embodiment” or “an embodiment” means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the invention. The appearances of the phrase “in one embodiment” in various places in the specification do not necessarily all refer to the same embodiment.
(13) In one embodiment, it is advantageous to have non-planar surfaces of integrated active devices, transistor circuits, transducers or micro systems, to change the geometry of interactions, interconnections among these devices, sub-systems, or interactions, interconnections with an external system, or external systems. Integrated devices with non-planar shapes or geometries may enable new computational architectures (such as a ball-shaped geometry is a “round-table forum” in 3D optimizing the interactions, communications, and interconnections between computational elements on the surfaces, and communication/interaction link inside the sphere). It enables new ways of interfacing electronics or photonics to biological neural systems in general (such as in the brain-machine interface (BMI), quasi-spherical surfaces are frequently encountered).
(14) For example, in the case of an artificial retina, the interface between the prosthesis device and the retina at the back of a human eyeball is a quasi-spherical surface with a radius of curvature of ˜12.5 mm. To minimize the complexity of interconnections through eyeballs, it is desirable to collocate the interfacing micro electrodes and electronic circuitry, and together in close proximity to the surface of retina neurons. This disclosure teaches the method to form the typically rigid semiconductor electronics into the non-planar (here, quasi-spherical) shape.
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(16) In one embodiment, assembly 100A may comprise flexible chips 103 with light sensors, electrodes, driving circuits, etc. Flexible chips 103 may be mechanically constrained to be curved in a desired shape or deformation via fixture structure 101. For example, fixture structure 101 may comprise a flexible polymer material shaped or deformed with a desired curvature. Flexible chips 103 may be bonded or fixed to fixture structure 101 to remain curved in the desired shape.
(17) Turning now to
(18) The non-planar geometry of assembly 100B may enable computational architectures based on connections or other applicable non-planner shaped features. For example, a ball-shaped geometry in a sphere assembly may be a “round-table forum” in 3D (three dimensional) geometry for optimizing the interactions, communications, and interconnections between computational elements (or circuitry of flexible chips) on the surfaces of the sphere assembly, and communication/interaction links for elements located inside the sphere assembly.
(19) Turning now to
(20) Alternatively, in
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(22) In some embodiments, stressed thin films, such as stressed film layers 207, may be deposited in either side or both sides of a thin structure or chip to achieve desired deformation (e.g. with a certain degrees bending) for the chip. For example, stressed thin films may be pre-compressed or pre-stretched to apply bending force in different directions. Optionally, stressed thin films can be patterned (for example, in annular shapes or long stripes by photolithography and etching processes) during the fabrication process to create various curved shapes (e.g. in a wavy manner or other applicable forms) for the thin structure. Structure 200 may curl when released from thick carrier wafer (or handle wafer) 209 attached via glue 211.
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(24) According to one embodiment, desired deformation may include chip bending curvature. For example, if flexible chips are to be deformed into a non-planar spherical patch from a planar disk, the required reduction in the circumference of the outer circle of the flexible chips can be calculated. In one embodiment, estimation of the chip bending curvature caused by deposited thin films with residual film stresses (on a relatively thick substrate) may be based on “Stoney Equation” (or approximation equation) when the displacement from the substrate bending is much less than the wafer thickness (e.g. thickness of device layers 205). For larger stresses on thin chips, numerical methods may be used to calculate the chip bending curvature without over-estimating the displacement via the approximation equation, as the displacement can easily be larger than the substrate thickness due to two-dimensional constraints.
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(26) In one embodiment, thin chips 305 may comprise a circular chip with several radial slots (one or more) extending outward in the direction from the center of the circular chip (in a straight path or in a curved path, a spiral path, a zigzag path or other applicable paths) in fan/wedge shape with the surplus perimeters removed. The radial slots may extend from perimeter of thin chips 305 and stop at tips (e.g. fine tip about 1 μm in width) of the slots, such as tip 307 for slot 301, before (or at a distance from) reaching the center of thin chips 305. In one embodiment, tips of slots may be located within a thin chip to accommodate, for example, resolution limitation of micro fabrication process and/or increased stress intensity factors at the tip of the slot induced by chip deformation. Corners around tips of slots, such as around tip 307 of slot 301, may be rounded to reduce stress concentration associated with sharp corners and spread out stress over rounded slot corners when an associated chip is deformed or bended.
(27) A slot may be formed by removing (or cutting, slitting), such as through deep reactive ion etching in the micro fabrication process, a portion of narrow channel area (e.g. a cutout, a longitudinal opening or narrow opening) of a chip, such as slot 301 of thin chips 305. The slot can reduce deformation stress, such as tangential in-plane stress, of the chip and increase allowable degrees of deformation of the chip. In one embodiment, the slot may break direct communication, within the chip, between circuit elements crossing the slots, thus jumpers (through the bonding pads to the constraining flex or another constraining chip, as will be described in the following), or longer power rails and data buses around the slots may be needed to distribute the power, ground & signal lines.
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(31) Turning now to
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(33) At sequence 500B of
(34) Turning now to
(35) In one embodiment, heat and pressure may be applied for bonding between thin chips 509 and flex 507, for example, to solder metal pads and corresponding matching pads together. Thin chips may be held on press unit (e.g. top press) 505, for example, via vacuum or electrostatics forces. Press 517 may be pressed against holder unit 501 after alignment of pads of thin chips 509 and matching pads of flex 507.
(36) In some embodiments, flex 507 may be made through a clear bottom holder such as holder 501. Multiple layers of chips may be bonded via pressure and heat applied between a press unit and holder unit 501. Holder unit 501 may be associated with different shapes or styles of recesses to deform a flex or flexible chips, such as flex 507, depending on different chip designs. When the bonding is completed, at sequence 500E of
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(39) Turning now to
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(42) In one embodiment, a backfill layer, such as backfill 707, between adjacent chips of a non-planar assembly stacking multiple chips may facilitate heat dissipation between the chips. A backfill layer may comprise thermal conductive dielectric material to control the temperature rise of the assembled structure (or non-planar chips) in operation. For example, heat generated from high speed processing circuitry embedded inside a non-planar assembly may be allowed to pass through both bonding pads and backfill layers to help cool down the non-planar assembly. In one embodiment, a backfill layer may reduce or eliminate thermal insulation of air gaps in a non-planner assembly. Alternatively, the non-planar assembly may be immersed in a liquid, such as silicon oil, to fill up air gaps to provide cooling effects.
(43) The stack is not limited to two layers, or limited to round shapes. Multiple chips non-planar 3D stack with staggered slots can be formed. Power, signals and data can jump between layers to cross the slots to distribute electrical power and signals between stacked pieces and adjacent pieces. Since the active devices will be under bending stresses, the stress-induced effects such as the increase of trans-conductance for tensile stresses in both longitudinal and transverse directions on N-type MOS transistors, and either increase or decrease in the case of P-type transistors may be taken into account and pre-compensated in the system design.
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(45) In one embodiment, first thin chip 807 and second thin chip 809 may be separately held by press unit 803 and holder unit 805 either by vacuum, electrostatics or other means. For example, press unit 803 or holder unit 805 may comprise vacuum chucks with rings of small holes or openings of vacuum channels to provide suction forces to hold thin chips. Press unit 803 and holder unit 805 may be associated with matching surfaces to deform the thin chips held. In one embodiment, first thin chips 807, when held by press unit 803, may be deformed over first curved surface 811 of press unit 803. Second thin chips 809, when held by holder unit 805, may be deformed over second curved surface 813 of holder unit 805. First thin chips 807 and/or second thin chips 809 may include slots to increase flexibility of the chips to deform (or curve, bend). First curved surface 811 and second curved surface 813 may be of a common curvature to match each other.
(46) At sequence 800B of
(47) Press unit 803 may rotate in three rotational dimensions for aligning chips held. In one embodiment, press unit 803 may be constrained to move in one translational dimension, for example, towards or away from holder unit 805, to allow surfaces of holders, e.g. first curved surface 811 and second curved surface 813, to match each other. In some embodiments, surfaces of the holders may match with a common center of curvature (or ball center).
(48) As press unit 803 and holder unit 805 are brought together, heat and pressure may be applied for bonding between first thin chips 807 and second thin chips 809 at specific area of thin metal film bonding region, such as bonding area 819. Thin metal film bonding region may include pads aligned with matching pads between the thin chips. In one embodiment, pads may melt together using controlled ranges of elevated temperatures. For example, heat of about 100-180 degrees C. (Celsius) may be used for tin/lead based pads. Alternatively, heat of about 350-450 degrees C. may be needed for pads made of gold alloy.
(49) At sequence 800C of
(50) In the foregoing specification, the invention has been described with reference to specific exemplary embodiments thereof. It will be evident that various modifications may be made thereto without departing from the broader scope of the invention as set forth in the following claims. The invention is not limited to the particular forms, drawings, scales, and detailed information disclosed. The specification and drawings are, accordingly, to be regarded in an illustrative sense rather than a restrictive sense.