GAS-MEASURING CHIP, PORTABLE CHIP MEASUREMENT SYSTEM AND METHOD FOR OPERATING A PORTABLE CHIP MEASUREMENT SYSTEM
20170322171 · 2017-11-09
Inventors
Cpc classification
G01N27/4143
PHYSICS
G01N27/27
PHYSICS
International classification
G01N27/27
PHYSICS
G01N27/414
PHYSICS
Abstract
A gas-measuring chip (10), used with a gas-measuring device (100) of a portable chip measurement system, has a carrier (11) and measuring channels (20, 20′, 20″). A regenerable, nonconsumable sensor (30, 30′, 30″) is arranged in each measuring channel. A method includes inserting the gas-measuring chip (10) into the gas-measuring device (100) and connecting one measuring channel of the gas-measuring chip (10) to a pumping system (120, 121) of the gas-measuring device (100). A measurement is carried out with a first measuring channel (20, 20′, 20′) with a switching over to a measuring channel different from the first measuring channel. The sensors (30, 30′, 30″) of the measuring channel used last is regenerated and optionally simultaneously there is a measurement with the measuring channel switched over to. There is a switching over to a measuring channel, which is different from the measuring channel last used for the measurement.
Claims
1. A gas-measuring chip for use with a gas-measuring device of a portable chip measurement system, the gas-measuring chip comprising: a carrier; at least two measuring channels; and at least one regenerable, nonconsumable sensor arranged in each of the measuring channels.
2. A gas-measuring chip in accordance with claim 1, wherein the measuring channels are configured to be connected to a pumping system of the gas-measuring device.
3. A gas-measuring chip in accordance with claim 1, wherein the gas-measuring chip has a contact device, which is configured to transmit information of the sensors to an analysis unit of the gas-measuring device.
4. A gas-measuring chip in accordance with claim 1, further comprising an information carrier configured for transmitting information on the gas-measuring chip to the gas-measuring device.
5. A gas-measuring chip in accordance with claim 1, wherein the at least one regenerable, nonconsumable sensor comprises a plurality of regenerable, nonconsumable sensors arranged in one of the measuring channels.
6. A gas-measuring chip in accordance with claim 5, wherein a plurality of the regenerable sensors are arranged in series within the one of the measuring channels.
7. A gas-measuring chip in accordance with claim 5, wherein the regenerable sensors are selected from among cantilever sensors, surface-acoustic wave sensors, quartz crystal microbalances, optical systems, and field effect transistor systems.
8. A gas-measuring chip in accordance with claim 1, wherein a printed circuit board, on which the sensors of said measuring channel are arranged, is arranged in at least one of the measuring channels.
9. A gas-measuring chip in accordance with claim 5, wherein at least one of the measuring channels has a plurality of sensors, which are based on different principles of measurement.
10. A gas-measuring chip in accordance with claim 10, wherein all sensors of one measuring channel are based on the same principle of measurement.
11. A portable chip measurement system comprising: a gas-measuring chip; a portable gas-measuring device, wherein the gas-measuring device has a receptacle, into which the gas-measuring chip is inserted; at least one pumping system; and an analysis unit, wherein the gas-measuring chip comprises: a carrier; at least two measuring channels; and at least one regenerable, nonconsumable sensor arranged in each of the measuring channels.
12. A method for operating a portable chip measurement system comprising a gas-measuring chip, a portable gas-measuring device, wherein the gas-measuring device has a receptacle, into which the gas-measuring chip is insertable, at least one pumping system; and an analysis unit wherein the gas-measuring chip comprises: a carrier; at least two measuring channels; and at least one regenerable, nonconsumable sensor arranged in each of the measuring channels, the method comprising the steps of: inserting the gas-measuring chip into the gas-measuring device and connecting at least one of the measuring channels of the gas-measuring chip to the pumping system of the gas-measuring device; carrying out a measurement with a first measuring channel; switching over to a second measuring channel different from the first measuring channel; regenerating the sensors of the first measuring channel used last; carrying out a measurement with the second measuring channel either after the step of regenerating the sensors or simultaneously with the step of regenerating the sensors; switching over to another measuring channel, which other measuring channel is different from the second measuring channel (20, 20′, 20″) used last.
13. A method in accordance with claim 11, wherein the step of regenerating the sensors comprises heating of the measuring channels.
14. A method in accordance with claim 13, wherein a maximum time for heating a measuring channel corresponds to a product t.sub.K×M, in which t.sub.K=measuring time and M=a number of measuring channels−1.
15. A method in accordance with claim 13, wherein the temperature for the heating is about 30° C. to about 150° C.
16. A portable chip measurement system in accordance with claim 11, wherein the gas-measuring chip further comprises a contact device configured to transmit information of the sensors to an analysis unit of the gas-measuring device.
17. A portable chip measurement system in accordance with claim 11, further comprising an information carrier configured to transmit information relating to the gas-measuring chip to the gas-measuring device.
18. A portable chip measurement system in accordance with claim 11, wherein the at least one regenerable, nonconsumable sensor comprises a plurality of regenerable, nonconsumable sensors, each being arranged in one of the measuring channels.
19. A portable chip measurement system in accordance with claim 18, wherein the plurality regenerable sensors are arranged in series within the one of the measuring channels.
20. A portable chip measurement system in accordance with claim 11, wherein the regenerable sensors are selected from among cantilever sensors, surface-acoustic wave sensors, quartz crystal microbalances, optical systems, and field effect transistor systems.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
[0038] In the drawings:
[0039]
[0040]
[0041]
[0042]
[0043]
[0044]
[0045]
[0046]
[0047]
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[0049]
DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0050] Referring to the drawings, the gas-measuring chip 10 shown in
[0051] Furthermore, an information carrier 12 is arranged on the carrier 11 of the gas-measuring chip 10. The information that is contained in or on this information carrier 12 is gas-measuring chip-specific or sensor-specific data, such as the name of the detectable analyte, the measurement range of the sensors of the gas-measuring chip 10, possible or minimal measuring time and the like.
[0052] The gas-measuring chip 10 has, furthermore, a contact device 13. This is configured as a lateral strip on the carrier 11. Other embodiment variants, e.g., contact sections, contact pins or the like, are, of course, conceivable.
[0053] It is seen in
[0054] It is seen, furthermore, in
[0055] The gas inlet 21 and the gas outlet 22 of the measuring channel 20 are, in addition, closed by septum seals 23. These septum seals 23 can be punctured when the gas-measuring chip 10 is inserted into a gas-measuring device 100. A gas sample will then flow through the gas inlet 21 into the measuring channel 20 and through the measuring channel 20. The gas sample now flows past the sensor 30. A correspondingly suitable analyte, possibly contained in the gas sample, can then interact with the sensor 30. The sensor 30 subsequently sends a correspondingly suitable signal. This signal is transmitted, as was described above, from the printed circuit board 24 to the contact device 13. The gas sample then flows out of the measuring channel through the gas outlet 22. The gas-measuring chip 10, which will be described below and is shown in
[0056]
[0057]
[0058]
[0059] A plurality of sensors 30, 30′, 30″ are arranged in each of the gas-measuring channels 20. These sensors 30, 30′, 30″ may differ in both their principles of measurement and their specificity for a particular analyte to be detected. Different sensors 30, 30′, 30″ are arranged in each measuring channel 20, 20′, 20″ in the exemplary embodiment shown in
[0060] Identical sensors 30, 30′, 30″ are arranged in each of the measuring channels 20, 20′, 20″ in the example shown in
[0061] It is therefore seen that the gas-measuring chip 10 in
[0062] The sensors 30, 30′, 30″ are selected from among cantilever sensors, surface-acoustic wave sensors, quartz crystal microbalances, optical systems, field effect transistor systems or the like. In a special embodiment, the sensors 30, 30′, 30″ are field effect transistor systems, preferably CCFET sensors as described in
[0063]
[0064] The analysis unit 130 of the gas-measuring device 100 according to the present invention can be connected directly or indirectly to the contact device 13 of the gas-measuring chip 10 in any case. The gas-measuring device 100 has a contact element (not shown) for this, which is likewise arranged in the receptacle 110 and which can establish an electrically conductive connection between the contact device 13 and the analysis unit 130. The contact element may be a contact surface, a contact pin or the like.
[0065] Furthermore, a reading unit 150 is provided in the embodiment variant of the gas-measuring device 100 shown in
[0066] The gas-measuring device 100 according to the exemplary embodiment shown in
[0067] The second pumping system 121 shown in the exemplary embodiment according to
[0068] The operating elements 140 and the display 160 are used to make possible the comfortable handling of the gas-measuring device 100 or of the portable chip measurement system for a user.
[0069] Thus,
[0070] A method as is schematically shown can be carried out with such a system. In a first step a), the gas-measuring chip 10 is inserted into the gas-measuring device 100 for starting the method. At least one of the measuring channels 20, 20′, 20″ of the gas-measuring chip 10 is connected to the pumping system 120, 121 of the gas-measuring device 100 when the gas-measuring chip 10 is inserted. If the gas-measuring device 100 is equipped with a second pumping system 121 corresponding to, for example,
[0071] It is thus seen that the first step of the method according to the present invention, namely, step a) in a gas-measuring device 100 corresponding to
[0072] Subsequent to step a), a first measurement is carried out with a first measuring channel 20, 20′, 20″ according to step b) of the method shown in
[0073] If the measuring system is exposed, as was described above, to a very high analyte concentration, or detection of another analyte is desired, for which no suitable sensor 30, 30′, 30″ is arranged in the measuring channel 20, 20′, 20″ used in step b), the process is switched over in the next step c) from the first measuring channel 20, 20′, 20″, which is used in step b), to a new measuring channel 20, 20′, 20″. The sensors 30, 30′, 30″ arranged in the first measuring channel 20, 20′, 20″, which were used for the first measurement in step b), can then regenerate in the next step d), i.e., the analytes adsorbed on their surfaces can now be desorbed. At the same time, a further measurement can be carried out in step d) with the measuring channel 20, 20′, 20″, to which the process was switched over in step c), or the measurement started in step b) with the first measuring channel 20, 20′, 20″ can be continued with this measuring channel 20, 20′, 20″, to which the process was switched over. The switchover in step c) takes place by the chip 10 being conveyed either forward or backward within the receptacle 110 of the gas-measuring device 100. The gas-measuring device 100 may contain a conveying system in an embodiment variant, not shown. As an alternative, the switchover in step c) is brought about by the pumping system 120 being switched over within the gas-measuring device 100 such that the gas sample to be analyzed is drawn through another measuring channel 20, 20′, 20″.
[0074] The regeneration of the sensors in step d) comprises, in one embodiment variant, the heating of the measuring channels 20, 20′, 20. The temperature within the respective measuring channel 20, 20′, 20″ is increased for this for a certain time to a temperature of about 30° C. to about 150° C. The temperature of the sensors 30, 30′, 30″, which are arranged in the corresponding measuring channel 20, 20′, 20″, is also increased in the process. In one embodiment variant, the temperature is increased to about 40° C. to about 130° C. In another embodiment variant, the temperature is increased to about 50° C. to about 120° C. In yet another embodiment variant, the temperature is increased to 80° C.
[0075] In another embodiment variant, the regeneration of the sensors 30, 30′, 30″ additionally includes the flushing of the measuring channels 20, 20′, 20″ with analyte-free air. Provisions are made in this connection in a first embodiment variant for the regeneration to comprise both the flushing and the above-mentioned heating of the measuring channel 20, 20′, 20″. Provisions are made in another variant for the regeneration to comprise the flushing or heating of the measuring channel 20, 20′, 20″. It is obvious that a plurality of measuring channels 20, 20′, 20″ may also always be regenerated simultaneously in all these variants.
[0076] The maximum time for the regeneration and hence for the flushing and/or heating of the measuring channel 20, 20′, 20″ corresponds to the product of the measuring time t.sub.K and the number of channels that are arranged on the gas-measuring chip 10 minus 1, i.e., to the product t.sub.K×M, in which t.sub.K=measuring time and M=(number of measuring channels−1).
[0077] If the sensors 30, 30′, 30″ to be regenerated in step d) are fully regenerated and are again ready to be used or the measurement carried out in step d) has ended, the process is again switched over to another measuring channel 20, 20′, 20″ in step e), as is seen in
[0078] It is seen, furthermore, in
[0079] If no repetition according to step f) is desired, the method according to the present invention has ended.
[0080] It is seen that the greater the number of measuring channels 20, 20′, 20″ arranged on the respective gas-measuring chip 10, the longer may be the duration of the regeneration of the sensors 30, 30′, 30″. If, for example, a gas-measuring chip 10 has five measuring channels 20, 20′, 20″ and each measuring channel shall be used for a duration of two minutes for the measurement corresponding to step b) or step d), the sensors 30, 30′, 30″ which in the measuring channels 20, 20′, 20″ that are not being used now can be regenerated each for eight minutes without the two-minute measurement frequency having to be reduced.
[0081] Therefore, the method shown in
[0082] It is, furthermore, seen in
[0083] The present invention is not limited to one of the embodiments described, but may be modified in many different ways. All the features and advantages, including design details, arrangement in space and method steps, which appear from the claims, the description and the drawings, may be essential for the present invention both in themselves and in the many different combinations as well.
[0084] While specific embodiments of the invention have been shown and described in detail to illustrate the application of the principles of the invention, it will be understood that the invention may be embodied otherwise without departing from such principles.