HEMOSTATIC FABRIC CONTAINING TRYPSIN AND PREPARATION METHOD THEREOF

Abstract

The disclosure provides a hemostatic fabric containing trypsin, wherein the hemostatic fabric comprises molecular sieve/fiber composite and trypsin; molecular sieve/fiber composite comprises molecular sieves and a fiber; the molecular sieves are independently dispersed on a fiber surface of the fiber without agglomeration and directly contact the fiber surface; a surface of the molecular sieve contacted with the fiber is an inner surface, and a surface of the molecular sieve uncontacted with the fiber is an outer surface; growth-matched coupling is formed between the molecular sieves and the fiber on the inner surface of the molecular sieves; the inner surface and outer surface are composed of molecular sieve nanoparticles. In the present disclosure, trypsin is specifically combined with the molecular sieve/fiber composite, which maintains a high procoagulant activity, thereby obtaining a hemostatic fabric with excellent coagulation effect.

Claims

1. A hemostatic fabric containing trypsin, wherein the hemostatic fabric comprises a molecular sieve/fiber composite and a trypsin; the molecular sieve/fiber composite comprises molecular sieves and a fiber; the molecular sieves are independently dispersed on a fiber surface of the fiber without agglomeration and directly contact the fiber surface; a first surface of the molecular sieve contacted with the fiber is defined as an inner surface, and a second surface of the molecular sieve uncontacted with the fiber is defined as an outer surface; a growth-matched coupling is formed between the molecular sieves and the fiber on the inner surface of the molecular sieves; a particle size D90 of the molecular sieve microparticles is 0.01 to 50 μm, a particle size D50 of the molecular sieve microparticles is 0.005 to 30 μm; the inner surface and the outer surface are composed of molecular sieve nanoparticles.

2. The hemostatic fabric of claim 1, wherein the adhesive content of the contact surface between the molecular sieves and the fiber is zero.

3. The hemostatic fabric of claim 1, wherein the inner surface is a planar surface matched with the fiber surface, and the outer surface is a non-planar surface.

4. The hemostatic fabric of claim 1, wherein for molecular sieves dispersed independently on the fiber surface, each of the molecular sieve microparticles has its own independent boundary.

5. The hemostatic fabric of claim 1, wherein a detection method for forming the growth-matched coupling is performed in conditions as follows: a retention rate of the molecular sieves on the fiber of molecular sieve/fiber composite is greater than or equal to 90% under an ultrasonic condition for 20 minutes or more.

6. The hemostatic fabric of claim 1, wherein the molecular sieve is a molecular sieve after metal ion exchange.

7. The hemostatic fabric of claim 6, wherein the metal ion is selected from the group consisting of strontium ion, calcium ion, magnesium ion and combination thereof.

8. The hemostatic fabric of claim 1, wherein the surface of the molecular sieve contains hydroxyl groups.

9. The hemostatic fabric of claim 1, wherein the particle size D90 of the molecular sieve microparticles is 0.1 to 30 μm, and the particle size D50 of the molecular sieve microparticles is 0.05 to 15 μm.

10. The hemostatic fabric of claim 1, wherein the average size of the molecular sieve nanoparticles of the outer surface is larger than the average size of the molecular sieve nanoparticles of the inner surface.

11. The hemostatic fabric of claim 1, wherein the mass ratio of trypsin to molecular sieve is 1:200-4:10.

12. The hemostatic fabric of claim 1, wherein the molecular sieve is selected from the group consisting of X-type molecular sieve, Y-type molecular sieve, A-type molecular sieve, ZSM-5 molecular sieve, chabazite, β-molecular sieve, mordenite, L-type molecular sieve, P-type molecular sieve, merlinoite, AlPO4-5 molecular sieve, AlPO4-11 molecular sieve, SAPO-31 molecular sieve, SAPO-34 molecular sieve, SAPO-11 molecular sieve, BAC-1 molecular sieve, BAC-3 molecular sieve, and BAC-10 molecular sieve, and combination thereof.

13. The hemostatic fabric of claim 1, wherein the fiber is a polymer containing hydroxyl groups in a repeating unit.

14. The hemostatic fabric of claim 1, wherein the fiber is selected from the group consisting of silk fiber, chitin fiber, rayon fiber, acetate fiber, carboxymethyl cellulose, bamboo fiber, cotton fiber, linen fiber, wool, wood fiber, lactide polymer fiber, glycolide polymer fiber, polyester fiber, polyamide fiber, polypropylene fiber, polyethylene fiber, polyvinyl chloride fiber, polyacrylonitrile fiber, viscose fiber, and combination thereof.

15. The hemostatic fabric according to claim 1, wherein the molecular sieves are independently dispersed on the fiber surface means that the minimum distance between the molecular sieve microparticle and the nearest molecular sieve microparticle is greater than or equal to one half of the sum of the particle sizes of the two molecular sieve microparticles, that is:
d≥r.sub.1+r.sub.2; wherein r.sub.1 and r.sub.2 respectively represent one half of the particle size of two adjacent molecular sieve microparticles; and d represents the minimum distance between two adjacent molecular sieve microparticles.

16. A preparation method for a hemostatic fabric containing trypsin according to claim 1, wherein the preparation method comprises the following steps: (a) preparing a suspension of a molecular sieve/fiber composite; and (b) mixing the suspension of the molecular sieve/fiber composite with a trypsin to make a trypsin adsorb on a surface of the molecular sieve/fiber composite; a synthesis method of the molecular sieve/fiber composite is an in-situ growth method, and the in-situ growth method includes the following steps: (i) preparing a molecular sieve precursor solution and mixing it with the fiber; the fiber has not been subjected to pretreatment, and the pretreatment refers to a treatment method that destroys fiber structure of the fiber; and (ii) processing the mixture of fiber and molecular sieve precursor solution in step (i) with heat treatment to obtain a molecular sieve/fiber composite.

17. The preparation method of claim 16, wherein the molecular sieve precursor solution does not include a templating agent.

18. The preparation method of claim 16, wherein in the step (ii), the temperature of the heat treatment is 60 to 220° C., and the time of heat treatment is 4 to 240 h.

19. A hemostatic composite, wherein the hemostatic composite comprises a hemostatic fabric of claim 1.

20. The hemostatic composite of claim 19, wherein the hemostatic composite material is selected from the group consisting of hemostatic bandage, hemostatic gauze, hemostatic cloth, hemostatic clothing, hemostatic cotton, hemostatic suture, hemostatic paper, hemostatic band-aid, and combination thereof.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0090] FIG. 1 is a schematic diagram showing the destruction of a fiber structure caused by pretreatment of fiber in the prior art.

[0091] FIG. 2 is a scanning electron microscope image of a molecular sieve/fiber composite after pretreatment of fiber in the prior art, in which the molecular sieve is wrapped on the fiber surface in an agglomerated form (Journal of Porous Materials, 1996, 3 (3): 143-150).

[0092] FIG. 3 is a scanning electron microscope image of a molecular sieve/fiber composite after pretreatment of fiber in the prior art, in which the molecular sieve is wrapped on the fiber surface in an agglomerated or lumpy form (Cellulose, 2015, 22 (3): 1813-1827).

[0093] FIG. 4 is a scanning electron microscope image of a molecular sieve/fiber composite after pretreatment of fiber in the prior art, in which the molecular sieve is partially agglomerated and unevenly distributed on the fiber surface (Journal of Porous Materials, 1996, 3 (3): 143-150).

[0094] FIG. 5 is a scanning electron microscope image of a molecular sieve/fiber composite after pretreatment of fiber the prior art, in which a gap exists between the fiber and the molecular sieve (Journal of Porous Materials, 1996, 3 (3): 143-150).

[0095] FIG. 6 is a scanning electron microscope image of a Na-LTA molecular sieve/nanocellulose fiber composite bonded by polydiallyl dimethyl ammonium chloride in the prior art (ACS Appl. Mater. Interfaces 2016, 8, 3032-3040).

[0096] FIG. 7 is a scanning electron microscope image of a NaY molecular sieve/fiber composite bonded by a cationic and anionic polymer adhesive in the prior art (Microporous & Mesoporous Materials, 2011, 145 (1-3): 51-58).

[0097] FIG. 8 is a schematic diagram of a molecular sieve/fiber composite prepared by blend spinning in the prior art.

[0098] FIG. 9 is a schematic diagram of molecular sieve/fiber composite prepared by electrospinning in the prior art (U.S. Pat. No. 7,739,452B2).

[0099] FIG. 10A is a scanning electron microscope image of a molecular sieve/fiber composite according to the present disclosure (Bar=10 μm) (test parameter SU80100 3.0 kV; 9.9 mm).

[0100] FIG. 10B is a scanning electron microscope image of the molecular sieve/fiber composite according to the present disclosure (Bar=2 μm) (test parameter SU80100 3.0 kV; 9.9 mm).

[0101] FIG. 11A is a scanning electron microscope image of fibers in the molecular sieve/fiber composite before the fibers are bonded with the molecular sieve (test parameter SU80100 3.0 kV; 9.9 mm).

[0102] FIG. 11B is a scanning electron microscope image of molecular sieves in the molecular sieve/fiber composite after the fibers are removed from the hemostatic compound (test parameter SU80100 3.0 kV; 9.9 mm).

[0103] FIG. 12 shows scanning electron microscope images of the inner surface (the contact surface between the molecular sieve and the fiber) (Bar=300 nm) and the outer surface (Bar=500 nm) of the molecular sieve of the molecular sieve/fiber composite according to the present disclosure (test parameter SU80100 5.0 kV; 9.9 mm).

[0104] FIG. 13 shows statistical distribution diagrams of particle sizes of nanoparticles on the inner surface and the outer surface of the molecular sieve of the molecular sieve/fiber composite according to the present disclosure.

[0105] FIG. 14 is a scanning electron microscope image of a molecular sieve according to Comparative Example 1 (test parameter SU80100 5.0 kV; 9.9 mm).

[0106] FIG. 15 is a schematic diagram showing the different binding strength of the molecular sieves and fibers of the molecular sieve/fiber compound between the Comparative Example 2 and the present disclosure, with the influence of the growth-matched coupling between molecular sieves and fibers.

[0107] FIG. 16 is a schematic diagram of a molecular sieve/fiber composite bonded by an adhesive in the prior art; the fiber, the adhesive, and the molecular sieve form a sandwich-like structure, and the intermediate layer is an adhesive.

[0108] FIG. 17A is a scanning electron microscope image of Combat Gauze commercialized by Z-Medica Co., Ltd. in Comparative Example 11 (Bar=50 μm).

[0109] FIG. 17B is a scanning electron microscope image of Combat Gauze commercialized by Z-Medica Co., Ltd. in Comparative Example 11 (Bar=5 μm).

[0110] FIG. 18 is a picture of a clay/fiber composite in an aqueous solution in the prior art.

[0111] FIG. 19 is a graph of clay retention rate of clay/fiber composite of the prior art in an aqueous solution under ultrasonic condition for different times.

[0112] FIGS. 20A-20B are schematic diagram of the positional relationship between two adjacent molecular sieve microparticles on the fiber surface of the hemostatic compound; wherein, FIG. 20A is the aggregation of molecular sieve on the fiber surface in the composite in the prior art, and FIG. 20B is the molecular sieve is independently dispersed on the fiber surface in the composite in the present disclosure.

[0113] FIG. 21 is a schematic diagram of a hemostatic fabric containing trypsin of the present disclosure.

DETAILED DESCRIPTION OF THE DISCLOSURE

[0114] The present disclosure is further described below with reference to the drawings and embodiments.

[0115] The “degree of ion exchange” is the ion exchange capacity of the compensation cations outside the molecular sieve framework and cations in the solution. The method for detecting the ion exchange capacity is: immersing molecular sieve/fiber composite in a 5M concentration strontium chloride, calcium chloride or magnesium chloride solution at room temperature for 12 hours to obtain a molecular sieve/fiber composite after ion exchange, and measuring the degree of strontium ion, calcium ion or magnesium ion exchange of the molecular sieves of molecular sieve/fiber composite after ion exchange.

[0116] “Effective specific surface area of molecular sieve” shows the specific surface area of the molecular sieve on the fiber surface in the molecular sieve/fiber composite. The detection method of the effective specific surface area of the molecular sieve:the specific surface area of the molecular sieve/fiber composite is analyzed by nitrogen isothermal adsorption and desorption, and the effective specific surface area of the molecular sieve=the specific surface area of the molecular sieve/fiber composite−the specific surface area of the fiber.

[0117] Detection method of “content of molecular sieve on fiber surface”: the mass fraction of molecular sieve on the fiber is analyzed using a thermogravimetric analyzer.

[0118] The detection method of “uniform distribution of molecular sieves on the fiber surface” is: randomly taking n samples of the molecular sieve/fiber composite at different locations and analyzing the content of the molecular sieve on the fiber surface, where n is a positive integer greater than or equal to 8. The coefficient of variation is also called the “standard deviation rate”, which is the ratio of the standard deviation to the mean multiplied by 100%. The coefficient of variation is an absolute value that reflects the degree of dispersion of the data. The smaller the value of the coefficient of variation, the smaller the degree of dispersion of the data, indicating that the smaller the difference in the content of molecular sieves on the fiber surface, the more uniform the distribution of molecular sieves on the fiber surface. The coefficient of variation of the content of the molecular sieves in the n samples is ≤15%, indicating that the molecular sieves are uniformly distributed on the fiber surface. Preferably, the coefficient of variation of the content of the molecular sieves is ≤10%, indicating that the molecular sieves are uniformly distributed on the fiber surface. Preferably, the coefficient of variation of the content of the molecular sieves is ≤5%, indicating that the molecular sieves are uniformly distributed on the fiber surface. Preferably, the coefficient of variation of the content of the molecular sieves is ≤2%, indicating that the molecular sieves are uniformly distributed on the fiber surface. Preferably, the coefficient of variation of the content of the molecular sieves is ≤1%, indicating that the molecular sieves are uniformly distributed on the fiber surface. Preferably, the coefficient of variation of the content of the molecular sieves is ≤0.5%, indicating that the molecular sieves are uniformly distributed on the fiber surface. Preferably, the coefficient of variation of the content of the molecular sieves is ≤0.2%, indicating that the molecular sieves are uniformly distributed on the fiber surface.

[0119] The detection methods of D50 and D90 are: using scanning electron microscope to observe the molecular sieve microparticles on the surface of the molecular sieve/fiber composite, and carrying out statistical analysis of particle size. D50 refers to the particle size corresponding to the cumulative particle size distribution percentage of the molecular sieve microparticles reaching 50%. D90 refers to the particle size corresponding to the cumulative particle size distribution percentage of the molecular sieve microparticles reaching 90%.

[0120] The detection method of the binding strength between the molecular sieve and the fiber is: putting molecular sieve/fiber composite in deionized water under ultrasonic condition for 20 min or more, analyzing the content of the molecular sieve on the fiber surface by using a thermogravimetric analyzer, comparing the content of molecular sieve on the fiber surface before and after ultrasound and calculating the retention rate of molecular sieve on the fiber. The retention rate=(content of the molecular sieve on the fiber surface before the ultrasound−content of the molecular sieve on the fiber surface after the ultrasound)×100%/content of the molecular sieve on the fiber surface before the ultrasound. If the retention rate is greater than or equal to 90%, it indicates that molecular sieve and fiber form a growth-matched coupling, and molecular sieve is firmly bonded to fiber.

[0121] Detection method of hemostatic function: The hemostatic function of hemostatic fabric is evaluated by using a rabbit femoral artery lethal model. The specific steps are as follows: (1) before the experiment, white rabbits were anesthetized with sodium pentobarbital intravenously (45 mg/kg); their limbs and head were fixed, and supine on the experimental table; part of the hair was removed to expose the right groin of the hind limb. (2) Then, the femoral skin and muscle were cut longitudinally to expose the femoral artery, and the femoral artery was partially cut off (about half of the circumference). After the femoral artery was allowed to squirt freely for 30 seconds, the blood at the wound was cleaned with cotton gauze, and then the hemostatic material (5 g) was quickly pressed to the wound. After pressing for 60 seconds, the hemostatic material is lifted up slightly every 10 seconds to observe the coagulation of the injured part and the coagulation time is recorded. Infrared thermometers are used to detect changes in wound temperature (before and after using hemostatic fabric).

(3) After hemostasis, observe the wound and suture the wound. The survival of the animals is observed for 2 hours after hemostasis. The survival rate=(total number of experimental white rabbits-number of deaths of white rabbits observed for 2 hours after hemostasis)×100%/total number of experimental white rabbits, wherein the number of experimental white rabbits in each group is n, n is a positive integer greater than or equal to 6. (4) The difference in weight of the hemostatic fabric before and after use was recorded as the amount of blood loss during wound hemostasis.

Example 1

[0122] The preparation method of the Y-type molecular sieve/cotton fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with cotton fiber, and the mass ratio of the cotton fiber and the molecular sieve precursor solution is 1:20.
(2) The cotton fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve/cotton fiber composite.
(3) The Y-type molecular sieve/cotton fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the Y-type molecular sieve/cotton fiber composite to obtain the Y-type molecular sieve/cotton fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:200.

[0123] Ten samples of the prepared Y-type molecular sieve/cotton fiber composite were randomly taken at different locations, and the content of the Y-type molecular sieve on the fiber surface was analyzed by a thermogravimetric analyzer. The content of molecular sieve on the fiber in the ten samples was 25 wt %, 24.9 wt %, 25.1 wt %, 25.2 wt %, 25 wt %, 25 wt %, 24.9 wt %, 25 wt %, 25.1 wt %, 24.9 wt %. The average content of molecular sieves on the fibers in the ten samples was 25 wt %, the standard deviation of the samples is 0.1 wt %, and the coefficient of variation is 0.4%, which indicates that the Y-type molecular sieve is uniformly distributed on the fiber surface.

[0124] The prepared Y-type molecular sieve/cotton fiber composite was observed with a scanning electron microscope. Hemispherical molecular sieves with an average particle size of 5 μm are independently dispersed on the fiber surface (FIGS. 10A-10B). The molecular sieves microparticles of the molecular sieve/fiber composite are observed with a scanning electron microscope, and are performed statistical analysis of particle size to obtain a particle size D90 value of 25 μm and a particle size D50 value of 5 μm. The molecular sieves are obtained after removing the fibers by calcination, and was observed with a scanning electron microscope. The inner surface of the molecular sieves in contact with the fiber is planar surface (caused by tight binding with the fiber), and the outer surface is spherical surface. The planar surface of the inner surface of the molecular sieves is a rough surface (FIG. 11B). The outer surface of the molecular sieve is composed of nanoparticles with corner angles, and the inner surface (the contact surface with the fiber) is composed of nanoparticles without corner angles (FIG. 12). The nanoparticles without corner angles make the inner surface of the molecular sieve match with the fiber surface better, which is beneficial to the combination of the molecular sieve and the fiber. The average size of nanoparticles of the inner surface (61 nm) is significantly smaller than that of the outer surface (148 nm), and small-sized particles are more conducive to binding with fibers tightly (FIG. 13). The detection method of the binding strength between the molecular sieve and the fiber: the Y-type molecular sieve/cotton fiber composite is under ultrasonic condition in deionized water for 20 min, and the content of the Y-type molecular sieves on the fiber surface is analyzed by using a thermogravimetric analyzer. It is found that the content of the molecular sieve on the fiber surface is the same before and after ultrasonic condition. It shows that the retention rate of molecular sieve on the fiber is 100%, which indicates that the growth-matched coupling is formed between the molecular sieve and the fiber. The molecular sieve in the Y-type molecular sieve/cotton fiber composite was analyzed by nitrogen isothermal adsorption and desorption, and a hysteresis loop was found in the isothermal adsorption curve, indicating that the molecular sieve has a mesoporous structure. Using the method for detecting the effective specific surface area of the molecular sieve as described above, the effective specific surface area of the molecular sieve in the Y-type molecular sieve/cotton fiber composite prepared in this embodiment was measured to be 490 m.sup.2g.sup.−1. Using the method for detecting the ion exchange capacity of the molecular sieve in the Y-type molecular sieve/cotton fiber composite, the degree of calcium ion exchange is 99.9%, the degree of magnesium ion exchange is 97%, and the degree of strontium ion exchange is 90%.

Comparative Example 1

[0125] (1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.
(2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.

[0126] The effective specific surface area of the Y-type molecular sieve was 490 m.sup.2g.sup.−1, the degree of calcium ion exchange was 99.9%, the degree of magnesium ion exchange was 97%, and the degree of strontium ion exchange was 90%.

[0127] The effective specific surface area and ion exchange capacity of the above Y-type molecular sieve are used as reference values to evaluate the performance of the molecular sieve to the fiber surface in the Comparative Examples described below. The difference between this Comparative Example 1 and Example 1 is that only the Y-type molecular sieve is synthesized without adding fibers (the traditional solution growth method). Using a scanning electron microscope (FIG. 14), the synthesized molecular sieve is a complete microsphere composed of nanoparticles, and there is no rough planar surface (inner surface) in contact with the fibers, compared with Example 1.

Comparative Example 2

[0128] (1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.
(2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.
(3) The above Y-type molecular sieve was added with deionized water to uniformly disperse the Y-type molecular sieve in an aqueous solution.
(4) Immerse the cotton fiber in the solution prepared in step (3) and soak for 30 min.
(5) Dry at 65° C. to obtain a Y-type molecular sieve/cotton fiber composite (impregnation method).
(6) The Y-type molecular sieve/cotton fiber composite (impregnation method) is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the Y-type molecular sieve/cotton fiber composite (impregnation method) to obtain the Y-type molecular sieve/cotton fiber hemostatic fabric (impregnation method), and the mass ratio of trypsin to molecular sieve is 1:200.

[0129] The difference between this Comparative Example and Example 1 is that only the Y-type molecular sieve is synthesized without adding fibers (the traditional solution growth method). Using a scanning electron microscope, the synthesized molecular sieve is a complete microsphere composed of nanoparticles, and there is no rough planar surface (inner surface) in contact with the fibers, compared with Example 1. Therefore, there is no growth-matched coupling between the molecular sieve and the fiber surface (FIG. 15). The binding strength between the molecular sieve and the fiber was measured. The Y-type molecular sieve/cotton fiber composite (impregnation method) was under the ultrasonic condition for 20 min, the retention rate of the molecular sieve on the fiber was 5%, indicating that the molecular sieve of Y-type molecular sieve/cotton fiber composite (impregnation method) has a weak binding effect with the fiber, and the molecular sieve easily falls off (FIG. 15).

Comparative Example 3

[0130] (1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.
(2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.
(3) The above Y-type molecular sieve was added with deionized water to uniformly disperse the Y-type molecular sieve in an aqueous solution.
(4) Spray the solution prepared in step (3) on cotton fibers.
(5) Dry at 65° C. to obtain a Y-type molecular sieve/cotton fiber composite (spray method).
(6) The Y-type molecular sieve/cotton fiber composite (spray method) is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the Y-type molecular sieve/cotton fiber composite (spray method) to obtain the Y-type molecular sieve/cotton fiber hemostatic fabric (spray method), and the mass ratio of trypsin to molecular sieve is 1:200.

[0131] The difference between this Comparative Example and Example 1 is that the synthesized molecular sieve is sprayed onto cotton fibers. Using a scanning electron microscope, there is no rough planar surface (inner surface) in contact with the fibers compared with Example 1. Therefore, there is no growth-matched coupling between the molecular sieve and the fiber surface. The binding strength between the molecular sieve and the fiber was measured. The Y-type molecular sieve/cotton fiber composite (spray method) was under the ultrasonic condition for 20 min, the retention rate of the molecular sieve on the fiber was 2%, indicating that the molecular sieve of Y-type molecular sieve/cotton fiber composite (spray method) has a weak binding effect with the fiber, and the molecular sieve easily falls off.

Comparative Example 4

[0132] Refer to references for experimental steps (ACS Appl Mater Interfaces, 2016, 8(5):3032-3040).

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.
(2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.
(3) The above Y-type molecular sieve was added with deionized water to uniformly disperse the Y-type molecular sieve in an aqueous solution.
(4) Cotton fibers were immersed in a 0.5 wt % polydiallyl dimethyl ammonium chloride (polyDADMAC) aqueous solution at 60° C. for 30 minutes to achieve adsorption of Y-type molecular sieves (polyDADMAC is an adhesive 1).
(5) Dry at 65° C. to obtain a Y-type molecular sieve/cotton fiber composite (including adhesive 1).
(6) The Y-type molecular sieve/cotton fiber composite (including adhesive 1) is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the Y-type molecular sieve/cotton fiber composite (including adhesive 1) to obtain the Y-type molecular sieve/cotton fiber hemostatic fabric (including adhesive 1), and the mass ratio of trypsin to molecular sieve is 1:200.

[0133] The difference between this Comparative Example and Example 1 is that the synthesized molecular sieve is bonded to cotton fibers through an adhesive. After detection of scanning electron microscope, there is no rough planar surface (inner surface) in contact with the fiber, so there is no growth-matched coupling. The binding strength between the molecular sieve and the fiber was measured. The retention rate of the molecular sieve on the fiber of the Y-type molecular sieve/cotton fiber composite (including adhesive 1) was 50% under ultrasonic condition for 20 min, indicating that the molecular sieve has a weak binding strength with the fiber, and the molecular sieve easily falls off. After detection of scanning electron microscope, the molecular sieve was unevenly distributed on the fiber surface, and there was agglomeration of the molecular sieve. After testing, with the addition of adhesive, the effective specific surface area of the molecular sieve became 320 m.sup.2g.sup.−1, the degree of calcium ion exchange became 75.9%, the degree of magnesium ion exchange became 57%, and the degree of strontium ion exchange became 50%. The composite with added adhesive reduces the effective contact area between the molecular sieve and the reaction system, and reduces the ion exchange and pore substance exchange capacity of the molecular sieve.

[0134] Ten samples of the prepared Y-type molecular sieve/cotton fiber composite (including adhesive 1) were randomly taken at different locations, and the content of the Y-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 25 wt %, the standard deviation of the samples is 10 wt %, and the coefficient of variation is 40%, which indicates that the Y-type molecular sieve is unevenly distributed on the fiber surface.

Comparative Example 5

[0135] Refer to references for experimental steps (Colloids & Surfaces B Biointerfaces, 2018, 165:199).

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.
(2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.
(3) The above Y-type molecular sieve was dispersed in a polymeric N-halamine precursor water/ethanol solution (polymeric N-halamine precursor is an adhesive 2).
(4) The solution prepared in the step (3) was sprayed on cotton fibers.
(5) Dry at 65° C. to obtain a Y-type molecular sieve/cotton fiber composite (including adhesive 2).
(6) The Y-type molecular sieve/cotton fiber composite (including adhesive 2) is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the Y-type molecular sieve/cotton fiber composite (including adhesive 2) to obtain the Y-type molecular sieve/cotton fiber hemostatic fabric (including adhesive 2), and the mass ratio of trypsin to molecular sieve is 1:200.

[0136] The difference between this Comparative Example and Example 1 is that the molecular sieves with an adhesive were sprayed onto cotton fibers. After detection of scanning electron microscope, there is no rough planar surface (inner surface) in contact with the fiber, so there is no growth-matched coupling. The binding strength between the molecular sieve and the fiber was measured. The retention rate of the molecular sieve on the fiber of Y-type molecular sieve/cotton fiber composite (including adhesive 2) was 41% under ultrasonic condition for 20 min, indicating that the molecular sieve has a weak binding strength with the fiber, and the molecular sieve easily falls off. From detection of scanning electron microscope, the molecular sieve was unevenly distributed on the fiber surface, and there was agglomeration of the molecular sieve. From testing, with the addition of adhesive, the effective specific surface area of the molecular sieve became 256 m.sup.2g.sup.−1, the degree of calcium ion exchange became 65.9%, the degree of magnesium ion exchange became 47%, and the degree of strontium ion exchange became 42%. The composite with added adhesive reduces the effective contact area between the molecular sieve and the reaction system, and reduces the ion exchange and pore substance exchange capacity of the molecular sieve, which is not conducive to the adsorption of trypsin.

[0137] Ten samples of the prepared Y-type molecular sieve/cotton fiber composite (including adhesive 2) were randomly taken at different locations, and the content of the Y-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 25 wt %, the standard deviation of the samples is 4 wt %, and the coefficient of variation is 16%, which indicates that the Y-type molecular sieve is unevenly distributed on the fiber surface.

Comparative Example 6

[0138] Refer to references for experimental steps (Key Engineering Materials, 2006, 317-318:777-780).

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.
(2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.
(3) The Y-type molecular sieve sample was dispersed in a silica sol-based inorganic adhesive (adhesive 3) solution to obtain a slurry of a molecular sieve and adhesive mixture.
(4) The prepared slurry in the step (3) was coated on cotton fibers, and then kept at room temperature for 1 h, and then kept at 100° C. for 1 h. The fibers were completely dried to obtain a Y-type molecular sieve/cotton fiber composite (including adhesive 3).
(5) The Y-type molecular sieve/cotton fiber composite (including adhesive 3) is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the Y-type molecular sieve/cotton fiber composite (including adhesive 3) to obtain the Y-type molecular sieve/cotton fiber hemostatic fabric (including adhesive 3), and the mass ratio of trypsin to molecular sieve is 1:200.

[0139] The difference between this Comparative Example and Example 1 is that the molecular sieves with a silica sol-based adhesive were coated on the cotton fibers. From detection of scanning electron microscope, there is no rough planar surface (inner surface) in contact with the fiber, so there is no growth-matched coupling. The binding strength between the molecular sieve and the fiber was measured. The retention rate of the molecular sieve on the fiber of the Y-type molecular sieve/cotton fiber composite (including adhesive 3) was 46% under ultrasonic condition for 20 min, indicating that the molecular sieve has a weak binding strength with the fiber, and the molecular sieve easily falls off. From detection of scanning electron microscope, the molecular sieve was unevenly distributed on the fiber surface, and there was agglomeration of the molecular sieve. From testing, with the addition of adhesive, the effective specific surface area of the molecular sieve became 246 m.sup.2g.sup.−1, the degree of calcium ion exchange became 55.9%, the degree of magnesium ion exchange became 57%, and the degree of strontium ion exchange became 40%. The composite with added adhesive reduces the effective contact area between the molecular sieve and the reaction system, and reduces the ion exchange and pore substance exchange capacity of the molecular sieve, which is not conducive to the adsorption of trypsin.

[0140] Ten samples of the prepared Y-type molecular sieve/cotton fiber composite (including adhesive 3) were randomly taken at different locations, and the content of the Y-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 25 wt %, the standard deviation of the samples is 8.5 wt %, and the coefficient of variation is 34%, which indicates that the Y-type molecular sieve is unevenly distributed on the fiber surface.

Comparative Example 7

[0141] Refer to references for experimental steps (Journal of Porous Materials, 1996, 3(3):143-150).

(1) The fibers were chemically pretreated. The fibers were first treated with ether for 20 minutes and sonicated in distilled water for 10 minutes.
(2) A molecular sieve precursor solution was prepared, and a starting material was composed of 7.5Na.sub.2O:Al.sub.2O.sub.3:10SiO.sub.2:230H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution, followed by magnetic stirring for 1 h and standing at room temperature for 24 h. The molecular sieve precursor solution was mixed with pretreated cotton fibers.
(3) The pretreated cotton fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 100° C. for 6 h to obtain a Y-type molecular sieve/cotton fiber composite (pretreatment of fiber).
(4) The Y-type molecular sieve/cotton fiber composite (pretreatment of fiber) is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the Y-type molecular sieve/cotton fiber composite (pretreatment of fiber) to obtain the Y-type molecular sieve/cotton fiber hemostatic fabric (pretreatment of fiber), and the mass ratio of trypsin to molecular sieve is 1:200.

[0142] The difference between this Comparative Example and Example 1 is that the fiber is pretreated, but the structure of the fiber itself is seriously damaged, which affects the characteristics such as the flexibility and elasticity of the fiber, and the fiber becomes brittle and hard. Therefore, the advantages of fiber as a carrier cannot be fully utilized. From detection by a scanning electron microscope, the molecular sieve was wrapped in the outer layer of the fiber, and there was still a gap between the fiber and the molecular sieve, indicating that this technology cannot tightly combine molecular sieve and fiber. Compared with Example 1, there is no rough planar surface (inner surface) in contact with the fiber, so there is no growth-matched coupling. The binding strength between the molecular sieve and the fiber was measured. The retention rate of the molecular sieve on the fiber of Y-type molecular sieve/cotton fiber composite (pretreatment of fiber) was 63% under ultrasonic condition for 20 min, indicating that the molecular sieve has a weak binding strength with the fiber, and the molecular sieve easily falls off. From testing, the agglomeration of molecular sieve makes the effective specific surface area of the molecular sieve to become 346 m.sup.2g.sup.−1, the degree of calcium ion exchange become 53%, the degree of magnesium ion exchange become 52%, and the degree of strontium ion exchange become 42%, which greatly reduces the effective contact area between the effective molecular sieve and the reaction system, and reduces the ion exchange and pore substance exchange capacity of the molecular sieve, which is not conducive to the adsorption of trypsin.

[0143] Ten samples of the prepared Y-type molecular sieve/cotton fiber composite (pretreatment of fiber) were randomly taken at different locations, and the content of the Y-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 25 wt %, the standard deviation of the samples is 9 wt %, and the coefficient of variation is 36%, which indicates that the Y-type molecular sieve is unevenly distributed on the fiber surface.

Comparative Example 8

[0144] Refer to Chinese patent CN104888267A for experimental steps.

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.
(2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.
(3) Prepare polyurethane urea stock solution.
(4) The Y-type molecular sieve is ground in a dimethylacetamide solvent to obtain a Y-type molecular sieve solution.
(5) The polyurethane urea stock solution and the Y-type molecular sieve solution are simultaneously placed in a reaction container, and spandex fibers are prepared through a dry spinning process, and finally woven into a Y-type molecular sieve/spandex fiber composite (blend spinning).
(6) The Y-type molecular sieve/spandex fiber composite (blend spinning) is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the Y-type molecular sieve/spandex fiber composite (blend spinning) to obtain the Y-type molecular sieve/spandex fiber hemostatic fabric (blend spinning), and the mass ratio of trypsin to molecular sieve is 1:200.

[0145] The difference between this Comparative Example and Example 1 is that the Y-type molecular sieve is blended and spun into the fiber, and there is no growth-matched coupling, and the molecular sieve and the fiber are simply physically mixed. In addition, the effective specific surface area of the molecular sieve becomes 126 m.sup.2g.sup.−1, the degree of calcium ion exchange becomes 45.9%, the degree of magnesium ion exchange becomes 27%, and the degree of strontium ion exchange becomes 12%. The hemostatic fabric prepared by the blend spinning greatly reduces the effective contact area between the effective molecular sieve and the reaction system, and reduces the ion exchange and pore substance exchange capacity of the molecular sieve, which is not conducive to the adsorption of trypsin.

[0146] The difference between this Comparative Example and Example 1 is that the Y-type molecular sieve is blended and spun into the fiber. From detection by a scanning electron microscope, molecular sieve and fiber were simply physically mixed, and there was no growth-matched coupling. From testing, this method makes the effective specific surface area of the molecular sieve become 126 m.sup.2g.sup.−1, the degree of calcium ion exchange become 45.9%, the degree of magnesium ion exchange become 27%, and the degree of strontium ion exchange become 12%. The Y-type molecular sieve/spandex fiber composite (blend spinning) greatly reduces the effective contact area between the effective molecular sieve and the reaction system, and reduces the ion exchange and pore substance exchange capacity of the molecular sieve.

Comparative Example 9

[0147] (1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution is mixed with cotton fiber, and the mass ratio of the cotton fiber and the molecular sieve precursor solution is 1:0.3.
(2) The cotton fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve/cotton fiber composite. The content of Y-type molecular sieve was 90 wt %.

[0148] The difference between this Comparative Example and Example 1 is that the content of the Y-type molecular sieves is different. The content of the Y-type molecular sieves of this Comparative Example is greater than 80 wt %. From detection by a scanning electron microscope, the molecular sieves are clumped and wrapped on the fiber surface. The molecular sieves are not independently dispersed on the fiber surface, resulting in fiber stiffening. From testing, the agglomeration of molecular sieves makes the effective specific surface area of the molecular sieve become 346 m.sup.2g.sup.−1, the degree of calcium ion exchange become 53%, the degree of magnesium ion exchange become 52%, and the degree of strontium ion exchange become 42%. Both the effective specific surface area and ion exchange capacity are significantly reduced, which is not conducive to the adsorption of trypsin.

Example 2

[0149] The preparation method of the chabazite/cotton fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with cotton fiber, and the mass ratio of the cotton fiber and the molecular sieve precursor solution is 1:0.5.
(2) The cotton fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 80° C. for 36 h to obtain a chabazite/cotton fiber composite.
(3) The chabazite/cotton fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the chabazite/cotton fiber composite to obtain the chabazite/cotton fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 4:10.

[0150] Ten samples of the prepared chabazite/cotton fiber composite were randomly taken at different locations, and the content of the chabazite on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 25 wt %, the standard deviation of the samples is 2.5 wt %, and the coefficient of variation is 10%, which indicates that the chabazite is uniformly distributed on the fiber surface.

Example 3

[0151] The preparation method of the X-type molecular sieve/silk fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 5.5Na.sub.2O:1.65K.sub.2O:Al.sub.2O.sub.3:2.2SiO.sub.2:122H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with silk fiber, and the mass ratio of the silk fiber and the molecular sieve precursor solution is 1:10.
(2) The silk fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 100° C. for 12 h to obtain a X-type molecular sieve/silk fiber composite.
(3) The X-type molecular sieve/silk fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the X-type molecular sieve/silk fiber composite to obtain the X-type molecular sieve/silk fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 2:10.

[0152] Eight samples of the prepared X-type molecular sieve/silk fiber composite were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the eight samples was 15 wt %, the standard deviation of the samples is 1.5 wt %, and the coefficient of variation is 10%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 4

[0153] The preparation method of the A-type molecular sieve/polyester fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 3Na.sub.2O:Al.sub.2O.sub.3:2SiO.sub.2:120H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polyester fiber, and the mass ratio of the polyester fiber and the molecular sieve precursor solution is 1:50.
(2) The polyester fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 100° C. for 4 h to obtain a A-type molecular sieve/polyester fiber composite.
(3) The A-type molecular sieve/polyester fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the A-type molecular sieve/polyester fiber composite to obtain the A-type molecular sieve/polyester fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:20.

[0154] Ten samples of the prepared A-type molecular sieve/polyester fiber composite were randomly taken at different locations, and the content of the A-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 50 wt %, the standard deviation of the samples is 7.5 wt %, and the coefficient of variation is 15%, which indicates that the A-type molecular sieve is uniformly distributed on the fiber surface.

Example 5

[0155] The preparation method of the ZSM-5 molecular sieve/polypropylene fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 3.5Na.sub.2O:Al.sub.2O.sub.3:28SiO.sub.2:900H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polypropylene fiber, and the mass ratio of the polypropylene fiber and the molecular sieve precursor solution is 1:200.
(2) The polypropylene fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 180° C. for 42 h to obtain a ZSM-5 molecular sieve/polypropylene fiber composite.
(3) The ZSM-5 molecular sieve/polypropylene fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the ZSM-5 molecular sieve/polypropylene fiber composite to obtain the ZSM-5 molecular sieve/polypropylene fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0156] Ten samples of the prepared ZSM-5 molecular sieve/polypropylene fiber composite were randomly taken at different locations, and the content of the ZSM-5 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 30 wt %, the standard deviation of the samples is 1.5 wt %, and the coefficient of variation is 5%, which indicates that the ZSM-5 molecular sieve is uniformly distributed on the fiber surface.

Example 6

[0157] The preparation method of the β-molecular sieve/rayon fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 2Na.sub.2O:1.1K.sub.2O Al.sub.2O.sub.3:50SiO.sub.2:750H.sub.2O:3HCl in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with rayon fiber, and the mass ratio of the rayon fiber and the molecular sieve precursor solution is 1:100.
(2) The rayon fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 135° C. for 25 h to obtain a β-molecular sieve/rayon fiber composite.
(3) The β-molecular sieve/rayon fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the β-molecular sieve/rayon fiber composite to obtain the β-molecular sieve/rayon fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:100.

[0158] Eight samples of the prepared β-molecular sieve/rayon fiber composite were randomly taken at different locations, and the content of the β-molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the eight samples was 25 wt %, the standard deviation of the samples is 2 wt %, and the coefficient of variation is 8%, which indicates that the β-molecular sieve is uniformly distributed on the fiber surface.

Example 7

[0159] The preparation method of the mordenite/acetate fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 5.5Na.sub.2O:Al.sub.2O.sub.3:30SiO.sub.2:810H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with acetate fiber, and the mass ratio of the acetate fiber and the molecular sieve precursor solution is 1:300.
(2) The acetate fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 170° C. for 24 h to obtain a mordenite/acetate fiber composite.
(3) The mordenite/acetate fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the mordenite/acetate fiber composite to obtain the mordenite/acetate fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:50.

[0160] Ten samples of the prepared mordenite/acetate fiber composite were randomly taken at different locations, and the content of the mordenite on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 35 wt %, the standard deviation of the samples is 5.25 wt %, and the coefficient of variation is 15%, which indicates that the mordenite is uniformly distributed on the fiber surface.

Example 8

[0161] The preparation method of the L-type molecular sieve/carboxymethyl cellulose hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 2.5K.sub.2O:Al.sub.2O.sub.3:12SiO.sub.2:155H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with carboxymethyl cellulose, and the mass ratio of the carboxymethyl cellulose and the molecular sieve precursor solution is 1:1.
(2) The carboxymethyl cellulose and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 220° C. for 50 h to obtain a L-type molecular sieve/carboxymethyl cellulose composite.
(3) The L-type molecular sieve/carboxymethyl cellulose composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the L-type molecular sieve/carboxymethyl cellulose composite to obtain the L-type molecular sieve/carboxymethyl cellulose hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:50.

[0162] Ten samples of the prepared L-type molecular sieve/carboxymethyl cellulose composite were randomly taken at different locations, and the content of the L-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 10 wt %, the standard deviation of the samples is 0.2 wt %, and the coefficient of variation is 2%, which indicates that the L-type molecular sieve is uniformly distributed on the fiber surface.

Example 9

[0163] The preparation method of the P-type molecular sieve/bamboo fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:400H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with bamboo fiber, and the mass ratio of the bamboo fiber and the molecular sieve precursor solution is 1:2.
(2) The bamboo fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 150° C. for 96 h to obtain a P-type molecular sieve/bamboo fiber composite.
(3) The P-type molecular sieve/bamboo fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the P-type molecular sieve/bamboo fiber composite to obtain the P-type molecular sieve/bamboo fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:50.

[0164] Twenty samples of the prepared P-type molecular sieve/bamboo fiber composite were randomly taken at different locations, and the content of the P-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the twenty samples was 80 wt %, the standard deviation of the samples is 4 wt %, and the coefficient of variation is 5%, which indicates that the P-type molecular sieve is uniformly distributed on the fiber surface.

Example 10

[0165] The preparation method of the merlinoite/linen fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:320H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with linen fiber, and the mass ratio of the linen fiber and the molecular sieve precursor solution is 1:1000.
(2) The linen fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 120° C. for 24 h to obtain a merlinoite/linen fiber composite.
(3) The merlinoite/linen fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the merlinoite/linen fiber composite to obtain the merlinoite/linen fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0166] Fifteen samples of the prepared merlinoite/linen fiber composite were randomly taken at different locations, and the content of the merlinoite on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 30 wt %, the standard deviation of the samples is 0.3 wt %, and the coefficient of variation is 1%, which indicates that the merlinoite is uniformly distributed on the fiber surface.

Example 11

[0167] The preparation method of the X-type molecular sieve/wool hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with wool, and the mass ratio of the wool and the molecular sieve precursor solution is 1:20.
(2) The wool and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 60° C. for 16 h to obtain a X-type molecular sieve/wool composite.
(3) The X-type molecular sieve/wool composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the X-type molecular sieve/wool composite to obtain the X-type molecular sieve/wool hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0168] Fifteen samples of the prepared X-type molecular sieve/wool composite were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 27 wt %, the standard deviation of the samples is 2.1 wt %, and the coefficient of variation is 7.8%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 12

[0169] The preparation method of the X-type molecular sieve/wood fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with wood fiber, and the mass ratio of the wood fiber and the molecular sieve precursor solution is 1:5.
(2) The wood fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 90° C. for 24 h to obtain a X-type molecular sieve/wood fiber composite.
(3) The X-type molecular sieve/wood fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the X-type molecular sieve/wood fiber composite to obtain the X-type molecular sieve/wood fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0170] Fifteen samples of the prepared X-type molecular sieve/wood fiber composite were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 42 wt %, the standard deviation of the samples is 2.1 wt %, and the coefficient of variation is 5%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 13

[0171] The preparation method of the X-type molecular sieve/lactide polymer fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with lactide polymer fiber, and the mass ratio of the lactide polymer fiber and the molecular sieve precursor solution is 1:50.
(2) The lactide polymer fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 90° C. for 30 h to obtain a X-type molecular sieve/lactide polymer fiber composite.
(3) The X-type molecular sieve/lactide polymer fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the X-type molecular sieve/lactide polymer fiber composite to obtain the X-type molecular sieve/lactide polymer fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0172] Fifteen samples of the prepared X-type molecular sieve/lactide polymer fiber composite were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 26 wt %, the standard deviation of the samples is 1.1 wt %, and the coefficient of variation is 4.2%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 14

[0173] The preparation method of the X-type molecular sieve/glycolide polymer fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with glycolide polymer fiber, and the mass ratio of the glycolide polymer fiber and the molecular sieve precursor solution is 1:200.
(2) The glycolide polymer fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 120° C. for 24 h to obtain a X-type molecular sieve/glycolide polymer fiber composite.
(3) The X-type molecular sieve/glycolide polymer fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the X-type molecular sieve/glycolide polymer fiber composite to obtain the X-type molecular sieve/glycolide polymer fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0174] Fifteen samples of the prepared X-type molecular sieve/glycolide polymer fiber composite were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 37 wt %, the standard deviation of the samples is 0.2 wt %, and the coefficient of variation is 0.5%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 15

[0175] The preparation method of the X-type molecular sieve/polylactide-glycolide polymer fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polylactide-glycolide polymer fiber, and the mass ratio of the polylactide-glycolide polymer fiber and the molecular sieve precursor solution is 1:20.
(2) The polylactide-glycolide polymer fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 90° C. for 24 h to obtain a X-type molecular sieve/polylactide-glycolide polymer fiber composite.
(3) The X-type molecular sieve/polylactide-glycolide polymer fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the X-type molecular sieve/polylactide-glycolide polymer fiber composite to obtain the X-type molecular sieve/polylactide-glycolide polymer fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0176] Fifteen samples of the prepared X-type molecular sieve/polylactide-glycolide polymer fiber composite were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 20 wt %, the standard deviation of the samples is 0.04 wt %, and the coefficient of variation is 0.2%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 16

[0177] The preparation method of the X-type molecular sieve/polyamide fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polyamide fiber, and the mass ratio of the polyamide fiber and the molecular sieve precursor solution is 1:0.8.
(2) The polyamide fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 90° C. for 24 h to obtain a X-type molecular sieve/polyamide fiber composite.
(3) The X-type molecular sieve/polyamide fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the X-type molecular sieve/polyamide fiber composite to obtain the X-type molecular sieve/polyamide fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0178] Fifteen samples of the prepared X-type molecular sieve/polyamide fiber composite were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 50 wt %, the standard deviation of the samples is 2 wt %, and the coefficient of variation is 4%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 17

[0179] The preparation method of the X-type molecular sieve/rayon-polyester fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with rayon-polyester fiber, and the mass ratio of the rayon-polyester fiber and the molecular sieve precursor solution is 1:50.
(2) The rayon-polyester fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 110° C. for 28 h to obtain a X-type molecular sieve/rayon-polyester fiber composite.
(3) The X-type molecular sieve/rayon-polyester fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the X-type molecular sieve/rayon-polyester fiber composite to obtain the X-type molecular sieve/rayon-polyester fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0180] Eight samples of the prepared X-type molecular sieve/rayon-polyester fiber composite were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the eight samples was 5 wt %, the standard deviation of the samples is 0.05 wt %, and the coefficient of variation is 1%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 18

[0181] The preparation method of the X-type molecular sieve/chitin fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with chitin fiber, and the mass ratio of the chitin fiber and the molecular sieve precursor solution is 1:1.5.
(2) The chitin fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 90° C. for 24 h to obtain a X-type molecular sieve/chitin fiber composite.
(3) The X-type molecular sieve/chitin fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the X-type molecular sieve/chitin fiber composite to obtain the X-type molecular sieve/chitin fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0182] Fifteen samples of the prepared X-type molecular sieve/chitin fiber composite were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 20 wt %, the standard deviation of the samples is 2.5 wt %, and the coefficient of variation is 12.5%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 19

[0183] The preparation method of the AlPO.sub.4-5 molecular sieve/polyethylene fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of Al.sub.2O.sub.3:1.3P.sub.2O.sub.5:1.3HF:425H.sub.2O:6C.sub.3H.sub.7OH in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polyethylene fiber, and the mass ratio of the polyethylene fiber and the molecular sieve precursor solution is 1:20.
(2) The polyethylene fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 180° C. for 6 h to obtain the AlPO.sub.4-5 molecular sieve/polyethylene fiber composite.
(3) The AlPO.sub.4-5 molecular sieve/polyethylene fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the AlPO.sub.4-5 molecular sieve/polyethylene fiber composite to obtain the AlPO.sub.4-5 molecular sieve/polyethylene fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0184] Fifteen samples of the prepared AlPO.sub.4-5 molecular sieve/polyethylene fiber composite were randomly taken at different locations, and the content of the AlPO.sub.4-5 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 18 wt %, the standard deviation of the samples is 2.5 wt %, and the coefficient of variation is 13.9%, which indicates that the AlPO.sub.4-5 molecular sieve is uniformly distributed on the fiber surface.

Example 20

[0185] The preparation method of the AlPO.sub.4-11 molecular sieve/polyvinyl chloride fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of Al.sub.2O.sub.3:1.25P.sub.2O.sub.5:1.8HF:156H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polyvinyl chloride fiber, and the mass ratio of the polyvinyl chloride fiber and the molecular sieve precursor solution is 1:0.5.
(2) The polyvinyl chloride fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 145° C. for 18 h to obtain the AlPO.sub.4-11 molecular sieve/polyvinyl chloride fiber composite.
(3) The AlPO.sub.4-11 molecular sieve/polyvinyl chloride fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the AlPO.sub.4-11 molecular sieve/polyvinyl chloride fiber composite to obtain the AlPO.sub.4-11 molecular sieve/polyvinyl chloride fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0186] Fifteen samples of the prepared AlPO.sub.4-11 molecular sieve/polyvinyl chloride fiber composite were randomly taken at different locations, and the content of the AlPO.sub.4-11 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 28 wt %, the standard deviation of the samples is 2 wt %, and the coefficient of variation is 7.1%, which indicates that the AlPO.sub.4-11 molecular sieve is uniformly distributed on the fiber surface.

Example 21

[0187] The preparation method of the SAPO-31 molecular sieve/polyacrylonitrile fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of Al.sub.2O.sub.3:P.sub.2O.sub.5:0.5SiO.sub.2:60H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polyacrylonitrile fiber, and the mass ratio of the polyacrylonitrile fiber and the molecular sieve precursor solution is 1:1000.
(2) The polyacrylonitrile fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 175° C. for 14.5 h to obtain a SAPO-31 molecular sieve/polyacrylonitrile fiber composite.
(3) The SAPO-31 molecular sieve/polyacrylonitrile fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the SAPO-31 molecular sieve/polyacrylonitrile fiber composite to obtain the SAPO-31 molecular sieve/polyacrylonitrile fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0188] Fifteen samples of the prepared SAPO-31 molecular sieve/polyacrylonitrile fiber composite were randomly taken at different locations, and the content of the SAPO-31 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 34 wt %, the standard deviation of the samples is 5 wt %, and the coefficient of variation is 14.7%, which indicates that the SAPO-31 molecular sieve is uniformly distributed on the fiber surface.

Example 22

[0189] The preparation method of the SAPO-34 molecular sieve/viscose fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of Al.sub.2O.sub.3:1.06P.sub.2O.sub.5:1.08SiO.sub.2:2.09morpholine:60H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with viscose fiber, and the mass ratio of the viscose fiber and the molecular sieve precursor solution is 1:20.
(2) The viscose fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 175° C. for 14.5 h to obtain a SAPO-34 molecular sieve/viscose fiber composite.
(3) The SAPO-34 molecular sieve/viscose fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the SAPO-34 molecular sieve/viscose fiber composite to obtain the SAPO-34 molecular sieve/viscose fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0190] Fifteen samples of the prepared SAPO-34 molecular sieve/viscose fiber composite were randomly taken at different locations, and the content of the SAPO-34 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 1 wt %, the standard deviation of the samples is 0.01 wt %, and the coefficient of variation is 1%, which indicates that the SAPO-34 molecular sieve is uniformly distributed on the fiber surface.

Example 23

[0191] The preparation method of the SAPO-11 molecular sieve/chitin fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of Al.sub.2O.sub.3:P.sub.2O.sub.5:0.5 SiO.sub.2:60H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with chitin fiber, and the mass ratio of the chitin fiber and the molecular sieve precursor solution is 1:1.5.
(2) The chitin fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 175° C. for 48 h to obtain a SAPO-11 molecular sieve/chitin fiber composite.
(3) The SAPO-11 molecular sieve/chitin fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the SAPO-11 molecular sieve/chitin fiber composite to obtain the SAPO-11 molecular sieve/chitin fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0192] Fifteen samples of the prepared SAPO-11 molecular sieve/chitin fiber composite were randomly taken at different locations, and the content of the SAPO-11 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 35 wt %, the standard deviation of the samples is 1.5 wt %, and the coefficient of variation is 5%, which indicates that the SAPO-11 molecular sieve is uniformly distributed on the fiber surface.

Example 24

[0193] The preparation method of the BAC-1 molecular sieve/chitin fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 1.5B.sub.2O.sub.3:2.25Al.sub.2O.sub.3:2.5CaO:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with chitin fiber, and the mass ratio of the chitin fiber and the molecular sieve precursor solution is 1:100.
(2) The chitin fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 200° C. for 72 h to obtain a BAC-1 molecular sieve/chitin fiber composite.
(3) The BAC-1 molecular sieve/chitin fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the BAC-1 molecular sieve/chitin fiber composite to obtain the BAC-1 molecular sieve/chitin fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0194] Fifteen samples of the prepared BAC-1 molecular sieve/chitin fiber composite were randomly taken at different locations, and the content of the BAC-1 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 0.5 wt %, the standard deviation of the samples is 0.04 wt %, and the coefficient of variation is 8%, which indicates that the BAC-1 molecular sieve is uniformly distributed on the fiber surface.

Example 25

[0195] The preparation method of the BAC-3 molecular sieve/chitin fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 3B.sub.2O.sub.3:Al.sub.2O.sub.3:0.7Na.sub.2O:100H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with chitin fiber, and the mass ratio of the chitin fiber and the molecular sieve precursor solution is 1:2.
(2) The chitin fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 200° C. for 240 h to obtain a BAC-3 molecular sieve/chitin fiber composite.
(3) The BAC-3 molecular sieve/chitin fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the BAC-3 molecular sieve/chitin fiber composite to obtain the BAC-3 molecular sieve/chitin fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0196] Fifteen samples of the prepared BAC-3 molecular sieve/chitin fiber composite were randomly taken at different locations, and the content of the BAC-3 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 27 wt %, the standard deviation of the samples is 0.08 wt %, and the coefficient of variation is 0.3%, which indicates that the BAC-3 molecular sieve is uniformly distributed on the fiber surface.

Example 26

[0197] The preparation method of the BAC-10 molecular sieve/chitin fiber hemostatic fabric of the present disclosure includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 2.5B.sub.2O.sub.3:2Al.sub.2O.sub.3:CaO:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with chitin fiber, and the mass ratio of the chitin fiber and the molecular sieve precursor solution is 1:20.
(2) The chitin fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 160° C. for 72 h to obtain a BAC-10 molecular sieve/chitin fiber composite.
(3) The BAC-10 molecular sieve/chitin fiber composite is prepared into a suspension, and trypsin is mixed with the suspension. The trypsin is adsorbed on the BAC-10 molecular sieve/chitin fiber composite to obtain the BAC-10 molecular sieve/chitin fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 1:10.

[0198] Fifteen samples of the prepared BAC-10 molecular sieve/chitin fiber composite were randomly taken at different locations, and the content of the BAC-10 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 21 wt %, the standard deviation of the samples is 0.9 wt %, and the coefficient of variation is 4.2%, which indicates that the BAC-10 molecular sieve is uniformly distributed on the fiber surface.

[0199] Wherein, the mass ratio of trypsin to molecular sieve in the hemostatic fabric containing trypsin according to the present disclosure is effective in the range of 1:200-4:10.

[0200] The fibers used in Examples 1-26 of the present disclosure have not been subjected to pretreatment, and the pretreatment refers to a treatment method that destroys fiber structure of the fiber. Pretreatment method is selected from any one or more of chemical treatment, mechanical treatment, ultrasonic treatment, microwave treatment, and the like. The method of chemical treatment is divided into treatment with base compound, acid compound, organic solvent, etc. The base compound may be selected from any one or more of NaOH, KOH, Na.sub.2SiO.sub.3, etc. The acid compound may be selected from any one or more of hydrochloric acid, sulfuric acid, nitric acid, etc. The organic solvent may be selected from any one or more of ether, acetone, ethanol etc. Mechanical treatment can be by crushing or grinding fibers.

[0201] Further, the molecular sieve precursor solution and the fiber in Examples 1-26 of the present disclosure are mixed, and the mixing is to uniformly contact any surface of the fiber with the molecular sieve precursor solution.

[0202] Further, the molecular sieve precursor solution and the fiber in Examples 1-26 of the present disclosure are mixed, and the operation means of mixing is selected from any one or more ways of spraying, dropping, and injecting the molecular sieve precursor solution on the fiber surface.

[0203] Further, the molecular sieve precursor solution and the fiber in Examples 1-26 of the present disclosure are mixed, and the molecular sieve precursor solution is sprayed on the fiber surface. The spraying rate is 100-1000 mL/min; preferably, the spraying rate is 150-600 mL/min; preferably, the spraying rate is 250-350 mL/min.

[0204] Further, the molecular sieve precursor solution and the fiber in Examples 1-26 of the present disclosure are mixed, and the molecular sieve precursor solution is dropped on the fiber surface, and the dropping rate is 10 mL/h to 1000 mL/h; preferably, the dropping rate is 15 mL/h to 500 mL/h; preferably, the dropping rate is 20 mL/h to 100 mL/h; preferably, the dropping rate is 30 mL/h to 50 mL/h.

[0205] Further, the molecular sieve precursor and the fiber in Examples 1-26 of the present disclosure are mixed, and the operation means of mixing is selected from any one or more ways of rotating, turning, and moving the fiber to uniformly contact with the molecular sieve precursor solution.

Comparative Examples 10 and 11

[0206] Commercially available granular molecular sieve materials (Quikclot) and Combat Gauze from Z-Medica Co., Ltd., were taken as Comparative Examples 10 and 11, respectively. The hemostatic function of the materials was evaluated using a rabbit femoral artery lethal model.

[0207] Among them, the commercial Combat Gauze is an inorganic hemostatic material (clay, kaolin) attached to the fiber surface. Observed from the scanning electron microscope, the inorganic hemostatic material is unevenly distributed on the fiber surface (FIG. 17), and the material is not bonded to the fiber surface, and it is easy to fall off from the fiber surface. Clay retention rate on the gauze fiber is 10% or less under ultrasonic condition for 1 min; clay retention rate on the gauze fiber is 5% or less under ultrasonic condition for 5 min (FIG. 18); clay retention rate on the gauze fiber is 5% or less under ultrasonic condition for 20 min. This defective structural form limits the hemostatic properties of the hemostatic product and risks causing sequelae or other side effects.

Comparative Example 12

[0208] The preparation method of the Y-type molecular sieve/cotton fiber composite includes the following steps:

(1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with cotton fiber, and the mass ratio of the cotton fiber and the molecular sieve precursor solution is 1:20.
(2) The cotton fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve/cotton fiber composite.

[0209] Detection method of hemostatic function of Y-type molecular sieve/cotton fiber composite: The hemostatic function of Y-type molecular sieve/cotton fiber composite is evaluated by using a rabbit femoral artery lethal model. The specific steps are as follows: (1) before the experiment, white rabbits were anesthetized with sodium pentobarbital intravenously (45 mg/kg); their limbs and head were fixed, and supine on the experimental table; part of the hair was removed to expose the right groin of the hind limb. (2) Then, the femoral skin and muscle were cut longitudinally to expose the femoral artery, and the femoral artery was partially cut off (about half of the circumference). After the femoral artery was allowed to squirt freely for 30 seconds, the blood at the wound was cleaned with cotton gauze, and then the Y-type molecular sieve/cotton fiber composite (5 g) was quickly pressed to the wound. After pressing for 60 seconds, the Y-type molecular sieve/cotton fiber composite is lifted up slightly every 10 seconds to observe the coagulation of the injured part and the coagulation time is recorded. Infrared thermometers are used to detect changes in wound temperature. (3) After hemostasis, observe the wound and suture the wound. The survival of the animals is observed for 2 hours after hemostasis. The survival rate=(total number of experimental white rabbits−number of deaths of white rabbits observed for 2 hours after hemostasis)×100%/total number of experimental white rabbits, wherein the number of experimental white rabbits in each group is n, n is a positive integer greater than or equal to 6.

(4) The difference in weight of the Y-type molecular sieve/cotton fiber composite before and after use was recorded as the amount of blood loss during wound hemostasis.

Comparative Example 13

[0210] Detection method of hemostatic function of trypsin: The hemostatic function of trypsin is evaluated by using a rabbit femoral artery lethal model. The specific steps are as follows: (1) before the experiment, white rabbits were anesthetized with sodium pentobarbital intravenously (45 mg/kg); their limbs and head were fixed, and supine on the experimental table; part of the hair was removed to expose the right groin of the hind limb. (2) Then, the femoral skin and muscle were cut longitudinally to expose the femoral artery, and the femoral artery was partially cut off (about half of the circumference). After the femoral artery was allowed to squirt freely for 30 seconds, the blood at the wound was cleaned with cotton gauze, and then the trypsin (5 g) was quickly pressed to the wound. After pressing for 60 seconds, the trypsin is lifted up slightly every 10 seconds to observe the coagulation of the injured part and the coagulation time is recorded. Infrared thermometers are used to detect changes in wound temperature. (3) After hemostasis, observe the wound and suture the wound. The survival of the animals is observed for 2 hours after hemostasis. The survival rate=(total number of experimental white rabbits−number of deaths of white rabbits observed for 2 hours after hemostasis)×100%/total number of experimental white rabbits, wherein the number of experimental white rabbits in each group is n, n is a positive integer greater than or equal to 6.

(4) The difference in weight of the trypsin before and after use was recorded as the amount of blood loss during wound hemostasis.

[0211] Comparison between Example 1 and Comparative Examples 12,13 shows that the hemostatic time of rabbit femoral artery of molecular sieve/fiber composite in Comparative Example 12 was 2.5 min, and the blood loss was 4±0.5 g; the hemostatic time of rabbit femoral of trypsin in Comparative Example 13 was 5 min, and the blood loss was 7.5±0.9 g, and the trypsin powder blocked the blood vessels, and it was not easy to control the amount of use; while the hemostatic time of the rabbit femoral artery of the molecular sieve/fiber hemostatic fabric in Example 1 was 1 min, and the blood loss was 2±0.5 g. Therefore, the hemostatic effect of the hemostatic fabric containing trypsin of the present disclosure is far better than that of the molecular sieve/fiber composite or trypsin alone, wherein the clotting time is greatly shortened, and the amount of blood loss is significantly reduced. The molecular sieve (pore structure and metal cation) on the surface of the molecular sieve/fiber composite in the hemostatic fabric positively regulates the spatial conformation and spatial orientation of trypsin, so that the trypsin on the surface of the molecular sieve/fiber composite promotes clotting cascade. During the process, the activity of converting prothrombin into thrombin is improved. The overall effect of the hemostatic fabric containing trypsin of the present disclosure formed by the synergistic effect of trypsin and molecular sieve/fiber composite is much better than that of trypsin or molecular sieve/fiber composite alone, and its procoagulant activity is far superior to that of trypsin alone, and the procoagulant activity is also better than that of molecular sieve fiber complex alone. In the event of accidental bleeding, the hemostatic fabric containing trypsin can effectively stop bleeding, minimize the risk of death from aorta bleeding, and reduce damage to important organs.

[0212] The certain size of the molecular sieve in the hemostatic fabric can promote the uniform distribution of the molecular sieve on the fiber surface. The size of the molecular sieve and the average particle diameters of the inner and outer surface nanoparticles in the prepared hemostatic fabric of Examples 1-26 are shown in Table 1, according to the observation of the scanning electron microscope. In order to evaluate the binding strength between the molecular sieve and the fiber, the prepared molecular sieve/fiber composite of Examples 1-26 were ultrasonicated in deionized water for 20, 40, 60, and 80 minutes, respectively. After ultrasonic testing, the retention rates of the molecular sieve on the fibers are shown in Table 2. In order to show that the molecular sieve in the molecular sieve/fiber composite of hemostatic fabric of the present disclosure maintains a good structure and performance on the fiber, after testing, the effective specific surface area and ion exchange capacity of the molecular sieve of molecular sieve/fiber composite of Examples 1-26 are shown in Table 3. In order to illustrate the superior hemostatic properties of hemostatic fabric, a rabbit femoral artery lethal model was used to evaluate the hemostatic function of hemostatic fabric of Examples 1-26 and hemostatic material of Comparative Examples. After observing and testing, statistical data of hemostatic performance are shown in Table 4.

TABLE-US-00001 TABLE 1 The particle size of molecular sieve of the molecular sieve/fiber composite and the average particle size of the nanoparticles on the inner and outer surfaces Average particle Average particle Molecular Molecular size of the size of the Serial sieve sieve nanoparticles on the nanoparticles on the number Material D90/pm D50/pm outer surfaces/nm inner surfaces/nm Example 1 Y-type molecular sieve/cotton fiber 25 5 148 61 composite Example 2 Chabazite/cotton fiber composite 4 2 200 31 Example 3 X-type molecular sieve/silk fiber 20 10 256 51 composite Example 4 A-type molecular sieve/polyester 50 30 141 12 fiber composite Example 5 ZSM-5 molecular 30 15 190 11 sieve/polypropylene fiber composite Example 6 β-molecular sieve/rayon fiber 6 4 110 33 composite Example 7 Mordenite/acetate fiber composite 7 3 109 23 Example 8 L-type molecular 8 5.5 300 22 sieve/carboxymethyl cellulose composite Example 9 P-type molecular sieve/bamboo fiber 10 8 240 60 composite Example 10 Merlinoite/linen fiber composite 5 1 200 12 Example 11 X-type molecular sieve/wool 10 5 240 4 composite Example 12 X-type molecular sieve/wood fiber 0.1 0.05 3 2 composite Example 13 X-type molecular sieve/lactide 0.01 0.005 3 2 polymer fiber composite Example 14 X-type molecular sieve/glycolide 0.5 0.25 10 4 polymer fiber composite Example 15 X-type molecular sieve/polylactide- 1 0.5 30 20 glycolide polymer fiber composite Example 16 X-type molecular sieve/polyamide 5 2.5 30 20 fiber composite Example 17 X-type molecular sieve/rayon- 20 13 195 68 polyester fiber composite Example 18 X-type molecular sieve/chitin fiber 20 10 150 100 composite Example 19 A1PO4-5 molecular 7.5 5.5 500 22 sieve/polyethylene fiber composite Example 20 A1PO4-11 molecular sieve/poly vinyl 5 4 200 2 chloride fiber composite Example 21 SAPO-31 molecular 3 2 109 25 sieve/polyacrylonitrile fiber composite Example 22 SAPO-34 molecular sieve/viscose 5 4 110 33 fiber composite Example 23 SAPO-11 molecular sieve/chitin fiber 8 5 211 10 composite Example 24 BAC-1 molecular sieve/chitin fiber 12 10 256 51 composite Example 25 BAC-3 molecular sieve/chitin fiber 15 8 500 32 composite Example 26 BAC-10 molecular sieve/chitin fiber 10 8 50 4 composite

TABLE-US-00002 TABLE 2 The binding strength of molecular sieve and fiber of molecular sieve/fiber composite Retention rate of Retention rate of Retention rate of Retention rate of molecular sieves molecular sieves molecular sieves molecular sieves on fibers under on fibers under on fibers under on fibers under Serial ultrasonic condition ultrasonic condition ultrasonic condition ultrasonic condition number Material for 20 min for 40 min for 60 min for 80 min Example 1 Y-type molecular sieve/cotton 100% 100% 100% 100% fiber composite Example 2 Chabazite/cotton fiber 100% 100% 100% 100% composite Example 3 X-type molecular sieve/silk  95%  95%  95%  95% fiber composite Example 4 A-type molecular 100% 100% 100% 100% sieve/polyester fiber composite Example 5 ZSM-5 molecular  98%  98%  98%  98% sieve/polypropylene fiber composite Example 6 β-molecular sieve/rayon fiber 100% 100% 100% 100% composite Example 7 Mordenite/acetate fiber  91%  91%  91%  91% composite Example 8 L-type molecular  99%  99%  99%  99% sieve/carboxymethyl cellulose composite Example 9 P-type molecular sieve/bamboo 100% 100% 100% 100% fiber composite Example 10 Merlinoite/linen fiber 100% 100% 100% 100% composite Example 11 X-type molecular sieve/wool  90%  90%  90%  90% composite Example 12 X-type molecular sieve/wood 100% 100% 100% 100% fiber composite Example 13 X-type molecular sieve/lactide 100% 100% 100% 100% polymer fiber composite Example 14 X-type molecular 100% 100% 100% 100% sieve/glycolide polymer fiber composite Example 15 X-type molecular 100% 100% 100% 100% sieve/polylactide-glycolide polymer fiber composite Example 16 X-type molecular  94%  94%  94%  94% sieve/polyamide fiber composite Example 17 X-type molecular sieve/rayon-  96%  96%  96%  96% polyester fiber composite Example 18 X-type molecular sieve/chitin  91%  91%  91%  91% fiber composite Example 19 AlPO.sub.4-5 molecular 100% 100% 100% 100% sieve/polyethylene fiber composite Example 20 AlPO.sub.4-11 molecular 100% 100% 100% 100% sieve/polyvinyl chloride fiber composite Example 21 SAPO-31 molecular  90%  90%  90%  90% sieve/polyacrylonitrile fiber composite Example 22 SAPO-34 molecular 100% 100% 100% 100% sieve/viscose fiber composite Example 23 SAPO-11 molecular sieve/chitin 100% 100% 100% 100% fiber composite Example 24 BAC-1 molecular sieve/chitin 100% 100% 100% 100% fiber composite Example 25 BAC-3 molecular sieve/chitin 100% 100% 100% 100% fiber composite Example 26 BAC-10 molecular sieve/chitin  99%  99%  99%  99% fiber composite

TABLE-US-00003 TABLE 3 Effective specific surface area and ion exchange capacity of molecular sieves of molecular sieve/fiber composite Effective specific Degree of Degree of Degree of Serial surface area of molecular calcium ion magnesium ion Strontium ion number Material sieves/(m.sup.2g.sup.−1) exchange exchange exchange Example 1 Y-type molecular sieve/cotton fiber 490 99.9%.sup.  97% 90% composite Example 2 Chabazite/cotton fiber composite 853 90.2%.sup.  92% 80% Example 3 X-type molecular sieve/silk fiber 741 91% 81% 80% composite Example 4 A-type molecular sieve/polyester 502 85% 77% 70% fiber composite Example 5 ZSM-5 molecular 426 80% 77% 70% sieve/polypropylene fiber composite Example 6 β-molecular sieve/rayon fiber 763 95% 87% 85% composite Example 7 Mordenite/acetate fiber composite 412 95% 87% 85% Example 8 L-type molecular 858 85% 81% 80% sieve/carboxymethyl cellulose composite Example 9 P-type molecular sieve/bamboo fiber 751 91% 90% 85% composite Example 10 Merlinoite/linen fiber composite 510 98.5%.sup.  97% 90% Example 11 X-type molecular sieve/wool 494 98% 97% 91% composite Example 12 X-type molecular sieve/wood fiber 492 99% 97% 93% composite Example 13 X-type molecular sieve/lactide 496 98.9%.sup.  97% 90% polymer fiber composite Example 14 X-type molecular sieve/glycolide 480 97% 97% 91% polymer fiber composite Example 15 X-type molecular sieve/polylactide- 499 99.7%.sup.  95% 87% glycolide polymer fiber composite Example 16 X-type molecular sieve/polyamide 495 95% 94% 90% fiber composite Example 17 X-type molecular sieve/rayon- 846 91.2%.sup.  90% 83% polyester fiber composite Example 18 X-type molecular sieve/chitin fiber 751 91% 90% 85% composite Example 19 AlPO4-5 molecular 426 — — — sieve/polyethylene fiber composite Example 20 AlPO4-11 molecular sieve/polyvinyl 763 — — — chloride fiber composite Example 21 SAPO-31 molecular 412 — — — sieve/polyacrylonitrile fiber composite Example 22 SAPO-34 molecular sieve/viscose 858 — — — fiber composite Example 23 SAPO-11 molecular sieve/chitin fiber 510 — — — composite Example 24 BAC-1 molecular sieve/chitin fiber 494 — — — composite Example 25 BAC-3 molecular sieve/chitin fiber 492 — — — composite Example 26 BAC-10 molecular sieve/chitin fiber 496 — — — composite

TABLE-US-00004 TABLE 4 Hemostatic function of different hemostatic fabric Rising temperature Blood Serial Hemostatic Hemostatic of wound loss Ease of Debridement Wound Survival number material time (° C.) (g) use effect condition rate Example 1 Y-type molecular 1 min No .sup. 2 ± 0.5 Tailored Easy to remove, Dry and 100% sieve/cotton fiber for wound no other well healed hemostatic fabric size and removal practical required needs Example 2 Chabazite/cotton 0.8 min No .sup. 1 ± 0.5 Tailored Easy to remove, Dry and 100% fiber hemostatic for wound no other well healed fabric size and removal practical required needs Example 3 X-type molecular 0.8 min No .sup. 1 ± 0.4 Tailored Easy to remove, Dry and 100% sieve/silk fiber for wound no other well healed hemostatic fabric size and removal practical required needs Example 4 A-type molecular 1 min No 1.5 ± 0.8 Tailored Easy to remove, Dry and 100% sieve/polyester fiber for wound no other well healed hemostatic fabric size and removal practical required needs Example 5 ZSM-5 molecular 1.5 min No .sup. 2 ± 0.8 Tailored Easy to remove, Dry and 100% sieve/polypropylene for wound no other well healed fiber hemostatic size and removal fabric practical required needs Example 6 β-molecular 1 min No 1.5 ± 0.8 Tailored Easy to remove, Dry and 100% sieve/rayon fiber for wound no other well healed hemostatic fabric size and removal practical required needs Example 7 Mordenite/acetate 1.1 min No 1.7 ± 0.4 Tailored Easy to remove, Dry and 100% fiber hemostatic for wound no other well healed fabric size and removal practical required needs Example 8 L-type molecular 1.5 min No 2.1 ± 0.4 Tailored Easy to remove, Dry and 100% sieve/carboxymethyl for wound no other well healed cellulose hemostatic size and removal fabric practical required needs Example 9 P-type molecular 1.2 min No 2.1 ± 0.7 Tailored Easy to remove, Dry and 100% sieve/bamboo fiber for wound no other well healed hemostatic fabric size and removal practical required needs Example 10 Merlinoite/linen fiber 1.2 min No 2.1 ± 0.7 Tailored Easy to remove, Dry and 100% hemostatic fabric for wound no other well healed size and removal practical required needs Example 11 X-type molecular 1 min No .sup. 2 ± 0.5 Tailored Easy to remove, Dry and 100% sieve/wool hemostatic for wound no other well healed fabric size and removal practical required needs Example 12 X-type molecular 1.1 min No .sup. 2 ± 0.5 Tailored Easy to remove, Dry and 100% sieve/wood fiber for wound no other well healed hemostatic fabric size and removal practical required needs Example 13 X-type molecular 1.4 min No 2.3 ± 0.3 Tailored Easy to remove, Dry and 100% sieve/lactide polymer for wound no other well healed fiber hemostatic size and removal fabric practical required needs Example 14 X-type molecular 1.1 min No 2.1 ± 0.5 Tailored Easy to remove, Dry and 100% sieve/glycolide for wound no other well healed polymer fiber size and removal hemostatic fabric practical required needs Example 15 X-type molecular 1.1 min No 1.8 ± 0.5 Tailored Easy to remove, Dry and 100% sieve/polylactide- for wound no other well healed glycolide polymer size and removal fiber hemostatic practical required fabric needs Example 16 X-type molecular 1.2 min No 2.1 ± 0.5 Tailored Easy to remove, Dry and 100% sieve/polyamide fiber for wound no other well healed hemostatic fabric size and removal practical required needs Example 17 X-type molecular 1.2 min No 2.2 ± 0.5 Tailored Easy to remove, Dry and 100% sieve/rayon-polyester for wound no other well healed fiber hemostatic size and removal fabric practical required needs Example 18 X-type molecular 1 min No 1.5 ± 0.4 Tailored Easy to remove, Dry and 100% sieve/chitin fiber for wound no other well healed hemostatic fabric size and removal practical required needs Example 19 AlPO4-5 molecular 1 min No 1.5 ± 0.8 Tailored Easy to remove, Dry and 100% sieve/polyethylene for wound no other well healed fiber hemostatic size and removal fabric practical required needs Example 20 AlPO4-11 molecular 1.1 min No 1.7 ± 0.4 Tailored Easy to remove, Dry and 100% sieve/polyvinyl for wound no other well healed chloride fiber size and removal hemostatic fabric practical required needs Example 21 SAPO-31 molecular 1.1 min No 1.6 ± 0.4 Tailored Easy to remove, Dry and 100% sieve/polyacrylonitrile for wound no other well healed fiber hemostatic size and removal fabric practical required needs Example 22 SAPO-34 molecular 1.2 min No .sup. 2 ± 0.7 Tailored Easy to remove, Dry and 100% sieve/viscose fiber for wound no other well healed hemostatic fabric size and removal practical required needs Example 23 SAPO-11 molecular 1.3 min No 2.2 ± 0.5 Tailored Easy to remove, Dry and 100% sieve/chitin fiber for wound no other well healed hemostatic fabric size and removal practical required needs Example 24 BAC-1 molecular 1.2 min No 2.2 ± 0.5 Tailored Easy to remove, Dry and 100% sieve/chitin fiber for wound no other well healed hemostatic fabric size and removal practical required needs Example 25 BAC-3 molecular 1 min No 1.5 ± 0.8 Tailored Easy to remove, Dry and 100% sieve/chitin fiber for wound no other well healed hemostatic fabric size and removal practical required needs Example 26 BAC-10 molecular 1.2 min No 1.7 ± 0.1 Tailored Easy to remove, Dry and 100% sieve/chitin fiber for wound no other well healed hemostatic fabric size and removal practical required needs Comparative Y-type molecular 5.4 min 2 ± 1 7.4 ± 0.1 Tailored Part of the A large  60% Example 2 sieve/cotton fiber for wound molecular sieves blood clot hemostatic fabric size and fall from the forms on (impregnation practical fiber and stick the surface method) needs to the wound, of the making them wound, difficult to which is remove generally healed Comparative Y-type molecular 5.1 min 3 ± 1 6.6 ± 0.1 Tailored Part of the A large  55% Example 3 sieve/cotton fiber for wound molecular sieves blood clot hemostatic fabric size and fall from the forms on (spray method) practical fiber and stick the surface needs to the wound, of the making them wound, difficult to which is remove generally healed Comparative Y-type molecular 5.8 min 7 ± 1 5.2 ± 0.2 Tailored Part of the A large  65% Example 4 sieve/cotton fiber for wound molecular sieves blood clot hemostatic fabric size and fall from the forms on (including adhesive 1) practical fiber and stick the surface needs to the wound, of the making them wound, difficult to which is remove generally healed Comparative Y-type molecular 5.2 min 4 ± 1 8.1 ± 0.2 Tailored Part of the A large  45% Example 5 sieve/cotton fiber for wound molecular sieves blood clot hemostatic fabric size and fall from the forms on (including adhesive 2) practical fiber and stick the surface needs to the wound, of the making them wound, difficult to which is remove generally healed Comparative Y-type molecular 5.5 min 2 ± 1 7.2 ± 0.1 Tailored Part of the A large  40% Example 6 sieve/cotton fiber for wound molecular sieves blood clot hemostatic fabric size and fall from the forms on (including adhesive 3) practical fiber and stick the surface needs to the wound, of the making them wound, difficult to which is remove generally healed Comparative Y-type molecular 6.2 min 2 ± 1 6.6 ± 0.1 hard and Part of the A large  45% Example 7 sieve/cotton fiber brittle, molecular sieves blood clot hemostatic fabric and does fall from the forms on (pretreatment of fiber) not make fiber and stick the surface good to the wound, of the contact making them wound, with the difficult to which is wound remove generally healed Comparative Y-type molecular 5.3 min No 8.1 ± 0.1 Tailored Easy to remove, A large  40% Example 8 sieve/spandex fiber for wound no other blood clot hemostatic fabric size and removal forms on (blend spinning) practical required the surface needs of the wound, which is generally healed Comparative Quikclot molecular 4 min 10 ± 2  7.5 ± 0.9 Difficult The granules The wound  50% Example 10 sieve granule to adjust need to be with slight dosage washed several bums was times with washed by physiological physiologic saline, and can al saline, plug in blood and it was vessels easy to rebleed. Comparative Combat Gauze 7.5 min No 12.7 ± 0.8  Tailored Part of the clay A large  40% Example 11 (Clay/fiber for wound falls off the blood clot composite) size and fibers. Due to forms on practical the large amount the wound needs of bleeding, a surface, large area of making it blood clot is difficult to formed on the observe the wound surface, actual which adheres blood to the wound vessel surface and is healing easy to rebleed when cleared. Comparative Y-type molecular 2.5 min No .sup. 4 ± 0.5 Tailored Easy to remove, Dry and 100% Example 12 sieve/cotton fiber for wound no other well healed composite size and removal practical required needs Comparative Trypsin 5 min No 7.5 ± 0.9 Difficult The granules The wound  50% Example 13 to adjust need to be need to be dosage washed several washed with times with physiological physiological saline. saline, and trypsin powder can plug in blood vessels

[0213] The above results show that: Examples 1-26 list the molecular sieve/fiber hemostatic fabric with different molecular sieves and different fibers, and the inner surface of the molecular sieve of the molecular sieve/fiber composite of hemostatic fabric of Examples 1-26 in contact with the fibers is a rough planar surface matched with the fiber surface. Ultrasound the molecular sieve/fiber composite in deionized water for ≥20 min, and use a thermogravimetric analyzer to analyze the content of molecular sieves on the fiber surface. The retention rate of molecular sieves is ≥90%, indicating that a growth-matched coupling is formed between the molecular sieve and the fiber. The molecular sieve is firmly bonded to the fiber. The adhesive content of the contact surface between the molecular sieve and the fiber is zero in Examples 1-26 of the present disclosure, and the degree of calcium ion exchange of the molecular sieve is ≥90%, the degree of magnesium ion exchange is ≥75%, and the degree of strontium ion exchange is ≥70%. It overcomes the defects of high synthetic cost, low effective surface area, and clogging of molecular sieve channels, which exists on the fibers through the adhesive, and the molecular sieve/fiber of the present disclosure is conducive to the adsorption of trypsin.

[0214] Although the molecular sieve/fiber hemostatic fabric has a reduced amount of molecular sieve compared to the molecular sieve granules, the hemostatic effect of the molecular sieve/fiber hemostatic fabric is obviously better than the commercial molecular sieve granules (Quikclot), which further solves the problem of water absorption and heat release. The molecular sieve of the present disclosure is uniformly distributed on the fiber surface with a certain size, and a growth-matched coupling is formed between the molecular sieve and the fiber. The molecular sieve has a strong binding strength with the fiber. The molecular sieve has a high effective specific surface area and substance exchange capacity on the fiber surface, which can efficiently combine with trypsin. The hemostatic effect of hemostatic fabric is superior to that of composite materials with weak binding strength between molecular sieves and fiber or low effective specific surface area or low material exchange capacity in the prior art. The hemostatic fabric has a short hemostatic time, low blood loss, and high survival rate in the rabbit femoral artery lethal model, and the hemostatic fabric are safe during hemostatic process. In addition, the molecular sieve/fiber hemostatic fabric also have the following advantages as a hemostatic material: (i) the wound surface after hemostasis is easy to clean up and convenient for post-processing by professionals; (ii) hemostatic fabric can be tailored for wound size and practical needs; (iii) the wound after hemostasis is dry and heals well after treated with the hemostatic fabric.

[0215] The above embodiments are only used to illustrate the present disclosure and are not used to limit the scope of the present disclosure. In addition, it should be understood that after reading the teaching of the present disclosure, those skilled in the art can make various changes or modifications to the present disclosure, and these equivalent forms also fall within the scope defined by the appended claims of the present application.