ASSEMBLY AND METHOD FOR THE PREPARATION OF A WOUND DRESSING

Abstract

Wound dressing assembly including (i) blood-clotting mold device having an enclosure defined between walls of a main body and a removable closure over an opening and configured for introduction of blood thereinto, and (ii) coagulation initiator in amount sufficient to coagulate blood introduced into the enclosure to form a blood clot. The formed blood clot is transferable onto a wound. Method for preparing a wound dressing by introducing a volume of blood into the enclosure of the blood-clotting mold device, maintaining the blood within the enclosure for time sufficient to permit clotting of the blood to obtain a blood clot; removing said the closure to open the enclosure; and extracting the blood clot from the enclosure. The formed blood clot may be used in a method for dressing a wound by fixation of the clot onto the wound.

Claims

1. A wound dressing assembly comprising a blood-clotting mold device having a sealed enclosure defined between walls of a main body and a removable closure over an opening and is configured for introduction of blood thereinto, a coagulation initiator in an amount sufficient to coagulate blood introduced into the enclosure to form a blood clot, wherein at least one of the walls and closure is pierceable by needle the formed blood clot is transferable onto a wound.

2. The wound dressing assembly of claim 1, wherein said coagulation initiator is comprised within the enclosure.

3.-4. (canceled)

5. The wound dressing assembly of claim 1, wherein the device for transferring is a dressing material, e.g. gauze, and a tool for removal and transfer the blood clot onto a dressing or the wound.

6.-7. (canceled)

8. The wound dressing assembly of claim 1, wherein the enclosure has the general shape of a blister and the closure is a removable film.

9. (canceled)

10. The wound dressing assembly of claim 1 wherein the enclosure contains a blood-clot scaffold matrix.

11. A method for preparing a wound dressing, comprising: introducing a volume of blood into an enclosure of a blood-clotting mold device, the enclosure being defined between walls of a main body sealed by a removable closure, and comprises a coagulation initiator; maintaining the blood within the enclosure for a time sufficient to permit clotting of the blood to thereby obtain a blood clot; removing said closure to open the enclosure; and extracting the blood clot from the enclosure; wherein at least one of said walls and closure is pierceable by needle and said introducing comprises piercing at least one of the wall and closure and injecting the blood therethrough.

12. (canceled)

13. The method of claim 11, wherein the enclosure comprises a blood clot-support matrix and said extracting comprised removal of the clot with said matrix.

14.-15. (canceled)

16. The method of claim 11, wherein the enclosure has the general shape of a blister.

17. The method of claim 11, wherein the enclosure is first pierced to form a vent and then the blood is injected.

18. The method of claim 11, wherein the blood is whole blood.

19. A method for dressing a wound, comprising: introducing a volume of blood into an enclosure that is defined between walls of a main body sealed by a removable cover, and comprises a coagulation initiator; maintaining the blood within the enclosure for a time sufficient to permit clotting of the blood to thereby obtain a blood clot; removing said closure to open the enclosure; extracting the blood clot from the enclosure; and fixing the blood clot onto the wound; wherein at least one of said walls and closure is pierceable by needle and said introducing comprises piercing at least one of the wall and closure and injecting the blood therethrough.

20. The method of claim 19, wherein said fixing is with a dressing material.

21. The method of claim 19, wherein the enclosure comprises a blood clot-support matrix, and wherein said extracting comprised removal of the blood clot with the matrix.

22.-23. (canceled)

24. The method of claim 19, wherein the enclosure has the general shape of a blister.

25. (canceled)

26. The method of claim 19, wherein the blood is whole blood.

27. A wound dressing assembly comprising: a blood-clotting mold device comprising a sealed enclosure in a shape of a blister defined between walls of the blister and an opening sealed by a removable closure, at least one of the walls and closure being pierceable by a needle; a coagulation initiator in an amount sufficient to coagulate blood introduced into the enclosure to form a blood clot.

28. The wound dressing assembly of claim 27, wherein the enclosure contains a blood-clot scaffold matrix.

29. A method for preparing a wound dressing, comprising: introducing a volume of blood into an enclosure of a blood-clotting mold device comprising a sealed enclosure defined between walls of the blister and an opening sealed by a removable closure, at least one of the walls and closure being pierceable by a needle, the enclosure having a shape of a blister; maintaining the blood within the blister for a time sufficient to permit clotting of the blood to thereby obtain a blood clot; removing said closure to open the enclosure; and extracting the blood clot from the enclosure.

30. The method of claim 29, wherein said enclosure comprises a support matrix and said extracting is of a blood clot with said support matrix.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0031] In order to better understand the subject matter that is disclosed herein and to exemplify how it may be carried out in practice, embodiments will now be described, by way of non-limiting example only, with reference to the accompanying drawings, in which:

[0032] FIG. 1 is a picture providing a bottom perspective view of an enclosure, according to an embodiment of this disclosure, which is in the form of a blister.

[0033] FIGS. 2A and 2B are side perspective views illustrating the injection of blood into the enclosure.

[0034] FIG. 3 shows the removal of the closure revealing the clot formed within the enclosure.

[0035] FIG. 4 is a schematic illustration of a wound dressing prepared according to an embodiment of this disclosure.

DETAILED DESCRIPTION OF EMBODIMENTS

[0036] The embodiments illustrated in the annexed drawings include an enclosure in the form of a blister, which is an exemplary embodiment of the broader context of the present disclosure. Thus, this description of specific embodiments is intended for illustration of the more general principle of this disclosure and is not intended to be limiting.

[0037] Referring first to FIG. 1, shown is a picture of an enclosure generally designated 100 and in the shape of a blister, having a main body 102 with a blister depression 104 and a flat rim 106. Fitted onto the rim is a removable closure 108 in the form of a laminate/film.

[0038] Contained within the enclosure 100 is a coagulating initiator substance 110 which may be in the form of a liquid, powder, granulate, etc. The coagulation initiator may, for example, be kaolin. Also contained in the enclosure is a blood clot-supporting (scaffold) matrix 112 which may be made of gauze, of a polymeric mesh, etc., held at its peripheral portions between the rim and the closure and having a central portion within the enclosure.

[0039] Blood, typically whole blood, is withdrawn and then injected into the enclosure, as shown in FIGS. 2A and 2B. Specifically, a needle 120 of a syringe 122 that contains the whole blood pierces the closure 108 and blood is injected until it fills a significant portion of the enclosure, sufficient to cover the blood clot-supporting scaffold matrix 112, as seen in FIG. 2B. It is possible, also, to initially pierce the closure so as to form a vent opening, e.g. by the blood injection needle, and inject the blood only subsequently.

[0040] The blood is then maintained in the enclosure for a time sufficient for the blood to coagulate and after clotting the film 108 is removed to reveal a blood clot complex 130 that includes a blood clot 132 embedded with the blood clot-supporting scaffold matrix 112, as seen in FIG. 3.

[0041] This blood clot complex 130 that includes the blood clot 132 and blood clot-supporting matrix 112 can then be combined with a dressing material 134, as seen in FIG. 4; the dressing material being, for example, gauze, to form a dressing-clot complex. This dressing-clot complex combination can be transferred onto the wound; alternatively, after opening of the cover of the blister and revealing the blood clot complex, as seen in FIG. 3, the blood clot complex can be transferred onto a wound and the dressing material applied thereon while the former is on the wound.