Method And System For Ultrasound Induced Hyperthermia With Microwave Thermometry Feedback

Abstract

A device for providing hyperthermia treatment includes an ultrasound energy generator configured to apply low intensity ultrasound to target tissue. The low intensity ultrasound energy induces therapeutic heating in the tissue at or below the surface of the skin. In order to control the temperature of the tissue during therapy, a microwave radiometer, such as a Dicke radiometer, can be used to measure the temperature of the tissue and feed back the temperature measurement to the ultrasound energy generator to control ultrasonic energy produced and control the temperature of the target tissue.

Claims

1-10. (canceled)

11. An ultrasound hyperthermia system comprising: a controllable ultrasound energy source producing ultrasonic energy at a predefined frequency in a range of 0.5-5.0 Megahertz (MHz) and a predefined intensity in a range of 0.1-3.0 Watts per cubic centimeter (W/cm.sup.2), the ultrasonic energy inducing heating of a tissue at a target site to bring the tissue to a predefined temperature, the controllable ultrasound energy source including an ultrasound generator configured to generate an ultrasound signal in the form of an arbitrary ultrasound waveform, the arbitrary ultrasound waveform having an adjustable amplitude at the predefined frequency, an amplifier communicatively coupled with the ultrasound generator and configured to amplify the ultrasound signal into an amplified ultrasound signal, an impedance matching network communicatively with the amplifier and configured to match capacitive loads of the amplified ultrasound signal for maximizing power transfer through the ultrasound hyperthermia system, and a piezoelectric ultrasound transducer communicatively coupled to the ultrasound generator via the impedance matching network, the piezoelectric ultrasound transducer producing the ultrasonic energy based on the amplified ultrasound signal; a water-filled cone coupling the piezoelectric ultrasound transducer, via a sterile membrane, to the tissue, the water-filled cone including recirculated and degassed chilled water, the water-filled cone focusing the ultrasonic energy to heat the tissue; a microwave radiometer including a microwave antenna for detecting a microwave signal caused by the ultrasonic energy heating the tissue, an internal calibrated temperature source configured to determine an absolute temperature, and a Radio Frequency (RF) switch communicatively coupled with the microwave antenna and the internal calibrated temperature source, the RF switch being configured to detect, based on the microwave signal, a tissue temperature relative to the absolute temperature, a local oscillator configured to produce a baseband signal in a range of 1-6 Gigahertz (GHz), a Radio Frequency (RF) mixer communicatively coupled with the RF switch and the local oscillator, the RF mixer being configured to filter and mix down background noise in the microwave signal, a digital signal processor communicatively coupled with the RF mixer and RF switch, the digital signal processor configured to integrate the baseband signal for a period of time to determine a baseband energy of the microwave signal, determine an actual temperature by comparing the absolute temperature with the tissue temperature, feed back the actual temperature to the ultrasound generator, and adjust the predefined frequency and the predefined intensity from initial values to adjusted values within the respective ranges.

12. The ultrasound hyperthermia system of claim 11, further comprising a control loop communicatively coupled with the digital signal processor, the control loop configured to maintain the tissue temperature at a value required for achieving hyperthermia.

13. The ultrasound hyperthermia system of claim 12, wherein the control loop is a proportional-integral-derivative (PID) controller.

14. The ultrasound hyperthermia system of claim 11, wherein the ultrasonic transducer heats the target site of the tissue to a predefined site temperature in a range of 38-44 degrees Celsius.

15. The ultrasound hyperthermia system of claim 14, wherein the piezoelectric ultrasonic transducer heats a portion of the target site of the tissue at least 2.0 centimeters below a surface of the target site to a predefined sub-site temperature in a range of 38-44 degrees Celsius.

16. A method of providing ultrasound based heating to produce hyperthermia, the method comprising: generating, via an ultrasound generator, an ultrasound signal in the form of an arbitrary ultrasound waveform, the arbitrary ultrasound waveform having an adjustable amplitude at a predefined frequency in a range of 0.5-5.0 Megahertz (MHz); amplifying, via an amplifier, the ultrasound signal into an amplified ultrasound signal; matching, via an impedance matching network, capacitive loads of the amplified ultrasound signal for maximizing power transfer; producing, via a piezoelectric ultrasound transducer, ultrasonic energy at the predefined frequency and a predefined intensity in a range of 0.1-3.0 Watts per cubic centimeter (W/cm.sup.2); based on the ultrasonic energy, inducing heating of a tissue at a target site to bring the tissue to a predefined temperature; focusing the ultrasonic energy, via a water-filled cone, on the target site to heat the tissue; recirculating and degassing chilled water flowing through the water-filled cone; detecting, via a microwave antenna, a microwave signal caused by the ultrasonic energy heating the tissue; determining, via an internal calibrated temperature source, an absolute temperature; detecting, based on the microwave signal and via a Radio Frequency (RF) switch, a tissue temperature relative to the absolute temperature; producing, via local oscillator, a baseband signal of 1-6 Gigahertz (GHz); filtering and mixing down, via a RF mixer, background noise in the microwave signal; integrating, via a digital signal processor, the baseband signal for a period of time to determine a baseband energy of the microwave signal; determining, via the digital signal processor, an actual temperature by comparing the absolute temperature with the tissue temperature; feeding back, via the digital signal processor, the actual temperature to the ultrasound generator; and adjusting, via the digital signal processor, the predefined frequency and the predefined intensity from initial values to adjusted values within the respective ranges.

17. The method of claim 16, further comprising maintaining, via a control loop, the tissue temperature at a value required for achieving hyperthermia.

18. The method of claim 17, wherein the control loop is a proportional-integral-derivative (PID) controller.

19. The method of claim 16, further comprising the target site of the tissue to a predefined site temperature in a range of 38-44 degrees Celsius.

20. The method of claim 19, further comprising heating a portion of the target site of the tissue at least 2.0 centimeters below a surface of the target site to a predefined sub-site temperature in a range of 38-44 degrees Celsius.

Description

BRIEF DESCRIPTION OF THE FIGURES

[0010] The accompanying drawings, which are incorporated into this specification, illustrate one or more exemplary embodiments of the inventions and, together with the detailed description, serve to explain the principles and applications of these inventions. The drawings and detailed description are illustrative, and are intended to facilitate an understanding of the inventions and their application without limiting the scope of the invention. The illustrative embodiments can be modified and adapted without departing from the spirit and scope of the inventions.

[0011] FIG. 1 is a diagrammatic view of an ultrasound based hyperthermia treatment system according to some embodiments of the invention.

[0012] FIG. 2 is a more detailed diagrammatic view of an ultrasound based hyperthermia treatment system according to some embodiments of the invention.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

[0013] The present invention is directed to methods and systems for using ultrasonic energy for hyperthermia therapies that produce non-ablative heating of tissue. In accordance with some embodiments of the invention, an ultrasound signal generator drives an ultrasound transducer to produce low intensity ultrasonic energy that can be applied to a treatment site in tissue. The low intensity ultrasonic energy induces heating and raises the temperature of the tissue at the treatment site. In accordance with some embodiments of the invention, a microwave radiometer can be aimed at the treatment site and used to determine the temperature of the tissue at the treatment site by measuring the microwave energy received from the treatment site. The temperature determined by the radiometer can be fed back into the ultrasound generator to control the ultrasonic energy applied to the treatment site to adjust and maintain the temperature of treatment site according to a predefined temperature.

[0014] When the ultrasound signal is applied to treatment site in tissue, the ultrasonic energy induces heating. The amount of heating is in part a function of the density of the tissue in the treatment site and physiologic composition of the tissue, such as water and fat content. In addition, the density and physiologic composition of the tissue can change during the course of treatment resulting in temperature variations that can limit the effectiveness of the hyperthermia therapy. Thus, it is desirable to be able to determine the temperature of tissue at the treatment site during the course of the therapy and to control the application of ultrasound energy as required to maintain the desired temperature for the specified therapy. In accordance with some embodiments of the invention, it can be desirable to maintain a constant temperature or temperature range (e.g., 41° C. or 38-44° C.) over at least part of the course of treatment. In accordance with some embodiments of the invention, it can be desirable to apply temperature profile (e.g., the temperature changes with time according to a plan or program) over at least part of the course of treatment.

[0015] FIG. 1 shows a diagrammatic view of an ultrasound hyperthermia system 100 according to some embodiments of the invention. The ultrasound hyperthermia system 100 includes a controllable ultrasound energy source 200 and a microwave radiometer 300. The ultrasound energy source 200 produces ultrasonic energy at a predefined frequency (e.g. 0.5-5.0 MHz) and a predefined intensity (e.g., 0.1-3.0 W/cm.sup.2) to induce heating of tissue at a target site 110 on the skin surface and at least 2.0 cm below the skin surface. The ultrasound energy source 200 can be controlled by an input signal to control the frequency and the intensity to regulate the heating induced in the target site 110. The ultrasonic energy can be increased to increase the temperature at the target site 110 and the ultrasonic energy can be decreased to decrease the temperature at the target site 110.

[0016] The microwave radiometer 300 measures the microwave energy emanating from the tissue at the treatment site 110 and uses the measured microwave energy to determine the temperature of the tissue at the treatment site 110. The temperature determined by the microwave radiometer can be fed back 355 to the ultrasound energy source 200 and used to control the output of the ultrasound generator and the ultrasound transducer to control the temperature induced by the ultrasound energy. In accordance with some embodiments of the invention, the set point temperature can be controlled to an accuracy of +/−0.5-1.0° C. or better.

[0017] In operation, the ultrasound energy source 200 can be configured to generate a predefined frequency and intensity of ultrasound energy that is applied to induce heating of tissue at the target site 110 and is expected to bring the tissue to a predefined temperature. While the ultrasound energy is being applied, the microwave radiometer is determining the temperature of the tissue at the target site 110 and sending the temperature values (and/or a signal 355 determined as function of the temperature values) to the ultrasound energy source 200. The ultrasound energy source 200 uses the temperature values (and/or the signal 355) to adjust the frequency and/or intensity of the ultrasound energy as it is being applied to the tissue at the target site 110 to raise or lower the tissue temperature to the predefined value or range.

[0018] FIG. 2 shows a more detailed diagrammatic view of an ultrasound hyperthermia system 100 according to some embodiments of the invention. In accordance with some embodiments of the invention, the ultrasound energy source 200 can include an ultrasound generator 240 coupled through an amplifier 230 and an impedance matching network 220 to an ultrasound transducer 210. The ultrasound generator 240 can be used to generate an arbitrary ultrasound waveform with an adjustable amplitude at frequency in the range, for example, from 0.5-5.0 MHz. In accordance with some embodiments of the invention, the ultrasound generator 240 can be, for example, an Agilent 3320 ultrasound generator. Depending on the desired level ultrasound energy and heating, the ultrasound signal can be amplified, for example, using an ENI 550L RF amplifier. The amplified ultrasound signal can be input into a piezoelectric ultrasound transducer to produce that ultrasound energy that can be applied to the tissue in the target site. Depending on the design of the amplifier and the ultrasound transducer, an impedance matching network can be used to couple the amplifier and transducer to match the capacitive loads of those components to maximize the power transfer through the system. In accordance with some embodiments of the invention, the ultrasonic transducer can be coupled via a recirculating, chilled water-filled cone through a sterile membrane to the patient tissue. The recirculating water can be chilled, for example, using an Oasis 170 pump/chiller, and can also be degassed using, for example, a Liqui-Cel membrane contactor 4×8 inline degasser, in order to remove any gas bubbles that may inhibit good coupling of the ultrasonic energy to the patient tissue. The sterile membrane can be disposable to prevent the spread of disease by the system that is in contact with patient tissue.

[0019] According to some embodiments of the invention, the water filled cone can act as a lens to control the focus of the ultrasound energy and different water filled cone configurations can be used to produce the desired ultrasound energy distribution to accommodate the dimensions of the target site.

[0020] In accordance with some embodiments of the invention, the microwave sensor can be focused on the volume of tissue being heated by the ultrasound transducer and can detect an emanating signal in the range from about 1 and 6 GHz. The microwave radiometer 300 includes a microwave antenna 310 and, for example, can be constructed based on the architecture of a Dicke Radiometer. The microwave radiometer 300 can include an internal calibrated resistor or other calibrated temperature source 330 that is used to determine an absolute temperature. The microwave radiometer 300 detects the temperature of the tissue relative to that of the calibrated temperature source using the RF switch 320. The ambient microwave background noise in the received microwave signal can be filtered and mixed down using the RF mixer 340 that is connected to a local oscillator 345 (e.g., that can be configured to produce a reference signal from 1 and 6 GHz) to produce a baseband signal. The baseband signal can be integrated for a period of time to determine the baseband energy of the measure microwave signal. This energy is proportional to the temperature, or thermal noise, detected by the antenna and compared to the calibrated internal source in order to determine the actual temperature.

[0021] In accordance with some of the embodiments of the invention, the microwave radiometer determines a measure of the temperature of the tissue as it is exposed to the ultrasonic energy. The measure of temperature provided by the microwave radiometer can be fed back 355 by the signal processor/controller 350 to the ultrasound generator 240 to adjust the level (e.g., signal frequency and intensity) of ultrasound output. In accordance with some embodiments, a control loop, such as a PID controller, can be used to control ultrasound energy output in order to maintain the temperature in the ultrasound focal volume at the required temperature for hyperthermia.

[0022] The microwave radiometer can include a signal processor/controller 350 that processes the baseband signal to determine the temperature of the tissue. The signal processor/controller 350 can include one or more digital signal processors and/or one or more microprocessors and associated memories for storing computer programs that can be used to process the baseband signal and determine the temperature of the tissue being treated.

[0023] Other embodiments are within the scope and spirit of the invention. For example, due to the nature of software, functions described above can be implemented using software, hardware, firmware, hardwiring, or combinations of any of these. Features implementing functions may also be physically located at various positions, including being distributed such that portions of functions are implemented at different physical locations.

[0024] Further, while the description above refers to the invention, the description may include more than one invention.