TOOLS AND TECHNIQUES FOR IMAGE-GUIDED RESECTION
20200085512 ยท 2020-03-19
Inventors
- Brendan Reimer (Eden Prairie, MN, US)
- Meir Dahan (St. Louis Park, MN, US)
- Gord Scarth (Eden Prairie, MN, US)
Cpc classification
A61B5/055
HUMAN NECESSITIES
A61B34/20
HUMAN NECESSITIES
A61B90/10
HUMAN NECESSITIES
A61B2017/00911
HUMAN NECESSITIES
A61B18/1492
HUMAN NECESSITIES
A61B18/22
HUMAN NECESSITIES
International classification
A61B34/20
HUMAN NECESSITIES
Abstract
A region within a body of an imaging subject can be imaged to identify a tumor locus in a three dimensional coordinate system. An opening in the body of the imaging subject can be formed to provide an access location. Using an actuator, a surgical tool can be guided to traverse the access location to access the tumor locus, the surgical tool guided along a specified trajectory in the three dimensional coordinate system by the actuator and configured to resect and remove a first portion of the tumor within the tumor locus.
Claims
1. A surgical system, comprising: a surgical tool configured to resect a first portion of a tumor including traversing a lumen defined by a cannula to access a tumor locus, the tumor locus located within a body of an imaging subject; an actuator configured to position the surgical tool according to a three dimensional coordinate system, the positioning including using information obtained from imaging a region within the imaging subject to identify the tumor locus in the three dimensional coordinate system; wherein the surgical tool and the actuator are compatible with an imaging system and operable within or nearby the imaging system; and wherein the imaging system comprises a computed tomography (CT) imaging system.
2. The surgical system of claim 1, comprising the cannula; wherein the actuator is configured to position the cannula according to the three dimensional coordinate system, the positioning including using information obtained from imaging a region within the imaging subject to identify the tumor locus in the three dimensional coordinate system.
3. The surgical system of claim 2, comprising a laser ablation tool configured to provide laser radiation to thermally ablate a second portion of the tumor including traversing the lumen defined by the cannula to access the tumor locus; and wherein the actuator is configured to position the laser ablation tool according to the three dimensional coordinate system, the positioning including using information obtained from imaging a region within the imaging subject to identify the tumor locus in the three dimensional coordinate system; and wherein the laser ablation tool is compatible with the imaging system and operable within or nearby the imaging system.
4-7. (canceled)
8. The surgical system of claim 1, wherein the surgical tool is configured to: cut tissue at a distally-located portion of the surgical tool; and aspirate tissue through a lumen defined by the surgical tool.
9. The surgical system of claim 1, wherein the surgical tool is configured to deliver irrigation to a distally-located portion of the surgical tool.
10. The surgical system of claim 1, wherein the surgical tool is configured to cauterize tissue at a distally-located portion of the surgical tool.
11. The surgical system of claim 1, wherein the surgical tool is configured to cut tissue in a direction extending axially from a distally-located portion of the surgical tool.
12. The surgical system of claim 1, wherein the surgical tool is configured to cut tissue in a direction extending radially from a distally-located portion of the surgical tool.
13. The surgical system of claim 1, wherein the surgical tool is configured to access the tumor locus including traversing a bony structure.
14. The surgical system of claim 13, wherein the bony structure comprises a cranium.
15. The surgical system of claim 14, wherein one or more of the cannula or the surgical tool are configured to inhibit or suppress leakage of cerebrospinal fluid (CSF) during a surgical procedure.
16. The surgical system of claim 15, wherein the cannula or surgical tool include a seal to inhibit or suppress the leakage.
17. The surgical system of claim 16, wherein the seal includes an inflatable structure.
18-22. (canceled)
23. A surgical system, comprising: a cannula, a surgical tool configured to resect a first portion of a tumor within a tumor locus located within a bony structure of subject including traversing a lumen defined by the cannula to access the tumor locus; a laser ablation tool configured to provide laser radiation to thermally ablate a second portion of the tumor including traversing the lumen defined by the cannula to access the tumor locus; and an actuator configured to stereotactically position the cannula, the surgical tool, and the laser ablation tool according to a three dimensional coordinate system, the stereotactic positioning including using information obtained from imaging a region within the bony structure of the subject to identify a tumor locus in the three dimensional coordinate system; wherein the cannula, the surgical tool, the laser ablation tool, and the actuator are compatible with a nuclear magnetic resonance imaging system and operable within a magnetic field established by the nuclear magnetic resonance imaging system.
24. The surgical system of claim 23, wherein the surgical tool is configured to: deliver irrigation to a distally-located portion of the surgical tool; cut tissue a distally-located portion of the surgical tool; and aspirate tissue through a lumen defined by the surgical tool.
25. The surgical system of claim 23, wherein the surgical tool is configured to cut tissue in a direction extending axially from a distally-located portion of the surgical tool.
26. The surgical system of claim 23, further comprising the nuclear magnetic resonance imaging system.
27. The surgical system of claim 23, wherein the bony structure comprises a cranium.
28. The surgical system of claim 23, wherein the first and second portions of the tumor overlap.
29-70. (canceled)
71. A surgical system, comprising: a cannula defining a lumen; a surgical tool configured to resect a first portion of a tumor including traversing the lumen defined by the cannula to access a tumor locus, the tumor locus located within a body of an imaging subject; an actuator configured to position the cannula and the surgical tool according to a three dimensional coordinate system, the positioning including using information obtained from imaging a region within the imaging subject to identify the tumor locus in the three dimensional coordinate system; wherein the surgical tool and the actuator are compatible with an imaging system and operable within or nearby the imaging system; wherein the surgical tool is configured to access the tumor locus by traversing a bony structure comprising cranium; and wherein one or more of the cannula or the surgical tool are configured to inhibit or suppress leakage of cerebrospinal fluid (CSF) during a surgical procedure.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
[0006]
[0007]
[0008]
[0009]
[0010]
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[0012]
DETAILED DESCRIPTION
[0013]
[0014]
[0015] The actuator can include an electrically-actuated or mechanically-actuated positioners to provide multiple degrees of freedom, such as can include linear translation in one or more axes or rotation in one or more axes, as shown generally by the arrows located nearby the actuator 106 in
[0016] Such control can be executed according to a predetermined program or at least in part in response to user input, such as can include a commanded input from a user directing the motion. Other actuation apparatus or techniques can be used, such as a stereotactic frame including a fixation device anchored to the imaging subject 100, to perform the surgical techniques described herein. Use of the actuator 106 can allow a precise trajectory 190 to be planned and then followed during surgery (or revised during surgery using further imaging), such as to position the surgical tool 104 within or nearby the identified tumor 102 location.
[0017] Positioning of the surgical tool 105 using the actuator 106 can be referred to generally as a stereotactic technique, even though such a technique need not require use of a physical stereotactic frame coupled between the imaging subject 100 and the surgical tool 104. For example, the actuator can include a surgical robot anchored to a surgical operating table or platform, and the surgical operating table can include a fixation device to anchor the imaging subject to the table or platform. The actuator 106 and surgical tool 104 can be compatible with various imaging modalities such as CT or MRI, such as to facilitate intra-operative imaging during tumor identification or resection, or in support of (e.g., during) other diagnosis or treatment such as electrocautery or ablation.
[0018]
[0019] A gas source 194 can be provided, such as to assist in maintaining a pressure equilibrium between the region 110 within the imaging subject 100 and a region surrounding the imaging subject. For example, as discussed other examples described herein, leakage of fluid such as cerebrospinal fluid (CSF) can be inhibited or prevented, such as at least in part by managing (e.g., limiting) a pressure differential between the region surrounding the imaging subject 100 and a region 110 within the imaging subject, such as nearby a distal tip portion of the surgical tool 104. Elsewhere, one or more seals or other features can be included, such as to avoid gas or liquid leakage from the access location 112, such as when the access location 112 is through the cranium or dura. In an example, the surgical tool 104 can be configured to provide irrigation, such as in one or more of an axial or radial direction. Such irrigation can include saline provided by an irrigation source 192. The surgical tool can be configured to perform other techniques in addition or instead of those mentioned above, such as can include electrocautery or tissue resection using a distally-extending member deployed through or along the surgical tool 104 (e.g., a mechanical cutter such as a shear as shown and described in relation to
[0020]
[0021]
[0022] In an example, an imaging operation can be performed with the surgical tool 104 partially retracted from the reduced tumor 102F or with the surgical tool 104 entirely removed from the region 110 within the imaging subject 100. As mentioned in relation to other examples herein, other surgical devices or tools can be used before or after the surgical tool 104 is used. For example, the surgical tool 104 can be removed entirely, and a laser ablation tool can be used to further treat (e.g., ablate) the reduced tumor 102F.
[0023] In another example, ablation can be performed, and the surgical tool 104 can be used after ablation to resect ablated portions of a tumor, such as to suppress or inhibit one or more of edema or swelling. For example, an ablation technique can be used to treat a tumor in a minimally-invasive manner. In an illustrative example, such a procedure can include using an ablation tool that is about 1 to about 2 millimeters (mm) in diameter to ablate a tissue volume on the order of about 10 cubic centimeters (cc) or larger, such as can include a radius of ablation from the ablation tool of about 2 centimeters (cm). To suppress or inhibit edema or swelling, the surgical tool 104 can then be used to remove at least a portion of a tumor after ablation.
[0024]
[0025]
[0026]
[0027] The present inventors have recognized, among other things, that a size and shape of the region 115 can inhibit ablation of an entirety of a tumor. Accordingly, a combination of mechanical tissue removal (such as using the surgical tool 104) and ablation can be used, such as including reducing the tumor using mechanical tissue removal, to a locus then treatable using ablation. In the example of
[0028]
[0029]
[0030] In an example, the interior seal 332 can include a balloon structure, for example, such as in the shape of a torus. The balloon structure can include a controlled inflation level, such as to provide a seal that forms to a surrounding area (such as between the surgical tool 104 and the cannula 108, or between the surgical tool 194 and surrounding anatomy (e.g., dura or inner cranium in the example of brain surgery) where the cannula 108 is not used or beyond the extent of the cannula 108.
[0031] The cannula 108 can include other features, such as an exterior seal 330. Such an exterior seal can include a rigid or flexible material, such as can include ribs or other features such as to suppress or inhibit leakage of gas or liquid in an annular region between the cannula 108 and tissue of the imaging subject 100. In another example, the exterior seal 330 can include one or more of a ring or torus, such as located between a flanged portion of the cannula 108 and an exterior surface of the imaging subject 100, As in the example of an interior seal 332 mentioned above, the ring or torus can include a balloon structure, such as inflatable to conform to surrounding structures (e.g., forming to the cranium in the example of brain surgery).
[0032] In another example, the exterior seal 330 can include a combination of features, such as located under a flange or shoulder of the cannula 108 and along the exterior wall of at least a portion of the cannula 108. As mentioned in relation to other examples described herein, suppression of leakage of gas or liquid across the seals 330 or 332 can be assisted or established at least in part by managing a pressure differential between the region 110 within the imaging subject 100 as compared to a region outside the region 110.
[0033]
[0034]
[0035] In an illustrative example, imaging can be performed such as before ablation to determine an appropriate ablation program, and the ablation program can include positioning the ablation tool 114 along the specified trajectory using the actuator 106 and rotating the ablation tool to direct ablation to particular regions, also using the actuator 106. In another illustrative example, imaging can be performed after ablation to assess whether further ablation is necessary or to determine a revised trajectory. One or more of the cannula 108, the surgical tool 104, or the laser ablation tool 114 can be compatible with one or more imaging techniques, such as to permit intra-operative imaging. For example, the actuator 106 can be one or more of compatible with nuclear magnetic resonance imaging apparatus or computed tomography apparatus. In this manner, confirmation of progress in treating or resecting a tumor can be provided by near-real-time or real-time imaging. In an example, imaging information can be obtained during various stages of treatment, such as to guide resection and assess progress, or to guide ablation or assess ablation effectiveness. In an example, as mentioned above, a tumor can relax or can be encouraged to fill a void formed by resected tissue, such as to facilitate ablation or further resection, or tumor tissue can be removed after ablation to suppress or inhibit swelling or edema. Intra-operative imaging can be used to assess a degree of relaxation or to determine a revised trajectory or other protocol for further treatment.
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VARIOUS NOTES & EXAMPLES
[0040] Each of these non-limiting examples can stand on its own, or can be combined in various permutations or combinations with one or more of the other examples.
[0041] The above detailed description includes references to the accompanying drawings, which form a part of the detailed description. The drawings show, by way of illustration, specific embodiments in which the invention can be practiced. These embodiments are also referred to herein as examples. Such examples can include elements in addition to those shown or described. However, the present inventors also contemplate examples in which only those elements shown or described are provided. Moreover, the present inventors also contemplate examples using any combination or permutation of those elements shown or described (or one or more aspects thereof), either with respect to a particular example (or one or more aspects thereof), or with respect to other examples (or one or more aspects thereof) shown or described herein.
[0042] In the event of inconsistent usages between this document and any documents so incorporated by reference, the usage in this document controls.
[0043] In this document, the terms a or an are used, as is common in patent documents, to include one or more than one, independent of any other instances or usages of at least one or one or more. In this document, the term or is used to refer to a nonexclusive or, such that A or B includes A but not B, B but not A, and A and B, unless otherwise indicated. In this document, the terms including and in which are used as the plain-English equivalents of the respective terms comprising and wherein. Also, in the following claims, the terms including and comprising are open-ended, that is, a system, device, article, composition, formulation, or process that includes elements in addition to those listed after such a term in a claim are still deemed to fall within the scope of that claim. Moreover, in the following claims, the terms first, second, and third, etc. are used merely as labels, and are not intended to impose numerical requirements on their objects.
[0044] Method examples described herein can be machine or computer-implemented at least in part. Some examples can include a computer-readable medium or machine-readable medium encoded with instructions operable to configure an electronic device to perform methods as described in the above examples. An implementation of such methods can include code, such as microcode, assembly language code, a higher-level language code, or the like. Such code can include computer readable instructions for performing various methods. The code may form portions of computer program products. Further, in an example, the code can be tangibly stored on one or more volatile, non-transitory, or non-volatile tangible computer-readable media, such as during execution or at other times. Examples of these tangible computer-readable media can include, but are not limited to, hard disks, removable magnetic disks, removable optical disks (e.g., compact disks and digital video disks), magnetic cassettes, memory cards or sticks, random access memories (RAMs), read only memories (ROMs), and the like.
[0045] The above description is intended to be illustrative, and not restrictive. For example, the above-described examples (or one or more aspects thereof) may be used in combination with each other. Other embodiments can be used, such as by one of ordinary skill in the art upon reviewing the above description. The Abstract is provided to comply with 37 C. F. R. 1.72(b), to allow the reader to quickly ascertain the nature of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. Also, in the above Detailed Description, various features may be grouped together to streamline the disclosure. This should not be interpreted as intending that an unclaimed disclosed feature is essential to any claim. Rather, inventive subject matter may lie in less than all features of a particular disclosed embodiment. Thus, the following claims are hereby incorporated into the Detailed Description as examples or embodiments, with each claim standing on its own as a separate embodiment, and it is contemplated that such embodiments can be combined with each other in various combinations or permutations. The scope of the invention should be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled.