BIOPSY CONTAINER ASSEMBLY

Abstract

A biopsy container assembly having a container with a lower chamber suitable for containing a buffer liquid, and a cap coupled with the container. The cap being provided with a chamber that contains a biopsy liquid sealed by a membrane, and a crown with a toothing-suitable for tearing off the membrane of the cap. The crown is also suitable for being disposed in the container in an initial position, wherein the toothing is directed downwards in order not to interfere with the membrane of the cap when the cap is closed on the container, and in an operating position, wherein the toothing is directed upwards in order to tear off the membrane of the cap when the cap is closed on the container.

Claims

1. Cutlery tray comprising at least one longitudinal cavity wherein cutlery is to be disposed, said longitudinal cavity comprising: an inclined bottom surface comprising an upper transverse section and a lower transverse section; two longitudinal lateral edges with said inclined bottom surface in intermediate position between them; a transverse edge disposed at the lower transverse section and extending between the two longitudinal lateral edges; an inclined mobile partition disposed in said longitudinal cavity, between the two longitudinal lateral edges; connection means configured in such a way that said inclined mobile partition can be alternatively disposed in: a first position, wherein said inclined mobile partition is superimposed to said inclined bottom surface; a second position, wherein said inclined mobile partition projects with respect to said inclined bottom surface beyond the upper transverse section in such a way to increase the length of the supporting surface for the cutlery.

2. The cutlery tray of claim 1, wherein said connection means comprise: a pair of lateral pins in axially aligned position, each one of them being connected to the inclined mobile partition and being directed towards one of the two longitudinal lateral edges; and a pair of holes in axially aligned position, each one of them being obtained in one of said two longitudinal lateral edges of said cavity and revolvingly housing one of said lateral pins.

3. The cutlery tray of claim 1, wherein said connection means comprise: at least one slider that is integral with said inclined mobile partition; and a guide for said at least one slider, wherein said slider slides; said guide being provided on said inclined bottom surface or on one of the longitudinal lateral edges of said longitudinal cavity.

4. The cutlery tray of claim 1, wherein said connection means comprise: at least first and second grooves obtained on the two longitudinal lateral edges of said longitudinal cavity; and projections obtained on the mobile partition and suitably shaped in such a way to be inserted in said grooves.

5. The cutlery tray prof claim 1, comprising one or more consecutive longitudinal cavities that are aligned longitudinally and have the same width.

6. The cutlery tray of claim 5, wherein the longitudinal lateral edges of the two or more longitudinal cavities are monolithic.

7. The cutlery tray of claim 6, wherein the longitudinal lateral edges extend for the entire length of the cutlery tray.

8. The cutlery tray of claim 6, comprising a transverse cavity comprising a horizontal bottom surface with higher width than the longitudinal cavity.

9. The cutlery tray prof claim 8, wherein said transverse cavity extends for the entire width of the cutlery tray.

10. The cutlery tray of claim 1, wherein said inclined bottom surface of the longitudinal cavity comprises two portions with different inclination, of which at least one is not horizontal.

11. The cutlery tray of claim 1, comprising quick-connection means for the longitudinal lateral edges.

Description

[0027] Additional features of the invention will be clearer from the following detailed description, which refers to a merely illustrative, not limiting embodiment, shown in the appended figures, wherein:

[0028] FIG. 1 is an exploded perspective view of the biopsy container assembly according to the invention;

[0029] FIG. 2 is an axial view of the biopsy container assembly of FIG. 1;

[0030] FIGS. 3 and 4 are two perspective views of a crown of the biopsy container assembly of FIG. 1, taken from a different angle;

[0031] FIG. 5 is a perspective view of a cap of the biopsy container assembly of FIG. 1;

[0032] FIG. 6 is an axial view of the biopsy container assembly in closed condition before use;

[0033] FIG. 7 is an axial view of the biopsy container assembly during a closing of the cap, after introducing a bioptic sample and after turning the crown upside down;

[0034] FIG. 8 is a view of the biopsy container assembly after the closing of the cap, which has determined a rupture of a sealing film;

[0035] FIG. 9 is an exploded perspective view of a second embodiment of a biopsy container assembly;

[0036] FIG. 10 is an axial view of the biopsy container assembly of FIG. 2;

[0037] FIG. 11 is an axial view of the biopsy container assembly of FIG. 10 in assembled condition.

[0038] With reference to FIGS. 1 to 8, the biopsy container assembly of the invention is described, which is generally indicated with reference numeral 1.

[0039] With reference to FIGS. 1 and 2, the biopsy container assembly (1) comprises: [0040] a container (2), [0041] a crown (3) mounted inside the container (2), and [0042] a cap (4) applied on the container (2).

[0043] The container (2) has a substantially cylindrical shape, is internally empty and is open on top.

[0044] The container (2) has a bottom wall (20) and a lower lateral wall (21) that defines a lower chamber (C1). The lower lateral wall (21) is joined to an upper lateral wall (22) by means of a step-shaped collar (23) that projects outward from the lower lateral wall (21), acting as a shoulder. The upper lateral wall (22) has an external thread (24). The upper lateral wall (22) terminates with an upper edge (25). The upper lateral wall (22) forms an upper chamber (C2) that is open to the outside and communicates with the lower chamber (C1).

[0045] The diameter of the upper chamber (C2) is larger than the diameter of the lower chamber (C1). The height of the upper chamber (C2) is lower than the height of the lower chamber (C1). The volume of the lower chamber (C1) is larger than the volume of the upper chamber (C2).

[0046] With reference to FIG. 6, the lower chamber (C1) is suitable for being partially filled with a buffer liquid (L1) consisting of a buffer solution, which is not harmful to the human body. For illustrative purposes, the level of the buffer liquid (L1) is lower than half the height of the lower lateral wall of the container.

[0047] The container (2) is made of a hard plastic material, such as injection molded polypropylene, preferably in one piece.

[0048] With reference to FIGS. 3 and 4, the crown (3) comprises a base wall (30) with discoidal shape. A lateral wall (31) with cylindrical shape extends from the base wall (30). A collar (32) with annular shape protrudes radially outward from the lateral wall (31) of the crown. The collar (32) of the crown is suitable for abutting the collar (22) of the container. Therefore, the diameter of the collar (32) of the crown is lower than the internal diameter of the upper chamber (C2) and higher than the internal diameter of the lower chamber (C1).

[0049] The lateral wall (31) of the crown has an edge with a toothing (33) that protrudes with respect to the base wall (30). The toothing (33) may include triangular teeth. The toothing (33) is disposed in a first edge of the lateral wall of the crown and the collar (32) is disposed in a second edge of the lateral wall of the crown.

[0050] The base wall (30) of the crown comprises a plurality of holes (34) suitable for letting a liquid pass through. A cylindrical shank (35) protrudes axially from the base wall (30) of the crown, and is disposed coaxially inside the lateral wall (31) of the crown.

[0051] A plurality of apertures (36) is obtained in the lateral wall (31) of the crown near the collar (32).

[0052] The external diameter of the base wall (30) and of the lateral wall (31) of the crown is lower than the internal diameter of the lower chamber (C1) of the container. In view of the above, as shown in FIG. 6, the base wall (30) and the lateral wall of the crown are inserted in the lower chamber (C1) of the container until the collar (32) of the crown abuts the collar (28) of the container. In such a case, the toothing (33) of the crown is directed downward and the crown is in an initial position.

[0053] The height of the crown (3) is lower than half the height of the lower lateral wall (21) of the container. In this way, the crown is not in contact with the buffer fluid (L1) contained in the container.

[0054] The crown (3) can be turned upside down (rotated by 180° relative to a horizontal axis) with respect to the initial position of FIG. 6. As shown in FIG. 7, when the crown is turned upside down, the crown is in an operating position wherein the toothing (33) of the crown is directed upward and the collar (32) of the crown abuts the collar (28) of the container. In such a situation, an annular empty space (G) with a width equal to the radial thickness of the collar (32) of the crown is generated between the lateral wall (31) of the crown and the upper lateral wall (22) of the container.

[0055] The crown (3) is made of a hard plastic material, such as injection molded polypropylene, preferably in one piece.

[0056] With reference to FIGS. 2 and 5, the cap (4) has a substantially cylindrical shape and is open on the bottom. The cap has a lateral wall (40) joined to an upper wall (41).

[0057] The lateral wall (40) of the cap has an internal thread (42) suitable for being screwed on the external thread (24) of the container. An internal wall (43) with cylindrical shape protrudes in lower position from the upper wall (41) of the cap, coaxially inside the lateral wall (40) of the cap. The internal wall (43) has a lower edge (44).

[0058] The internal wall (43) and the upper wall (41) of the cap form a chamber (C3) suitable for containing a biopsy fluid (L2), such as 8% P/V formalin. As it is known, the exhalations of biopsy fluid are harmful to the human organism.

[0059] The cap (4) is made of a hard plastic material, such as injection molded polypropylene, preferably in one piece.

[0060] A membrane (5) is attached to the lower edge (44) of the internal wall of the cap so as to seal the biopsy fluid (L2) inside the chamber (C3) of the cap. For illustrative purposes, the membrane (5) may consist of an aluminum sheet that is co-extruded with polyolefins and may have a thickness comprised between 0.5 and 0.2 mm, preferably 0.1 mm. The membrane (5) may be heat-sealed to the lower edge (44) of the internal wall of the cap.

[0061] The volume of the chamber (C3) of the cap is lower than half the volume of the chamber (C1) of the container, so that a mixture of the buffer fluid (L1) and of the biopsy fluid does not completely fill the chamber (C1) of the container.

[0062] An annular empty space (45) suitable for accommodating the upper lateral wall (22) of the container is provided between the internal wall (43) and the lateral wall (40) of the cap.

[0063] The thickness of the internal wall (43) of the cap is lower than the width of the empty space (G) between the lateral wall (31) of the crown and the upper lateral wall (22) of the container. In view of the above, the cylindrical wall (43) of the cap can fit into the empty space (G) between the lateral wall (31) of the crown and the upper lateral wall (22) of the container, as shown in FIG. 8.

[0064] The upper wall (41) of the cap has an annular groove (46) disposed internally relative to the internal wall (43). The annular groove (46) is suitable for accommodating the toothing (33) of the crown, when the crown is in operating position and the cap is closed, as shown in FIG. 8.

[0065] After screwing the cap (4), the holes (34) in the base wall of the crown abut the upper wall of the cap (41). In this way, the upper wall of the cap (41) closes the holes of the base wall of the crown, preventing the mixture of buffer fluid and biopsy fluid from going into an empty space provided between the base wall of the crown and the upper wall of the cap.

[0066] Following is a description of the operation of the biopsy container assembly (1).

[0067] With reference to FIG. 6, initially, the chamber (C1) of the container is partially filled with the buffer fluid (L1); the crown (3) is disposed in the container in the initial position with the toothing (33) directed downward; the biopsy fluid (L2) is contained in the chamber (C3) of the cap; and the internal thread (42) of the cap is screwed into the external thread (24) of the container.

[0068] The cap (4) is unscrewed and is removed from the container (2) and the crown (3) is removed from the container (1).

[0069] With reference to FIG. 7, a bioptic sample (6) is disposed in the buffer fluid (L1); the crown (3) is turned upside down and inserted into the container with the toothing (33) directed upward, and the internal thread (42) of the cap is screwed on the internal thread (24) of the container, causing the translation of the cap toward the container.

[0070] With reference to FIG. 8, the toothing (33) of the crown tears off the membrane (5) of the cap and, because of gravity and of the pressure due to the upward thrust of the crown (3), the biopsy fluid (L2) leaves the chamber (C3) of the cap, passes through the crown (3) and reaches the lower chamber (C1) of the container where it is mixed with the buffer fluid (L1). Otherwise said, the crown (3) acts as a plunger to ensure that all of the biopsy fluid (L2) leaves the chamber (C3) of the cap.

[0071] The container assembly (1) according to the invention has been designed to solve all problems of the container assemblies of the prior art, because the container assembly (1) can be used as a standard container: [0072] unscrewing of the cap (4) and easy introduction of any type of biopsy (6) in the buffer fluid (L1); [0073] screwing of the cap (4) with simultaneous activation of the crown (3) to break the membrane (5) and let the biopsy fluid (L2) flow out; [0074] the biopsy (6) is housed in a space devoid of empty spaces or slots; [0075] unscrewing of the cap (4) and easy extraction of the biopsy (6).

[0076] With reference to FIGS. 9-11, a container assembly (100) according to a second embodiment is described.

[0077] In the following description, parts that are identical or correspond to the ones described above will be indicated with the same numerals, omitting their detailed description.

[0078] The biopsy container assembly (100) comprises [0079] a container (2), [0080] a crown (3) mounted in the container (2), [0081] a cap (4) applied on the container (2), and [0082] a safety strap (7) disposed between the container (2) and the cap (4) to prevent the lowering of the cap (4) on the container (2).

[0083] In particular, the container (2) has a collar (29) that protrudes externally under the thread (25) of the container. The lateral wall (40) of the cap (4) has a lower edge (49). The safety strap (7) is disposed on the collar (29) of the container. The lower edge (49) of the lateral wall (40) of the cap abuts the safety strap (7) that prevents the cap from being screwed and additionally lowered.

[0084] In such a case, the crown (3) is not rotated, and remains always with the toothing (33) directed upwards, namely towards the membrane (5). The safety strap (5) prevents the cap from being lowered and the toothing (33) of the crown from tearing off the membrane (5) before use. When the container assembly is to be used, the user removes the safety strap (7), screws the cap (4) onto the container (3) and the toothing (33) of the crown tears off the membrane (5) so that the biopsy fluid (L2) contained in the chamber (C3) of the cap falls in the chamber (C1) of the container with the buffer solution (L1).

[0085] In such a case, the crown (3) has an external lateral wall (37) that surrounds the lateral wall (31) of the crown so as to generate an annular empty space (38) that is open on top.

[0086] The cap (4) has an intermediate lateral wall (47) with cylindrical shape, disposed between the internal lateral wall (43) of the cap and the lateral wall (40) of the cap. In this manner, the cap (4) has a first annular empty space (45a) between the internal lateral wall (43) and the intermediate lateral wall (47) and a second annular empty space (45b) between the intermediate lateral wall (47) and the lateral wall (40).

[0087] When the cap (4) is screwed on the container (2), the internal lateral wall (43) of the cap enters the annular empty space (38) of the crown; the external lateral wall (37) of the crown enters the first annular empty space (45a) of the cap; and the upper lateral wall (22) of the container enters the second annular empty space (45b) of the cap.

[0088] It must be considered that in both embodiments of the container assemblies, because of the rupture of the membrane (5), the cap (4) is lowered and the upper wall (41) of the cap acts as a plunger to push the biopsy fluid (L2) through the holes (34) of the base wall of the crown. Thus, the biopsy fluid (L2) falls not only by gravity, but also because of the thrust of the cap.

[0089] In order to overcome the drawbacks of the prior art, after tearing off the membrane (5), the biopsy fluid (L2) in the chamber (C3) of the cap is pushed into the chamber (C1) of the container during the closing of the cap (4). It is essential that the proportion between biopsy liquid (L2) (concentrated formalin) and buffer solution (L1) is respected in order to provide a ready-to-use liquid.

[0090] At the same time, if the container is turned upside down, the potential passage of the bioptic sample (6) by means of reflux from the container (2) to the membrane (5), which is fragmented after being torn off, must be prevented.

[0091] In order to solve such a problem, in the container assembly according to the invention, the cap (4) acts as a plunger, wherein the upper wall (41) of the cap pushes the biopsy fluid (L2) through the holes (34) in the base wall (30) of the crown. In such a way, the holes (34) can be sufficiently small, for example with a diameter lower than 2 mm, preferably 1 mm, in such a way to prevent that the biopsy sample (6) passes through the base wall of the crown, reaches the ruptured membrane (5) and gets stuck in the membrane.

[0092] When screwing and lowering the cap (4), the membrane (5) abuts the toothing (33) of the crown, which cuts the membrane (5) on a peripheral edge of the membrane, pierces small holes in the membrane and breaks the membrane along its peripheral edge. In such a situation, the biopsy fluid (L2), which is sufficiently dense, will not fall into the holes (34) in the base wall (30) of the crown by gravity because said holes (34) are sufficiently small.

[0093] A subsequent screwing of the cap (4) will cause the penetration of the crown (3) in the chamber (C3) of the cap with the biopsy fluid (L2) and the upper wall (41) of the cap will cause a forced pressure on the biopsy fluid (L2) that forces the biopsy fluid (L2) to forcedly pass through the holes (34) disposed on the base wall of the crown.

[0094] The membrane (5), which has been previously detached by the toothing of the crown, will be accompanied by the crown towards an upper portion of the chamber (C3) of the cap, without interfering with the holes (34) of the base wall of the crown that allow for the passage of the biopsy liquid (L2) because the tolerance between the wall of the chamber (C3) of the cap and the circumference of the detached membrane (5) allows the passage of the biopsy liquid (L2). A complete screwing of the cap (4) will cause the crown (3) to abut the upper wall of the cap, and the base wall (30) of the crown will adhere to the upper wall (41) of the cap, closing all the holes (34) in the base wall of the crown under pressure. In such a way, it impossible even for very small samples to pass through the holes (34) in the base wall of the crown.

[0095] By simply screwing the cap (4), such a mechanism forces the entire amount of biopsy liquid (L2) to flow down under pressure, while simultaneously closing all the openings that may be a source of reflux for the tissue samples or for the cells, guaranteeing a correct concentration of the solution and maintaining all samples inside the container.