Power supplying apparatus for neural activity recorder reducing common-mode signal applied to electrodes connected to the neural activity recorder
10263580 ยท 2019-04-16
Assignee
Inventors
Cpc classification
H03F2203/45136
ELECTRICITY
H03F2203/45526
ELECTRICITY
H03F2200/261
ELECTRICITY
H03F2203/45138
ELECTRICITY
H03F2203/45524
ELECTRICITY
A61B5/24
HUMAN NECESSITIES
H03F3/45224
ELECTRICITY
H03F3/4565
ELECTRICITY
H03F3/45237
ELECTRICITY
International classification
H03F3/72
ELECTRICITY
Abstract
Disclosed is a differential voltage supplying apparatus configured to supply, to a neural activity recorder, an input signal generated by combining, with a direct current (DC) power supply, a common-mode signal determined from a voltage applied to a detection electrode and a reference electrode connected to the neural activity recorder, and improve a common-mode rejection ratio of the neural activity recorder and generate a DC power supply.
Claims
1. A differential voltage supplying apparatus, comprising: a differential voltage generator configured to generate a first input signal and a second input signal from a power supply, wherein a difference between the first input signal and the second input signal is determined based on a preset potential difference; and a common-mode signal combiner configured to combine a common-mode signal with each of the first input signal and the second input signal, wherein the first input signal combined with the common-mode signal and the second input signal combined with the common-mode signal are inputted into a neural activity recorder having a plurality of detection electro nodes, wherein the common-mode signal is determined based on a voltage applied to an electrode attached to a body of a user to allow the neural activity recorder to measure a neural activity of the user.
2. The differential voltage supplying apparatus of claim 1, wherein the common-mode signal combiner is configured to determine the common-mode signal using a common-mode signal electrode configured to measure a voltage applied to an electrode of the neural activity recorder.
3. The differential voltage supplying apparatus of claim 1, wherein the differential voltage generator is configured to generate the first input signal and the second input signal separated from the power supply and a ground electrode.
4. The differential voltage supplying apparatus of claim 1, wherein the common-mode signal combiner is configured to combine the common-mode signal with each of the first input signal and the second input signal to compensate for an influence of an impedance of a positive input terminal of a low-noise amplifier (LNA) included in the neural activity recorder and an impedance of a negative input terminal of the LNA, on a common-mode rejection ratio of the LNA.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) These and/or other aspects, features, and advantages of the present disclosure will become apparent and more readily appreciated from the following description of example embodiments, taken in conjunction with the accompanying drawings of which:
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DETAILED DESCRIPTION
(10) The following detailed description is provided to assist the reader in gaining a comprehensive understanding of the methods, apparatuses, and/or systems described herein. However, various changes, modifications, and equivalents of the methods, apparatuses, and/or systems described herein will be apparent after an understanding of the disclosure of this application. For example, the sequences of operations described herein are merely examples, and are not limited to those set forth herein, but may be changed as will be apparent after an understanding of the disclosure of this application, with the exception of operations necessarily occurring in a certain order. Also, descriptions of features that are known in the art may be omitted for increased clarity and conciseness.
(11) The features described herein may be embodied in different forms, and are not to be construed as being limited to the examples described herein. Rather, the examples described herein have been provided merely to illustrate some of the many possible ways of implementing the methods, apparatuses, and/or systems described herein that will be apparent after an understanding of the disclosure of this application.
(12) Terms such as first, second, A, B, (a), (b), and the like may be used herein to describe components. Each of these terminologies is not used to define an essence, order, or sequence of a corresponding component but used merely to distinguish the corresponding component from other component(s). For example, a first component may be referred to as a second component, and similarly the second component may also be referred to as the first component.
(13) It should be noted that if it is described in the specification that one component is connected, coupled, or joined to another component, a third component may be connected, coupled, and joined between the first and second components, although the first component may be directly connected, coupled or joined to the second component. In addition, it should be noted that if it is described in the specification that one component is directly connected or directly joined to another component, a third component may not be present therebetween. Likewise, expressions, for example, between and immediately between and adjacent to and immediately adjacent to may also be construed as described in the foregoing.
(14) The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting. As used herein, the singular forms a, an, and the, are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms comprises, comprising, includes, and/or including, when used herein, specify the presence of stated features, integers, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, operations, elements, components, and/or groups thereof.
(15) Unless otherwise defined, all terms, including technical and scientific terms, used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure pertains based on an understanding of the present disclosure. Terms, such as those defined in commonly used dictionaries, are to be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and the present disclosure, and are not to be interpreted in an idealized or overly formal sense unless expressly so defined herein.
(16) Hereinafter, some example embodiments will be described in detail with reference to the accompanying drawings. Regarding the reference numerals assigned to the elements in the drawings, it should be noted that the same elements will be designated by the same reference numerals, wherever possible, even though they are shown in different drawings.
(17)
(18) Referring to
(19) The first input signal and the second input signal that are generated by the differential voltage generator 120 may be used as a power supply for the neural activity recorder 140. That is, the differential voltage generator 120 may generate such an independent power supply that is separated from the power supply 110 and a ground. The neural activity recorder 140 may collect a plurality of neural activities through channels respectively corresponding to the neural activities. The neural activity recorder 140 may be connected to a detection electrode provided for each of the channels, and to a reference electrode configured to provide a reference voltage to measure a voltage of the detection electrode. The detection electrode and the reference electrode may be attached to different portions of a body of a user.
(20) The neural activity recorder 140 may include a low-noise amplifier (LNA) provided for each of the channels. A positive input terminal of the LNA may be connected to a corresponding detection electrode, and a negative input terminal of the LNA may be connected to the reference electrode. The LNA may receive power from the first input signal and the second input signal.
(21) The common-mode signal combiner 130 may combine a common-mode signal with each of the first input signal and the second input signal and supply, to the neural activity recorder 140, the first input signal and the second input signal that are combined with the common-mode signal. The common-mode signal may be determined based on a voltage applied to an electrode attached to the body of the user, for example, the detection electrode and the reference electrode, to allow the neural activity recorder 140 to measure a neural activity of the user. As illustrated in
(22) As illustrated in
(23)
(24) Referring to
(25) Referring to
(26) Referring to
(27) Referring to the equivalent circuit illustrated in
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(29) In Equation 1, CMRR.sub.AMP denotes a common-mode rejection ratio CMRR of the LNA 210. Because the LNA 210 is not an ideal operational amplifier (OP-AMP), a value of CMRR.sub.AMP may be determined to be a finite value based on an internal element of the LNA 210. Referring to Equation 1, a common-mode rejection ratio of the LNA 210 may be improved by
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The common-mode signal measured through the common-mode signal electrode is combined with each of the first input signal and the second input signal. Thus, in theory, there is no difference between the voltage V.sub.CM of the common-mode signal measured through the common-mode signal electrode and the voltage V.sub.CM2 of the common-mode signal combined with each of the first input signal and the second input signal. There may be no difference between the voltage V.sub.CM and the voltage V.sub.CM2, and thus the common-mode rejection ratio CMRR.sub.sys may become infinite in theory.
(31) However, when the common-mode signal is combined with each of the first input signal and the second input signal, there may be a slight difference between the voltage V.sub.CM of the common-mode signal measured through the common-mode signal electrode and the voltage V.sub.CM2 of the common-mode signal combined with each of the first input signal and the second input signal. Despite such a difference between the voltage V.sub.CM and the voltage V.sub.CM2, the common-mode rejection ratio CMRR.sub.sys may be improved by 40 decibels (dB) or more.
(32) In conclusion, the common-mode signal combiner may combine, with a first input signal and a second input signal, a common-mode signal measured at a detection electrode or a reference electrode, and thus improve a common-mode rejection ratio of the neural activity recorder. Thus, an influence of a difference between an impedance of a positive input terminal of an LNA and an impedance of a negative input terminal of the LNA on the common-mode rejection ratio may be compensated for by the common-mode signal combiner, and thus, although the number of channels of the neural activity recorder increases, the common-mode rejection ratio of the neural activity recorder may be maintained at a certain value or greater.
(33) In detail, referring back to Equation 1, when the number of channels is 1 (N=1) and there is no difference between the impedance of the positive input terminal of the LNA 210 and the impedance of the negative input terminal of the LNA 210, the common-mode rejection ratio CMRR.sub.sys of the LNA 210 may be
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The common-mode rejection ratio CMRR.sub.sys may be represented as
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on a log scale. That is, the common-mode rejection ratio CMRR.sub.sys of the LNA 210 may be limited by CMRR.sub.AMP.
(36) Thus, although a difference between the impedance of the positive input terminal of the LNA 210 and the impedance of the negative input terminal of the LNA 210 occurs as the number of channels, for example, N, increases, the common-mode rejection ratio CMRR.sub.sys may be maintained at
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or greater. The neural activity recorder may minimize the difference between the voltage V.sub.CM and the voltage V.sub.CM2, the common-mode rejection ratio CMRR.sub.sys may be improved. For example, in a case in which an error between the voltage V.sub.CM and the voltage V.sub.CM2 is less than 1%,
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and thus the common-mode rejection ratio CMRR.sub.sys may be improved by 40 dB or more.
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(40) A multi-channel neural recording amplifier system according to an example embodiment employing a differentially regulated rejection ratio enhancement (DR.sup.3E) scheme is illustrated in
(41) As a result, common-mode disturbances may not affect the differential output even in the presence of input-impedance mismatches or when the CM rejection capability of the amplifier becomes limited. Thus, refer to
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(44) As a result, refer to
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(46) According to
(47) As shown in
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(50) In-vivo measurements on the subthalamic nucleus of an anesthetized Sprague Dawley rat recorded successfully using the proposed DR.sup.3E neural amplifier is shown in
(51) The present invention provides a neural recording system that employs a differentially regulated rejection ratio enhancement scheme that improves the CMRR/TCMRR/PSRR performance by several tens of dBs over prior works, without the need for any bulky decoupling capacitors. Furthermore, the internal clock sources of the system may provide a high-quality clock for the system, obviating the need for bulky crystal oscillators. Thus, the proposed DR.sup.3E neural recording system paves a way for further miniaturization. Finally, though the proposed work is presented in the context of neural recording, it is also suitable for other biomedical signal acquisition applications where high CMRR/PSRR performance is essential.
(52) The components described in the example embodiments of the present disclosure may be achieved by hardware components including at least one digital signal processor (DSP), a processor, a controller, an application specific integrated circuit (ASIC), a programmable logic element such as a field programmable gate array (FPGA), other electronic devices, and combinations thereof. At least some of the functions or the processes described in the example embodiments of the present disclosure may be achieved by software, and the software may be recorded on a recording medium. The components, the functions, and the processes described in the example embodiments of the present disclosure may be achieved by a combination of hardware and software.
(53) The processing device described herein may be implemented using hardware components, software components, and/or a combination thereof. For example, the processing device and the component described herein may be implemented using one or more general-purpose or special purpose computers, such as, for example, a processor, a controller and an arithmetic logic unit (ALU), a digital signal processor, a microcomputer, a field programmable gate array (FPGA), a programmable logic unit (PLU), a microprocessor, or any other device capable of responding to and executing instructions in a defined manner. The processing device may run an operating system (OS) and one or more software applications that run on the OS. The processing device also may access, store, manipulate, process, and create data in response to execution of the software. For purpose of simplicity, the description of a processing device is used as singular; however, one skilled in the art will be appreciated that a processing device may include multiple processing elements and/or multiple types of processing elements. For example, a processing device may include multiple processors or a processor and a controller. In addition, different processing configurations are possible, such as parallel processors.
(54) The software may include a computer program, a piece of code, an instruction, or some combination thereof, to independently or collectively instruct or configure the processing device to operate as desired. Software and data may be embodied permanently or temporarily in any type of machine, component, physical or virtual equipment, computer storage medium or device, or in a propagated signal wave capable of providing instructions or data to or being interpreted by the processing device. The software also may be distributed over network coupled computer systems so that the software is stored and executed in a distributed fashion. The software and data may be stored by one or more non-transitory computer readable recording mediums. The non-transitory computer readable recording medium may include any data storage device that can store data which can be thereafter read by a computer system or processing device. Examples of the non-transitory computer readable recording medium include read-only memory (ROM), random-access memory (RAM), CD-ROMs, magnetic tapes, floppy disks, optical data storage devices. Also, functional programs, codes, and code segments that accomplish the examples disclosed herein can be easily construed by programmers skilled in the art to which the examples pertain based on and using the flow diagrams and block diagrams of the figures and their corresponding descriptions as provided herein.
(55) The methods according to the above-described example embodiments may be recorded in non-transitory computer-readable media including program instructions to implement various operations of the above-described example embodiments. The media may also include, alone or in combination with the program instructions, data files, data structures, and the like. The program instructions recorded on the media may be those specially designed and constructed for the purposes of example embodiments, or they may be of the kind well-known and available to those having skill in the computer software arts. Examples of non-transitory computer-readable media include magnetic media such as hard disks, floppy disks, and magnetic tape; optical media such as CD-ROM discs, DVDs, and/or Blue-ray discs; magneto-optical media such as optical discs; and hardware devices that are specially configured to store and perform program instructions, such as read-only memory (ROM), random access memory (RAM), flash memory (e.g., USB flash drives, memory cards, memory sticks, etc.), and the like. Examples of program instructions include both machine code, such as produced by a compiler, and files containing higher level code that may be executed by the computer using an interpreter. The above-described devices may be configured to act as one or more software modules in order to perform the operations of the above-described example embodiments, or vice versa.
(56) While this disclosure includes specific examples, it will be apparent to one of ordinary skill in the art that various changes in form and details may be made in these examples without departing from the spirit and scope of the claims and their equivalents. The examples described herein are to be considered in a descriptive sense only, and not for purposes of limitation. Descriptions of features or aspects in each example are to be considered as being applicable to similar features or aspects in other examples. Suitable results may be achieved if the described techniques are performed in a different order, and/or if components in a described system, architecture, device, or circuit are combined in a different manner, and/or replaced or supplemented by other components or their equivalents. Therefore, the scope of the disclosure is defined not by the detailed description, but by the claims and their equivalents, and all variations within the scope of the claims and their equivalents are to be construed as being included in the disclosure.