Single infrared sensor capnography
11484222 · 2022-11-01
Assignee
Inventors
Cpc classification
A61B5/082
HUMAN NECESSITIES
A61B5/0077
HUMAN NECESSITIES
A61B5/11
HUMAN NECESSITIES
A61B2562/0233
HUMAN NECESSITIES
A61B5/0816
HUMAN NECESSITIES
International classification
A61B5/08
HUMAN NECESSITIES
A61B5/083
HUMAN NECESSITIES
A61B5/11
HUMAN NECESSITIES
Abstract
The present disclosure presents methods, systems and devices for performing capnography (respiratory CO.sub.2) monitoring using a respiratory CO.sub.2 sensor and a breath tracking mechanism for tracking and/or detecting phases of the breath wherein the measurements of the CO.sub.2 sensor may provide baseline CO.sub.2 values, and modulate/quantify the respiratory CO.sub.2 levels according to the baseline values.
Claims
1. A capnography device, comprising: a respiratory-tracking system, configured to provide a tracking-signal indicative of baseline-phases within respiratory cycles, wherein the baseline-phases are confined between an end of inhalation and a start of exhalation; a carbon dioxide (CO.sub.2) sensor having an absorption chamber, an IR source, and an IR sensor; wherein the absorption chamber is configured to provide respiratory CO.sub.2 measurements of a subject's exhaled respiratory gasses within the absorption chamber and is filled with ambient air during the baseline-phase; wherein the IR source is configured to provide IR radiation through the subject's exhaled respiratory gasses within the absorption chamber to the IR sensor; wherein the IR source is configured, along with a detector, for detecting IR intensities of radiation irradiated from the IR source and passed through the exhaled respiratory gases within the absorption chamber; and a processing system that is communicatively coupled to the respiratory-tracking system and the CO.sub.2 sensor, for receiving the respiratory CO.sub.2 measurements from the CO.sub.2 sensor and, in real time and without a need for measuring and compensating for drifts between plural CO.sub.2 sensors: determining the baseline-phases from the tracking-signal derived by the processing circuitry, wherein the baseline-phases comprise baseline CO.sub.2 measurements performed when the absorption chamber is filled with ambient air during a hold phase associated with null gas flow, and wherein the baseline CO.sub.2 measurements are indicative of ambient CO.sub.2; distinguishing the baseline CO.sub.2 measurements from the respiratory CO.sub.2 measurements by use of the processing circuitry, and determining a CO.sub.2 value derived by the processing circuitry based on the baseline CO.sub.2 measurements and the respiratory CO.sub.2 measurements.
2. The device of claim 1, wherein the processing circuitry is configured to derive the CO.sub.2 value by factoring the respiratory CO.sub.2 measurements with the baseline CO.sub.2 measurements.
3. The device of claim 1, wherein the processing circuitry is configured to derive the CO.sub.2 value based on the baseline CO.sub.2 measurements and the respiratory CO.sub.2 measurements by: establishing a baseline level from the baseline CO.sub.2 measurements; and dividing the respiratory CO.sub.2 measurements by the baseline level, thereby deriving the CO.sub.2 value.
4. The device of claim 1, wherein the respiratory-tracking system is configured to obtain a signal from the CO.sub.2 sensor and detect various respiratory phases based on changes in the obtained signal.
5. The device of claim 1, wherein the respiratory-tracking system comprises a heart rate sensor.
6. The device of claim 1, wherein the respiratory-tracking system comprises a chest displacement tracking system configured to provide a signal indicative of displacement in the chest of the subject.
7. The device of claim 6, wherein the chest displacement tracking system comprises a belt configured to be placed on or wrap around a chest of the subject and provide chest displacement tracking by measuring the expansion and contraction of the chest.
8. A method for monitoring carbon dioxide (CO.sub.2) in exhaled respiratory gasses of a subject, the method comprising: obtaining a tracking-signal, wherein the tracking-signal is indicative of respiration-phases within a respiratory cycle; identifying, via processing circuitry, a baseline-phase based on the tracking-signal, wherein the baseline-phase comprises baseline CO.sub.2 measurements associated with ambient CO.sub.2; obtaining, via a CO.sub.2 sensor having an absorption chamber, an IR source, and an IR sensor, respiratory CO.sub.2 measurements of the subject within the absorption chamber, wherein the respiratory CO.sub.2 measurements comprise a concentration of CO.sub.2 in the exhaled respiratory gasses; wherein the absorption chamber is filled with ambient air during the baseline-phase; wherein the IR source is configured to provide IR radiation through the subject's exhaled respiratory gases within the absorption chamber to the IR sensor; wherein the IR source is configured, along with a detector, for detecting IR intensities of radiation irradiated from the IR source and passed through the exhaled respiratory gasses within the absorption chamber; and, in real time and without a need for measuring and compensating for drifts between plural CO.sub.2 sensors: distinguishing, via the processing circuitry, the baseline CO.sub.2 measurements that are performed when the absorption chamber is filled with ambient air during a hold phase associated with null gas flow from the respiratory CO.sub.2 measurements, based on the identified baseline-phase; and determining, via the processing circuitry, respiratory CO.sub.2 values based on the distinguished baseline CO.sub.2 measurements and the respiratory CO.sub.2 measurements, thereby, forming a capnogram.
9. The method of claim 8, wherein determining the respiratory CO.sub.2 values based on the distinguished baseline CO.sub.2 measurements and the respiratory CO.sub.2 measurements comprises establishing a baseline level from the baseline CO.sub.2 measurements.
10. The method of claim 9, wherein determining the respiratory CO.sub.2 values based on the distinguished baseline CO.sub.2 measurements and the respiratory CO.sub.2 measurements further comprises subtracting the baseline level from the respiratory CO.sub.2 measurements, thereby determining the respiratory CO.sub.2 values.
11. The method of claim 8, wherein obtaining the tracking-signal indicative of respiration-phases within the respiratory cycle comprises obtaining the tracking-signal from a respiratory-tracking system.
12. The method of claim 11, wherein the respiratory-tracking system comprises a chest movement-tracking device.
13. The method of claim 12, wherein the chest movement-tracking device comprises a belt or strap configured to be placed on or around the chest or torso of the subject and to measure the expansion and contraction thereof.
14. The method of claim 8, wherein the baseline-phase is a phase in the respiratory cycle that is confined between the end of inhalation and start of exhalation, and in which the respiratory gas flow is idle.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) Examples illustrative of embodiments are described below with reference to figures attached hereto. In the figures, identical structures, elements or parts that appear in more than one figure are generally labeled with a same numeral in all the figures in which they appear. Alternatively, elements or parts that appear in more than one figure may be labeled with different numerals in the different figures in which they appear. Dimensions of components and features shown in the figures are generally chosen for convenience and clarity of presentation and are not necessarily shown in scale. The figures are listed below.
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DETAILED DESCRIPTION
(11) In the following description, various aspects of the disclosure will be described. For the purpose of explanation, specific configurations and details are set forth in order to provide a thorough understanding of the different aspects of the disclosure. However, it will also be apparent to one skilled in the art that the disclosure may be practiced without specific details being presented herein. Furthermore, well-known features may be omitted or simplified in order not to obscure the disclosure.
(12) The current capnography systems commonly utilize two distinct IR sensors, one of which is configured to measure the CO.sub.2 concentration in respiratory gas of a subject, while the other IR sensor is utilized for establishing a baseline value. The CO2 level values are commonly interpreted using the reference intensity (I.sub.0) that might be change due to various effects. Therefore, in order to keep a constant baseline value for reliable CO2 level measurements, a correction/calibration (such as auto-zero) is commonly done using a second reference sensor or an external breathing tracking device. The established baseline value is commonly used for calibrating the measurements of the main sensor to provide meaningful/quantifiable CO.sub.2 concentration measurements in the respiratory gas.
(13) Reference is now made to
(14) Capnography system 100 further includes an analyzer 116, configured to obtain measurements from main-sensor 114 and reference-sensor 130, and to modulate the measurements of main-sensor 114 according to the baseline measurements of reference-sensor 130. Analyzer 116 then provides CO.sub.2 levels to be displayed on a monitor 118. Analyzers of this type are well-known in the art.
(15) The need for a second IR sensor, such as reference-sensor 130, results in complicating the capnographic systems and affects the form-factor of the system as well as the cost thereof.
(16) According to some embodiments, there are provided herein capnographic systems, devices and methods for achieving quantifiable CO.sub.2 measurements using an IR sensor configured to measure respiratory CO.sub.2 concentrations, and a breath/respiratory tracking mechanism for tracking respiration cycles and identifying “baseline-phases” within the respiration cycles. According to some embodiments, the CO.sub.2 measurements of the IR sensor during at least some baseline-phases are indicative of CO.sub.2 measurements of the respiratory zero CO.sub.2 level (that may be referred to as an ambient measurements in some embodiments).
(17) According to some embodiments, the respiratory-tracking mechanism is configured to provide a tracking-signal indicative of baseline-phases within respiratory cycles (or other phases within respiratory cycles, for example within inhalation), and the carbon dioxide (CO.sub.2) IR sensor, configured to provide respiratory CO.sub.2 measurements of respiratory gasses within an absorption-chamber to facilitate flow of respiratory gasses therethrough. According to some embodiments, the devices and systems may include processing circuitry, an analysis unit and/or an analyzer configured to obtain respiratory CO.sub.2 measurements from the CO.sub.2 sensor, detect baseline-phases from the tracking-signal, distinguish baseline CO.sub.2 measurements from the respiratory CO.sub.2 measurements, associated with baseline-phases, and derive CO.sub.2 levels based on the baseline CO.sub.2 measurements and the respiratory CO.sub.2 measurements.
(18) According to some embodiments, the term “CO.sub.2 sensor” may refer to a device or unit configured to measure CO.sub.2 molecule concentration in gas. According to some embodiments, a CO.sub.2 sensor may include an “IR sensor” for detecting IR intensities of radiation irradiated from an IR source and passed through a CO.sub.2 containing gas. The detection of high IR intensities may indicate low CO.sub.2 molecule concentration within the gas, while the detection of low IR intensities may indicate high CO.sub.2 molecule concentration within the gas.
(19) According to some embodiments, the respiratory tracking mechanism is configured to track at least some respiration cycles of a user/subject, and to indicate various phases therein.
(20) According to some embodiments, the respiratory tracking mechanism is configured to provide indication of the following phases: Inspiration phase: the phase in which gas is inspired into the respiratory system of the subject, associated with negative gas flow (from the respiratory system outwards) and an expansion of the torso or parts thereof. Expiration phase: the phase in which gas is expired from the respiratory system, associated with positive gas flow (from the respiratory system outwards) and a contraction of the torso or parts thereof.
(21) According to some embodiments, the respiratory tracking mechanism is further configured to provide indication of the following intermediary phases: Hold phase: The phase confined between by the end of the inspiration phase and the beginning of the expiration phase, associated with null gas flow (from the respiratory system outwards) and an expanded torso or parts thereof. Vacant phase: The phase confined between by the end of the expiration phase and the beginning of the inspiration phase, associated with null gas flow (from the respiratory system outwards) and a contracted torso or parts thereof.
(22) According to some embodiments, during a hold phase, the absorption-chamber is filled with ambient gas. According to some embodiments, the CO.sub.2 measurements within the chamber during the hold phases may be representative of a respective zero-level or baseline level of CO.sub.2. According to some embodiments, the terms “zero-level” and “baseline-level” are interchangeable and may refer to an ambient CO.sub.2 measurement level.
(23) According to some embodiments, the hold phases are referred to as “baseline-phases” and the CO.sub.2 measurements within the chamber during the baseline-phases may be representative of ambient CO.sub.2 measurements and may be utilized for establishing a baseline value for the capnography.
(24) Reference is now made to
(25) According to some embodiments, IR radiation 220 passes through respiratory gas 208 within absorption chamber 206 and at least some of radiation 220 is absorbed by CO.sub.2 molecules 215 within respiratory gas 206 and the rest of radiation 220 or parts thereof then reaches IR sensor 214, which measures IR intensities. When IR sensor 214 measures high IR intensities, it may indicate low CO.sub.2 molecule 215 concentrations within respiratory gas 208 in chamber 206. On the other hand, when IR sensor 214 measures low IR intensities, it may indicate low CO.sub.2 molecule 215 concentration within respiratory gas 208 in chamber 206. According to some embodiments, the IR intensity measurements/readings are provided to an analyzer 216 configured to analyze the measurements and derive quantifiable CO.sub.2 measurements therefrom.
(26) According to some embodiments, breath tracker 230 is configured to track the breath/respiration cycles of a user/subject. According to some embodiments, the tracking is indicative of baseline-phases, in which gas 208 within chamber 206 is representative of ambient gas, and as a result, CO.sub.2 concentration measurements during the baseline-phases may be indicative, among other factors, of a background ambient CO.sub.2 concentration, and therefore provide baseline CO.sub.2 measurements.
(27) According to some embodiments, analyzer 216 is further configured to associate CO.sub.2 measurements by CO.sub.2 sensor 210 with respiration/breath phases. According to some embodiments, analyzer 216 is configured to identify baseline-phases and associate baseline CO.sub.2 measurements to them.
(28) According to some embodiments, analyzer 216 is further configured to establish a baseline value from the baseline CO.sub.2 measurements. According to some embodiments, analyzer 216 is configured to adjust the respiratory CO.sub.2 measurements based on the established baseline value and provide CO.sub.2 levels to a monitor 218 for displaying the capnogram (CO.sub.2 levels). The analyzer 216 may be a known analyzer (such as those available from Medtronic) reconfigured to process the information/signals from the CO.sub.2 sensor 210 and the breath tracker 230 in accordance with the techniques disclosed herein.
(29) In current capnography systems, a zeroing/calibration loop is commonly performed during capnography measurements to compensate on measurement drifts between the two sensors (the main CO.sub.2 sensor and the reference CO.sub.2 sensor), and for obtaining calibrated CO.sub.2 measurement. Advantageously, reducing the number of sensors to only one sensor may simplify the zeroing/calibration loop by obviating the need for measuring and compensating on the drifts between the two sensors.
(30) As used herein, the term “absorption-chamber” may refer to a cavity/chamber structure configured to facilitate a flow of respiratory gasses therein for measuring CO.sub.2 levels within the gas, for example by measuring the absorption of radiated IR waves.
(31) Advantageously, simplifying the zeroing loop (baselining) during capnography may avail the utilization of one IR sensor instead of two sensors as in common capnographic devices. As a result, the overall complexity of the capnography system is reduced and the configuration and/or maintenance thereof may be simplified.
(32) Reference is now made to
(33) According to some embodiments, analysis unit 306 is configured to identify baseline-phases from the tracking signal, and to associate CO.sub.2 measurements with the baseline phases. According to some embodiments, the CO.sub.2 measurements associated with the baseline-phases are referred to as baseline CO.sub.2 measurements. According to some embodiments, analysis unit 306 is configured to establish a baseline value from the baseline CO.sub.2 measurements. According to some embodiments, analysis unit 306 is configured to provide CO.sub.2 levels by offsetting/altering/modifying the respiratory CO.sub.2 measurements based on the established baseline value.
(34) According to some embodiments, a breath/respiration tracking mechanism, unit or device may include tracking the expansion and contraction of the torso of a user, or parts thereof (such as the chest area). According to some embodiments, the breath/respiration tracking mechanism may include one or more accelerometers, motion sensors, proximity sensors or the like. According to some embodiments, the breath/respiration tracking mechanism may include a camera configured to obtain visual imagery of the torso area of a user, or parts thereof. According to some embodiments, the breath/respiration tracking mechanism may include one or more microphones configured to obtain audial signals associated with the breath activity of a user.
(35) According to some embodiments, the analysis unit or analyzer may include processing circuitry configured to provide one or more of the functions associated with the analysis unit. According to some embodiments, the analysis unit may include a computer, a mobile device, a server, an FPGA system, an ASIC system or the like. According to some embodiments, the analysis unit may be connected to the CO.sub.2 sensor, the breath tracking unit and/or the display wirelessly or through wired communication. According to some embodiments, the analysis unit may be connected to a local network or a wide network. According to some embodiments, the analysis unit may provide CO.sub.2 levels to a distant user or location through internet/cellular/satellite communication.
(36) Reference is now made to
(37) Additionally, computer 404 is further configured to obtain CO.sub.2 samples or respiratory gas samples from a sampler, such as mask 406 or any consumable unit for obtaining respiratory gas samples, and to measure the respiratory CO.sub.2 concentration within the gas using a CO.sub.2 sensor (not shown).
(38) According to some embodiments, computer 404 identifies baseline-phases from the respiratory cycles and/or respiratory phases, and associates CO.sub.2 measurements to these phases to create baseline CO.sub.2 measurements. According to some embodiments, computer 404 may establish a baseline value based on the baseline CO.sub.2 measurements, and to modulate the respiratory CO.sub.2 measurements according to the established baseline.
(39) According to some embodiments, camera 410 may be configured to obtain infrared imagery of subject 430, or torso 432. According to some embodiments, camera 410 may be configured to provide motion (gradient) indications of various points in the field of view thereof. According to some embodiments, camera 404 may be configured to provide a “floating point” or “tracking point” or a selected or predetermined point on subject 430 or torso 432.
(40) According to some embodiments, breathing/respiration of a user may result in movements in the torso area. According to some embodiments, the movements may include expansion and/or contraction of various areas of the torso, such as the chest area, thorax area, and/or the abdomen area. According to some embodiments, the movements may include elevation and withdrawal of the shoulder area.
(41) Reference is now made to
(42) According to some embodiments, controller 504 is further configured to obtain CO.sub.2 samples or respiratory gas samples from a sampler, such as mask 506, and to measure the respiratory CO.sub.2 concentration measurements within the gas using a CO.sub.2 sensor (not shown). According to some embodiments, controller 504 identifies baseline-phases from the respiratory cycles and/or respiratory phases, and associates CO.sub.2 measurements to these phases to create baseline CO.sub.2 measurements. According to some embodiments, controller 504 may establish a baseline value based on the baseline CO.sub.2 measurements, and to modulate the respiratory CO.sub.2 measurements according to the established baseline.
(43) Reference is now made to
(44) According to some embodiments, controller 604 is further configured to obtain CO.sub.2 samples or respiratory gas samples from a sampler, such as mask 606, and to measure the respiratory CO.sub.2 concentration measurements within the gas using a CO.sub.2 sensor (not shown). According to some embodiments, controller 604 identifies baseline-phases from the respiratory cycles and/or respiratory phases, and associates CO.sub.2 measurements to these phases to create baseline CO.sub.2 measurements. According to some embodiments, controller 604 may establish a baseline value based on the baseline CO.sub.2 measurements, and to modulate the respiratory CO.sub.2 measurements according to the established baseline.
(45) Reference is now made to
(46) Reference is now made to
(47) According to some embodiments, modulating, altering, modifying and/or manipulating the respiratory CO.sub.2 measurements may include subtracting/deducing the baseline value therefrom to obtain CO.sub.2 levels. According to some embodiments, modulating, altering, modifying and/or manipulating the respiratory CO.sub.2 measurements may include dividing the respiratory CO.sub.2 measurements by the baseline value to obtain CO.sub.2 levels.
(48) Reference is now made to
(49) According to some embodiments, the method may proceed by returning to step 904 for establishing a new baseline value, or ending the monitoring and tracking (step 912).
(50) According to some embodiments, the respiratory CO.sub.2 levels may be interpreted/derived from the respiratory CO.sub.2 measurements by dividing it with I.sub.0 (the baseline/zeroing level). For example, if I.sub.x refers to the intensity of IR radiation detected at the IR sensor, and I.sub.0 is the baseline/zero level, then the respiratory CO.sub.2 levels may be obtained by dividing as follows: respiratory CO.sub.2 levels=I.sub.x/I.sub.0.
(51) According to some embodiments, the IR sensors is configured to measure radiation/light intensities at an approximately 200 nm IR wavelength margin around a nominal 4.2 um point.
(52) In comparison, in current capnography (utilizing two IR sensors) there may be three types of measured intensities:
(53) I.sub.0=the original intensity of the lamp (reference sensor)
(54) I.sub.x0=the intensity at CO2 zero level during inhalation (main sensor)
(55) I.sub.x=the intensity at non-zero level of CO2 during exhalation (main sensor)
(56) The baseline is commonly derived from the portion I.sub.x0/I.sub.0, where I.sub.x0 and I.sub.0 are measured in parallel by main and reference sensor, correspondingly.
(57) The I.sub.0 value might change due to drifts and I.sub.x might be affected by the ambient air instant conditions, and this requires signal corrections/calibrations. Therefore, in case of utilizing two sensors in parallel, the reference signal (I.sub.0) is constantly measured to provide quantifiable CO2 measurements, and advantageously when a single sensor is utilized it may be alternately measured using external tracking device.
(58) As used herein, the terms “CO.sub.2 levels” and “CO.sub.2 values” are interchangeable and may relate to values/levels indicative of CO.sub.2 concentration in a gas, and may be derived by manipulating/altering CO.sub.2 measurements obtained from a CO.sub.2 sensor.
(59) The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting. As used herein, the singular forms “a”, “an” and “the” are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms “comprises” or “comprising,” when used in this specification, specify the presence of stated features, integers, steps, operations, elements, or components, but do not preclude or rule out the presence or addition of one or more other features, integers, steps, operations, elements, components, or groups thereof.
(60) While a number of exemplary aspects and embodiments have been discussed above, those of skill in the art will recognize certain modifications, additions and sub-combinations thereof. It is therefore intended that the following appended claims and claims hereafter introduced be interpreted to include all such modifications, additions and sub-combinations as are within their true spirit and scope.