CHEMICAL COMPOSITIONS AND METHODS OF USE

Abstract

The present invention is directed to methods for detecting a plasma cell dyscrasia like myeloma or MGUS, methods for determining whether a plasma cell dyscrasiais stable or progressive, methods for determining a risk for disease relapse, and methods for determining a response by a subject having a plasma cell dyscrasia to a therapy.

Claims

1. A kit comprising at least one of: ##STR00001## or any combination thereof, and at least one species of probe that hybridizes to at least one of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NFKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, UBE2J.

2. The kit of claim 1, wherein the kit comprises: ##STR00002##

3. The kit of claim 1, wherein the kit comprises: ##STR00003##

4. The kit of claim 1, wherein the kit comprises: ##STR00004##

5. The kit of claim 1, wherein the kit comprises: ##STR00005##

6. The kit of claim 1, wherein the kit comprises: ##STR00006##

7. The kit of claim 1, wherein the kit comprises: ##STR00007##

8. The kit of claim 1, wherein the at least one probe further comprises at least one detectable label.

9. The kit of claim 1, wherein the kit comprises at least 28 species of probe, wherein the at least 31 species of probe bind to each of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NFKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, UBE2J.

10. The kit of claim 1, wherein the kit further comprises at least one species of probe that binds to at least one housekeeping gene.

11. The kit of claim 10, wherein the at least one housekeeping gene is selected from ALG9, SEPN, YWHAQ, VPS37A, PRRC2B, DOPEY2, NDUFB11, ND4, MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLP0, TFRC, MORF4L1, 18S, PPIA, PGK1, RPL13A, B2M, YWHAZ, SDHA, HPRT1, TOX4, and TPT1.

12. A method of treating cancer in a subject in need thereof, the method comprising administering to the subject at least one therapeutically effective amount of at least one of: ##STR00008## targeted therapy, biological therapy, chemotherapy, corticosteroids, stem cell transplantation, radiation therapy, or any combination thereof.

13. The method of claim 12, wherein the method comprises administering at least one therapeutically effective amount of: ##STR00009##

14. The method of claim 12, wherein the method comprises administering at least one therapeutically effective amount of: ##STR00010##

15. The method of claim 12, wherein the method comprises administering at least one therapeutically effective amount of: ##STR00011##

16. The method of claim 12, wherein the method comprises administering at least one therapeutically effective amount of: ##STR00012##

17. The method of claim 12, wherein the method comprises administering at least one therapeutically effective amount of: ##STR00013##

18. The method of claim 12, wherein the method comprises administering at least one therapeutically effective amount of: ##STR00014##

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0027] FIG. 1A and FIG. 1B show a graph showing interactive and functional analyses of the normalized 31 target transcripts (26 genes, 5 splice variants) markers of myeloma. Gene transcripts were significantly functionally linked at an interactome level consistent with a common pattern of regulatory activity. Two trancripts, MCL1 and COPA, were linked with Chromosome 1q, an area known to exhibit amplification in myeloma. At a functional level, the markers identified captured a series of biological processes including angiogenesis, apoptosis, immune responsiveness, phenotype definition, protein processing (secretion), proliferation, RNA processing and survival. A number of the transcripts encoded genes that were either potential drug targets or markers for drug target efficacy.

[0028] FIG. 2A and FIG. 2B are graphs showing the receiver operator cuver analysis and metrics for MelanomX (normalized expression of the 26 genes and 5 splice variants) in Test Set I. FIG. 2A is a graph showing that the area under the curve (AUC) was 0.990.005 (p<0.0001) for differentiating between myeloma (n=57) and controls (n=23). FIG. 2B is a graph showing that the metrics for MelanomX as a diagnostic has sensitivity>95%, specificity 100%, PPV 100%, NPV 88.5%. The overall accuracy was 96% in Test Set I.

[0029] FIG. 3A and FIG. 3B are graphs showing MyelomX scores in MGUS (n=18) versus controls (n=155). FIG. 3A is a graph showing that MGUS patients (n=18) exhibited significantly higher (399%, p<0.0001) scores than controls. Control levels were 128%. FIG. 3B is a graph showing that the AUC for differentiating MGUS from controls was 0.970.01 (p<0.0001).

[0030] FIG. 4A and FIG. 4B are graphs showing MyelomX scores in different multiple myeloma sub-groups. FIG. 4A is a graph showing that newly diagnosed patients (n=53) exhibited significantly higher (7525; p<0.0001) scores than in those with clinically stable disease (n=56; 3120). Patients with refractory disease (n=26) also presented with higher scores (9217; p<0.0001 vs. stable disease). FIG. 4B is a graph showing that the AUC for differentiating stable from refractory disease was 0.970.03 (p<0.0001).

[0031] FIG. 5A, FIG. 5B and FIG. 5C are graphs showing MyelomX scores in Test Set II.

[0032] FIG. 5A is a graph showing that the mean MyelomX score in multiple myelomas (n=81) was significantly higher (4714, p<0.0001) than the control group (n=155; 128). FIG. 5B is a graph showing that the AUC was 0.970.01 (p<0.0001) for differentiating between myeloma and controls. FIG. 5C is a graph showing that the metrics for MelanomX as a diagnostic (using 20 as a cut-off) has sensitivity 97.5%, specificity 93.6%, PPV 88.8%, NPV 98.6%. The overall accuracy was 94% in Test Set II.

[0033] FIG. 6 is a graph showing the effect of therapy on MelanomX. Therapy significantly (p<0.0001) decreased the score from 5914 (pre-therapy) to 3512 in 40 patients. Ten patients all with high scores (>40) relapsed at an early time point (within one year).

[0034] FIG. 7 is a graph showing the effect of 3 months bortemozib therapy on MelanomX. Therapy significantly (p<0.0001) decreased the score from 649 (pre-therapy) to 2312 in 15 patients who responded to therapy. Eight patients who were refractory exhibited elevated scores (609, p=NS vs. pre-treatment).

[0035] FIG. 8A and FIG. 8B are a set of graphs showing MyelomX score in 3 different myeloma cell lines. FIG. 8A identifies the cell lines demonstrate elevated expression-MyelomX score ranging from 60 (MM-1R) to 86 (RPMI-8226). FIG. 8B identifies that spiking these cells into blood from a subject that does not have a myeloma or other plasma cell dyscrasia, resulted in detectable gene expression and scores. A minimum of 1 cell/ml of blood could be consistently identified.

[0036] FIG. 9A and FIG. 9B are a set of graphs showing the MyelomX score in different FAC-sorted (CD138+) and matched whole blood samples from 3 different multiple myeloma patients. FIG. 9A identifies the scores from FACS samples and whole bloods and identifies the scores are positive and identical. FIG. 9B identifies that gene expression in FACS samples compared to matched blood samples is highly concordant (correlation 0.90) consistent with the assay detecting circulating multiple myeloma cells.

DETAILED DESCRIPTION OF THE INVENTION

[0037] The details of the invention are set forth in the accompanying description below. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, illustrative methods and materials are now described. Other features, objects, and advantages of the invention will be apparent from the description and from the claims. In the specification and the appended claims, the singular forms also include the plural unless the context clearly dictates otherwise. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. All patents and publications cited in this specification are incorporated herein by reference in their entireties.

[0038] Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells over-produce and secrete into the blood stream a myeloma protein, i.e., an abnormal monoclonal antibody or portion thereof. A plasma cell dyscrasia can develop in different stages. The MGUS stage can be non-IgM MGUS, IgM MGUS, light chain MGUS, or monoclonal gammopathy of renal significance. The smoldering multiple myeloma (SMM) stage can be non-IgM SMM, smoldering Waldenstrm's macroglobulinemia, or light chain SMM. The malignant sgate can be solitary plasmacytoma, non-secretory multiple myeloma, plasma cell myeloma with concomitant chronic lymphocytic leukemia/monoclonal B-Cell lymphocytosis, Waldenstrm's macroglobulinemia, multiple myeloma, light chain multiple myeloma, or plasma cell leukemia. In some embodiments, the plasma cell dyscrasia is MGUS. In some embodiments, the plasma cell dyscrasia is myeloma.

[0039] The symptoms and signs can vary greatly for patients having myelomas, as many organs can be affected by myelomas. Symptoms can include, but are not limited to, bone pain, anemia, kidney failure, infection, and neurological symptoms (e.g., weakness, confusion, fatigue, headache, visual changes, retinopathy, radicular pain, loss of bowel, bladder control, or carpal tunnel syndrome).

[0040] Traditionally, myelomas can be diagnosed through a bood test or urine test. Myeloma cells produce M proteins and beta-2 microglobulin, which can be detected by a blood test. M proteins can also be detected by urine tests. Myelomas can be diagnosed through examination of the bone marrow. Specifically, a sample of bone marrow is removed, and the sample is examined for myeloma cells. Specialized tests, such as fluorescence in situ hybridization (FISH) can analyze myeloma cells to understand their chromosome abnormalities. Tests are also done to measure the rate at which the myeloma cells are dividing. Imaging tests can also be performed to detect bone problems associated with multiple myeloma. Tests may include X-ray, MRI, CT or positron emission tomography (PET).

[0041] The present disclosure provides a MyelomX score that can be used for, inter alia, identifying active disease, providing an assessment of treatment responses, predicting risk of relapse, or identifying minimal residual in conjunction with standard clinical assessment and imaging. Measurements of circulating plasma cell dyscrasia transcriptsthe MyelomXcan identify plasma cell dyscrasias, and decreases in the MyelomX score correlate with the efficacy of therapeutic interventions such as proteasome inhibitors and immunomodulators. Targeted gene expression profile of RNA can be isolated from the biological samples (e.g., peripheral blood) of patients with plasma cell dyscrasias. This expression profile can be evaluated in an algorithm and converted to an output (prediction).

[0042] In one aspect, the present disclosure relates to a method for detecting a plasma cell dyscrasia in a subject in need thereof, comprising: (a) determining the expression level of at least 32 biomarkers from a test sample from the subject by contacting the test sample with a plurality of agents specific to detect the expression of the at least 32 biomarkers, wherein the at least 32 biomarkers comprise ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NEKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, UBE2J1, and at least one housekeeping gene; (b) normalizing the expression level of each of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NFKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, and UBE2J1 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NFKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, and UBE2J1; (c) inputting each normalized expression level into an algorithm to generate a score; (d) comparing the score with a first predetermined cutoff value; and (e) producing a report, wherein the report identifies the presence of a plasma cell dyscrasia in the subject when the score is equal to or greater than the first predetermined cutoff value or determining the absence of a plasma cell dyscrasia in the subject when the score is below the first predetermined cutoff value, wherein the first predetermined cutoff value is 20 on a scale of 0 to 100.

[0043] The identity of the splice variants for NFKBIZ, NR4A1, PRKAA1, SCYL2, and SP1 can be found at Table 2.

[0044] Among the provided methods are those that are able to classify or detect a plasma cell dyscrasia such as MGUS and myeloma. In some embodiments, the provided methods can identify or classify a plasma cell dyscrasia in a human biological sample. In some embodiments, the biological sample is a blood, serum, plasma, or a neoplastic tissue. In some examples, the methods can provide such information with a specificity, sensitivity, and/or accuracy of at least 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%.

[0045] The agents can be any agents for detection of the biomarkers, and typically are isolated polynucleotides or isolated polypeptides or proteins, such as antibodies, for example, those that specifically hybridize to or bind to the at least 32 biomarkers.

[0046] The biomarker can be RNA, cDNA, or protein. When the biomarker is RNA, the RNA can be reverse transcribed to produce cDNA (such as by RT-PCR), and the produced cDNA expression level is detected. The expression level of the biomarker can be detected by forming a complex between the biomarker and a labeled probe or primer. When the biomarker is RNA or cDNA, the RNA or cDNA can be detected by forming a complex between the RNA or cDNA and a labeled nucleic acid probe or primer. The complex between the RNA or cDNA and the labeled nucleic acid probe or primer can be a hybridization complex.

[0047] When the biomarker is protein, the protein can be detected by forming a complex between the protein and a labeled antibody. The label can be any label, for example a fluorescent label, chemiluminescence label, radioactive label, etc. The protein level can be measured by methods including, but not limited to, immunoprecipitation, ELISA, Western blot analysis, or immunohistochemistry using an agent, e.g., an antibody, that specifically detects the protein encoded by the gene.

[0048] In some embodiments, the methods are performed by contacting the test sample with one of the provided agents, more typically with a plurality of the provided agents, for example, a set of polynucleotides that specifically bind to the at least 32 biomarkers. In some embodiments, the set of polynucleotides includes DNA, RNA, cDNA, PNA, genomic DNA, or synthetic oligonucleotides. In some embodiments, the methods include the step of isolating RNA from the test sample prior to detection, such as by RT-PCR, e.g., QPCR. Thus, in some embodiments, detection of the biomarkers, such as expression levels thereof, includes detecting the presence, absence, or amount of RNA. In one example, the RNA is detected by PCR or by hybridization.

[0049] In some embodiments, the polynucleotides include sense and antisense primers, such as a pair of primers that is specific to each of the at least 32 biomarkers. In one aspect of this embodiment, the detection of the at least 32 biomarkers is carried out by PCR, typically quantitative or real-time PCR. For example, in one aspect, detection is carried out by producing cDNA from the test sample by reverse transcription; then amplifying the cDNA using the pairs of sense and antisense primers that specifically hybridize to the panel of at least 32 biomarkers, and detecting products of the amplification.

[0050] The test sample can be any biological fluid obtained from the subject. Preferably, the test sample is blood, serum, plasma, or a neoplastic tissue. In some embodiments, the test sample is a blood sample.

[0051] The first predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects free of a neoplastic disease. Preferably, the reference sample is blood, serum, plasma, or non-neoplastic tissue.

[0052] The subject in need thereof can be a subject diagnosed with a plasma cell dyscrasia, a subject having at least one plasma cell dyscrasia symptom, or a subject have a predisposition or familial history for developing a plasma cell dyscrasia. The subject can be any mammal. Preferably, the subject is human. The terms subject and patient are used interchangeably herein.

[0053] In some embodiments, the method can further include determining a mathematically-derived expression level score of the at least 32 biomarkers in the test sample. This is the MyelomX score, which has a scale of 0 to 100. The MyelomX score is the product of a classifier built from a predictive classification algorithm, e.g., XGB, RF, glmnet, cforest, CART, treebag, knn, nnet, SVM-radial, SVM-linear, NB, mlp, or logistic regression modelling. In some embodiments, the predictive classification algorithm used is XGB.

[0054] The method can further include treating the subject identified as having a plasma cell dyscrasia with targeted therapy, biological therapy, chemotherapy, corticosteroids, stem cell transplantation, radiation therapy, or a combination thereof. Targeted therapy can include the use of proteasome inhibitors. In some embodiments, the targeted therapy can include bortezomib and/or carfilzomib. Biological therapy can include immunomodulators. In some embodiments, the biological therapy can include thalidomide, lenalidomide, and/or pomalidomide. Chemotherapy can include any known chemotherapeutic drugs. Corticosteroids can be prednisone or dexamethasone.

[0055] The present disclosure also provides a method for determining whether a plasma cell dyscrasia in a subject is stable or progressive, comprising: (a) determining the expression level of at least 32 biomarkers from a test sample from the subject by contacting the test sample with a plurality of agents specific to detect the expression of the at least 32 biomarkers, wherein the at least 32 biomarkers comprise ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NEKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, UBE2J1, and at least one housekeeping gene; (b) normalizing the expression level of each of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NEKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, and UBE2J1 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NFKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, and UBE2J1; (c) inputting each normalized expression level into an algorithm to generate a score; (d) comparing the score with a second predetermined cutoff value; and (e) producing a report, wherein the report identifies that the plasma cell dyscrasia is progressive when the score is equal to or greater than the second predetermined cutoff value or identifies that the plasma cell dyscrasia is stable when the score is below the second predetermined cutoff value, wherein the second predetermined cutoff value is 40 on a scale of 0 to 100.

[0056] The second predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects whose plasma cell dyscrasias are demonstrating disease progression.

[0057] The present disclosure also provides a method for determining a risk of disease relapse in a subject having a plasma cell dyscrasia, comprising: (a) determining the expression level of at least 32 biomarkers from a test sample from the subject after treatment by contacting the test sample with a plurality of agents specific to detect the expression of the at least 32 biomarkers, wherein the at least 32 biomarkers comprise ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NEKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, UBE2J1, and at least one housekeeping gene; (b) normalizing the expression level of each of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NEKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, and UBE2J1 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NEKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, and UBE2J1; (c) inputting each normalized expression level into an algorithm to generate a score; (d) comparing the score with a third predetermined cutoff value; and (e) producing a report, wherein the report identifies that the subject has a high risk of disease relapse when the score is equal to or greater than the third predetermined cutoff value or identifies that the subject has a low risk of disease relapse when the score is below the third predetermined cutoff value, wherein the third predetermined cutoff value is 40 on a scale of 0 to 100.

[0058] The third predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects whose plasma cell dyscrasias are being adequately controlled by therapies.

[0059] The present disclosure also provides a method for determining a response by a subject having a plasma cell dyscrasia to a therapy, comprising: (a) determining a first expression level of at least 31 biomarkers from a first test sample from the subject at a first time point by contacting the first test sample with a plurality of agents specific to detect the expression of the at least 31 biomarkers, wherein the at least 31 biomarkers comprise ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NFKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, and UBE2J1; (b) determining a second expression level of the at least 31 biomarkers from a second test sample from the subject at a second time point by contacting the second test sample with a plurality of agents specific to detect the expression of the at least 31 biomarkers, wherein the second time point is after the first time point and after the administration of the therapy to the subject; (c) comparing the first expression level with the second expression level; and (d) producing a report, wherein the report identifies that the subject is responsive to the therapy when the second expression level is significantly decreased as compared to the first expression level.

[0060] In some embodiments, the methods can predict treatment responsiveness to, or determine whether a patient has become clinically stable following, or is responsive or non-responsive to, a plasma cell dyscrasia treatment, such as a drug therapy (for example, an immunotherapy or targeted therapy). In some cases, the methods can do so with a specificity, sensitivity, and/or accuracy of at least 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%.

[0061] In some embodiments, the first and second test samples can be of the same type. In some embodiments, the first and second test samples can be of different types.

[0062] In some embodiments, the therapy can be a drug therapy. The drug therapy can be an immunotherapy, a targeted therapy, a chemotherapy, or a combination thereof. In some embodiments, the therapy can be a radiation therapy.

[0063] In some embodiments, the first time point is prior to the administration of the therapy to the subject. In some embodiments, the first time point is after the administration of the therapy to the subject. The second time point can be a few days, a few weeks, or a few months after the first time point. For example, the second time point can be at least 1 day, at least 7 days, at least 14 days, at least 30 days, at least 60 days, or at least 90 days after the first time point.

[0064] In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 10% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 20% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 25% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 30% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 40% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 50% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 60% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 70% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 80% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 90% less than the first expression level.

[0065] In some embodiments, the method further comprises determining a third expression level of the at least 32 biomarkers from a third test sample from the subject at a third time point by contacting the third test sample with a plurality of agents specific to detect the expression of the at least 32 biomarkers, wherein the third time point is after the second time point. The method can further comprise creating a plot showing the trend of the expression level change.

[0066] The present disclosure also provides an assay comprising: (a) determining the expression level of biomarkers consisting essentially of the following 32 biomarkers from a test sample from a patient diagnosed of a plasma cell dyscrasia or a subject suspected of having a plasma cell dyscrasia: ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NFKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, UBE2J1, and at least one housekeeping gene; (b) normalizing the expression level of each of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NEKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, and UBE2J1 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NEKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, and UBE2J1; (c) inputting each normalized expression level into an algorithm to generate a score; and (d) comparing the score with a first predetermined cutoff value.

[0067] The present disclosure also provides an assay comprising: (a) determining the expression level of biomarkers consisting of the following 32 biomarkers from a test sample from patient diagnosed of a plasma cell dyscrasia or a subject suspected of having a plasma cell dyscrasia: ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NEKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, UBE2J1, and at least one housekeeping gene; (b) normalizing the expression level of each of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NEKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, and UBE2J1 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NFKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, and UBE2J1; (c) inputting each normalized expression level into an algorithm to generate a score; and (d) comparing the score with a first predetermined cutoff value.

[0068] In some embodiments, the at least one housekeeping gene is selected from the group consisting of ALG9, SEPN, YWHAQ, VPS37A, PRRC2B, DOPEY2, NDUFB11, ND4, MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLP0, TFRC, MORF4L1, 18S, PPIA, PGK1, RPL13A, B2M, YWHAZ, SDHA, HPRT1, TOX4, and TPT1. In some embodiments, the housekeeping gene is TPT1.

[0069] In some embodiments, two or more housekeeping genes can be used in normalizing the expression levels. For example, when two housekeeping genes are used, the method can comprise: (1) normalizing the expression level of each of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NFKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, and UBE2J1 to the expression level of a first housekeeping gene; (2) normalizing the expression level of each of ASXL1, BHLHE40, BTG2, COPA, FBXW7, GNA13, IL8, JMJD1C, LARS2, MALAT1, MBNL1, MCL1, NFKBIZ (2 splice variants), NR4A1 (2 splice variants), PDE4B, PIAS2, PRKAA1 (2 splice variants), SCYL2 (2 splice variants), SMARCD2, SP1 (2 splice variants), SRSF5, TAGAP, TANK, TLE4, TSC22D3, and UBE2J1 to the expression level of a second housekeeping gene; and (3) averaging the first normalized expression level and the second normalized expression level to obtain an averaged normalized expression level.

[0070] The sequence information of the plasma cell dyscrasia biomarkers and housekeepers is shown in Table 1.

TABLE-US-00001 TABLE1 PlasmacelldyscrasiaBiomarker/HousekeeperSequenceInformation Gene RefSeq SEQID Name Accession Sequence NO: ASXL1 NM_001164603.1 CACACCCACGGCAGACACGCACGCACCCGGGCGCCGAAGG 1 GAAAGCCGCGTCTCGCCCTCCCGCCCCGCCGTCGGTCCTG TCTCAGTCCCTCAGCAGAGCGGGAAAGCGGAGGCCGGAGC CGTGACCTCTGACCCCGTGGTTATGCGGAGCCGCCGCATT CCTTAGCGATCGCGGGGCAGCCGCCGCTGCCGCCGTGGGC GACTGACGCAGCGCGGGCGCGTGGAGCCGCCGCCGCCCCT CCCCCACCGCCGCTCTCGCGCCAGCCGGTCCCCGCGTGCC CGCCCCTTCTCCCCGGCCGCACCCGAGACCTCGCGCGCCG CCGCTGCCACGCGCCCCCCCCACCGCCGCCGCCGCCCCAG CCCCGCGCCACCGCCCCAGCCCGCCCAGCCCGGAGGTCCC GCGTGGAGCTGCCGCCGCCGCCGGGGAGAAGGATGAAGGA CAAACAGAAGAAGAAGAAGGAGCGCACGTGGGCCGAGGCC GCGCGCCTGGTATTAGAAAACTACTCGGATGCTCCAATGA CACCAAAACAGATTCTGCAGGTCATAGAGGCAGAAGGACT AAAGGAAATGAGAAGTGGGACTTCCCCTCTCGCATGCCTC AATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGGGT TGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCT CAAGGTGTGAGCCACTGCACCAGGCCCCTTCATCTTAATT TTAATATATCTTTGAATAAACACCATTGTATGAACCTGCT GTAAGCTTGGGAGTGGTCTGTTAGTCTACAGCTTGTGTCT GAGATGTGCTAATTGAATATTTGCTCAGTACCTCATCTTA ACTGCCTTTGGCTTTATGTTGCTTATCCTTCATAGTATCT TGTTCATTGGCCTTTTACATCCATAGGCATCACTTCTCTG ATATTCGTTGTGCTCTTTTAATGGATTAATGGTTTGCTTG GTTGGTTCCTCTAGTTAGACTGTAAACTCCTTGAGAGCAG AGTCTGTATTTTATTAATTACCCACAGTACTAGGTACATA GTTGCCTTCAATAAATATATATTTAATGAAAAAAAAAAAA AAAA BHLHE40 NM_003670.2 CGCCTCCCCGCCCGCCCCACTTCTCATTCACTTGGCTCGC 2 ACGGCGCAGACAGACCGCGCAGGGAGCACACACCGCCAGT CTGTGCGCTGAGTCGGAGCCAGAGGCCGCGGGGACACCGG GCCATGCACGCCCCCAACTGAAGCTGCATCTCAAAGCCGA AGATTCCAGCAGCCCAGGGGATTTCAAAGAGCTCAGACTC AGAGGAACATCTGCGGAGAGACCCCCGAAGCCCTCTCCAG GGCAGTCCTCATCCAGACGCTCCGCTAGTGCAGACAGGAG CGCGCAGTGGCCCCGGCTCGCCGCGCCATGGAGCGGATCC CCAGCGCGCAACCACCCCCCGCCTGCCTGCCCAAAGCACC GGGACTGGAGCACGGAGACCTACCAGGGATGTACCCTGCC CACATGTACCAAGTGTACAAGTCAAGACGGGGAATAAAGC GGAGCGAGGACAGCAAGGAGACCTACAAATTGCCGCACCG GCTCATCGAGAAAAAGAGACGTGACCGGATTAACGAGTGC ATCGCCCAGCTGAAGGATCTCCTACCCGAACATCTCAAAC TTACAACTTTGGGTCACTTGGAAAAAGCAGTGGTTCTTGA ACTTACCTTGAAGCATGTGAAAGCACTAACAAACCTAATT GATCAGCAGCAGCAGAAAATCATTGCCCTGCAGAGTGGTT TACAAGCTGGTGAGCTGTCAGGGAGAAATGTCGAAACAGG TCAAGAGATGTTCTGCTCAGGTTTCCAGACATGTGCCCGG GAGGTGCTTCAGTATCTGGCCAAGCACGAGAACACTCGGG ACCTGAAGTCTTCGCAGCTTGTCACCCACCTCCACCGGGT GGTCTCGGAGCTGCTGCAGGGTGGTACCTCCAGGAAGCCA TCAGACCCAGCTCCCAAAGTGATGGACTTCAAGGAAAAAC CCAGCTCTCCGGCCAAAGGTTCGGAAGGTCCTGGGAAAAA CTGCGTGCCAGTCATCCAGCGGACTTTCGCTCACTCGAGT GGGGAGCAGAGCGGCAGCGACACGGACACAGACAGTGGCT ATGGAGGAGAATCGGAGAAGGGCGACTTGCGCAGTGAGCA GCCGTGCTTCAAAAGTGACCACGGACGCAGGTTCACGATG GGAGAAAGGATCGGCGCAATTAAGCAAGAGTCCGAAGAAC CCCCCACAAAAAAGAACCGGATGCAGCTTTCGGATGATGA AGGCCATTTCACTAGCAGTGACCTGATCAGCTCCCCGTTC CTGGGCCCACACCCACACCAGCCTCCTTTCTGCCTGCCCT TCTACCTGATCCCACCTTCAGCGACTGCCTACCTGCCCAT GCTGGAGAAGTGCTGGTATCCCACCTCAGTGCCAGTGCTA TACCCAGGCCTCAACGCCTCTGCCGCAGCCCTCTCTAGCT TCATGAACCCAGACAAGATCTCGGCTCCCTTGCTCATGCC CCAGAGACTCCCTTCTCCCTTGCCAGCTCATCCGTCCGTC GACTCTTCTGTCTTGCTCCAAGCTCTGAAGCCAATCCCCC CTTTAAACTTAGAAACCAAAGACTAAACTCTCTAGGGGAT CCTGCTGCTTTGCTTTCCTTCCTCGCTACTTCCTAAAAAG CAACAAAAAAGTTTTTGTGAATGCTGCAAGATTGTTGCAT TGTGTATACTGAGATAATCTGAGGCATGGAGAGCAGATTC AGGGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGCGTGTG CGTGCACATGTGTGCCTGCGTGTTGGTATAGGACTTTAAA GCTCCTTTTGGCATAGGGAAGTCACGAAGGATTGCTTGAC ATCAGGAGACTTGGGGGGGATTGTAGCAGACGTCTGGGCT TTTCCCCACCCAGAGAATAGCCCCCTTCGATACACATCAG CTGGATTTTCAAAAGCTTCAAAGTCTTGGTCTGTGAGTCA CTCTTCAGTTTGGGAGCTGGGTCTGTGGCTTTGATCAGAA GGTACTTTCAAAAGAGGGCTTTCCAGGGCTCAGCTCCCAA CCAGCTGTTAGGACCCCACCCTTTTGCCTTTATTGTCGAC GTGACTCACCAGACGTCGGGGAGAGAGAGCAGTCAGACCG AGCTTTCTGCTAACATGGGGAGGTAGCAGGCACTGGCATA GCACGGTAGTGGTTTGGGGAGGTTTCCGCAGGTCTGCTCC CCACCCCTGCCTCGGAAGAATAAAGAGAATGTAGTTCCCT ACTCAGGCTTTCGTAGTGATTAGCTTACTAAGGAACTGAA AATGGGCCCCTTGTACAAGCTGAGCTGCCCCGGAGGGAGG GAGGAGTTCCCTGGGCTTCTGGCACCTGTTTCTAGGCCTA ACCATTAGTACTTACTGTGCAGGGAACCAAACCAAGGTCT GAGAAATGCGGACACCCCGAGCGAGCACCCCAAAGTGCAC AAAGCTGAGTAAAAAGCTGCCCCCTTCAAACAGAACTAGA CTCAGTTTTCAATTCCATCCTAAAACTCCTTTTAACCAAG CTTAGCTTCTCAAAGGCCTAACCAAGCCTTGGCACCGCCA GATCCTTTCTGTAGGCTAATTCCTCTTGCCCAACGGCATA TGGAGTGTCCTTATTGCTAAAAAGGATTCCGTCTCCTTCA AAGAAGTTTTATTTTTGGTCCAGAGTACTTGTTTTCCCGA TGTGTCCAGCCAGCTCCGCAGCAGCTTTTCAAAATGCACT ATGCCTGATTGCTGATCGTGTTTTAACTTTTTCTTTTCCT GTTTTTATTTTGGTATTAAGTCGTTGCCTTTATTTGTAAA GCTGTTATAAATATATATTATATAAATATATTAAAAAGGA AAATGTTTCAGATGTTTATTTGTATAATTACTTGATTCAC ACAGTGAGAAAAAATGAATGTATTCCTGTTTTTGAAGAGA AGAATAATTTTTTTTTTCTCTAGGGAGAGGTACAGTGTTT ATATTTTGGAGCCTTCCTGAAGGTGTAAAATTGTAAATAT TTTTATCTATGAGTAAATGTTAAGTAGTTGTTTTAAAATA CTTAATAAAATAATTCTTTTCCTGTGGAAGAGAAAAAAAA AAAAAAAAAAAAAAAAAAAAA BTG2 NM_006763.2 CAGGGTAACGCTGTCTTGTGGACCCGCACTTCCCACCCGA 3 GACCTCTCACTGAGCCCGAGCCGCGCGCGACATGAGCCAC GGGAAGGGAACCGACATGCTCCCGGAGATCGCCGCCGCCG TGGGCTTCCTCTCCAGCCTCCTGAGGACCCGGGGCTGCGT GAGCGAGCAGAGGCTTAAGGTCTTCAGCGGGGCGCTCCAG GAGGCACTCACAGAGCACTACAAACACCACTGGTTTCCCG AAAAGCCGTCCAAGGGCTCCGGCTACCGCTGCATTCGCAT CAACCACAAGATGGACCCCATCATCAGCAGGGTGGCCAGC CAGATCGGACTCAGCCAGCCCCAGCTGCACCAGCTGCTGC CCAGCGAGCTGACCCTGTGGGTGGACCCCTATGAGGTGTC CTACCGCATTGGGGAGGACGGCTCCATCTGCGTCTTGTAC GAGGAGGCCCCACTGGCCGCCTCCTGTGGGCTCCTCACCT GCAAGAACCAAGTGCTGCTGGGCCGGAGCAGCCCCTCCAA GAACTACGTGATGGCAGTCTCCAGCTAGGCCCTTCCGCCC CCGCCCTGGGCGCCGCCGTGCTCATGCTGCCGTGACAACA GGCCACCACATACCTCAACCTGGGGAACTGTATTTTTAAA TGAAGAGCTATTTATATATATTATTTTTTTTTAAGAAAGG AGGAAAAGAAACCAAAAGTTTTTTTTAAGAAAAAAAATCC TTCAAGGGAGCTGCTTGGAAGTGGCCTCCCCAGGTGCCTT TGGAGAGAACTGTTGCGTGCTTGAGTCTGTGAGCCAGTGT CTGCCTATAGGAGGGGGAGCTGTTAGGGGGTAGACCTAGC CAAGGAGAAGTGGGAGACGTTTGGCTAGCACCCCAGGAAG ATGTGAGAGGGAGCAAGCAAGGTTAGCAACTGTGAACAGA GAGGTCGGGATTTGCCCTGGGGGAGGAAGAGAGGCCAAGT TCAGAGCTCTCTGTCTCCCCCAGCCAGACACCTGCATCCC TGGCTCCTCTATTACTCAGGGGCATTCATGCCTGGACTTA AACAATACTATGTTATCTTTTCTTTTATTTTTCTAATGAG GTCCTGGGCAGAGAGTGAAAAGGCCTCTCCTGATTCCTAC TGTCCTAAGCTGCTTTTCTTGAAATCATGACTTGTTTCTA ATTCTACCCTCAGGGGCCTGTAGATGTTGCTTTCCAGCCA GGAATCTAAAGCTTTGGGTTTTCTGAGGGGGGGGAGGAGG GAACTGGAGGTTATTGGGGTTAGGATGGAAGGGAACTCTG CACAAAACCTTTGCTTTGCTAGTGCTGCTTTGTGTGTATG TGTGGCAAATAATTTGGGGGTGATTTGCAATGAAATTTTG GGACCCAAAGAGTATCCACTGGGGATGTTTTTTGGCCAAA ACTCTTCCTTTTGGAACCACATGAAAGTCTTGATGCTGCT GCCATGATCCCTTTGAGAGGTGGCTCAAAAGCTACAGGGA ACTCCAGGTCCTTTATTACTGCCTTCTTTTCAAAAGCACA ACTCTCCTCTAACCCTCCCCTCCCCCTTCCCTTCTGGTCG GGTCATAGAGCTACCGTATTTTCTAGGACAAGAGTTCTCA GTCACTGTGCAATATGCCCCCTGGGTCCCAGGAGGGTCTG GAGGAAAACTGGCTATCAGAACCTCCTGATGCCCTGGTGG GCTTAGGGAACCATCTCTCCTGCTCTCCTTGGGATGATGG CTGGCTAGTCAGCCTTGCATGTATTCCTTGGCTGAATGGG AGAGTGCCCCATGTTCTGCAAGACTACTTGGTATTCTTGT AGGGCCGACACTAAATAAAAGCCAAACCTTGGGCACTGTT TTTTCTCCCTGGTGCTCAGAGCACCTGTGGGAAAGGTTGC TGTCTGTCTCAGTACAATCCAAATTTGTCGTAGACTTGTG CAATATATACTGTTGTGGGTTGGAGAAAAGTGGAAAGCTA CACTGGGAAGAAACTCCCTTCCTTCAATTTCTCAGTGACA TTGATGAGGGGTCCTCAAAAGACCTCGAGTTTCCCAAACC GAATCACCTTAAGAAGGACAGGGCTAGGGCATTTGGCCAG GATGGCCACCCTCCTGCTGTTGCCCCTTAGTGAGGAATCT TCACCCCACTTCCTCTACCCCCAGGTTCTCCTCCCCACAG CCAGTCCCCTTTCCTGGATTTCTAAACTGCTCAATTTTGA CTCAAAGGTGCTATTTACCAAACACTCTCCCTACCCATTC CTGCCAGCTCTGCCTCCTTTTCAACTCTCCACATTTTGTA TTGCCTTCCCAGACCTGCTTCCAGTCTTTATTGCTTTAAA GTTCACTTTGGGCCCACAGACCCAAGAGCTAATTTTCTGG TTTGTGGGTTGAAACAAAGCTGTGAATCACTGCAGGCTGT GTTCTTGCATCTTGTCTGCAAACAGGTCCCTGCCTTTTTA GAAGCAGCCTCATGGTCTCATGCTTAATCTTGTCTCTCTT CTCTTCTTTATGATGTTCACTTTAAAAACAACAAAACCCC TGAGCTGGACTGTTGAGCAGGCCTGTCTCTCCTATTAAGT AAAAATAAATAGTAGTAGTATGTTTGTAAGCTATTCTGAC AGAAAAGACAAAGGTTACTAATTGTATGATAGTGTTTTTA TATGGAAGAATGTACAGCTTATGGACAAATGTACACCTTT TTGTTACTTTAATAAAAATGTAGTAGGATAAAAAAAAA COPA NM_001098398.1 AGAAGGGAGACAGTGGCGGTCGCGGCGGGGCCGATCCGAG 4 AGTTCCCCTTAGAGAACGGAGCTCACGGGCGGGGAGGCCT CACCTGCTAGTAGGACGCAGAAAGACAGAAGGCGAAGGAG ACCCCGACTTCCCGGGTCAGCCCCAGAGCCACCCCCTGCC GTAGCCATCTTGCCTCTCTGCTGAGCGGAAGCCCCCGTTC GGCTCCTGTCTGTTAGCGGCCTCTCTAGGCTACCACTGAC ACCGTCTCTGTGGCCCGGAGCCTAAGAGACCGGAAGTTCG TGTTTCCAGGCGCTTCCGGAAACCGCGGGAGAGGGTCGCT GACGTGGAGGCGTCCGAAGGGCAGCAGGGTGTGTCGGGGC TCGGATTAAGACATCGGAGTCGGAGACCTGAGAGATGTTA ACCAAATTCGAGACCAAGAGCGCGCGGGTCAAAGGGCTCA GCTTTCACCCCAAAAGACCTTGGATCCTGACTAGTTTACA TAATGGGGTCATCCAGTTATGGGACTATCGGATGTGCACT CTCATTGACAAGTTTGATGAACATGATGGTCCAGTGCGAG GCATTGACTTCCATAAGCAGCAGCCACTGTTCGTCTCTGG AGGAGATGACTATAAGATTAAGGTTTGGAATTACAAGCTT CGGCGCTGTCTTTTCACATTGCTTGGGCACTTAGATTATA TTCGCACCACGTTTTTTCATCATGAATATCCCTGGATTCT GAGTGCCTCCGATGATCAGACCATCCGAGTGTGGAACTGG CAATCTAGAACCTGTGTTTGTGTGTTAACAGGGCACAACC ATTATGTGATGTGTGCTCAGTTCCACCCCACAGAAGACTT GGTAGTATCAGCCAGCCTGGACCAGACTGTGCGCGTTTGG GATATTTCTGGTCTGAGGAAAAAAAACCTGTCCCCTGGTG CGGTGGAATCGGATGTGAGAGGAATAACTGGGGTTGATCT ATTTGGAACTACAGATGCAGTGGTGAAGCATGTACTAGAG GGTCACGATCGTGGAGTAAACTGGGCTGCCTTCCACCCCA CTATGCCCCTTATTGTATCTGGGGCAGATGATCGTCAAGT GAAGATCTGGCGCATGAATGAATCAAAGGCATGGGAGGTT GATACCTGCCGGGGCCATTACAACAATGTATCTTGTGCCG TCTTCCACCCTCGCCAAGAGTTGATCCTCAGCAATTCTGA GGACAAGAGTATTCGAGTCTGGGATATGTCTAAGCGGACT GGGGTTCAGACTTTCCGCAGAGACCATGATCGTTTCTGGG TCCTAGCTGCTCACCCTAACCTTAACCTCTTTGCAGCAGG CCATGATGGTGGTATGATTGTGTTTAAGCTGGAACGGGAA CGGCCAGCCTATGCTGTTCATGGCAATATGCTACACTATG TCAAGGACCGATTCTTACGACAGCTGGATTTCAACAGCTC CAAAGATGTAGCTGTGATGCAGTTGCGGAGTGGTTCCAAG TTTCCAGTATTCAATATGTCATACAATCCAGCAGAAAATG CAGTCCTGCTTTGTACAAGAGCTAGCAATCTAGAGAATAG TACCTATGACCTGTACACCATCCCTAAAGATGCTGACTCC CAGAATCCTGATGCGCCTGAAGGGAAACGATCCTCAGGCC TGACAGCCGTTTGGGTCGCTCGAAATCGGTTTGCTGTCCT AGATCGGATGCATTCGCTTCTGATCAAGAATCTGAAGAAT GAGATCACCAAAAAGGTACAGGTGCCCAACTGTGATGAGA TCTTCTATGCTGGCACAGGCAATCTCCTGCTTCGAGATGC GGACTCTATCACACTCTTTGACGTACAGCAGAAGCGGACT CTGGCATCTGTGAAGATTTCTAAAGTGAAATACGTTATCT GGTCAGCAGACATGTCACATGTAGCACTACTAGCCAAACA CGAACACTCATGCCCTTTGCCTCTTACAGCCATTGTGATC TGTAACCGCAAACTGGATGCTTTATGTAACATTCATGAGA ACATTCGTGTCAAGAGTGGGGCCTGGGATGAGAGTGGGGT ATTTATCTATACCACAAGCAACCACATCAAATATGCTGTC ACCACTGGGGACCACGGGATCATTCGAACTCTGGATTTAC CCATCTATGTCACACGGGTGAAGGGCAACAATGTATACTG CCTAGACAGGGAGTGTCGTCCCCGGGTACTCACCATTGAT CCCACTGAGTTCAAATTCAAGCTGGCCCTGATCAACAGAA AATATGATGAGGTACTGCACATGGTGAGGAATGCCAAACT AGTTGGCCAGTCTATTATTGCTTATCTCCAGAAGAAGGGC TATCCTGAAGTGGCACTGCATTTTGTCAAGGATGAGAAAA CTCGCTTTAGTCTGGCACTGGAGTGTGGAAACATTGAGAT TGCTCTGGAAGCAGCCAAAGCACTGGATGACAAGAACTGC TGGGAAAAGCTGGGAGAAGTGGCCCTGCTGCAGGGGAACC ACCAGATTGTGGAAATGTGCTATCAGCGTACCAAAAACTT TGACAAACTTTCCTTCCTGTATCTTATCACTGGCAACTTA GAAAAACTTCGCAAGATGATGAAGATTGCTGAGATCAGAA AGGACATGAGTGGCCACTATCAGAATGCCCTATACCTGGG TGATGTGTCAGAGCGTGTGCGGATCCTGAAGAACTGTGGA CAGAAGTCCCTGGCCTATCTCACAGCTGCTACCCATGGCT TAGATGAAGAAGCTGAGAGCCTAAAGGAGACATTTGACCC AGAGAAGGAGACAATCCCAGACATTGACCCTAATGCCAAG CTGCTCCAGCCACCTGCACCTATCATGCCATTGGATACCA ATTGGCCTTTATTGACTGTATCCAAAGGATTTTTTGAAGG CACCATTGCCAGCAAAGGGAAGGGAGGAGCACTGGCTGCT GACATTGACATTGACACTGTTGGTACAGAGGGCTGGGGAG AGGATGCAGAGCTGCAGTTGGATGAAGATGGGTTTGTGGA GGCTACAGAAGGTTTGGGGGATGATGCTCTTGGCAAGGGA CAGGAAGAAGGAGGTGGCTGGGATGTAGAAGAAGATCTGG AGCTCCCTCCTGAGCTGGATATATCCCCTGGGGCAGCTGG TGGGGCTGAAGATGGTTTCTTTGTGCCCCCAACCAAGGGA ACAAGTCCAACTCAGATCTGGTGTAATAACTCTCAGCTTC CAGTTGATCACATCCTGGCAGGCTCTTTCGAAACAGCCAT GCGGCTCCTTCATGACCAAGTAGGGGTAATCCAGTTTGGC CCCTACAAGCAACTGTTCCTACAGACATACGCCCGAGGCC GCACAACCTATCAGGCTCTGCCCTGCCTACCCTCCATGTA TGGCTATCCTAATCGCAACTGGAAGGATGCAGGGCTGAAG AATGGTGTACCAGCTGTGGGCCTGAAGCTTAATGACCTCA TCCAACGGTTGCAGCTGTGCTACCAGCTCACCACAGTTGG CAAATTTGAGGAGGCTGTGGAAAAATTCCGTTCCATCCTT CTCAGTGTGCCACTTCTTGTTGTGGACAATAAACAAGAGA TTGCAGAGGCCCAGCAGCTCATCACCATTTGCCGTGAGTA CATTGTGGGTTTGTCCGTGGAGACAGAAAGGAAGAAGCTG CCCAAAGAGACTCTAGAACAGCAGAAGCGCATCTGTGAGA TGGCAGCCTATTTCACCCACTCAAACCTGCAGCCTGTGCA CATGATCCTGGTGCTGCGTACAGCCCTCAATCTGTTCTTC AAGCTCAAGAACTTCAAGACAGCTGCCACCTTTGCTCGGC GCCTACTAGAACTCGGGCCCAAGCCTGAGGTGGCCCAACA GACCCGAAAAATCCTGTCTGCCTGTGAGAAGAATCCCACA GATGCCTACCAGCTCAATTATGACATGCACAACCCCTTTG ACATTTGTGCTGCATCATATCGGCCCATCTACCGTGGAAA GCCAGTAGAAAAGTGTCCACTCAGTGGGGCCTGCTATTCC CCTGAGTTCAAAGGTCAAATCTGCAGGGTCACCACAGTGA CAGAGATTGGCAAAGATGTGATTGGTTTAAGGATCAGTCC TCTGCAGTTTCGCTAAGGCCCCCTTTGTGTGCATGGGTCA GTCACCATATGTTCCCCCCAGAGAATGTGTCTATATCCTC CTTCTAACAGCACCTTCCCCCTGCAGCTACTCTTCAGATC TGGCTCTCTGTACCCTAAAACCTAGTATCTTTTTCTCTTC TATGGAAAATCCGAAGGTCTAAACTTGACTTTTTTGAGGT CTTCTCAACTTGACTACAGTTGTGCTCATAATTGTCCTTG CCTTTCCAGCTTAATTATTTTAAGGAACAAATGAAAACTC TGGGCTGGGTGGAGTGGCTCATACCTGTAATCCCAGCACT TTGGGAGGCTACGGTGGGCAGATCATCTGAGGCCAGGAGT TCGAGACCTGCCTGGCCAACATGGCAACACCCCGTCTCTA ATAAAAATATAAAAATTAGCCTGGCATGGTAGCATGCGCC TATAGTCCCAGCTGCTCAGGAGGCTGAGGCATGAGAATCG CTTGAACCTAGGAGGTGGAGGTTGCATTCAACTGAGATCA TACCACTTCATTCCAGCCTGGGTGACAGAGCAAGACTCTG TCTCAAAAAAAAAAAAAAGGAAAACTCTGTGATGGACATT TGTTTAGTAAATCCCTTCAGTATTTATCCCTCCTTTCCCC ACAGCAGCTTTCTTTCCTGTCAACTAGAAAGGAGCAGGAT GTAATAAATACATTTTGGTGTGACTAGGCCACACCAACTC TTAATCATCTCCCATTTTCCTTAGACATTTAAATTTCAAG GCAGGTACCCTCTGTGTACTCAGAAATTTGAAGAAGTTAT TTGGTTTTCCAAAATGCACACTGCGGGTTATTGATTTGTT CTTTACAACTATTGTTCTCATATTTCTCACACTAAATAAA TCTCTATGAGAGCTTCTTGACTTGGCCATTTATTTCTTGG ACACTCTCATGTTCTTGTTCACCCATGCAGGCACCCCACC AAAGTACATATCTTCCTTCCAGTAATAATTTTTAATTACA AAATAAACATCCACTATTGGAAAAAAAAAAAAAAAGCTAG CCGGGCATGGTGGTGGGTGCCTGTAATCCCAGCTACTCTG GAGGCTGAGGCAGAGGATTGCTTGAACCCGGGAGGCGGAG GTTGCAGTAAGCTGAGATCGCGCCACCGCACTCCAGCCTG GGCGACAGAGTGAGACTCCATCTCAAAAAAAAAGAAAGAA AAAAAGAAGCACATGTTTTTCATAGGGTATATATGAGGAC CTAAACTGCTGTGAAAATGATAGAAAGCAAGTAGCTCCCT TATTCTGTTTTTGATTGCAGCCTTTTATCTTTTGCTAATT ATAGCAATATTTATTGAGCACCTGCCATGTGACTGTCACT GTTCTAGATATTTTACATGTAATATACAGATAAAAGAATA GTACTTTATATATATTACAATGATACAATGATTACATTAA CAATACAATATTTTGCTTGTCATATGCTAAGAATAATTGG GTAGAGTGACATTACTGTGCCTTCGATTAAAATAAGTACT TTTTTGCGTGTTAAATTCATGTTTTCAATAAATAATAAAT GCATATAGTTGAAAAATCAGTAAATA FBXW7 NM_001013415.1 AGACAGGTCAGGACATTTGGTAGGGGAAGGTTGAAAGACA 5 AAAGCAGCAGGCCTTGGGTTCTCAGCCTTTTAAAAACTAT TATTAAATATATATTTTTAAAATTTAGTGGTTAGAGCTTT TAGTAATGTGCCTGTATTACATGTAGAGAGTATTCGTCAA CCAAGAGGAGTTTTAAAATGTCAAAACCGGGAAAACCTAC TCTAAACCATGGCTTGGTTCCTGTTGATCTTAAAAGTGCA AAAGAGCCTCTACCACATCAAACTGTGATGAAGATATTTA GCATTAGCATCATTGCCCAAGGCCTCCCTTTTTGTCGAAG ACGGATGAAAAGAAAGTTGGACCATGGTTCTGAGGTCCGC TCTTTTTCTTTGGGAAAGAAACCATGCAAAGTCTCAGAAT ATACAAGTACCACTGGGCTTGTACCATGTTCAGCAACACC AACAACTTTTGGGGACCTCAGAGCAGCCAATGGCCAAGGG CAACAACGACGCCGAATTACATCTGTCCAGCCACCTACAG GCCTCCAGGAATGGCTAAAAATGTTTCAGAGCTGGAGTGG ACCAGAGAAATTGCTTGCTTTAGATGAACTCATTGATAGT TGTGAACCAACACAAGTAAAACATATGATGCAAGTGATAG AACCCCAGTTTCAACGAGACTTCATTTCATTGCTCCCTAA AGAGTTGGCACTCTATGTGCTTTCATTCCTGGAACCCAAA GACCTGCTACAAGCAGCTCAGACATGTCGCTACTGGAGAA TTTTGGCTGAAGACAACCTTCTCTGGAGAGAGAAATGCAA AGAAGAGGGGATTGATGAACCATTGCACATCAAGAGAAGA AAAGTAATAAAACCAGGTTTCATACACAGTCCATGGAAAA GTGCATACATCAGACAGCACAGAATTGATACTAACTGGAG GCGAGGAGAACTCAAATCTCCTAAGGTGCTGAAAGGACAT GATGATCATGTGATCACATGCTTACAGTTTTGTGGTAACC GAATAGTTAGTGGTTCTGATGACAACACTTTAAAAGTTTG GTCAGCAGTCACAGGCAAATGTCTGAGAACATTAGTGGGA CATACAGGTGGAGTATGGTCATCACAAATGAGAGACAACA TCATCATTAGTGGATCTACAGATCGGACACTCAAAGTGTG GAATGCAGAGACTGGAGAATGTATACACACCTTATATGGG CATACTTCCACTGTGCGTTGTATGCATCTTCATGAAAAAA GAGTTGTTAGCGGTTCTCGAGATGCCACTCTTAGGGTTTG GGATATTGAGACAGGCCAGTGTTTACATGTTTTGATGGGT CATGTTGCAGCAGTCCGCTGTGTTCAATATGATGGCAGGA GGGTTGTTAGTGGAGCATATGATTTTATGGTAAAGGTGTG GGATCCAGAGACTGAAACCTGTCTACACACGTTGCAGGGG CATACTAATAGAGTCTATTCATTACAGTTTGATGGTATCC ATGTGGTGAGTGGATCTCTTGATACATCAATCCGTGTTTG GGATGTGGAGACAGGGAATTGCATTCACACGTTAACAGGG CACCAGTCGTTAACAAGTGGAATGGAACTCAAAGACAATA TTCTTGTCTCTGGGAATGCAGATTCTACAGTTAAAATCTG GGATATCAAAACAGGACAGTGTTTACAAACATTGCAAGGT CCCAACAAGCATCAGAGTGCTGTGACCTGTTTACAGTTCA ACAAGAACTTTGTAATTACCAGCTCAGATGATGGAACTGT AAAACTATGGGACTTGAAAACGGGTGAATTTATTCGAAAC CTAGTCACATTGGAGAGTGGGGGGAGTGGGGGAGTTGTGT GGCGGATCAGAGCCTCAAACACAAAGCTGGTGTGTGCAGT TGGGAGTCGGAATGGGACTGAAGAAACCAAGCTGCTGGTG CTGGACTTTGATGTGGACATGAAGTGAAGAGCAGAAAAGA TGAATTTGTCCAATTGTGTAGACGATATACTCCCTGCCCT TCCCCCTGCAAAAAGAAAAAAAGAAAAGAAAAAGAAAAAA ATCCCTTGTTCTCAGTGGTGCAGGATGTTGGCTTGGGGCA ACAGATTGAAAAGACCTACAGACTAAGAAGGAAAAGAAGA AGAGATGACAAACCATAACTGACAAGAGAGGCGTCTGCTG TCTCATCACATAAAAGGCTTCACTTTTGACTGAGGGCAGC TTTGCAAAATGAGACTTTCTAAATCAAACCAGGTGCAATT ATTTCTTTATTTTCTTCTCCAGTGGTCATTGGGCAGTGTT AATGCTGAAACATCATTACAGATTCTGCTAGCCTGTTCTT TTACCACTGACAGCTAGACACCTAGAAAGGAACTGCAATA ATATCAAAACAAGTACTGGTTGACTTTCTAATTAGAGAGC ATCTGCAACAAAAAGTCATTTTTCTGGAGTGGAAAAGCTT AAAAAAATTACTGTGAATTGTTTTTGTACAGTTATCATGA AAAGCTTTTTTTTTTTTTTTTTTGCCAACCATTGCCAATG TCAATCAATCACAGTATTAGCCTCTGTTAATCTATTTACT GTTGCTTCCATATACATTCTTCAATGCATATGTTGCTCAA AGGTGGCAAGTTGTCCTGGGTTCTGTGAGTCCTGAGATGG ATTTAATTCTTGATGCTGGTGCTAGAAGTAGGTCTTCAAA TATGGGATTGTTGTCCCAACCCTGTACTGTACTCCCAGTG GCCAAACTTATTTATGCTGCTAAATGAAAGAAAGAAAAAA GCAAATTATTTTTTTTTATTTTTTTTCTGCTGTGACGTTT TAGTCCCAGACTGAATTCCAAATTTGCTCTAGTTTGGTTA TGGAAAAAAGACTTTTTGCCACTGAAACTTGAGCCATCTG TGCCTCTAAGAGGCTGAGAATGGAAGAGTTTCAGATAATA AAGAGTGAAGTTTGCCTGCAAGTAAAGAATTGAGAGTGTG TGCAAAGCTTATTTTCTTTTATCTGGGCAAAAATTAAAAC ACATTCCTTGGAACAGAGCTATTACTTGCCTGTTCTGTGG AGAAACTTTTCTTTTTGAGGGCTGTGGTGAATGGATGAAC GTACATCGTAAAACTGACAAAATATTTTAAAAATATATAA AACACAAAATTAAAATAAAGTTGCTGGTCAGTCTTAGTGT TTTACAGTATTTGGGAAAACAACTGTTACAGTTTTATTGC TCTGAGTAACTGACAAAGCAGAAACTATTCAGTTTTTGTA GTAAAGGCGTCACATGCAAACAAACAAAATGAATGAAACA GTCAAATGGTTTGCCTCATTCTCCAAGAGCCACAACTCAA GCTGAACTGTGAAAGTGGTTTAACACTGTATCCTAGGCGA TCTTTTTTCCTCCTTCTGTTTATTTTTTTGTTTGTTTTAT TTATAGTCTGATTTAAAACAATCAGATTCAAGTTGGTTAA TTTTAGTTATGTAACAACCTGACATGATGGAGGAAAACAA CCTTTAAAGGGATTGTGTCTATGGTTTGATTCACTTAGAA ATTTTATTTTCTTATAACTTAAGTGCAATAAAATGTGTTT TTTCATGTTA GNA13 NM_006572.5 CTCCTTCCCTCCCTCCCTCCCCCGCTGTCCTGGCCCGCCC 6 TGCCCGGCCCGCCCTGCGAGTCAGTTCGCTGGTTCCCTCC CTCCCTGGGCGCGCTCGGGCCGCCGCCGCGCTCCCCGCCC TCGAGCCTCGGTGCCGGAGCCGCCCGCCGCCGGAGGAGGA GGTGGAGGGAGCCGGAGGGGCCCGCCGAGGCGGCGGCGGC GGCGGCAAGATGGCGGACTTCCTGCCGTCGCGGTCCGTGC TGTCCGTGTGCTTCCCCGGCTGCCTGCTGACGAGTGGCGA GGCCGAGCAGCAACGCAAGTCCAAGGAGATCGACAAATGC CTGTCTCGGGAAAAGACCTATGTGAAGCGGCTGGTGAAGA TCCTGCTGCTGGGCGCGGGCGAGAGCGGCAAGTCCACCTT CCTGAAGCAGATGCGGATCATCCACGGGCAGGACTTCGAC CAGCGCGCGCGCGAGGAGTTCCGCCCCACCATCTACAGCA ACGTGATCAAAGGTATGAGGGTGCTGGTTGATGCTCGAGA GAAGCTTCATATTCCCTGGGGAGACAACTCAAACCAACAA CATGGAGATAAGATGATGTCGTTTGATACCCGGGCCCCCA TGGCAGCCCAAGGAATGGTGGAAACAAGGGTTTTCTTACA ATATCTTCCTGCTATAAGAGCATTATGGGCAGACAGCGGC ATACAGAATGCCTATGACCGGCGTCGAGAATTTCAACTGG GTGAATCTGTAAAATATTTCCTGGATAACTTGGATAAACT TGGAGAACCAGATTATATTCCATCACAACAAGATATTCTG CTTGCCAGAAGACCCACCAAAGGCATCCATGAATACGACT TTGAAATAAAAAATGTTCCTTTCAAAATGGTTGATGTAGG TGGTCAGAGATCAGAAAGGAAACGTTGGTTTGAATGTTTC GACAGTGTGACATCAATACTTTTCCTTGTTTCCTCAAGTG AATTTGACCAGGTGCTTATGGAAGATCGACTGACCAATCG CCTTACAGAGTCTCTGAACATTTTTGAAACAATCGTCAAT AACCGGGTTTTCAGCAATGTCTCCATAATTCTGTTCTTAA ACAAGACAGACTTGCTTGAGGAGAAGGTGCAAATTGTGAG CATCAAAGACTATTTCCTAGAATTTGAAGGGGATCCCCAC TGCTTAAGAGACGTCCAAAAATTCCTGGTGGAATGTTTCC GGAACAAACGCCGGGACCAGCAACAGAAGCCCTTATACCA CCACTTCACCACTGCTATCAACACGGAGAACATCCGCCTT GTTTTCCGTGACGTGAAGGATACTATTCTGCATGACAACC TCAAGCAGCTTATGCTACAGTGATGTACAAAAGACTTGCT GTTTTAATATCTTTTTGTGTTTTTGATGTTTTCTGTTTGT TTTGTTTTTTAAAATAGCAGTTTACAACCAGAATTAGAAC AATCTTAATTCTACGTTTAACTTCTTGAAAATCTTAGTAC TTTTTCTGCGGCCTTTGGTTTGTGGCTGAAAGCTGTTGAG TGACTCATCGCCAAGATTTGCTGTAATGCAGGCTTTGATC TGTTTCACCATGGCTTCTATTCAAGTCCAGTTAAAACCTC CCAGCTGACCTCAGACTAGGCATATTTCAGGCTTTAAATT ATTCTACTTTCCAAACTGAATTCTCCTGCAGTGCCAAGTA TCAAAGGTGTCCTTAAATACTTGTAGGGATGAGGTTAGGA ATATTCAGTTCCAAAACAAGATATCTTCTGTCCGCCTTAC ATATAGCAGTGACACTTGTTGCCTAACTTTATGGTGACCT CCTATTTTGTAAGGGCTGTTAGAAGTTCTATCTAAGAAAT GGCATTCTGTAGGTTTATAGAAGGTTTAGCCTTCATATTT TAATTGCTTGTATACACAACAGCTGTTTTGCTTTTAGATT TCTGTGTTTCTGAAGGTAATGTTCTTCCTGTTTTCAAGTT TACATAAGGATCTTTGGTCTGATGCTGATGAAGAGTTCAC AGGTGGTATGGGAGAGCAAAAGGCAAGCTAATGCTGTTTA CCGTGTTTTGGTCAAACGTAACGAGTGAAATAGAATTTGC CTTTCTCATATTTAATTATCATGTAGTTTAATGTACCATA TGTGAAACATTCTGGCCATAGCAGCAACTAAAAACTGCAA GCAACTTGGTAACAGAACTTTCTAAATAAACTTAACCTGT TCCAGAATGTCATGTATTTGACTTTTAAGCCCTATCTCAG TTGGTCAGTAAAGACCAATCCTTACTGTAGGAAATCATTG TTGTATCATCACAAACATCTATCTTTTGCTGTCCTGTCCA GTCCCATCAACTCCACACTGTGCCATTTGTGGCATCGTTT TGTTTATTTGGAGTTTGCTAAGGGCAGTATTTTTCTGTCA AGACTATTCAAGAAGGCATTATTTGAGATTCCTGTTCATT CTTGGTGTGTCTCTAACAGATACAGTATGTATACATTTGT ATAATTGTTGTTGTTGAAAGTCCAGCTTTTTTGAGGTATA TTTTAAATGTTTTAAGGATGCTTCTAAGGATCAGTAGTAA TTTTTTTAGTTCGCACCTAAAGATGATTACATTGACCTCC CCCGACTGCTTACCAAATTAAAATGTGTCCACGAAGTAGC TTTGTGATCGCAGATACATTCATAGTGAACTCATCAGAAT GGCTGGTTTGCAGTACTGAAATACTATCTTCTAGGCTGTA TGTAGTGCTACAATTAGAGAAACAGAAGTCCAAGGCTGGC GACAGCTTGAAAAGTCTGACAGCTTTTCTACTTTTCCTGA AAATTTTAAGACTGTGATATCTGTCATTTTACTGTATAGC TGACTGTGTACTCAGGTATTTTATTGGTCCTTGAAAGATT GGTCGTTATGGATCACCCAGCCTTTCCAAGTCAGTGGCTG TTGTTCTGTCTTGCTGTCTGATACGAGAGTGGGGCTTTTC AGTGAACTAACCAGGGATTGTTCTTGACATACCTGACTTT TCTCACATTTGAACTTCCACTATCATTGTATCCATATAAC TTCTAGCATTTTCATGCCATGGTAATCCATGAGCTACACA TACGTAGCCCGGCACCGTGATGCAAGTTCATGGTATCGTG CATGTTCGTGGTATCATGGTATCATTCATGCGTGTTTGAA TAGTTCTACATCTAGTGCTTCTTGCCAAAAAGAATACATT GTTTAAATTCACAAAATTAGCATAATTGCAGTGCTAATGA ATATCGGAATATGTGCACAGTAACATTTGGACTATTCATT GGAGAGTTTACCCATACATTTAGCAAATTGAATGGCCAAA ACATTTGACTCCAGTGAGGGCTCAAGTTAGATCCCTATAG AAAGAGGACACTTCATCTTACTTAAGTCATAGTTAAGATC TGTGATACGAACCATAGATATTGCCTGACAAAGCAGAAAT CACCAAGTTTCCCCCTTTTGAATTACCACCAAGAAGTGTT GAAACACCAAATAGATATCATGTTATTTTGGGCATTTGCA GTTTTCTTCCCTGCTGCATGTAATGTCTCAGAATCAACAT TCTTTTAAAATCTAGACTATATTTTGAGGCAATGAATTAC TTATATTCAACTTAGGCTTGTTTTGACATTCAGTAGAACT TTAAGTTCAATCTAAAGGCTTCAGTCCACATTTTTTTATA CGTTGTATTTTAAAAACGTTTGAAAGGAGTCTTACACCTG TATCATGAAAACTGAATCCTTTTGAAATACCACTATATGA AGAGAGAGATGAAATTTAGTGAACAGAATTGAAAAGGTGC TCATAATTTCACTATGCAAACTTACCCCAGTCTCTAAAAA AGTAATTTAGATTTAAAGTTCTTTGATGTATTTGATTTTC TAAATCTTTATGGTTATGATTTGGAATAAAATGTGCCTAA TCCTGTGTTACATTCTGTTCTTAAATCTGAATGCCTTCTC ATTTAATTCTGAGGAAATATCACACAAGTGTCTTCATTGA CCTTGAAGAAATGTATATACAGTTGCCTTATAAAACAACA TAAATTTAGACCATAACTTTTATAGAGAAAGGGTTTTGTC AAATGTTTTCTGAAAATCTGAGTAATTCAAAGCATGCCTC TGCCCCTTTAATATTTTTAATAACCTGCATTGTTGCTGTC TGCCAAATATTAAATTGAAATCTTCATTTCAATTTTATTA TCTGGAAAGGGCACTGGATTGCTCTGCAACCAAAGAAAGC AATATGGAATGAAAAAACTCATTCACTTTTGTCTTATTTT CTTTTAAGGTGTATTGGCATGTAATTTGCATAGAGAAGGT CCTCTGGTTAGTCTCTCAAATTGAGGCTGTTTAGGGAAAT CCTTATTCAGTTGGTGGCAGTGGTTGGTTTAAAGTAGAAG GAAATAAGATCGCCTTAATACCAGAAATGATTAGAAGTGC TGATTTAGATTCAACAAATACCATATGTCCTTATCATTTT TTGTAAGAAGAAATTGGTTAAGTCCTAACTTTCAATGTGT ACCCAAATACTTGTATTTATGCTTTTGATAAAATGTATTT TCAGCATTAATACACATCCGATTATGCCTTATTTATATAT GAAGAATAAAGTTACCATGTTACACTGTTATGTCCTAAAA TTCAAATCACTATTTGAGAAACCCTCAAATTGGTGCTTTC ATTATATAATGATACATTTAGACAAAACCCCAAACTAAGC CATTTGAAACAAGATTCTCTCCATTGCAGTTTGTAGCAAT GTTATTTCTGTGTATGTCATGAGAAGGCTAAATATCAGTG TTAATTTCTTGTTTGAATCCGTGAAATCATGCCTGTAAAG CCCAAACATTTGTAACAAACTCCCTAATAAATTTAGAGAA AGTCACTCTGTTACCATTTCATTTATTTTAGTTTTATTTG AGAAATTAAGACCAGAAGTTTTGCTCATGTCTTTTTCACT TGGAAATCTGACTTAGTACCTAGTTAATTTGTCTCTCTCC CATCATTTTAAGGCGTTCGCTTCTGTTAATCACAGATGAT CTGTCCTTGTGTTGTGCTGCTTGACTAAAAGCACTGTTTT GTTTTGTTTTGTTTTGTTTTTTAATGATAGGATACAGGGT GGCTTTTCAGTCTAGTAAACATGAGGAGGGGAGAGATTGT GGGTGGGTGTGGGTGTGTCCGCATGTCCCAAATACAGCAC ATGCCCATTTTTTTATGGTACGAGGTTAGGGCTTATTAAT AAATGTATACTAGATCTTGAAGTGTAAGTCTAAGTCTGAA CATTTTAAACAAGTTGGACTTTATGGCTTTTTCAAGTTCC ATCAAGTAGATACTAGTCTTAGGCTGGTAGGTGATTAACA ACATCATTTGGAGTACAGTGTTTGTACCACTAGCATTCTT ATGTCTGTACTTGAACGTGTAGTTAGCATTTAAGTTATGT TCACTCTTGTAGCATTCAGGTCTTACCATCTGGTTTCAAA TGCGAGAGCTTATATGAACATTGTTTTGAAAGCATGAATG ATATGGCAATATTTTATGTCTTGATAAGGAGAGTTTTGTG ACATATACAAATCTGCTGTTGATGATGAAAGTTTACAGGT GGATCAGAGTATGCTGGAACTCAGTGTGCATAAAATTTCA GTCAGTGAATATCACTGAACGTCATATACTACTTGGTATG TGACTTTGGTTTGTGTTAAGAAAGCTTGTATATAATATTT TTTGCCATAGTAAGTGAGAAATTGTCCTTAATCATGCCTG TTTGATGGTACTAGGAAAGAAAGGGGTAGAGATTAATTCT TGCACAGTATAAGCAACAGTGCAACAAACTATGCCATTTA CCTTTTACCTCTTACTTGAAGGCAGAATCGCAAAACGTTT GAAATGGCTTTTCTAAACTACTCTACTCTGGTGAGAGCTC ATTTACCACAAGAAGCCTTATAAAAAAGTATATTTTGTAA TAACCCCGTAGATACTGTACCTAACAAAACATGACTCGTA TTAGCTCTATAAAATATTTGTGGCTTAGGATTTTTTTTTT ACATATATCTTTTTATAACTTTCCAGGAACTAAGCACATT ATCTGATAATTGTTGTAAATTTTTTTGTCAGTGCTTTAGT TCAGGATGGGCAATAAATTATTTCTAAAGGAGGTCTAAAA GTGGAAAGAATGGTTTGATTTTATAAAATGAGTTGCTAGT TCATTACAGCTTTTTACTTTTGTACATATTTTGCAAAACA TTTGCCTCTTGCTATTAATATTTGCTTTGTAAAAATTACT GACATTTAATAAACATTTGTAAACAATTCAAAAAAAAAAA AAAAAA IL8 NM_000584.3 GAGGGTGCATAAGTTCTCTAGTAGGGTGATGATATAAAAA 7 GCCACCGGAGCACTCCATAAGGCACAAACTTTCAGAGACA GCAGAGCACACAAGCTTCTAGGACAAGAGCCAGGAAGAAA CCACCGGAAGGAACCATCTCACTGTGTGTAAACATGACTT CCAAGCTGGCCGTGGCTCTCTTGGCAGCCTTCCTGATTTC TGCAGCTCTGTGTGAAGGTGCAGTTTTGCCAAGGAGTGCT AAAGAACTTAGATGTCAGTGCATAAAGACATACTCCAAAC CTTTCCACCCCAAATTTATCAAAGAACTGAGAGTGATTGA GAGTGGACCACACTGCGCCAACACAGAAATTATTGTAAAG CTTTCTGATGGAAGAGAGCTCTGTCTGGACCCCAAGGAAA ACTGGGTGCAGAGGGTTGTGGAGAAGTTTTTGAAGAGGGC TGAGAATTCATAAAAAAATTCATTCTCTGTGGTATCCAAG AATCAGTGAAGATGCCAGTGAAACTTCAAGCAAATCTACT TCAACACTTCATGTATTGTGTGGGTCTGTTGTAGGGTTGC CAGATGCAATACAAGATTCCTGGTTAAATTTGAATTTCAG TAAACAATGAATAGTTTTTCATTGTACCATGAAATATCCA GAACATACTTATATGTAAAGTATTATTTATTTGAATCTAC AAAAAACAACAAATAATTTTTAAATATAAGGATTTTCCTA GATATTGCACGGGAGAATATACAAATAGCAAAATTGAGGC CAAGGGCCAAGAGAATATCCGAACTTTAATTTCAGGAATT GAATGGGTTTGCTAGAATGTGATATTTGAAGCATCACATA AAAATGATGGGACAATAAATTTTGCCATAAAGTCAAATTT AGCTGGAAATCCTGGATTTTTTTCTGTTAAATCTGGCAAC CCTAGTCTGCTAGCCAGGATCCACAAGTCCTTGTTCCACT GTGCCTTGGTTTCTCCTTTATTTCTAAGTGGAAAAAGTAT TAGCCACCATCTTACCTCACAGTGATGTTGTGAGGACATG TGGAAGCACTTTAAGTTTTTTCATCATAACATAAATTATT TTCAAGTGTAACTTATTAACCTATTTATTATTTATGTATT TATTTAAGCATCAAATATTTGTGCAAGAATTTGGAAAAAT AGAAGATGAATCATTGATTGAATAGTTATAAAGATGTTAT AGTAAATTTATTTTATTTTAGATATTAAATGATGTTTTAT TAGATAAATTTCAATCAGGGTTTTTAGATTAAACAAACAA ACAATTGGGTACCCAGTTAAATTTTCATTTCAGATAAACA ACAAATAATTTTTTAGTATAAGTACATTATTGTTTATCTG AAATTTTAATTGAACTAACAATCCTAGTTTGATACTCCCA GTCTTGTCATTGCCAGCTGTGTTGGTAGTGCTGTGTTGAA TTACGGAATAATGAGTTAGAACTATTAAAACAGCCAAAAC TCCACAGTCAATATTAGTAATTTCTTGCTGGTTGAAACTT GTTTATTATGTACAAATAGATTCTTATAATATTATTTAAA TGACTGCATTTTTAAATACAAGGCTTTATATTTTTAACTT TAAGATGTTTTTATGTGCTCTCCAAATTTTTTTTACTGTT TCTGATTGTATGGAAATATAAAAGTAAATATGAAACATTT AAAATATAATTTGTTGTCAAAGTAAAAAAAAAAAAAAA JMJD1C NM_001282948.1 CTCGTTCTCATTTGGGTGTCTGCACTGTTGGAAGCTACTG 8 CACTGTGTTTCCACGCAGACAGAGTACAGTGGGAAAGGCT TTCTCCAGCTGATGGATGGCTGTTCTCTTTATTTGGAGTA TCTTACTGGTTATGTAAGCGACCTCGAGAGAAATTATCCT GACCCAGATCGGAGGATGCAGTAGTGCTTCAGCTGCAGGA TTTCTTAGTCGTTAACACCACAGTGCTGATGACAAAGAGC GAGTTGTAATCCTCATCACTGCCAGGGCTGAGCCAGAGCA GACAGAAAATCGTCATTTGCTCGTTGGAGACTTGTTAGGT TACAGCTCCTGCTTCGTTCTGTGGTCTTGGCTTTTCTTCC TATACAATGACGCCGCTGCAAGTGAGCTCAGAAATGCTTG GTTTGAGAGCCATTTGCCTGTGATTTTTGAAGACTAAAGA AGTATTTACACTAGATACTCTTCCAGAACAAAATAGAAAT TTCAGCAAATACTTACTGACCTTTAAAGCCTTGTTGTGGA TTTCTGAGATTTAAAGATACTTTAAAATTCTCAAGAACAA AACTTTCAAACCTCTGGTTGAAAGAAATATACCCAGTTCA GTCACTGCAGTAGAATTCCTTGTAGATAAGCAACTGGATT TTTTAACTGAAGATAGTGCCTTTCAGCCCTACCAGGACGA CATAGACAGCCTAAACCCAGTTCTCAGGGACAACCCGCAG CTTCATGAGGAAGTGAAAGTCTGGGTAAAGGAACAAAAGG TTCAGGAGATTTTTATGCAAGGTCCTTATTCCTTAAATGG ATACAGAGTGAGAGTATATAGACAAGACTCTGCCACCCAG TGGTTTACTGGCATAATTACTCATCATGATCTCTTCACCC GCACCATGATCGTTATGAATGATCAGGTACTAGAACCACA GAATGTCGATCCTTCTATGGTTCAAATGACCTTTCTAGAT GATGTTGTTCACTCTTTGTTAAAAGGTGAAAATATTGGCA TTACATCACGACGCAGGTCTCGTGCCAATCAAAACGTCAA CGCTGTTCACAGCCATTATACACGTGCCCAAGCAAATAGT CCCAGACCAGCAATGAACTCCCAAGCTGCTGTACCAAAAC AGAATACACACCAGCAACAGCAACAAAGAAGTATCCGTCC AAATAAGAGGAAGGGCTCAGATAGCAGTATACCAGATGAA GAGAAGATGAAGGAGGAAAAATATGATTATATATCACGAG GAGAAAATCCTAAAGGTAAAAACAAACACTTGATGAATAA AAGAAGGAAACCTGAGGAGGATGAAAAGAAACTAAATATG AAAAGACTTCGAACTGACAATGTTTCAGACTTTTCTGAGA GCAGTGACTCAGAAAATTCAAATAAGAGAATAATAGATAA TTCCTCAGAACAGAAGCCAGAGAATGAATTGAAAAATAAA AATACTTCAAAAATAAATGGAGAAGAAGGAAAACCCCATA ATAATGAGAAGGCAGGAGAAGAGACCCTAAAAAATAGCCA GCCTCCCTGGGATCAAATACAGGAAGATAAAAAACATGAA GAAGCAGAGAAGCGGAAGTCTGTTGACACTCAGCTTCAAG AAGATATGATTATTCATTCGTCAGAACAGTCCACAGTTTC TGATCATAATTCTAATGATTTACTTCCTCAGGAATGCAAT ATGGATAAAACACATACCATGGAATTGCTACCAAAGGAGA AGTTTGTATCCAGACCACCCACACCAAAATGTGTTATTGA TATTACAAATGACACTAATTTAGAAAAGGTGGCTCAGGAA AACTCAAGTACCTTTGGCCTTCAGACACTTCAGAAAATGG ATCCTAATGTTAGTGATTCAAAACACTCTATTGCAAATGC AAAATTCTTGGAAACAGCAAAAAAAGATTCTGACCAGAGC TGGGTCAGTGATGTAGTTAAAGTGGATCTAACCCAATCAA GTGTTACAAATGCTTCTTCAGGAAATGATCACTTGAACAT GGAAAAAGAGAAGTATGTCTCTTACATTTCTCCTTTAAGT GCAGTTTCTGTCATGGAAGATAAGCTGCATAAGCGAAGTC CACCTCCAGAGACTATAAAATCTAAACTTAATACTTCAGT AGATACTCACAAGATAAAATCCAGCCCATCACCTGAAGTT GTTAAACCCAAAATAACTCATTCTCCTGATTCTGTAAAGT CTAAGGCCACTTATGTGAACAGCCAAGCTACTGGTGAAAG AAGATTGGCAAATAAGATAGAACATGAGCTATCAAGATGC AGTTTTCATCCAATTCCTACTCGAAGCAGTACATTAGAAA CTACAAAGAGTCCTCTTATCATTGATAAAAATGAGCATTT TACAGTTTACAGAGATCCTGCACTTATTGGGTCAGAAACA GGAGCTAATCATATTTCACCTTTCCTAAGCCAGCATCCTT TTCCTCTTCACTCCTCATCTCATAGAACCTGTTTAAATCC AGGTACCCATCATCCTGCCTTAACTCCTGCACCCCATTTA CTAGCCGGATCATCTAGTCAAACTCCATTACCTACCATTA ACACTCATCCTCTGACTAGTGGTCCACACCATGCTGTTCA TCACCCTCATTTACTTCCCACTGTGTTACCTGGAGTGCCT ACTGCCTCCTTACTTGGTGGCCACCCACGACTAGAGAGTG CTCATGCCAGCAGCTTGAGCCACTTAGCGCTAGCACACCA GCAACAACAACAGTTGTTACAGCACCAGTCACCTCATCTT CTTGGACAAGCCCATCCTTCTGCTTCATATAATCAGCTTG GACTTTATCCAATTATTTGGCAGTATCCAAATGGAACACA TGCATACTCAGGACTTGGTTTGCCTTCTTCTAAGTGGGTT CACCCAGAAAATGCAGTTAATGCTGAAGCTTCATTAAGGA GGAATTCTCCCAGTCCTTGGCTACATCAGCCCACCCCTGT GACCTCAGCAGATGGTATTGGATTACTTAGTCACATTCCT GTCAGACCTTCCAGTGCAGAGCCTCATCGGCCTCTTAAAA TTACAGCCCATTCCAGTCCACCATTGACAAAAACTTTAGT AGATCATCATAAGGAAGAATTAGAAAGAAAAGCTTTTATG GAACCATTACGGTCTGTTGCATCCACATCAGCCAAAAATG ACCTGGATCTAAATAGGTCACAGACTGGAAAAGATTGTCA CTTACATAGGCATTTTGTGGATCCAGTATTAAATCAGTTA CAGAGGCCACCCCAGGAGACTGGAGAGAGGTTAAACAAAT ACAAAGAGGAACACCGTCGAATTCTTCAAGAAAGTATTGA TGTTGCTCCCTTTACAACTAAAATCAAGGGACTTGAGGGT GAGAGAGAGAATTATTCCAGAGTGGCATCATCATCTTCCA GTCCTAAAAGCCATATCATCAAACAAGATATGGATGTAGA ACGCTCAGTATCAGATCTTTATAAAATGAAGCACTCAGTG CCTCAGAGTTTACCCCAAAGTAACTATTTCACTACATTGT CTAATAGTGTGGTCAATGAACCACCAAGATCATACCCATC CAAAGAAGTTTCAAATATTTACGGTGATAAACAGAGTAAT GCCCTTGCAGCGGCAGCAGCTAATCCTCAAACTCTGACTT CATTTATAACATCTCTTTCAAAGCCTCCACCTTTGATTAA ACACCAACCAGAAAGTGAAGGTTTAGTAGGCAAGATACCA GAACATCTTCCACATCAGATTGCATCTCACTCAGTAACAA CCTTCAGAAATGATTGTAGGAGTCCTACCCATTTGACAGT TTCTTCTACAAATACACTCCGCAGTATGCCTGCATTACAT AGAGCACCAGTATTTCACCCACCAATCCATCACAGCCTGG AAAGAAAGGAAGGCAGCTATAGTAGTCTTTCCCCTCCAAC TTTAACTCCGGTGATGCCAGTAAATGCTGGTGGTAAAGTT CAAGAATCACAGAAGCCTCCAACTCTAATACCCGAACCAA AAGACTCCCAGGCAAATTTTAAGAGTTCTTCAGAACAGAG TTTGACGGAGATGTGGAGACCTAATAATAACCTCAGCAAA GAGAAAACTGAATGGCATGTGGAGAAAAGCAGCGGAAAGT TACAGGCTGCTATGGCATCTGTCATTGTGCGTCCATCTTC TAGTACAAAAACTGATAGTATGCCAGCAATGCAGTTAGCT TCTAAAGATCGAGTTAGTGAAAGATCTTCAGCTGGGGCAC ATAAAACAGATTGCCTCAAACTAGCAGAAGCCGGAGAAAC TGGAAGAATCATTTTGCCAAATGTGAATTCAGACAGTGTT CACACAAAATCTGAAAAAAACTTTCAGGCTGTCTCACAGG GCAGTGTTCCCAGTTCAGTCATGTCTGCTGTAAATACGAT GTGTAATACCAAAACGGATGTAATCACATCTGCTGCCGAT ACTACCAGTGTTTCCAGCTGGGGTGGTTCAGAAGTAATTT CCTCTTTATCAAATACCATTTTGGCCTCTACATCATCAGA ATGTGTATCTTCAAAAAGTGTCAGTCAGCCAGTGGCTCAA AAACAAGAATGCAAGGTCAGCACCACAGCACCAGTTACAT TAGCCAGTAGTAAGACAGGAAGTGTTGTTCAACCCAGTTC TGGGTTCTCAGGCACAACTGATTTTATCCATTTAAAAAAG CACAAGGCAGCATTGGCTGCAGCTCAGTATAAAAGTAGTA ATGCCAGTGAGACTGAACCTAATGCTATAAAAAATCAGAC ACTTTCAGCCTCCCTTCCTCTGGATAGCACTGTAATCTGT AGTACAATTAACAAAGCAAACTCTGTAGGAAATGGGCAAG CTTCCCAGACAAGTCAACCAAACTACCATACTAAACTGAA AAAGGCCTGGCTCACCAGACACTCAGAAGAAGATAAAAAT ACTAATAAAATGGAAAATTCAGGGAATTCTGTATCAGAAA TTATTAAGCCATGTTCTGTCAACTTAATAGCCTCTACATC TAGTGATATACAAAATAGTGTAGATAGTAAGATCATAGTT GATAAATATGTAAAAGATGATAAAGTCAACAGGAGAAAAG CCAAAAGAACTTATGAATCTGGCTCTGAAAGTGGAGACTC AGATGAAAGTGAAAGCAAGTCAGAGCAAAGGACTAAAAGA CAACCTAAGCCAACTTACAAAAAGAAGCAAAATGATTTGC AAAAGAGAAAAGGTGAAATAGAAGAAGATTTGAAACCCAA TGGAGTTCTCAGCAGGAGTGCCAAAGAAAGAAGTAAACTG AAGTTGCAAAGCAACAGTAATACTGGCATTCCTCGTTCAG TATTGAAAGATTGGCGTAAAGTCAAGAAGCTGAAGCAAAC TGGGGAATCCTTTTTACAGGATGACTCCTGCTGTGAGATA GGGCCTAATTTACAAAAGTGTCGAGAATGTAGACTTATTC GCAGTAAAAAAGGAGAAGAACCAGCTCACTCACCAGTATT TTGTAGATTTTACTACTTTAGACGGTTGTCATTTAGTAAA AACGGAGTAGTTAGAATAGATGGTTTCTCTTCTCCTGACC AATATGATGATGAAGCTATGAGTTTGTGGACACATGAAAA TTTTGAAGATGATGAACTAGATATAGAGACTTCTAAATAT ATCTTGGATATAATAGGTGATAAGTTCTGTCAATTAGTAA CATCTGAAAAAACAGCTTTGTCCTGGGTGAAAAAGGATGC CAAAATTGCCTGGAAAAGAGCAGTGAGAGGAGTCCGGGAG ATGTGTGATGCATGTGAAGCAACATTGTTTAACATTCACT GGGTCTGCCAAAAATGTGGATTTGTGGTCTGCTTAGATTG TTACAAGGCAAAGGAAAGGAAGAGTTCTAGAGATAAAGAA CTATATGCTTGGATGAAGTGTGTGAAGGGACAGCCTCATG ATCACAAACATTTAATGCCAACCCAAATTATACCTGGTTC TGTTTTGACAGATCTTCTAGATGCCATGCACACTCTTAGG GAAAAATATGGTATTAAATCCCATTGTCATTGTACTAACA AACAGAATTTACAAGTTGGAAATTTTCCTACAATGAATGG TGTATCTCAAGTTTTACAGAATGTTCTTAATCACAGTAAT AAAATTTCTCTGTGCATGCCTGAGTCTCAGCAGCAAAATA CTCCTCCGAAGTCTGAGAAAAATGGTGGCAGCAGCCCAGA GAGTGATGTAGGCACAGATAACAAGTTAACTCCTCCAGAA TCCCAGTCACCACTGCACTGGTTAGCAGATCTTGCAGAGC AAAAAGCCAGAGAGGAAAAAAAAGAAAACAAAGAACTTAC CCTTGAAAACCAAATTAAAGAAGAAAGAGAACAAGACAAC TCTGAATCTCCAAATGGCAGAACATCACCTCTTGTGTCCC AGAATAATGAACAAGGCTCAACCTTACGGGATTTGCTGAC TACAACAGCTGGAAAGCTACGTGTGGGGTCTACAGATGCT GGCATTGCCTTTGCCCCAGTATATTCAATGGGAGCCCCAA GTAGCAAAAGTGGACGGACTATGCCTAACATTCTTGATGA CATAATTGCTTCAGTTGTTGAAAACAAAATTCCACCAAGT AAAACCTCCAAGATAAATGTAAAACCAGAGCTTAAAGAAG AGCCTGAAGAAAGCATAATATCTGCAGTGGATGAAAATAA TAAATTATACAGTGATATACCACATTCTTGGATCTGTGAG AAGCATATTTTATGGCTTAAGGATTATAAGAATAGCAGTA ATTGGAAGCTTTTCAAAGAATGTTGGAAACAAGGACAGCC TGCAGTGGTTTCTGGTGTGCATAAGAAAATGAACATTAGC CTATGGAAGGCGGAATCAATTAGTCTTGATTTTGGAGACC ACCAAGCTGATCTCCTGAACTGCAAAGATAGCATCATTTC AAATGCCAATGTTAAGGAATTCTGGGATGGTTTTGAAGAA GTTTCAAAACGGCAGAAAAACAAGAGTGGAGAAACAGTTG TTTTAAAATTGAAAGACTGGCCTTCAGGAGAAGACTTCAA GACTATGATGCCAGCAAGATACGAAGATCTTTTAAAAAGT CTGCCATTGCCAGAATATTGTAATCCAGAAGGAAAATTCA ATTTGGCCTCTCATTTGCCAGGATTTTTTGTACGTCCTGA TCTAGGACCCAGGTTGTGCAGTGCCTATGGTGTAGTTGCT GCTAAAGATCATGATATAGGAACAACAAATCTCCATATTG AAGTTTCTGATGTTGTAAATATACTAGTTTATGTTGGCAT AGCAAAAGGAAATGGCATTCTCTCAAAAGCAGGAATTCTC AAGAAATTTGAGGAAGAAGATTTGGATGACATTTTAAGGA AAAGATTGAAGGACTCAAGTGAAATACCTGGTGCTCTGTG GCATATTTATGCTGGGAAAGATGTTGACAAGATAAGGGAA TTTCTTCAAAAGATTTCAAAAGAACAAGGCCTTGAAGTTC TACCAGAACATGATCCAATACGTGACCAAAGTTGGTATGT GAACAAAAAGCTCCGTCAAAGGCTGCTTGAAGAATATGGA GTCAGAACCTGTACTCTTATTCAGTTCCTTGGTGATGCTA TTGTTTTGCCAGCGGGAGCACTTCATCAGGTTCAGAATTT TCACAGCTGTATTCAGGTAACTGAAGATTTTGTGTCTCCA GAACATCTTGTAGAGTCATTTCATTTAACACAGGAACTGA GACTTTTGAAGGAAGAAATCAATTATGATGATAAACTACA GGTTAAAAATATTTTGTATCATGCAGTCAAAGAAATGGTG AGAGCCTTGAAGATACACGAGGATGAAGTAGAGGATATGG AAGAAAATTAAGTGTGATCCAGTTTGATATTTTTAGGTTG TTGAACTGGGATTACTTAACCTTGAATGATGATATGTATG CACACTGACTTTAAGCTTCATAAAACCATCAGTGCCAAGA AATTCTCTTTGTAGTAATTACTTGTTACTGACACCACAGC AGTATAGCATATGTCACAGCTCCTGTGATTCAATGTTATA AAACAAGCAGAATTTTAAAAGCAGCACTATATAGCTGTTT TGTATTATAGTGTATATGATGTTTGTGAAAATGCCAGATT TAAAATGATGTATTTATTTTTGGTAAAAAATAAAAAATTC TATGCTATATTGTTGATCAAGTGTAAATGTGACCTTGTAC AGTTTACTAAAATTACTGATATTTTTCACTACATTGAGAC AGTTACTGTGAGAATAGGACACAAACACCAGCTATTGCCT GCATCTGGGAAATTGCTGAATCGCACAGCAGTCATGTCAT AATCAGAAAATTACTGCCAAATAATTGTAAAATTTGTAAA GTATAAAGTATATAAAGTAGATACTAAATACAGACACTTC AATATTTTGTTGAAGCTATTGACTGTACAATTAAACATTT TCAAAAGGTGTAATTTATTTAAAATTGTCTCATTTTGGTA AAATTTATGTGAACTTTTAAAGCTAAATATTAAACTTAAT ATGCTATGTAAATATATACATATATACATTTAATGATGTA TTTTTTTAAAACATTGGCTTGCTTTTGTTAAAGTGCAAGT GTTACATATGGCTTTGTACATTAAAGTTGAAAGGGGTTTT ACATTTTCCATTAAAAGGACTTTATCAAAAATTGA LARS2 NM_015340.3 TGACAACATGGCGGCGCCCATGGTCCGTGGCCCGGCAGTG 9 CTCGCCTAAAGGTGGAGAACGAGGAGTAGAGGAGCCGCAG GCCAGAGCCTGTGAGCAGATCCAGACCTACAGATAAAAAA CATTATTTAATCTATCTGGGATTTACTCCGGCTTATGATT TGAGGGCCTTCTCACCTTCTGAAGAATGGCTTCTGTTTGG CAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGC TAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGT AATTCCCGGATGTACCAGAAGCATCTACAGTGCCACGGGA AAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATG TTGAGAAATGGTGGCATCAACGAATAAAAGAACAGGCCTC CAAAATTTCAGAAGCTGATAAATCGAAGCCAAAATTTTAC GTGCTTTCCATGTTCCCTTATCCTTCTGGTAAGCTGCACA TGGGCCATGTGCGTGTCTACACCATCAGCGACACCATAGC ACGGTTCCAGAAGATGAGAGGGATGCAGGTCATCAACCCC ATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCG CAGTCGAGAGGAATCTACATCCACAAAGTTGGACACAAAG TAATATTAAACACATGAGGAAACAGCTTGATCGTCTGGGC CTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGTTTGC CAGATTACTACAAGTGGACTCAGTATCTCTTTATTAAACT GTATGAGGCTGGGCTGGCCTATCAAAAGGAGGCCCTGGTT AACTGGGACCCAGTGGATCAAACAGTGCTTGCCAATGAGC AGGTGGATGAACATGGCTGTTCATGGCGTTCTGGAGCAAA GGTGGAACAGAAGTACCTCAGACAATGGTTTATTAAGACA ACCGCTTATGCAAAGGCCATGCAGGACGCGTTGGCAGACC TTCCAGAATGGTATGGAATAAAAGGCATGCAAGCCCACTG GATTGGGGACTGTGTGGGCTGCCACCTGGACTTCACATTA AAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCT ATACGGCCACCCCTGAAGCCATTTATGGCACCTCCCACGT GGCCATCTCGCCCAGCCACAGACTCCTACATGGGCACAGC TCTCTGAAGGAAGCCTTGAGGATGGCCCTTGTCCCTGGCA AAGATTGCCTCACGCCTGTAATGGCTGTGAACATGCTTAC CCAGCAGGAGGTCCCTGTCGTTATTTTGGCCAAAGCTGAC TTGGAAGGCTCTCTGGATTCAAAAATAGGAATTCCCAGTA CTAGCTCAGAGGACACCATCTTAGCCCAAACCCTGGGCCT GGCCTACTCTGAAGTCATTGAAACTTTGCCAGATGGCACA GAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATGACCC GGCAGGATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGG GAAGAGAGTGGGTGGAGACGTGACAAGTGATAAACTGAAA GACTGGCTGATTTCACGGCAGCGGTACTGGGGCACACCAA TCCCCATTGTCCACTGCCCAGTCTGTGGCCCCACACCTGT GCCCCTGGAGGACTTGCCTGTGACCCTGCCCAACATCGCG TCTTTCACTGGCAAGGGAGGCCCCCCACTGGCCATGGCTT CAGAGTGGGTGAACTGCTCCTGCCCAAGGTGCAAGGGAGC AGCCAAGAGAGAGACAGACACGATGGATACCTTTGTTGAT TCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATC CACACAGCCCTTTTAACACAGCAGTGGCCGATTACTGGAT GCCTGTGGATTTGTACATTGGAGGGAAAGAACATGCCGTC ATGCACTTGTTCTATGCAAGATTCTTTAGTCATTTTTGCC ATGATCAAAAAATGGTTAAACATAGGGAGCCTTTTCATAA GCTGCTGGCCCAAGGCCTTATCAAGGGGCAGACATTCCGC CTACCATCTGGACAGTATCTACAGAGAGAGGAAGTGGATC TCACAGGTTCCGTTCCTGTTCATGCAAAAACGAAAGAGAA GTTAGAGGTGACGTGGGAGAAGATGAGTAAGTCCAAACAC AACGGGGTGGACCCAGAGGAAGTTGTGGAGCAGTATGGGA TCGACACGATTCGGCTCTACATCCTTTTTGCTGCCCCTCC TGAGAAGGATATCTTGTGGGATGTGAAAACTGATGCTCTC CCTGGGGTGCTGAGATGGCAACAACGACTGTGGACCTTGA CAACTCGGTTTATTGAGGCCAGGGCTTCTGGGAAGTCTCC CCAGCCTCAGCTGCTGAGTAACAAGGAGAAAGCTGAGGCC AGGAAGCTCTGGGAGTACAAGAACTCCGTCATCTCTCAGG TGACCACCCATTTCACAGAGGACTTCTCACTGAATTCTGC AATTTCTCAGCTGATGGGACTCAGCAATGCCCTCTCGCAA GCCTCTCAGAGCGTCATTCTCCACAGCCCCGAGTTTGAGG ATGCTTTGTGTGCCCTGATGGTAATGGCTGCTCCACTGGC CCCTCATGTAACCTCAGAGATCTGGGCAGGCCTGGCGCTG GTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCA GTGTGCTGCTCCAGGCATGGCCTGCTGTGGACCCGGAGTT CCTGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATC AACAATAAAGCTTGTGGCAAAATTCCTGTGCCCCAACAAG TTGCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCA AAGCGAGCTGGGTGTCAGGCTTTTGCAAGGACGAAGCATC AAGAAGTCCTTCCTTTCCCCGAGAACTGCCCTCATCAACT TCCTGGTGCAAGATTGACAGCCAGGAGGCTGCAGCTACCA CGAGGGCCTCTGAGGAACCTCCTTCCAGGCCTGGGATGAG GGGGCGATGTCTGCTGGCCCAGGGGAAGGGAAAAGACAAA TGTCTTGACTGTTGACCTCGGTCCTGTGGCAGACTGCAGT CAACAGTGTGCCTCTGTAGTGTGGCCTGGTGCTGGGGTGA AGGTGAGCTGGGCAAAGGAGAAATATGAGCTACTGAGGAG GGGGTTGGACATCCTGCCCCTCACCCCCCACCCACACTGC AGGTAGAGGAGGCCATCTGATCCCATGGGAAGCCATCAGA GACACTGCTGGTGGGAGCAGGAAGGAGCAGTGCCCCTCGA GCAGCCAGGAAGCCTGCGGATCTGGGAAATGGCTCTGCCT TAGGCACTTCTCGGGAATTTGAGGCCAGCCTGAGGAACTG CAGGACTCAGGTGCAATGTGCCAGCCACTTGGAACTGCTA ACTGAGCCTCCAGATGGTAGTGAATGGTCTCTTTGCCTTC AGGCTGGATGAGGAAGTCATTTAGGAAATGTTCAAATAAC CAATATGTGGAAATGGACACAGGGATCTTCTGAAGTTGCT TTGAATCAAAAGGCAGGCAGTGCTGGTTCCTCTGCCTGTG TCCCCACCACTCCCCAGCTCTGTCATGCAGGCCTGTCCTC CCCAACCCCAGCTGGATGTGCCTCCCAGGCCTGCTGTGGT TCTGACACACAGGATCCCAGGCAAGGCACCACTTCCTCAC ATGAATGAGGAGCAGCAAGTCATAACCACTCCCTTGGGTA TACAATTTGCTGTGTAGTGAAGTGGAACCAGGCTCAGGCT GCTGGTCCCAACCTCAGAGCCCCACCGCAGCCCAGTAGGG ATGCAGCACGCCCCAGAGGGCTCATGTGGGCCCCAGATGG CAATGCCACCATTGTTGATGTGACTCCAGAGCCAGTTATT AGGAAGAGCAAGCTCACCACAGAGGAGTGGAACTGAGGCC CCCCAGATGTTGCCTCCGGTGTCCAAGCCACAGCGGTCTG GCTGTTGGGAAGATGGCCAGGAATGGACTCATACCATTGG CACATTAGGCTAATCCTGGTTTTATGTGAAGTCAGCAATT AAGTGTTCCCACTAGAACTGACCTAAGCCACTGATTAATA TTTAATGAGGGAAGGTAGGGGAGAATCTAGCCATTTTATA ATGCCAGAAATCTATATATGTTATCTGATGCCATTTTTCT GAAGTAGCCTCACATGTGGTCCCCCTGCAGTTCAGCAGTT AACAGATGACTTTTTTAGTGTAATAAAATGTTTATCATCT ATG MALAT1 NR_002819.2 GTAAAGGACTGGGGCCCCGCAACTGGCCTCTCCTGCCCTC 10 TTAAGCGCAGCGCCATTTTAGCAACGCAGAAGCCCGGCGC CGGGAAGCCTCAGCTCGCCTGAAGGCAGGTCCCCTCTGAC GCCTCCGGGAGCCCAGGTTTCCCAGAGTCCTTGGGACGCA GCGACGAGTTGTGCTGCTATCTTAGCTGTCCTTATAGGCT GGCCATTCCAGGTGGTGGTATTTAGATAAAACCACTCAAA CTCTGCAGTTTGGTCTTGGGGTTTGGAGGAAAGCTTTTAT TTTTCTTCCTGCTCCGGTTCAGAAGGTCTGAAGCTCATAC CTAACCAGGCATAACACAGAATCTGCAAAACAAAAACCCC TAAAAAAGCAGACCCAGAGCAGTGTAAACACTTCTGGGTG TGTCCCTGACTGGCTGCCCAAGGTCTCTGTGTCTTCGGAG ACAAAGCCATTCGCTTAGTTGGTCTACTTTAAAAGGCCAC TTGAACTCGCTTTCCATGGCGATTTGCCTTGTGAGCACTT TCAGGAGAGCCTGGAAGCTGAAAAACGGTAGAAAAATTTC CGTGCGGGCCGTGGGGGGCTGGCGGCAACTGGGGGGCCGC AGATCAGAGTGGGCCACTGGCAGCCAACGGCCCCCGGGGC TCAGGCGGGGAGCAGCTCTGTGGTGTGGGATTGAGGCGTT TTCCAAGAGTGGGTTTTCACGTTTCTAAGATTTCCCAAGC AGACAGCCCGTGCTGCTCCGATTTCTCGAACAAAAAAGCA AAACGTGTGGCTGTCTTGGGAGCAAGTCGCAGGACTGCAA GCAGTTGGGGGAGAAAGTCCGCCATTTTGCCACTTCTCAA CCGTCCCTGCAAGGCTGGGGCTCAGTTGCGTAATGGAAAG TAAAGCCCTGAACTATCACACTTTAATCTTCCTTCAAAAG GTGGTAAACTATACCTACTGTCCCTCAAGAGAACACAAGA AGTGCTTTAAGAGGTATTTTAAAAGTTCCGGGGGTTTTGT GAGGTGTTTGATGACCCGTTTAAAATATGATTTCCATGTT TCTTTTGTCTAAAGTTTGCAGCTCAAATCTTTCCACACGC TAGTAATTTAAGTATTTCTGCATGTGTAGTTTGCATTCAA GTTCCATAAGCTGTTAAGAAAAATCTAGAAAAGTAAAACT AGAACCTATTTTTAACCGAAGAACTACTTTTTGCCTCCCT CACAAAGGCGGCGGAAGGTGATCGAATTCCGGTGATGCGA GTTGTTCTCCGTCTATAAATACGCCTCGCCCGAGCTGTGC GGTAGGCATTGAGGCAGCCAGCGCAGGGGCTTCTGCTGAG GGGGCAGGCGGAGCTTGAGGAAACCGCAGATAAGTTTTTT TCTCTTTGAAAGATAGAGATTAATACAACTACTTAAAAAA TATAGTCAATAGGTTACTAAGATATTGCTTAGCGTTAAGT TTTTAACGTAATTTTAATAGCTTAAGATTTTAAGAGAAAA TATGAAGACTTAGAAGAGTAGCATGAGGAAGGAAAAGATA AAAGGTTTCTAAAACATGACGGAGGTTGAGATGAAGCTTC TTCATGGAGTAAAAAATGTATTTAAAAGAAAATTGAGAGA AAGGACTACAGAGCCCCGAATTAATACCAATAGAAGGGCA ATGCTTTTAGATTAAAATGAAGGTGACTTAAACAGCTTAA AGTTTAGTTTAAAAGTTGTAGGTGATTAAAATAATTTGAA GGCGATCTTTTAAAAAGAGATTAAACCGAAGGTGATTAAA AGACCTTGAAATCCATGACGCAGGGAGAATTGCGTCATTT AAAGCCTAGTTAACGCATTTACTAAACGCAGACGAAAATG GAAAGATTAATTGGGAGTGGTAGGATGAAACAATTTGGAG AAGATAGAAGTTTGAAGTGGAAAACTGGAAGACAGAAGTA CGGGAAGGCGAAGAAAAGAATAGAGAAGATAGGGAAATTA GAAGATAAAAACATACTTTTAGAAGAAAAAAGATAAATTT AAACCTGAAAAGTAGGAAGCAGAAGAAAAAAGACAAGCTA GGAAACAAAAAGCTAAGGGCAAAATGTACAAACTTAGAAG AAAATTGGAAGATAGAAACAAGATAGAAAATGAAAATATT GTCAAGAGTTTCAGATAGAAAATGAAAAACAAGCTAAGAC AAGTATTGGAGAAGTATAGAAGATAGAAAAATATAAAGCC AAAAATTGGATAAAATAGCACTGAAAAAATGAGGAAATTA TTGGTAACCAATTTATTTTAAAAGCCCATCAATTTAATTT CTGGTGGTGCAGAAGTTAGAAGGTAAAGCTTGAGAAGATG AGGGTGTTTACGTAGACCAGAACCAATTTAGAAGAATACT TGAAGCTAGAAGGGGAAGTTGGTTAAAAATCACATCAAAA AGCTACTAAAAGGACTGGTGTAATTTAAAAAAAACTAAGG CAGAAGGCTTTTGGAAGAGTTAGAAGAATTTGGAAGGCCT TAAATATAGTAGCTTAGTTTGAAAAATGTGAAGGACTTTC GTAACGGAAGTAATTCAAGATCAAGAGTAATTACCAACTT AATGTTTTTGCATTGGACTTTGAGTTAAGATTATTTTTTA AATCCTGAGGACTAGCATTAATTGACAGCTGACCCAGGTG CTACACAGAAGTGGATTCAGTGAATCTAGGAAGACAGCAG CAGACAGGATTCCAGGAACCAGTGTTTGATGAAGCTAGGA CTGAGGAGCAAGCGAGCAAGCAGCAGTTCGTGGTGAAGAT AGGAAAAGAGTCCAGGAGCCAGTGCGATTTGGTGAAGGAA GCTAGGAAGAAGGAAGGAGCGCTAACGATTTGGTGGTGAA GCTAGGAAAAAGGATTCCAGGAAGGAGCGAGTGCAATTTG GTGATGAAGGTAGCAGGCGGCTTGGCTTGGCAACCACACG GAGGAGGCGAGCAGGCGTTGTGCGTAGAGGATCCTAGACC AGCATGCCAGTGTGCCAAGGCCACAGGGAAAGCGAGTGGT TGGTAAAAATCCGTGAGGTCGGCAATATGTTGTTTTTCTG GAACTTACTTATGGTAACCTTTTATTTATTTTCTAATATA ATGGGGGAGTTTCGTACTGAGGTGTAAAGGGATTTATATG GGGACGTAGGCCGATTTCCGGGTGTTGTAGGTTTCTCTTT TTCAGGCTTATACTCATGAATCTTGTCTGAAGCTTTTGAG GGCAGACTGCCAAGTCCTGGAGAAATAGTAGATGGCAAGT TTGTGGGTTTTTTTTTTTTACACGAATTTGAGGAAAACCA AATGAATTTGATAGCCAAATTGAGACAATTTCAGCAAATC TGTAAGCAGTTTGTATGTTTAGTTGGGGTAATGAAGTATT TCAGTTTTGTGAATAGATGACCTGTTTTTACTTCCTCACC CTGAATTCGTTTTGTAAATGTAGAGTTTGGATGTGTAACT GAGGCGGGGGGGAGTTTTCAGTATTTTTTTTTGTGGGGGT GGGGGCAAAATATGTTTTCAGTTCTTTTTCCCTTAGGTCT GTCTAGAATCCTAAAGGCAAATGACTCAAGGTGTAACAGA AAACAAGAAAATCCAATATCAGGATAATCAGACCACCACA GGTTTACAGTTTATAGAAACTAGAGCAGTTCTCACGTTGA GGTCTGTGGAAGAGATGTCCATTGGAGAAATGGCTGGTAG TTACTCTTTTTTCCCCCCACCCCCTTAATCAGACTTTAAA AGTGCTTAACCCCTTAAACTTGTTATTTTTTACTTGAAGC ATTTTGGGATGGTCTTAACAGGGAAGAGAGAGGGTGGGGG AGAAAATGTTTTTTTCTAAGATTTTCCACAGATGCTATAG TACTATTGACAAACTGGGTTAGAGAAGGAGTGTACCGCTG TGCTGTTGGCACGAACACCTTCAGGGACTGGAGCTGCTTT TATCCTTGGAAGAGTATTCCCAGTTGAAGCTGAAAAGTAC AGCACAGTGCAGCTTTGGTTCATATTCAGTCATCTCAGGA GAACTTCAGAAGAGCTTGAGTAGGCCAAATGTTGAAGTTA AGTTTTCCAATAATGTGACTTCTTAAAAGTTTTATTAAAG GGGAGGGGCAAATATTGGCAATTAGTTGGCAGTGGCCTGT TACGGTTGGGATTGGTGGGGTGGGTTTAGGTAATTGTTTA GTTTATGATTGCAGATAAACTCATGCCAGAGAACTTAAAG TCTTAGAATGGAAAAAGTAAAGAAATATCAACTTCCAAGT TGGCAAGTAACTCCCAATGATTTAGTTTTTTTCCCCCCAG TTTGAATTGGGAAGCTGGGGGAAGTTAAATATGAGCCACT GGGTGTACCAGTGCATTAATTTGGGCAAGGAAAGTGTCAT AATTTGATACTGTATCTGTTTTCCTTCAAAGTATAGAGCT TTTGGGGAAGGAAAGTATTGAACTGGGGGTTGGTCTGGCC TACTGGGCTGACATTAACTACAATTATGGGAAATGCAAAA GTTGTTTGGATATGGTAGTGTGTGGTTCTCTTTTGGAATT TTTTTCAGGTGATTTAATAATAATTTAAAACTACTATAGA AACTGCAGAGCAAAGGAAGTGGCTTAATGATCCTGAAGGG ATTTCTTCTGATGGTAGCTTTTGTATTATCAAGTAAGATT CTATTTTCAGTTGTGTGTAAGCAAGTTTTTTTTTAGTGTA GGAGAAATACTTTTCCATTGTTTAACTGCAAAACAAGATG TTAAGGTATGCTTCAAAAATTTTGTAAATTGTTTATTTTA AACTTATCTGTTTGTAAATTGTAACTGATTAAGAATTGTG ATAGTTCAGCTTGAATGTCTCTTAGAGGGTGGGCTTTTGT TGATGAGGGAGGGGAAACTTTTTTTTTTTCTATAGACTTT TTTCAGATAACATCTTCTGAGTCATAACCAGCCTGGCAGT ATGATGGCCTAGATGCAGAGAAAACAGCTCCTTGGTGAAT TGATAAGTAAAGGCAGAAAAGATTATATGTCATACCTCCA TTGGGGAATAAGCATAACCCTGAGATTCTTACTACTGATG AGAACATTATCTGCATATGCCAAAAAATTTTAAGCAAATG AAAGCTACCAATTTAAAGTTACGGAATCTACCATTTTAAA GTTAATTGCTTGTCAAGCTATAACCACAAAAATAATGAAT TGATGAGAAATACAATGAAGAGGCAATGTCCATCTCAAAA TACTGCTTTTACAAAAGCAGAATAAAAGCGAAAAGAAATG AAAATGTTACACTACATTAATCCTGGAATAAAAGAAGCCG AAATAAATGAGAGATGAGTTGGGATCAAGTGGATTGAGGA GGCTGTGCTGTGTGCCAATGTTTCGTTTGCCTCAGACAGG TATCTCTTCGTTATCAGAAGAGTTGCTTCATTTCATCTGG GAGCAGAAAACAGCAGGCAGCTGTTAACAGATAAGTTTAA CTTGCATCTGCAGTATTGCATGTTAGGGATAAGTGCTTAT TTTTAAGAGCTGTGGAGTTCTTAAATATCAACCATGGCAC TTTCTCCTGACCCCTTCCCTAGGGGATTTCAGGATTGAGA AATTTTTCCATCGAGCCTTTTTAAAATTGTAGGACTTGTT CCTGTGGGCTTCAGTGATGGGATAGTACACTTCACTCAGA GGCATTTGCATCTTTAAATAATTTCTTAAAAGCCTCTAAA GTGATCAGTGCCTTGATGCCAACTAAGGAAATTTGTTTAG CATTGAATCTCTGAAGGCTCTATGAAAGGAATAGCATGAT GTGCTGTTAGAATCAGATGTTACTGCTAAAATTTACATGT TGTGATGTAAATTGTGTAGAAAACCATTAAATCATTCAAA ATAATAAACTATTTTTATTAGAGAATGTATACTTTTAGAA AGCTGTCTCCTTATTTAAATAAAATAGTGTTTGTCTGTAG TTCAGTGTTGGGGCAATCTTGGGGGGGATTCTTCTCTAAT CTTTCAGAAACTTTGTCTGCGAACACTCTTTAATGGACCA GATCAGGATTTGAGCGGAAGAACGAATGTAACTTTAAGGC AGGAAAGACAAATTTTATTCTTCATAAAGTGATGAGCATA TAATAATTCCAGGCACATGGCAATAGAGGCCCTCTAAATA AGGAATAAATAACCTCTTAGACAGGTGGGAGATTATGATC AGAGTAAAAGGTAATTACACATTTTATTTCCAGAAAGTCA GGGGTCTATAAATTGACAGTGATTAGAGTAATACTTTTTC ACATTTCCAAAGTTTGCATGTTAACTTTAAATGCTTACAA TCTTAGAGTGGTAGGCAATGTTTTACACTATTGACCTTAT ATAGGGAAGGGAGGGGGTGCCTGTGGGGTTTTAAAGAATT TTCCTTTGCAGAGGCATTTCATCCTTCATGAAGCCATTCA GGATTTTGAATTGCATATGAGTGCTTGGCTCTTCCTTCTG TTCTAGTGAGTGTATGAGACCTTGCAGTGAGTTTATCAGC ATACTCAAAATTTTTTTCCTGGAATTTGGAGGGATGGGAG GAGGGGGTGGGGCTTACTTGTTGTAGCTTTTTTTTTTTTT ACAGACTTCACAGAGAATGCAGTTGTCTTGACTTCAGGTC TGTCTGTTCTGTTGGCAAGTAAATGCAGTACTGTTCTGAT CCCGCTGCTATTAGAATGCATTGTGAAACGACTGGAGTAT GATTAAAAGTTGTGTTCCCCAATGCTTGGAGTAGTGATTG TTGAAGGAAAAAATCCAGCTGAGTGATAAAGGCTGAGTGT TGAGGAAATTTCTGCAGTTTTAAGCAGTCGTATTTGTGAT TGAAGCTGAGTACATTTTGCTGGTGTATTTTTAGGTAAAA TGCTTTTTGTTCATTTCTGGTGGTGGGAGGGGACTGAAGC CTTTAGTCTTTTCCAGATGCAACCTTAAAATCAGTGACAA GAAACATTCCAAACAAGCAACAGTCTTCAAGAAATTAAAC TGGCAAGTGGAAATGTTTAAACAGTTCAGTGATCTTTAGT GCATTGTTTATGTGTGGGTTTCTCTCTCCCCTCCCTTGGT CTTAATTCTTACATGCAGGAACACTCAGCAGACACACGTA TGCGAAGGGCCAGAGAAGCCAGACCCAGTAAGAAAAAATA GCCTATTTACTTTAAATAAACCAAACATTCCATTTTAAAT GTGGGGATTGGGAACCACTAGTTCTTTCAGATGGTATTCT TCAGACTATAGAAGGAGCTTCCAGTTGAATTCACCAGTGG ACAAAATGAGGAAAACAGGTGAACAAGCTTTTTCTGTATT TACATACAAAGTCAGATCAGTTATGGGACAATAGTATTGA ATAGATTTCAGCTTTATGCTGGAGTAACTGGCATGTGAGC AAACTGTGTTGGCGTGGGGGTGGAGGGGTGAGGTGGGCGC TAAGCCTTTTTTTAAGATTTTTCAGGTACCCCTCACTAAA GGCACCGAAGGCTTAAAGTAGGACAACCATGGAGCCTTCC TGTGGCAGGAGAGACAACAAAGCGCTATTATCCTAAGGTC AAGAGAAGTGTCAGCCTCACCTGATTTTTATTAGTAATGA GGACTTGCCTCAACTCCCTCTTTCTGGAGTGAAGCATCCG AAGGAATGCTTGAAGTACCCCTGGGCTTCTCTTAACATTT AAGCAAGCTGTTTTTATAGCAGCTCTTAATAATAAAGCCC AAATCTCAAGCGGTGCTTGAAGGGGAGGGAAAGGGGGAAA GCGGGCAACCACTTTTCCCTAGCTTTTCCAGAAGCCTGTT AAAAGCAAGGTCTCCCCACAAGCAACTTCTCTGCCACATC GCCACCCCGTGCCTTTTGATCTAGCACAGACCCTTCACCC CTCACCTCGATGCAGCCAGTAGCTTGGATCCTTGTGGGCA TGATCCATAATCGGTTTCAAGGTAACGATGGTGTCGAGGT CTTTGGTGGGTTGAACTATGTTAGAAAAGGCCATTAATTT GCCTGCAAATTGTTAACAGAAGGGTATTAAAACCACAGCT AAGTAGCTCTATTATAATACTTATCCAGTGACTAAAACCA ACTTAAACCAGTAAGTGGAGAAATAACATGTTCAAGAACT GTAATGCTGGGTGGGAACATGTAACTTGTAGACTGGAGAA GATAGGCATTTGAGTGGCTGAGAGGGCTTTTGGGTGGGAA TGCAAAAATTCTCTGCTAAGACTTTTTCAGGTGAACATAA CAGACTTGGCCAAGCTAGCATCTTAGCGGAAGCTGATCTC CAATGCTCTTCAGTAGGGTCATGAAGGTTTTTCTTTTCCT GAGAAAACAACACGTATTGTTTTCTCAGGTTTTGCTTTTT GGCCTTTTTCTAGCTTAAAAAAAAAAAAAGCAAAAGATGC TGGTGGTTGGCACTCCTGGTTTCCAGGACGGGGTTCAAAT CCCTGCGGCGTCTTTGCTTTGACTACTAATCTGTCTTCAG GACTCTTTCTGTATTTCTCCTTTTCTCTGCAGGTGCTAGT TCTTGGAGTTTTGGGGAGGTGGGAGGTAACAGCACAATAT CTTTGAACTATATACATCCTTGATGTATAATTTGTCAGGA GCTTGACTTGATTGTATATTCATATTTACACGAGAACCTA ATATAACTGCCTTGTCTTTTTCAGGTAATAGCCTGCAGCT GGTGTTTTGAGAAGCCCTACTGCTGAAAACTTAACAATTT TGTGTAATAAAAATGGAGAAGCTCTAAA MBNL1 NM_001314057.1 CTTGCCGGCTTCCTTGCAAAGCCCGGTGCAAGGGCCTCTT 11 TCAAAATGAACCCACTGGTGTGCCTAGCAGTCGGTAGAAG AAGCGGGAGGGCGTCCGGTCTGCACGCCCGCCGCGAGGTT ACAATGCTGAACGCATGAGATGGAAGATACCAACGGGAGG CCGAGGGGATCCACGGCGCCCGCGCGGGCTCCGGCTTCCT CCTGCTCTCGGCGCCGCTGGGCGACCGCCCATGACCCGCT CTTGCGGGCTCTGTCCGGTTGACAGGCGACCCTGTGGCCC GGGGAAGCGCGGGAGGGCGCCGGCGGAAAGTTGAAGAGCG TTTTTCTCGCCGCCGCGTGCATTAGGAGCTCGACGAGTCC GCCCTGGGCTTCCTGGTGGGGCTGGGCGGGCGGGGGAGGG GCCGCGCAGCAGCAGCGGAAGCCAGACCTCGGCGATAAGA GGCTGCACAGCGACATGCAACAGTCTTTTCACTGCAGCTG AATGAGTTGTGGCGCCCACAATGCTCCCATGACAAGGAGC TGACAAGTTCCATTTTCCGTCGCGGGCATCTTGGAATCAT GACTCCCACAATGCCTTGGGCACTTGGTCGACAGTGGGGC CGCCTCTGAAAAAAAAATGTGAGAGCAGTCACTCAGGAAA TGTTGTTTAAGGGGAACCTTCTGGATCCTTTTCATGGCAC CATGGCAAGAAGAAGCTGTATCTTATCTATGGAAGATAAA GCATGGAGTTGGCTAATGGATGCTGATAGGACCATCTAGT TGCAGGAAAACAAGCTCAGGGCTCCCACTGATTCTACATT ATGGGCCGTTGCTCCAGGGAGAACTGCAAATATCTTCATC CACCCCCACATTTAAAAACGCAGTTGGAGATAAATGGACG CAATAACTTGATTCAGCAGAAGAACATGGCCATGTTGGCC CAGCAAATGCAACTAGCCAATGCCATGATGCCTGGTGCCC CATTACAACCCGTGCCAATGTTTTCAGTTGCACCAAGCTT AGCCACCAATGCATCAGCAGCCGCCTTTAATCCCTATCTG GGACCTGTTTCTCCAAGCCTGGTCCCGGCAGAGATCTTGC CGACTGCACCAATGTTGGTTACAGGGAATCCGGGTGTCCC TGTACCTGCAGCTGCTGCAGCTGCTGCACAGAAATTAATG CGAACAGACAGACTTGAGGTATGTCGAGAGTACCAACGTG GCAATTGCAACCGAGGAGAAAATGATTGTCGGTTTGCTCA TCCTGCTGACAGCACAATGATTGACACCAATGACAACACA GTCACTGTGTGTATGGATTACATCAAAGGGAGATGCTCTC GGGAAAAGTGCAAATACTTTCATCCCCCTGCACATTTGCA AGCCAAGATCAAGGCTGCCCAATACCAGGTCAACCAGGCT GCAGCTGCACAGGCTGCAGCCACCGCAGCTGCCATGACTC AGTCGGCTGTCAAATCACTGAAGCGACCCCTCGAGGCAAC CTTTGACCTGGGAATTCCTCAAGCTGTACTTCCCCCATTA CCAAAGAGGCCTGCTCTTGAAAAAACCAACGGTGCCACCG CAGTCTTTAACACTGGTATTTTCCAATACCAACAGGCTCT AGCCAACATGCAGTTACAACAGCATACAGCATTTCTCCCA CCAGGCTCAATATTGTGCATGACACCCGCTACAAGTGTTG TTCCCATGGTGCACGGTGCTACGCCAGCCACTGTGTCCGC AGCAACAACATCTGCCACAAGTGTTCCCTTCGCTGCAACA GCCACAGCCAACCAGATACCCATAATATCTGCCGAACATC TGACTAGCCACAAGTATGTTACCCAGATGTAGAATTTTCA TCACTAAACAATCATGCTAAAGAGGAAAGGACAGTGTGCT TGGTTAGAGTAAAGGACGAGGTCATTAGCCATATTGTATA TATCGTCAAGCAACACACACAAAAGTTCCTCAGCCACAAG ACATCCACATATTGCATGTTAACCAGAAGAAAAGACAACA TTTTCCGGAAATCCACTGCACACTGTTGCCTATACACTTT GTACATTTAATTGATATTTGTGCTGAGGTGATATTCCTGT CTAAAAGAACAACATTGTCTTTCTTTTCTAGCACAGAGTT ATGCATTCAAAGATGCATACCTAGTTAGTTTCCTATATAT TCATGCCATCTTGAAAAGACAGACTATGGTGTAACCATGA TTCTATTATGTATTGGTACGTCTGTAGACCAAGATATAAT TTTTTAAAAATAAGTTTATTTCTTTCAAGGTTTACAAATA ACAAAGGTGCACCTTGTATTTAAAATTGCCATTATAGATG AGAGCGTGCATGCACAGTCATTTTTGTTTAAGAGTAATAT TTTTAATGTAATAGATTGTAAGACGTGGTGAGGGAGGGAT CTGACAGAGATGAATGTGCCAAGCAAAACCACAACTGTGT ATATTTTAAAGCACATCATGGCTTTAAGTACCATGTTGTT AAGGATTCTCATGAAGTGCCATAGACTGTACATCAAATTA GAGTATTATTTCTTCAGTGTTATTGTTTTCAGAGCCACAT TTTGTTGCATATTTGCTAGTACTAATCAGTCAAAGGGCAC CATTCTTTTTTTTTTTTTTTGAAACCAAAGCTGTCTCAGA AATGGCCAATTTAACTTTACAGTAACAATAGACAGCACAA CACAAACTCTCTCAATACAGATAAACTCACACATACTGGA GATATATATATAATAGATATATATAAAATTATTTTAATGC ATTGTAGTGTAATATTTATGCATACTATACTGTATAACAT GTTATTCAAAAGGGATTGCCATTTCTGAGACACAGTAACA AAAAAATGAGGAAATTATTTTGCTTCTATTTATAGCCTCT GTCAAAAGTCAAAAGACTATAAATGCTTTGCAAAAATGGT TTCACGTTTGCTTAAATGCTTCATCACAGTCACATTCAAA ATAGTGACTCTAAACAAAGAAGAAAGCAGCACTGTCATCA GATGCATGATAAACCAAAATATGAAAATGGGAAATGTTTA ATTAACCTAGTAATTGGGTGGGTTAAGTACATGGGTGAAT TTTATATGTGATTTTTGTTTTGTTTTGTTTTGTTCAGATT AACTGCTTATAGCCTTAGAAAGCCTTTTACAAAATTAAAA AAAAAATAGATGTGCATTCAGTTTTTAAGAATGGAATCAT CCAAAGGAATTCCTTTTTTTGAGGTTTGGATGTTGCAGCT AGTAAAGGATATTTTTGCTCTGTTCAGCAGTTCTAAAAAT TGCTGAAGTAGGGGCCAGGTCACTGGTAGTTATAGTATGG AATGGGAGAAGTGAAAGTTCAGTTATAGAACTTTCCATAC TTCCAAGTTTACTGCAAGTTTTTATGCTTGAGAGAGATGC TTTCTAATATAAGACTGATGTGTTGATTTTACTGATTGTA CTGTACATCTATTAAAGCCTTAGATTATTACATTACGGGT TGGAACCCATACCAATGTAATTTCAATCGTGTTAAGAAAG TAATGGTGACTTCACATGTTATTGTAGTTAGTTACATTAT AGAATATTACTTATTTTTCTTGTTAAAATGTAGTTTTTCA TTTCCTACATTTATTAGATTTTCATTTTCTATTAACAATT GAATACCATTTCAGTTTATAGACTTGTTTTATTAGATTTT ACCAATGAATTTTTCAAAATACAAAAAAAAGTAGTTTTTC CTTCATAACATACTCAGTTTTGAATTACATGTAGTGTCAC ATGAATATTCGTATTGTTAACTAAATGATTTATATTTTAC TGATTTAATATTACAGTGTAAGAATGTCAGTCATTGTTAG TTCTTGTCTAGTTTTCATTAAAAGAACAAAGATCTTTTAT ATGGATATCTTATAAATATATAATCATTGCTAAGTAAGAA GTTAAGTTGTTGCTATCGCAACAATCCTGGCAGACAATTG AGTAATATTTTGATGATTTATTTTGTTTGTAATTAGTTAT TATAAGAAGATCTAGATCCTAGATATTAGAATAAAATTTA TTTTCTACTGTATCCATTTCAAATGTTAAAATATTGTTTA ATATTTTTGAAATCCCTGAGTATCAGGCCTTGTTATAAAT AAGCTGCATAATCAATAAATAGAACAAGGGACTTTTTGTT GATAATCCAAATACTCAAAGTTTACGTAATGAAAATTATA GCGTGTGTGCAAACTCTTGAGGGTTGATTATGCTGCAATT TAGCATGTTGGAACGTCTAGGGAGAAGGTTGACTTTTTGC ACTTCTGTATATAGTCAAAAGAGAGAAACCTGTATAATAG TAAGATCTTATTTTGAATAAAAACGTCTATAATTACAAGG AGTTTTGTTAAGGCTAATACAATGACAGACTGAGCAAAAT TGCTTGCAAAAGTGGCACAGAGTTAGCACTCCATACCCCT TCAAACATGTTGCTTTGCTTTCTTGTGGACAGCTTGTAGT TTGCCAGGATTTTTTCAGCTGGAAAGATACGCCATCCTTT CAAACCCTCATGACTGACAAAAACTCCATGGGGCCAAATC TGCCTGAAGATCATTACCAAAAATAGCAGGTACTTCTACC ATTAAGGTGAAATCATGGATCAGATATTCCTTACATTTTT CAAAACTACTGCATGTTTAAAACTTCAACAAAAAAAGAGA GAAAGAACTATACTAAGAACATATATTATTCAGATCAGTT TCTGCCAATTTCAGTGGTTTATTGTTCACAAAAAAATCTT CAAAACAAGTATTGACTTTCACAAAATTTAAATCATAAAC AGGCAAACCAAACAGCACACTGTAGCTATAGTTGTTATGT GATTGTTTTTTAATTGCTGTAGGATCCTGTTCTTTCAGCA GGTGAAAAATAAAACGCAGTTCAAATTTCATGGTTTTAAT TTTCAACTCAGAAGCACTCAAAAATGCAAAATGTGATAAT GGGCACTTGTTTAAAAGAATTAGTGTATCCAGCCTTCACT CCAGCTGGTTAAAAATGTTGCACTTATCAGCAACCCTACC ACTTTCATCTGCTGAAAGGACAAATGTGCTTGGTTTTACT ATTATGTAATCACAACTTACTTTCTGCTTGTAGTTGCTTA AAATTATGTATTTTGTCTTGGGCTGCAATTTGTTTTATGC TTATTTTATTATTACTGCAGTAGTTGACTTTGCTGTATGG AAAAATAAAGTGAAATTGCCCTAATAAAACTTCTCTTTCT TAAGTAAAAAAAAAAAAAAAAAAAAA MCL1 NM_001197320.1 GCGCAACCCTCCGGAAGCTGCCGCCCCTTTCCCCTTTTAT 12 GGGAATACTTTTTTTAAAAAAAAAGAGTTCGCTGGCGCCA CCCCGTAGGACTGGCCGCCCTAAAACCGTGATAAAGGAGC TGCTCGCCACTTCTCACTTCCGCTTCCTTCCAGTAAGGAG TCGGGGTCTTCCCCAGTTTTCTCAGCCAGGCGGCGGCGGC GACTGGCAATGTTTGGCCTCAAAAGAAACGCGGTAATCGG ACTCAACCTCTACTGTGGGGGGGCCGGCTTGGGGGCCGGC AGCGGCGGCGCCACCCGCCCGGGAGGGCGACTTTTGGCCA CCGGCGCCAAGGACACAAAGCCAATGGGCAGGTCTGGGGC CACCAGCAGGAAGGCGCTGGAGACCTTACGACGGGTTGGG GATGGCGTGCAGCGCAACCACGAGACGGCCTTCCAAGGCA TGCTTCGGAAACTGGACATCAAAAACGAAGACGATGTGAA ATCGTTGTCTCGAGTGATGATCCATGTTTTCAGCGACGGC GTAACAAACTGGGGCAGGATTGTGACTCTCATTTCTTTTG GTGCCTTTGTGGCTAAACACTTGAAGACCATAAACCAAGA AAGCTGCATCGAACCATTAGCAGAAAGTATCACAGACGTT CTCGTAAGGACAAAACGGGACTGGCTAGTTAAACAAAGAG GCTGGGATGGGTTTGTGGAGTTCTTCCATGTAGAGGACCT AGAAGGTGGCATCAGGAATGTGCTGCTGGCTTTTGCAGGT GTTGCTGGAGTAGGAGCTGGTTTGGCATATCTAATAAGAT AGCCTTACTGTAAGTGCAATAGTTGACTTTTAACCAACCA CCACCACCACCAAAACCAGTTTATGCAGTTGGACTCCAAG CTGTAACTTCCTAGAGTTGCACCCTAGCAACCTAGCCAGA AAAGCAAGTGGCAAGAGGATTATGGCTAACAAGAATAAAT ACATGGGAAGAGTGCTCCCCATTGATTGAAGAGTCACTGT CTGAAAGAAGCAAAGTTCAGTTTCAGCAACAAACAAACTT TGTTTGGGAAGCTATGGAGGAGGACTTTTAGATTTAGTGA AGATGGTAGGGTGGAAAGACTTAATTTCCTTGTTGAGAAC AGGAAAGTGGCCAGTAGCCAGGCAAGTCATAGAATTGATT ACCCGCCGAATTCATTAATTTACTGTAGTGTTAAGAGAAG CACTAAGAATGCCAGTGACCTGTGTAAAAGTTACAAGTAA TAGAACTATGACTGTAAGCCTCAGTACTGTACAAGGGAAG CTTTTCCTCTCTCTAATTAGCTTTCCCAGTATACTTCTTA GAAAGTCCAAGTGTTCAGGACTTTTATACCTGTTATACTT TGGCTTGGTTTCCATGATTCTTACTTTATTAGCCTAGTTT ATCACCAATAATACTTGACGGAAGGCTCAGTAATTAGTTA TGAATATGGATATCCTCAATTCTTAAGACAGCTTGTAAAT GTATTTGTAAAAATTGTATATATTTTTACAGAAAGTCTAT TTCTTTGAAACGAAGGAAGTATCGAATTTACATTAGTTTT TTTCATACCCTTTTGAACTTTGCAACTTCCGTAATTAGGA ACCTGTTTCTTACAGCTTTTCTATGCTAAACTTTGTTCTG TTCAGTTCTAGAGTGTATACAGAACGAATTGATGTGTAAC TGTATGCAGACTGGTTGTAGTGGAACAAATCTGATAACTA TGCAGGTTTAAATTTTCTTATCTGATTTTGGTAAGTATTC CTTAGATAGGTTTTTCTTTGAAAACCTGGGATTGAGAGGT TGATGAATGGAAATTCTTTCACTTCATTATATGCAAGTTT TCAATAATTAGGTCTAAGTGGAGTTTTAAGGTTACTGATG ACTTACAAATAATGGGCTCTGATTGGGCAATACTCATTTG AGTTCCTTCCATTTGACCTAATTTAACTGGTGAAATTTAA AGTGAATTCATGGGCTCATCTTTAAAGCTTTTACTAAAAG ATTTTCAGCTGAATGGAACTCATTAGCTGTGTGCATATAA AAAGATCACATCAGGTGGATGGAGAGACATTTGATCCCTT GTTTGCTTAATAAATTATAAAATGATGGCTTGGAAAAGCA GGCTAGTCTAACCATGGTGCTATTATTAGGCTTGCTTGTT ACACACACAGGTCTAAGCCTAGTATGTCAATAAAGCAAAT ACTTACTGTTTTGTTTCTATTAATGATTCCCAAACCTTGT TGCAAGTTTTTGCATTGGCATCTTTGGATTTCAGTCTTGA TGTTTGTTCTATCAGACTTAACCTTTTATTTCCTGTCCTT CCTTGAAATTGCTGATTGTTCTGCTCCCTCTACAGATATT TATATCAATTCCTACAGCTTTCCCCTGCCATCCCTGAACT CTTTCTAGCCCTTTTAGATTTTGGCACTGTGAAACCCCTG CTGGAAACCTGAGTGACCCTCCCTCCCCACCAAGAGTCCA CAGACCTTTCATCTTTCACGAACTTGATCCTGTTAGCAGG TGGTAATACCATGGGTGCTGTGACACTAACAGTCATTGAG AGGTGGGAGGAAGTCCCTTTTCCTTGGACTGGTATCTTTT CAACTATTGTTTTATCCTGTCTTTGGGGGCAATGTGTCAA AAGTCCCCTCAGGAATTTTCAGAGGAAAGAACATTTTATG AGGCTTTCTCTAAAGTTTCCTTTGTATAGGAGTATGCTCA CTTAAATTTACAGAAAGAGGTGAGCTGTGTTAAACCTCAG AGTTTAAAAGCTACTGATAAACTGAAGAAAGTGTCTATAT TGGAACTAGGGTCATTTGAAAGCTTCAGTCTCGGAACATG ACCTTTAGTCTGTGGACTCCATTTAAAAATAGGTATGAAT AAGATGACTAAGAATGTAATGGGGAAGAACTGCCCTGCCT GCCCATCTCAGAGCCATAAGGTCATCTTTGCTAGAGCTAT TTTTACCTATGTATTTATCGTTCTTGATCATAAGCCGCTT ATTTATATCATGTATCTCTAAGGACCTAAAAGCACTTTAT GTAGTTTTTAATTAATCTTAAGATCTGGTTACGGTAACTA AAAAAGCCTGTCTGCCAAATCCAGTGGAAACAAGTGCATA GATGTGAATTGGTTTTTAGGGGCCCCACTTCCCAATTCAT TAGGTATGACTGTGGAAATACAGACAAGGATCTTAGTTGA TATTTTGGGCTTGGGGCAGTGAGGGCTTAGGACACCCCAA GTGGTTTGGGAAAGGAGGAGGGGAGTGGTGGGTTTATAGG GGGAGGAGGAGGCAGGTGGTCTAAGTGCTGACTGGCTACG TAGTTCGGGCAAATCCTCCAAAAGGGAAAGGGAGGATTTG CTTAGAAGGATGGCGCTCCCAGTGACTACTTTTTGACTTC TGTTTGTCTTACGCTTCTCTCAGGGAAAAACATGCAGTCC TCTAGTGTTTCATGTACATTCTGTGGGGGGTGAACACCTT GGTTCTGGTTAAACAGCTGTACTTTTGATAGCTGTGCCAG GAAGGGTTAGGACCAACTACAAATTAATGTTGGTTGTCAA ATGTAGTGTGTTTCCCTAACTTTCTGTTTTTCCTGAGAAA AAAAAATAAATCTTTTATTCAAATACAGGGAAAAAAAAAA AAAAAAAA NFKBIZ NM_001005474.2 CTCCTCTTGCCACGAGGTCAGACGGCGAGTTCTTAGAGAA 13 AAAGGCTGCTTAGCTGCTGCTTATCATGTAACCTCAAAAG GAAACTGATCGTCTTTCTCATGCTGTCACGTACTTGGGTT ATTATCGCTGATTACAGCTGGAAACAATTGATTTGCTCTT ACGTATTTGTGTGACTTGACTCTTCAAACACAAAGGTTAA CAGGAAGATCTCGAGGGCCCTGGCTGAACTTCACCTTTTG GCTTTCTTGGCCTGATGCTGAACTCTCGAGGTTGAGCCCC ATATGGGGGTTGGCAGGCAGCAGAGAGGCCCCTTTCAAGG TGTTCGGGTAAAGAACTCAGTGAAGGAACTCCTGTTGCAC ATCCGAAGTCATAAACAGAAGGCTTCTGGCCAAGCTGTGG ATGATTTTAAGACACAAGGTGTGAACATAGAACAGTTCAG AGAATTGAAGAACACAGTATCATACAGTGGGAAAAGGAAA GGGCCCGATTCGTTGTCTGATGGACCTGCTTGCAAAAGGC CAGCTCTGTTGCATTCCCAATTTTTGACACCACCTCAAAC ACCAACGCCCGGGGAGAGCATGGAAGATGTTCATCTCAAT GAACCCAAACAGGAGAGCAGTGCTGATCTGCTTCAGAACA TTATCAACATTAAGAATGAATGCAGCCCCGTTTCCCTGAA CACAGTTCAAGTTAGCTGGCTGAACCCCGTGGTGGTCCCT CAGAGCTCCCCCGCAGAGCAGTGTCAGGACTTCCATGGAG GGCAGGTCTTTTCTCCACCTCAGAAATGCCAACCATTCCA AGTCAGGGGCTCCCAACAAATGATAGACCAGGCTTCCCTG TACCAGTATTCTCCACAGAACCAGCATGTAGAGCAGCAGC CACACTACACCCACAAACCAACTCTGGAATACAGTCCTTT TCCCATACCTCCCCAGTCCCCCGCTTATGAACCAAACCTC TTTGATGGTCCAGAATCACAGTTTTGCCCAAACCAAAGCT TAGTTTCCCTTCTTGGTGATCAAAGGGAATCTGAGAATAT TGCTAATCCCATGCAGACTTCCTCCAGTGTTCAGCAGCAA AATGATGCTCACTTGCACAGCTTCAGCATGATGCCCAGCA GCGCCTGTGAGGCCATGGTGGGGCACGAGATGGCCTCTGA CTCTTCAAACACTTCACTGCCATTCTCAAACATGGGAAAT CCAATGAACACCACACAGTTAGGGAAATCACTTTTTCAGT GGCAGGTGGAGCAGGAAGAAAGCAAATTGGCAAATATTTC CCAAGACCAGTTTCTTTCAAAGGATGCAGATGGTGACACG TTCCTTCATATTGCTGTTGCCCAAGGGAGAAGGGCACTTT CCTATGTTCTTGCAAGAAAGATGAATGCACTTCACATGCT GGATATTAAAGAGCACAATGGACAGAGTGCCTTTCAGGTG GCAGTGGCTGCCAATCAGCATCTCATTGTGCAGGATCTGG TGAACATCGGGGCACAGGTGAACACCACAGACTGCTGGGG AAGAACACCTCTGCATGTGTGTGCTGAGAAGGGCCACTCC CAGGTGCTTCAGGCGATTCAGAAGGGAGCAGTGGGAAGTA ATCAGTTTGTGGATCTTGAGGCAACTAACTATGATGGCCT GACTCCCCTTCACTGTGCAGTCATAGCCCACAATGCTGTG GTCCATGAACTCCAGAGAAATCAACAGCCTCATTCACCTG AAGTTCAGGAGCTTTTACTGAAGAATAAGAGTCTGGTTGA TACCATTAAGTGCCTAATTCAAATGGGAGCAGCGGTGGAA GCGAAGGATCGCAAAAGTGGCCGCACAGCCCTGCATTTGG CAGCTGAAGAAGCAAATCTGGAACTCATTCGCCTCTTTTT GGAGCTGCCCAGTTGCCTGTCTTTTGTGAATGCAAAGGCT TACAATGGCAACACTGCCCTCCATGTTGCTGCCAGCTTGC AGTATCGGTTGACACAATTAGATGCTGTCCGCCTGTTGAT GAGGAAGGGAGCAGACCCAAGTACTCGGAACTTGGAGAAC GAACAGCCAGTGCATTTGGTTCCCGATGGCCCTGTGGGAG AACAGATCCGACGTATCCTGAAGGGAAAGTCCATTCAGCA GAGAGCTCCACCGTATTAGCTCCATTAGCTTGGAGCCTGG CTAGCAACACTCACTGTCAGTTAGGCAGTCCTGATGTATC TGTACATAGACCATTTGCCTTATATTGGCAAATGTAAGTT GTTTCTATGAAACAAACATATTTAGTTCACTATTATATAG TGGGTTATATTAAAAGAAAAGAAGAAAAATATCTAATTTC TCTTGGCAGATTTGCATATTTCATACCCAGGTATCTGGGA TCTAGACATCTGAATTTGATCTCAATGGTAACATTGCCTT CAATTAACAGTAGCTTTTGAGTAGGAAAGGACTTTGATTT GTGGCACAAAACATTATTAATATAGCTATTGACAGTTTCA AAGCAGGTAAATTGTAAATGTTTCTTTAAGAAAAAGCATG TGAAAGGAAAAAGGTAAATACAGCATTGAGGCTTCATTTG GCCTTAGTCCCTGGGAGTTACTGGCGTTGGACAGGCTTCA GTCATTGGACTAGATGAAAGGTGTCCATGGTTAGAATTTG ATCTTTGCAAACTGTATATAATTGTTATTTTTGTCCTTAA AAATATTGTACATACTTGGTTGTTAACATGGTCATATTTG AAATGTATAAGTCCATAAAATAGAAAAGAACAAGTGAATT GTTGCTATTTAAAAAAATTTTACAATTCTTACTAAGGAGT TTTTATTGTGTAATCACTAAGTCTTTGTAGATAAAGCAGA TGGGGAGTTACGGAGTTGTTCCTTTACTGGCTGAAAGATA TATTCGAATTGTAAAGATGCTTTTTCTCATGCATTGAAAT TATACATTATTTGTAGGGAATTGCATGCTTTTTTTTTTTT TTCTCCCGAGACAGGGTCTTGCTCTGGCGCCCAGGCTGGA GTACAGTGGCATGATCTTGGCTCACTTCAGCCTTGACTTG GGCTCAAGTGATCCTCCTACCTGAGCCTTCTGAGTAACTG GAACTACAGGTGTGCACTCCTCGCCTGGCTAATTTTTTAT TTTTTGTACAGGCAGGATCTTGCCACCTTGCCCAGGCTGG TCTTGAACTCCTGAGCTCATGCCATCTGCCTGCCTTAGTC TCCCAAAATGCTGGGATTACAGGAGTGAGCCACCATGCCC GGCTGGCAGTTGCATGGAAGAGAACACCTCTTTATGGCTT ACCCTCTAGAATTTCTAATTTATGTGTTCTGTTGAAATTT TTGTTTTTTTACCTTTATTGAAACAACAAAAAGTCAGTAT TGAAACATATCTTCCTGTTTTCTGTTGTCAAATGATGATA ATGTGCCATGATGTTTTATATATATCATTCAGAAAAAGTT TTATTTTTTAATAACATTCTATTAACATTATTTTGCTTGC CGCTGGCATGCCTGAGGAATGTATTTGGCTTTGATTACAC ACTAAGTTTTTGTAATAAATTTGACTCATTAAAAACCTTT TTTTTTTAAAAAAAAAAAAAAAGAAAATCTCATTAGTGAA CTTATCTTTGCAGCTGAGTACTTAAATTCTTTTTAAAAAG ATACCCTTTGGATTGATCACATTGTTTGACCCAGTATGTC TTGTAGACACGTTAGTTATAATCACCTTGTATCTCTAAAT ATGGTGTGATATGAACCAGTCCATTCACATTGGAAAAACT GATGGTTTTAAATAAACTAATTCACTAATATTAAAAAAAAA NR4A1 NM_001202233.1 TTCCTGGTGTAAGCTTTGGTATGGATGGTGGCCGTCTCCC 14 TACAGACTGGGAGCTGTTAGAGGGCAGGGATCCTAGCTGA CACATCTATGTCCTCGCCTTGGTTGGAGGCCTCCACCATG GACAGAGGCCAGGCCCTGCCCCTCCCAGGCAGCCTGGCTC CTTCTGCTGGGCCCTGAAGGCAGACGGGATAATGTGGTTG GCCAAGGCCTGTTGGTCCATCCAGAGTGAGATGCCCTGTA TCCAAGCCCAATATGGGACACCAGCACCGAGTCCGGGACC CCGTGACCACCTGGCAAGCGACCCCCTGACCCCTGAGTTC ATCAAGCCCACCATGGACCTGGCCAGCCCCGAGGCAGCCC CCGCTGCCCCCACTGCCCTGCCCAGCTTCAGCACCTTCAT GGACGGCTACACAGGAGAGTTTGACACCTTCCTCTACCAG CTGCCAGGAACAGTCCAGCCATGCTCCTCAGCCTCCTCCT CGGCCTCCTCCACATCCTCGTCCTCAGCCACCTCCCCTGC CTCTGCCTCCTTCAAGTTCGAGGACTTCCAGGTGTACGGC TGCTACCCCGGCCCCCTGAGCGGCCCAGTGGATGAGGCCC TGTCCTCCAGTGGCTCTGACTACTATGGCAGCCCCTGCTC GGCCCCGTCGCCCTCCACGCCCAGCTTCCAGCCGCCCCAG CTCTCTCCCTGGGATGGCTCCTTCGGCCACTTCTCGCCCA GCCAGACTTACGAAGGCCTGCGGGCATGGACAGAGCAGCT GCCCAAAGCCTCTGGGCCCCCACAGCCTCCAGCCTTCTTT TCCTTCAGTCCTCCCACCGGCCCCAGCCCCAGCCTGGCCC AGAGCCCCCTGAAGTTGTTCCCCTCACAGGCCACCCACCA GCTGGGGGAGGGAGAGAGCTATTCCATGCCTACGGCCTTC CCAGGTTTGGCACCCACTTCTCCACACCTTGAGGGCTCGG GGATACTGGATACACCCGTGACCTCAACCAAGGCCCGGAG CGGGGCCCCAGGTGGAAGTGAAGGCCGCTGTGCTGTGTGT GGGGACAACGCTTCATGCCAGCATTATGGTGTCCGCACAT GTGAGGGCTGCAAGGGCTTCTTCAAGCGCACAGTGCAGAA AAACGCCAAGTACATCTGCCTGGCTAACAAGGACTGCCCT GTGGACAAGAGGCGGCGAAACCGCTGCCAGTTCTGCCGCT TCCAGAAGTGCCTGGCGGTGGGCATGGTGAAGGAAGTTGT CCGAACAGACAGCCTGAAGGGGCGGCGGGGCCGGCTACCT TCAAAACCCAAGCAGCCCCCAGATGCCTCCCCTGCCAATC TCCTCACTTCCCTGGTCCGTGCACACCTGGACTCAGGGCC CAGCACTGCCAAACTGGACTACTCCAAGTTCCAGGAGCTG GTGCTGCCCCACTTTGGGAAGGAAGATGCTGGGGATGTAC AGCAGTTCTACGACCTGCTCTCCGGTTCTCTGGAGGTCAT CCGCAAGTGGGCGGAGAAGATCCCTGGCTTTGCTGAGCTG TCACCGGCTGACCAGGACCTGTTGCTGGAGTCGGCCTTCC TGGAGCTCTTCATCCTCCGCCTGGCGTACAGGTCTAAGCC AGGCGAGGGCAAGCTCATCTTCTGCTCAGGCCTGGTGCTA CACCGGCTGCAGTGTGCCCGTGGCTTCGGGGACTGGATTG ACAGTATCCTGGCCTTCTCAAGGTCCCTGCACAGCTTGCT TGTCGATGTCCCTGCCTTCGCCTGCCTCTCTGCCCTTGTC CTCATCACCGACCGGCATGGGCTGCAGGAGCCGCGGCGGG TGGAGGAGCTGCAGAACCGCATCGCCAGCTGCCTGAAGGA GCACGTGGCAGCTGTGGCGGGCGAGCCCCAGCCAGCCAGC TGCCTGTCACGTCTGTTGGGCAAACTGCCCGAGCTGCGGA CCCTGTGCACCCAGGGCCTGCAGCGCATCTTCTACCTCAA GCTGGAGGACTTGGTGCCCCCTCCACCCATCATTGACAAG ATCTTCATGGACACGCTGCCCTTCTGACCCCTGCCTGGGA ACACGTGTGCACATGCGCACTCTCATATGCCACCCCATGT GCCTTTAGTCCACGGACCCCCAGAGCACCCCCAAGCCTGG GCTTGAGCTGCAGAATGACTCCACCTTCTCACCTGCTCCA GGAGGTTTGCAGGGAGCTCAAGCCCTTGGGGAGGGGGATG CCTTCATGGGGGTGACCCCACGATTTGTCTTATCCCCCCC AGCCTGGCCCCGGCCTTTATGTTTTTTGTAAGATAAACCG TTTTTAACACATAGCGCCGTGCTGTAAATAAGCCCAGTGC TGCTGTAAATACAGGAAGAAAGAGCTTGAGGTGGGAGCGG GGCTGGGAGGAAGGGATGGGCCCCGCCTTCCTGGGCAGCC TTTCCAGCCTCCTGCTGGCTCTCTCTTCCTACCCTCCTTC CACATGTACATAAACTGTCACTCTAGGAAGAAGACAAATG ACAGATTCTGACATTTATATTTGTGTATTTTCCTGGATTT ATAGTATGTGACTTTTCTGATTAATATATTTAATATATTG AATAAAAAATAGACATGTAGTTGGAACTGAAAAAAAAAAA AAA PDE4B NM_001037339.2 ATCACATACCCTAAAGAACCCTGGGATGACTAAGGCAGAG 15 AGAGTCTGAGAAAACTCTTTGGTGCTTCTGCCTTTAGTTT TAGGACACATTTATGCAGATGAGCTTATAAGAGACCGTTC CCTCCGCCTTCTTCCTCAGAGGAAGTTTCTTGGTAGATCA CCGACACCTCATCCAGGCGGGGGGTTGGGGGGAAACTTGG CACCAGCCATCCCAGGCAGAGCACCACTGTGATTTGTTCT CCTGGTGGAGAGAGCTGGAAGGAAGGAGCCAGCGTGCAAA TAATGAAGGAGCACGGGGGCACCTTCAGTAGCACCGGAAT CAGCGGTGGTAGCGGTGACTCTGCTATGGACAGCCTGCAG CCGCTCCAGCCTAACTACATGCCTGTGTGTTTGTTTGCAG AAGAATCTTATCAAAAATTAGCAATGGAAACGCTGGAGGA ATTAGACTGGTGTTTAGACCAGCTAGAGACCATACAGACC TACCGGTCTGTCAGTGAGATGGCTTCTAACAAGTTCAAAA GAATGCTGAACCGGGAGCTGACACACCTCTCAGAGATGAG CCGATCAGGGAACCAGGTGTCTGAATACATTTCAAATACT TTCTTAGACAAGCAGAATGATGTGGAGATCCCATCTCCTA CCCAGAAAGACAGGGAGAAAAAGAAAAAGCAGCAGCTCAT GACCCAGATAAGTGGAGTGAAGAAATTAATGCATAGTTCA AGCCTAAACAATACAAGCATCTCACGCTTTGGAGTCAACA CTGAAAATGAAGATCACCTGGCCAAGGAGCTGGAAGACCT GAACAAATGGGGTCTTAACATCTTTAATGTGGCTGGATAT TCTCACAATAGACCCCTAACATGCATCATGTATGCTATAT TCCAGGAAAGAGACCTCCTAAAGACATTCAGAATCTCATC TGACACATTTATAACCTACATGATGACTTTAGAAGACCAT TACCATTCTGACGTGGCATATCACAACAGCCTGCACGCTG CTGATGTAGCCCAGTCGACCCATGTTCTCCTTTCTACACC AGCATTAGACGCTGTCTTCACAGATTTGGAGATCCTGGCT GCCATTTTTGCAGCTGCCATCCATGACGTTGATCATCCTG GAGTCTCCAATCAGTTTCTCATCAACACAAATTCAGAACT TGCTTTGATGTATAATGATGAATCTGTGTTGGAAAATCAT CACCTTGCTGTGGGTTTCAAACTGCTGCAAGAAGAACACT GTGACATCTTCATGAATCTCACCAAGAAGCAGCGTCAGAC ACTCAGGAAGATGGTTATTGACATGGTGTTAGCAACTGAT ATGTCTAAACATATGAGCCTGCTGGCAGACCTGAAGACAA TGGTAGAAACGAAGAAAGTTACAAGTTCAGGCGTTCTTCT CCTAGACAACTATACCGATCGCATTCAGGTCCTTCGCAAC ATGGTACACTGTGCAGACCTGAGCAACCCCACCAAGTCCT TGGAATTGTATCGGCAATGGACAGACCGCATCATGGAGGA ATTTTTCCAGCAGGGAGACAAAGAGCGGGAGAGGGGAATG GAAATTAGCCCAATGTGTGATAAACACACAGCTTCTGTGG AAAAATCCCAGGTTGGTTTCATCGACTACATTGTCCATCC ATTGTGGGAGACATGGGCAGATTTGGTACAGCCTGATGCT CAGGACATTCTCGATACCTTAGAAGATAACAGGAACTGGT ATCAGAGCATGATACCTCAAAGTCCCTCACCACCACTGGA CGAGCAGAACAGGGACTGCCAGGGTCTGATGGAGAAGTTT CAGTTTGAACTGACTCTCGATGAGGAAGATTCTGAAGGAC CTGAGAAGGAGGGAGAGGGACACAGCTATTTCAGCAGCAC AAAGACGCTTTGTGTGATTGATCCAGAAAACAGAGATTCC CTGGGAGAGACTGACATAGACATTGCAACAGAAGACAAGT CCCCCGTGGATACATAATCCCCCTCTCCCTGTGGAGATGA ACATTCTATCCTTGATGAGCATGCCAGCTATGTGGTAGGG CCAGCCCACCATGGGGGCCAAGACCTGCACAGGACAAGGG CCACCTGGCCTTTCAGTTACTTGAGTTTGGAGTCAGAAAG CAAGACCAGGAAGCAAATAGCAGCTCAGGAAATCCCACGG TTGACTTGCCTTGATGGCAAGCTTGGTGGAGAGGGCTGAA GCTGTTGCTGGGGGCCGATTCTGATCAAGACACATGGCTT GAAAATGGAAGACACAAAACTGAGAGATCATTCTGCACTA AGTTTCGGGAACTTATCCCCGACAGTGACTGAACTCACTG ACTAATAACTTCATTTATGAATCTTCTCACTTGTCCCTTT GTCTGCCAACCTGTGTGCCTTTTTTGTAAAACATTTTCAT GTCTTTAAAATGCCTGTTGAATACCTGGAGTTTAGTATCA ACTTCTACACAGATAAGCTTTCAAAGTTGACAAACTTTTT TGACTCTTTCTGGAAAAGGGAAAGAAAATAGTCTTCCTTC TTTCTTGGGCAATATCCTTCACTTTACTACAGTTACTTTT GCAAACAGACAGAAAGGATACACTTCTAACCACATTTTAC TTCCTTCCCCTGTTGTCCAGTCCAACTCCACAGTCACTCT TAAAACTTCTCTCTGTTTGCCTGCCTCCAACAGTACTTTT AACTTTTTGCTGTAAACAGAATAAAATTGAACAAATTAGG GGGTAGAAAGGAGCAGTGGTGTCGTTCACCGTGAGAGTCT GCATAGAACTCAGCAGTGTGCCCTGCTGTGTCTTGGACCC TGCCCCCCACAGGAGTTGTACAGTCCCTGGCCCTGTTCCC TACCTCCTCTCTTCACCCCGTTAGGCTGTTTTCAATGTAA TGCTGCCGTCCTTCTCTTGCACTGCCTTCTGCGCTAACAC CTCCATTCCTGTTTATAACCGTGTATTTATTACTTAATGT ATATAATGTAATGTTTTGTAAGTTATTAATTTATATATCT AACATTGCCTGCCAATGGTGGTGTTAAATTTGTGTAGAAA ACTCTGCCTAAGAGTTACGACTTTTTCTTGTAATGTTTTG TATTGTGTATTATATAACCCAAACGTCACTTAGTAGAGAC ATATGGCCCCCTTGGCAGAGAGGACAGGGGTGGGCTTTTG TTCAAAGGGTCTGCCCTTTCCCTGCCTGAGTTGCTACTTC TGCACAACCCCTTTATGAACCAGTTTTGGAAACAATATTC TCACATTAGATACTAAATGGTTTATACTGAGCTTTTACTT TTGTATAGCTTGATAGGGGCAGGGGGCAATGGGATGTAGT TTTTACCCAGGTTCTATCCAAATCTATGTGGGCATGAGTT GGGTTATAACTGGATCCTACTATCATTGTGGCTTTGGTTC AAAAGGAAACACTACATTTGCTCACAGATGATTCTTCTGA ATGCTCCCGAACTACTGACTTTGAAGAGGTAGCCTCCTGC CTGCCATTAAGCAGGAATGTCATGTTCCAGTTCATTACAA AAGAAAACAATAAAACAATGTGAATTTTTATAATAAAATG TGAACTGATGTAGCAAATTACGCAAATGTGAAGCCTCTTC TGATAACACTTGTTAGGCCTCTTACTGATGTCAGTTTCAG TTTGTAAAATATGTTTCATGCTTTCAGTTCAGCATTGTGA CTCAGTAATTACAGAAAATGGCACAAATGTGCATGACCAA TGTATGTCTATGAACACTGCATTGTTTCAGGTGGACATTT TATCATTTTCAAATGTTTCTCACAATGTATGTTATAGTAT TATTATTATATATTGTGTTCAAATGCATTCTAAAGAGACT TTTATATGAGGTGAATAAAGAAAAGCATGATTAGATTAAA AAAA P1AS2 NM_001324046.1 CGGAGGCGGAGCTCCCGCGCCGTTCACGTGACGGGCCCGG 16 CTGTAGCGGCGGCGGCCGCGGCGTCTTAAGCGGCGCCCAG TGCAGGATGGTGCTGGAGGCGGCGGCGGCCGTGGTGGCGG CAGCGTCGTTGGCGGCAGCGGGAGTGGGTGCGGCGGCAGC GGCGGCGGCGCCCGCGGGTGGTATAAAATGGCGGATTTCG AAGAGTTGAGGGATCTCCAGTACAATGTTGAATAGAAGCT GTGATGGGGGCATCCTGATCTTGTTCCTGATTTTAAAGGG AATGCTTTCAAAGTTTCACAAGTGGCTGTACCATTTTACA TCCCTACCAGCAATGTATGGAGTGATCCAGTTTCTCAGCA TCCTCGCCAGCATTTGGTGTTATCAGTGTTTTTCATTTTA GCCATTCTGAATATGGTTTCTAGTTTTAGGGTTTCTGAAC TACAAGTATTACTAGGCTTTGCTGGACGGAATAAAAGTGG ACGCAAGCATGACCTCCTGATGAGGGCGCTGCATTTATTG AAGAGCGGCTGCAGCCCTGCGGTTCAGATTAAAATCCGAG AATTGTATAGACGCCGATATCCACGAACTCTTGAAGGACT TTCTGATTTATCCACAATCAAATCATCGGTTTTCAGTTTG GATGGTGGCTCATCACCTGTAGAACCTGACTTGGCCGTGG CTGGAATCCACTCGTTGCCTTCCACTTCAGTTACACCTCA CTCACCATCCTCTCCTGTTGGTTCTGTGCTGCTTCAAGAT ACTAAGCCCACATTTGAGATGCAGCAGCCATCTCCCCCAA TTCCTCCTGTCCATCCTGATGTGCAGTTAAAAAATCTGCC CTTTTATGATGTCCTTGATGTTCTCATCAAGCCCACGAGT TTAGTTCAAAGCAGTATTCAGCGATTTCAAGAGAAGTTTT TTATTTTTGCTTTGACACCTCAACAAGTTAGAGAGATATG CATATCCAGGGATTTTTTGCCAGGTGGTAGGAGAGATTAT ACAGTCCAAGTTCAGTTGAGACTTTGCCTGGCAGAGACAA GTTGCCCTCAAGAAGATAACTATCCAAATAGTCTATGTAT AAAAGTAAATGGGAAGCTATTTCCTTTGCCTGGCTATGCA CCACCGCCTAAAAATGGGATTGAACAGAAGCGCCCTGGAC GCCCCTTGAATATTACATCTTTAGTTAGGTTATCTTCAGC TGTGCCAAACCAAATTTCCATTTCTTGGGCATCAGAAATT GGGAAGAATTACTCTATGTCTGTATATCTTGTACGGCAGC TTACATCAGCCATGTTATTACAGAGATTAAAAATGAAAGG TATTAGAAACCCTGATCATTCCAGAGCACTAATTAAAGAA AAACTTACTGCAGATCCTGATAGTGAAATTGCTACAACTA GCCTTCGGGTATCCTTGATGTGCCCTTTAGGAAAAATGAG GCTGACAATCCCATGCCGTGCAGTGACTTGTACACATCTG CAGTGTTTTGATGCTGCCCTCTATCTACAAATGAATGAGA AAAAGCCCACCTGGATTTGTCCTGTGTGTGACAAAAAAGC TGCCTATGAAAGTCTAATATTAGATGGGCTTTTTATGGAA ATTCTCAATGACTGTTCTGATGTAGATGAGATCAAATTCC AAGAAGATGGTTCTTGGTGTCCAATGAGACCGAAGAAAGA AGCTATGAAAGTATCCAGCCAACCGTGTACAAAAATAGAA AGTTCAAGCGTCCTCAGTAAGCCTTGTTCAGTGACTGTAG CCAGTGAGGCAAGCAAGAAGAAAGTAGATGTTATTGATCT TACAATAGAAAGCTCTTCTGACGAAGAGGAAGACCCTCCT GCCAAAAGGAAATGCATCTTTATGTCAGAAACACAAAGCA GCCCAACCAAAGGGGTTCTCATGTATCAGCCATCTTCTGT AAGGGTGCCCAGTGTGACTTCGGTTGATCCTGCTGCTATT CCGCCTTCATTAACAGACTACTCAGTACCATTCCACCATA CGCCAATATCAAGCATGTCATCAGATTTGCCAGGTTTGGA TTTTCTTTCCCTTATTCCAGTTGATCCCCAGTCTCACCTC ACCCTTAACAGCAAGCAGTACGTCTGTCACCACCACCAGC TCCCATGAAAGCAGTACTCATGTTAGTTCATCCAGCAGCA GGAGTGAGACAGGGGTCATAACCAGCAGTGGAAGTAACAT TCCTGACATCATCTCATTGGACTAAAGGAGGACTCACTTG ATTCTGGGAATCATTCATCAGAACTGCTTTTTCTTGGATC TCTAGTCTGTGGAAACGTTCTTTTTTTTTTTTTTTTAATA ATTTGGTATTTATTGAAAGTCAGATGGATTCTTTTGCTTT CTGAGGGGTGAACACAGAAGACTGCAACAAGAACCAAATG ACATGCAAGGATTTTTCTTAATTATGCTGTACTCTCAGCA TCAGATACATTCAACCATAACTGTATCTTCCTGAGAGATG GATTTCACTTTCATACGTTAATGGATGGAGTCTACAAATC AGTGAAAAAAGTTTTTGTTAAAATAAAGAGCAATAAAATT ATGTAAATATTCAAGTAACCTTTTTTCTAATTAAAAAAAA AATTGTAATCACTGATTCTAGAATGACAGCAACTTCTGTT TAACCTTACGTGAAGGAAAAAAAATATATGGAAAGAACTT AATGTTTGCTGAATGAGTCCTTTCCATGGAGATTTGCTCT GTTTCATTGAAGTAATGAAGTTTCAGTACGTGGCCAAAGC TTGGATTCCACTTTTCGTCCTGCATTTCCACTTTTCTTCG TGATTGCATCAAAGAAAAATGGCATTCGTGTTACTTGGTT TTTTTCCTGCTTATCATTTACACTTTGACGTTGTTTGCTA ATGAGTGCTGTGTGAAGTTCTGGGATTTGGCTACTCTTCA TTGGTGATTATGTTTAAAAGCACTATGCAGATTCTGCCCT GACATAAAGTGTGTTATTATGTTTTTAGTAATTGTACATT TTTCATTCTAGAGTTTTCTATAAATTTGAGGCTTGCCTTC TCAAAAAAGAAACTATGCAGCCATTGAATGAAATGTCTTT GGGGTACGGTGTGACTGGAATGTTTGTTAGAAATTTGTTC ACACTATCAAATATTGATATCTTGGAGCCAGCAGAAGAGC AGATTTTGGGAGGTGGTAATAACAAAATTTAATTTCTTCC CAACAACTTAATTTTCTCATTTATTTTACAGAATAGTAGT GAAATATTTGATGAAACTTTGTATTTTGGTAGCACTACAT AGAAAATGTGTTTTAGATTTATGATGATCATATTTCTCAC CAATGTAATTTCAGTCTCAGCAGTGATTTTCAAACTTAGG GAAAGGGACAGCATTAGATTTTTTTTTTTTTTCATTTTTT TAAAATGATATCTTACCTGAAACTACAAACGACAAAAGAG AATTAGAAATGTTTGAATTAAAGTGAAGAAGGGTTGGGGG AGATGGGCCTGAACCCACTTCCTGTCTCAATCCATGCTAC CCCAAACACTCCAGGGAACCTCTGAGGTTTTATTGGGTGC ACTTTGAAAATTTCTCTTCTATAGTGTGTTTGTTTGATTT TAAATCACAGAGAAAACTGGGTTTTACTCTTAGAGAAACA TTTTCATCCAGTTTTTTAGTTTGCTTCATTTGACTTCCTA AATCATTTTTGAGTTCACAAGGATTTGGTACTTTTCTGTT TAGCTTTCTCTCTCTAAGCTTTATCTACCTTAAAAACAAA GTCCTTTTTTTAATGGCCAGTCCAACCAATTGATTTCTCA AACTGAAGTGCCCAGGTGTGGACTCATCAATTTCCGTTAG AATAGGGACATCCTACTTAAGAGTTGGTGCAGCTCCAAGG AGCTGACTTGTCCTTGCTTGGGGTTTTTTTTTTTTTTCTT TCACCTTCTCAAGTTTCCATGGCCTTTGTGTGTTCTTTTT ATGTTGATTTAAATTCATATGGTTTTCCACAAATCCCTTC TTTGGCTACATTGTCTCCTTATTCAATGGATTATCCCTTT GTGGGGGCTGCTTATTTTAAAGATGTTGGGGGGGAAACAA ACCCAAATCTACGAGCAGTAGTTGCACATAGTTGCCAGTT TTACCTTCTTAGTCATTAGATTTCCAAACCATGTTGCAGT TTTTTGGTCCAGATATAGTATTTCTTTCTAATAAAGTTTT ATGTTGCTGCTCTAAATACAGATGCAATATTTATTGACTC TGTAATCAGATAGAAAAAACTTAACTTGGTTTGTGTGGTA TGACTTATAAAGAAATGATGTATATTTGTTATTTTGTTAC CCTTTAGATTGTCAGAGACTCCCCCAATTTAATCAACAAA GTTTTATAAAGTAAATGAAAATATTAATAGAAATTAGTTT ATTTACTTGGTTCTTATAACTGATATCTCTGTGCTTTTAT AATTGTGATTTGTTTTTTTGTTTTTTTTTCTATTTTCTGT GAACAGTTTTAATGTTCGGTTTTGGTGTTTTACACTGAAA TTACATATAAATTTTTAATTTATTTCATACAGGCAACTTG CATTTTAAAAAATACACTTTGAAGTTTATCATCTTGAAAT TGGGGCTTACGTTGTTTATCTGTCTTGAGCATTAGTACTT TATGACTTTGGCCTTATGGCAACATCATGATTATTAATCC GTCAGCCTTTAATGTGGTCACTGTTTCTTATCCAGACCCT GACTTTCTAGTAGTTTATTTTGCTAGCCCAGATTTCTGCT TAACCAAATATAAGGGAGTTTCAGAGGGGTGATCTTAGCT GTCACCTAGATTCTGTCAGCCAACCAGTGATTGTCTGGAA TATCTTAGGAAATGAACTGTAATTGTCAGCCTCCTAAAAT CAATTTTTTTTTTTTTTTTTTTGAGGCTGAGTCTTGCTCT TGTTGCCCGGGATGGAGTGCAATGGTGCGATCTTGGCTCA CCGCAACCTCCACCTACAGGGTTCAAGCGATTCTCCTGCC TCAGCCTCCCGAGTAGCTGGGATTACAGGCATGTATCACC ACGCCCAGCTAATTTTGTATTTTTAGTAGATACGGGGTTT CTCCATTTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAG GTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTTA CAGGCGTGAGCCACCGCGCCTGGCCAAAATAAAATGTTTT TATCTTTCTTCACTTAGAACTATGAAGGCCTTTTCTTGTT CTGGTAACCCCCCACAGTGTAATTGGTGCTGAAAATAGTT TCGTGCCTGAGGTCTGTTGTCACTCACTCACTTTCTGACA ATTAGGTGAGCCACTTGAGGATTTTCTGGCCTGAAGTTAT AAAAACTTGGCATCTGTCCTAAGGTAATTGTAAAGGCAAA ATGAAAGCATTGAGGTGAATTTAGGTTATATGGCATTTAT CTGGTAATGTGTTTCAGAAAAGCTAGAATGAAAATGTGAT GTAAGGGATAGCAAGTGTAGGTTGATTCATAATTCTTGGT ATAAAACCAAGTTTTCCTTAGTCTTGAGGAATTTGAAGAA AGGTAAAATGTTGGATTTTAAGCAAAGTAGGATTGACCAG AGACTGTTCTGACTTTGACATTCAGACCTTTCAGATGTTC TTCCTTCAGACCAGTCCAAGACACTCAGCATTTCCAGCCA AGTTGTCTTTTTTTTCTGCCAATAAAGTATTCATTAGTTG ACGTTTGTTTGTATTTTAAGTAAAGTCAATTTTTTTTAAA GCATTAATTTAATTCACGGGTATGCCTTTCATTTCTCTGG CCTTCAGTTGGTTTAAAAAAAAAAAAAAAAAAAAAAGCAC TTAGCCGGACCATTCTTTCTTTAGTAAACATTTTTATTTT CTTAATTTTTCCTGAAAGATTTTCTTCATTTTCATGGAAT GTCATAATGACACTACCATTATTTTCTAGCTCTTTGCATA ATAGAAAAATGTAGAGCAGTGCACCATTTAAACACGTCTG ACATTGGATTTAGTGGTCCTAGGTTCATGTGATTTGGGAG CCTTAAGTTGTTATTTAGATTGATTCAGCCTGATTCACCA TCTTTTTTACTACAGTTCTACATGAATGTGGTGAAACAGG TAGAAGAAAATTAAGCATTTCTCTGCTTTTGGAGTCTAAT GTTCCTGCCTAGTGACTGGTTTGTAACACCCCCCTCACCC CTACTTTGTTAGGAACCTGCAATTCCTAAAAGAAATAAAT AAAGCTGTACCCAATGTCCATTCTTTAATGCTTGCCTGGT TGAATAATGTTTGTTTTTTCTGTTTATGTCAGTAGTACAT GCTTATTGTGGAAAATTTAGACAATACAGAAAAGTATAAC AATTAATTGCCTATGATTCTGTCACCAGAAAAAATCACTT GATATTTTTGCATCTTCCTTGCCATTGTCTTTGCTACTTC TGCATATTTTTACTTAGTTTCATCATTCTCAGTGTAATTT ATATCTTGGGGTTTTTCCCCGCAACCTACAGGCATTATTC CATGTCATTAAAACTGTGTCAACTATTATTAATTTTATGG TACTCCATTGTTATGGATGTGCCATGTTTCATATAACCTT TACTTATTTTGAACAGTTTAGATTATATCTCATAATGCCA CAATGAATGTCTTTGTGTATAAATTATTTTCTTAGGATAA AATACTGGAGGTGGAATTTCTAGTCAAGGGTATATGAACA CTTTTGTAGTTCTTGATTCATACCACTTTTCCACATGGGT ATGTTAATTTATACTGCAGCTAGATGGTATGGGAAGGGTG GTCTAGCCATATTTTCCAAGAACATGCAACGTTTTATCTT TATGCAGGCATCTGCACTAAGACCCTCTGCCTTTCTGACT CTATGGAACGGGGTTAACTGATATGGAGATCATTGGCAGA GATTTTCCCAAGCTTTCTTAGTTTTAAATATATCTGACAT GGGCCGGGTATGGAGGCTCACGCCTGTAATCCCAGCACTT TGGGAGGCCAAGGCGGGCAGATAATCTGAAGTCAGGAGTT GGAGACCAGCCTGGCTAACATGGAACATGGTGAAACCCCA TCTCTAGCAAAAACATAAATTAGGTGGGTGTGATGGCAGG CGCCTGTAGTCCCAGCTACTTGGGAGACCGAGGCAGGAGA ATCGCTTGAACCCAGGAGGCGGAGGATTTGCAGTGATCCG AGATTGTGCCACTGCACTCCAGCCTGGGTAACAAAGCAAG ACTCTCTAAAAAAAAAAAAAAAAAAAAAAAAAAATATATA TATATATATATATATATATATAAAATCTGACATGTTTCAG AAACACCTACGTATGGCTATCCAAGCTTTTCCCATGATTT TACTGGCACTGTAAAGTTGCACAAATATTCTTTGTCAGAC TACGTTTTCCATCTTTAGTTCAAAAGTTTTGTCACTTTTT AAAAAAAGCCTCTTGTACCTAAGGCCTGCCCTTAAGAGGT CAGCTCTCTTTTTCCTCTTCCTGTAGGCCCCATTATGGCC TTTCTGAGCTCCCCAAAGCCAGTAGAATCTACTGAGCCAA AGGCATTCCATCCCCAAACTGAAAAGTGGTAAGGCTAAAA GCTATAAAAACAGGCAAACATTGCCTGTTTTCACTTTATA TTCCCTTATGTTTCCAATAAGGGTAGCTGCAGGGAAAGAA AAAAACAGATTGCTACCTTCAGATGTTTGAGGTACAACAT TTTCTTGATTGGCGTAGCACAATCATTTCCCAAACTGCTT CCTATTTCTGAATGGCTTTTTTAAAAAGCTTTATTTTGTG TTCTCAAAGCTTAATTATTTTAAGTGACGAAGAGTGTTAC CGTGTTGTAGAATAGCATATGCCTCTTATTTTGGCCTTCA TCAAACTGTTTAATAAATGTTTAGAGTGTTTTGTAAGTAC ACGTGGAATAGAGTGTTACAGAAGTTTTGGTTCCAGACAT CAGGCAGCTTATAATCAAGGTTCCAAAAATCAAGAATTCT TAAGCTGGGCATGGTGGCTCATGCCTGTAATCCCAGCACT TTGGGAAGCCAAGGCAGGCAAATCACTTGAGGCCAGGAGT TTGAGACCAGCCTGGCCAACTTGGTAAAACCCCATCTCTA CTAAAAATACAAAAAATTAGGGCATGATGGCTCATGTCTG TAATCCCAGCTACTTGGGAGGCTGAGGGATGAGAATTGCT TGAACCTGAGAGGCGGAGGTTGCAGTGACTCAGGATCATG ACCCTGTACTCCAGCCTGGGTGACAGAGTGAGACCAAAAA AAAAAAAAAAAAAAAAAAAAAAAAGTAACAGGCATTGTGC AAAGAATTTTCCAAGAATGTCTCATTCTTGCAATGGCTTC TCAGAGGAAAGTGGTGTTATTCCCCATTTTACAAATGAAA CAGGTTTAGGTAAGTTTCCCAAGGTCACAGTGAATGAGTA GTGGACTTGGGAGTCTGACCTAGACTTACCCCAAAAGCTC TCTGCGTAAACTGAAGTGACGTTAATTAGCTGTGCTATCT AGGAGACTGATATGGGAATCTAGACTTAAAATTATGAGAA CTGGTTTCAGATGATGGCCAGAGTAATAAGGAAGGAGTGG ATGCTGAAGCCATTTCAAAGGAAGACTCAAGATTCAGTGA CTGAATATAGGAGTAAGGGTTGAGTGCATTTTTCATCCAT TTTTCAAGCCTGGGTAACTTGGATGTTAATGGCACTATCT ACAGAGACAGGAGGCAGTTTAGAGTGAAGACGAATCATGT ATGGGAGACAGTGATGAATGTTAAGCATGGGATTTCAGAA ATGAAGCATCCATGAGGCTCATTCCTGGTTTTTCTGCAGT CTTTTAAATAAAAGTACAAACCTCCCTTGTCATCCATTTT TGCCTTCACTTATCTCCATTCTGTATTATGTTCTAGTCAC GCCCCAGTCACTGATCCCTTCCTAGGCCATACTTGGCTAC ATCTTAGCCTTTTCTTTTGATTTTTCTCTTCACTGCCTTG CCCATTACAAATTTGGCTGCCACCTGAGGCCCTGCCATAC CCTACAGCTCACACCAGCGTGGGCTGTGTTCACATTCTAC ATATCTCAAGATACAGTGGTTGCTGTCCTTCCCCCCTACT GCATCGTTACACGTCTCTAAAAAATCTCTGCCTCTGAAGC TCATGCCAAGAGGTTATACTATCAGCTACCTCTAGTCTTA TAACTGCCTGATCATTCCCTTTGATTTGCTGGAAGCTTTG ACTCACAGTGTTCCTTGCCTTCCTTGATTCTGGTCATTAT TATTAATATCTTGAACATTCTATAGATGATTTATCCAAGT TGGTCTGTGAGGTATTGGTTACTTTACCTCCAGCATTTTC GTCTACTGAACCACGCTTTCTGTTTTCCTCTTTGCTACTT GTCCAGACTGTTCTTTCATTATTGCAGCCTTGAAGAAATC CTCAGTAACCTATCCATCCTCCGACATGACGTAGCATAGT TCCTTTGCCCATTCTCATCAGTTATAACAAATGTTATTGC CCTCTTTTCAGGCCACTTCCTTCTCAGAAGATGACTTTGC TGCTTAATTCAAACAGAAGGGACAGTCCGAAAGCATGATT TCTTCCCCACCTATGACCACCTCCATCCTTTTTTGTTTCC AGTTTCAGAGAATGAGGTAGGCCTTTAAGGCCAACTGACT CTGGTCTCCTCCTGTCATCTTCAGGACCTTCCTCTGTCAG ACTTCCCCTCTCTTATCTCCATGTCTCTCACCTCTCTACT GCTGCTTTTCTTGGCTTACAAATGGTCTCAGTCATCCAGT ATTTGAGATTATATTAGGTGCCAGGCATTGTATCAGGCAC TTGGAACACAAGGCAGGATCCTGCCCCCACCAAAGTTGTG CTCCAATAGCGTCAACAGAGGTGTGAAATAGGGAGATTAC AATGTTAATGGTAAAAGACAAAGTATAGGGTGCTACAAGA GCATGTAAATGAGGCACCTCAATGATTTAATAGAAGTAAT GTGGAGAAATGTGAGGATTGATGAAAAGCTTGTCCAAAAA GGGCCAGAAATGTTTAGAATTGCTGGAAGTTTGCTAAGGA ATATTGAGAAATATGCATAGATAGATCGTGAAGGGCCTTG TAAAACAGTGATGAGACATTGAAGAGTTTTCATGATCATT AGTAGTAATGAGAATTTGTTGAGTTTGGCATGATTATCTC CATATTACAAATGTGGAAACAGATTCTGACAGGATAAGCG ACTTACTTGCCCAGGGTCATGCAGCTTGTAATTGAGGAGT CAGGTTTCAAATCCAGTTTTAACTACTTTCTCAGAGGCCT TTCTTGATCATTCTATCTAAAAAGCAAGTGTTCCCTAACT ATTATCCCAGTACCCTGGTTTATATACTCTTAATACATAA AATAATCCCTGCATATTGTGTGTTTCCCCTACTAGATTGT AAGCTCCATGAGGGCAGAGGTGATAACTTTTTTCACTTGC ATCCCAGAGCCTAACATGATATGGGCTACATAGAAGGTGC CCAGTAAATATTGGTGGATGAAGAAATGGTGGATAACCAT TTGCATTTGACTTATGCTGACTGGAAATTCAATACCTTTG GAATATATAATACCTCAGCAGTAAGCATTCACCAAGAGAG GAAAACAGAAGGAGGTGCATGTTTAGGGTAGGTGGTACGG GAGATGGATGCTGAGGTGTTGAAAGGCAGCATACTCACCT TCTGAACTCCAAAACTTACAGGGGCAAGGGCCATTAATGA GGGGTGGGTAGAGCAGTGCACAGTGGGGATAATATGGGAG TAGGTGTATTAAACCTGGAAGTGTAAGCAACTCCTTGTAG ACCCACCCTACTGTGTATAAAAGGCTGGAGAAATTCTTCA TATGATCTACTCTAGGTTATGTACTGAGGACCACCTTATC TGGGTCAGGTACACTACACAGAGTGCTACAATATAATTGT AAACATAATTTATCCTCACTGTGATGGCTAGCCACCTGAC CCAAATCATTATTAGACTCAATACTTTGGAACTGGAACAA AAATCAGTTGACCTGATGTCTGAAAGACATGCCCACCTGC TATTTGACAAGCTATAGACATATCCTACCAATTGATGGGT AGTAGCACTGAAACTATGAAAGTGGATGAACTCATCCAGA GGAGTTGATGAGTGAGAAAAGAAGACTGGAAAAGGAACAC AAGGAAATCAAGAAGCAGCAGCTGAGACTGAAGGAAAATA ACGTGGTATTACAGAGGCCAAAAAATAGAGTATTTCAAGA AGCAAGTGGTTAGTGGAGTTAAAAGCTGCTGATACAACCT AAAAAAGTAAGTATCCATTTTTTAAAAAACTTTCATTTAA AATACCACCATATTTTATTGAATCTAAGTACCTGATTGTA AGACATTAAAGAAAAATTAAACCTGCTAATTAAA PRKAA1 NM_006251.5 AGCGCCATGCGCAGACTCAGTTCCTGGAGAAAGATGGCGA 17 CAGCCGAGAAGCAGAAACACGACGGGCGGGTGAAGATCGG CCACTACATTCTGGGTGACACGCTGGGGGTCGGCACCTTC GGCAAAGTGAAGGTTGGCAAACATGAATTGACTGGGCATA AAGTAGCTGTGAAGATACTCAATCGACAGAAGATTCGGAG CCTTGATGTGGTAGGAAAAATCCGCAGAGAAATTCAGAAC CTCAAGCTTTTCAGGCATCCTCATATAATTAAACTGTACC AGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGA ATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAG AATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCC AACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATAT GGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTT GATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTT CAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTG TGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGA AGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTG GGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATT TGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGT GATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTG TGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCAT GAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGG TTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATC CATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAA AGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTT CTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGG CAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAAT GAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCT GATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATC CTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGC ACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAA CACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTA GAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATG TAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTA AACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGA CAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGT GGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGAT GATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCAC AGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAG GAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAA GTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTC CTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGA ATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCA CAATAAACAGAAAACTTTGCTTATTTCTTTTGCAGCAATA AGCATGCATAATAAGTCACAGCCAAATGCTTCCATTTGTA ATCAAGTTATACATAATTATAACCGAGGGCTGGCGTTTTG GAATGCAATTTGCACAGGGATTGGAACATGATTTATAGTT AAAAGCCTAATATGCAGAAATGAATTAAGATCATTTTGTT GTTCATTGTGCAGTATGTATATAGCATAATATACACAGTG AATTATAGGTCTCAGGCTTACTTGATTTTTGGCTATTTTA TATTTAGTGTACACAGGGCTTTGAAATATTAATTTACATA AAGGCCTTCATATATTATTACGTGTTATATATTACGTGTT ATAAATTTATTCAATAAATATTTGCCTAGAATTCCCAAGA CCTTTATAGGTGATTTTGTTTTCTGGGCTCCTTAACTTCA TAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGAT AACTTCTTCCATATCCCTCCCTCTTTGTTTTTTTGAGACA GTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGT CTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGAT TCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCG TGTGCCACCACACCCGGCTAATTTTTCGTATTTTTAGTGT AGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACT CCTGACCGCGTGATCCACCACCTCAGCTTCCCAAAGTGGT GGGATTACAGGCGTGAGCCACCGCACCCGGCCTCCATATC CCCCTTTTAAAATTCTGTAGTGTATGGTAAGTCATATCAG ATATCAGACCTAATTTAAATTTCATTTTAGCTTTACAAGT CCAAAAACACAGAATTTATATATTCAGATACTCTAGCACT AATTTTAGTCTTAAAATATTCCCACGATATTCTGTACACA AAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATATACTG TAGATAAATCATATTATTTTTGCCAATTTCACAAATTCCT CTGGCCCATCATGTCAGTCATTATTGAGTATATGCACACA TTGCTACTTATTTGATTATGTATCTTTTAAATTGATTCAG TGCATAGAAAACTATCTCTTACAAACTTTAAGTGCTCTGA TATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAA AACAGAAAAATTGAAAAACTGTTTGGTAAGCACATGTATA TCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATT TGTTTTCTCTATACCTATATATGTATAGATACAGCTAGTT ATGCATATATATGCATATATGTGTTTGTTTGTGTATGTAT ATATGCTTTTTTCCCCCTGAACCATTTGGATGTTACAGAC ATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAG ATAATGACATTCTCCTAAAAATCCGTAATACCATTGTAAA AGTAATAATTCCCCAATATCATCTAATCAAGCCATATTTA AATTTCTGAAGTTAACTCCAAATTTCTTTATAGCTGATTA TTTCAAACTAGGATCCAATTAAAGTTTACATATGACACTT GGTTATAACTCTTTAGTTGGATATAACATTATTATTATTT TGATAAAATATGGAACAAATCAATTCTATTAATAAGTGGT CACATTTGTTTTGGGCTTAAATTACTTTTTAAAGATACTG GATTTTCCTAAGATTTCTGATTTACACTGATATTTTTTTT TGTCATTCTTAATTGCATCACACAATAGATGTAAATGAAG ATGTAGTCACCTCAGATAAAATTGGTATCGTGTATGATAA TATTGTATCATTTATATTTGCCTTATGTTAACTTTAAGAA ATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGA GCTATATTTTTTCTATTTTAAGAATCATATTTTAGGATTA TTTTTGGCAAATACAGTGAGCACTTATGTAACCAGATGAT AATGAACTCAAATGTCATGATAGCTTGCATAAATGGTGAC TCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACT GAATTCAAAAGAAAAATCTTGCTGCTTTTTGTCCAGGGCT TGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAA TAGAAGTTCCATTTAAATATGAGTTCAAAACTGTATTTAC TTTTTATGTGGCCCTCTCTTTAGGGGATTCTAATTTTACT TAGGGTCTCTAAGTGCAGCATAATGTTCCTGATGTTAACA GAAGACTGTATTTTTAAAGTTACAAATTTGTATATGGAAT TAAGTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGA AGAAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAATT GTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTATTGTG ATTCATTTTAGTTACTGTGTTTTATTTTGAAAATATTTAA ATATTGCACTTCTATAAATAGTATGATAAATGCACAGACA ATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGAAATG ACAACCTTTGGTTAAGTGTGTCAAGGTTGCAACAGAATTT TCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTG AAGAGGTAAGGGAGGCAATGCAAATGATTTTTAATCTTTT TTTATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTA TGCAACCATATTTTTACTTTGTCTTGACAACTGAAAGATG TATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTT TAAGTATAACAGATTTTACTGATATGTAAAAATTTTGCCA TTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACC AGGTTGGGGCATATGGGAGCTTAATATATCATATCTAATT TAAAATAATTTCACTGAAATAAACTCCATTGCTTTTACCT AATTTTTTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTT TAGATGATTTTATACAAAATCCTCTGCCTAGCACTGCTCT TTTTGATGTTGTAGTGACACCATTTACATTGAATTAATGC TTGGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTGT GTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGC TGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCATCTTCT CACCCATAATAGAAATTTTATTTCCATTGTGAGTTCTGAC AAGAATGAAATTCCACATACAACATAACTGTAAATTGTTG GTAGGTAGAAGTTAATATTTGTGGTTCATGTATATTTTGA CCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATT TAGAAATATGATATAATAAAGAAAAACTCCATTTATCATC TGTTA SCYL2 NM_001317784.1 AGGAAGTGACGTCATGCCCCCGGCCGGCAGGTCTTTTAGT 18 CTTTTTCCCCCTCCCTTACTCTTCGTCCCCGGTCCCTCCC CTCCCCACCCCTTTCCTTCTAGCTCCGACGTTTGCGGCCG CGGGGGCGGCGGAGGATATGGAGTAAAGCCAGAGTCAGTG GCCAGGCACGAAGGCAGAGCAGGAACAGCCAGGAGGCGTT TATTAGGGGGGCGGGGGGAAAGAGCCCCAGCACCGCCCCT CCTGGAAGAAGGAAGAGGTAACTATAACTACCCAATATTG CAGCCATGGAGTCCATGCTTAATAAATTGAAGAGTACTGT TACAAAAGTAACAGCTGATGTCACTAGTGCTGTAATGGGA AATCCTGTCACTAGAGAATTTGATGTTGGTCGACACATTG CCAGTGGTGGCAATGGGCTAGCTTGGAAGATTTTTAATGG CACAAAAAAGTCAACAAAGCAGGAAGTGGCAGTTTTTGTC TTTGATAAAAAACTGATTGACAAGTATCAAAAATTTGAAA AGGATCAAATCATTGATTCTCTAAAACGAGGAGTCCAACA GTTAACTCGGCTTCGACACCCTCGACTTCTTACTGTCCAG CATCCTTTAGAAGAATCCAGGGATTGCTTGGCATTTTGTA CAGAACCAGTTTTTGCCAGTTTAGCCAATGTTCTTGGTAA CTGGGAAAATCTACCTTCCCCTATATCTCCAGACATTAAG GATTATAAACTTTATGATGTAGAAACCAAATATGGTTTGC TTCAGGTTTCTGAAGGATTGTCATTCTTGCATAGCAGTGT GAAAATGGTGCATGGAAATATCACTCCTGAAAATATAATT TTGAATAAAAGTGGAGCCTGGAAAATAATGGGTTTTGATT TTTGTGTATCATCAACCAATCCTTCTGAACAAGAGCCTAA ATTTCCTTGTAAAGAATGGGACCCAAATTTACCTTCATTG TGTCTTCCAAATCCTGAATATTTGGCTCCTGAATACATAC TTTCTGTGAGCTGTGAAACAGCCAGTGATATGTATTCTTT AGGAACTGTTATGTATGCTGTATTTAATAAAGGGAAACCT ATATTTGAAGTCAACAAGCAAGATATTTACAAGAGTTTCA GTAGGCAGTTGGATCAGTTGAGTCGTTTAGGATCTAGTTC ACTTACAAATATACCTGAGGAAGTTCGTGAACATGTAAAG CTACTGTTAAATGTAACTCCGACTGTAAGACCAGATGCAG ATCAAATGACAAAGATTCCCTTCTTTGATGATGTTGGTGC AGTAACACTGCAATATTTTGATACCTTATTCCAAAGAGAT AATCTTCAGAAATCACAGTTTTTCAAAGGACTGCCAAAGG TTCTACCAAAACTGCCCAAGCGTGTCATTGTGCAGAGAAT TTTGCCTTGTTTGACTTCAGAATTTGTAAACCCTGACATG GTACCTTTTGTTTTGCCCAATGTTCTACTTATTGCTGAGG AATGCACCAAAGAAGAATATGTCAAATTAATTCTTCCTGA ACTTGGCCCTGTGTTTAAGCAGCAGGAGCCAATCCAGATT TTGTTAATTTTCCTACAAAAAATGGATTTGCTACTAACCA AAACCCCTCCTGATGAGATAAAGAACAGTGTTCTACCCAT GGTTTACAGAGCACTAGAAGCTCCTTCCATTCAGATCCAG GAGCTCTGTCTAAACATCATTCCAACCTTTGCAAATCTTA TAGACTACCCATCCATGAAAAACGCTTTGATACCAAGAAT TAAAAATGCTTGTCTACAAACATCTTCCCTTGCGGTTCGT GTAAATTCATTAGTGTGCTTAGGAAAGATTTTGGAATACT TGGATAAGTGGTTTGTACTTGATGATATCCTACCCTTCTT ACAACAAATTCCATCCAAGGAACCTGCGGTCCTCATGGGA ATTTTAGGTATTTACAAATGTACTTTTACTCATAAGAAGT TGGGAATCACCAAAGAGCAGCTGGCCGGAAAAGTGTTGCC TCATCTTATTCCCCTGAGTATTGAAAACAATCTTAATCTT AATCAGTTCAATTCTTTCATTTCCGTCATAAAAGAAATGC TTAATAGATTGGAGTCTGAACATAAGACTAAACTGGAGCA ACTTCATATAATGCAAGAACAGCAGAAATCTTTGGATATA GGAAATCAAATGAATGTTTCTGAGGAGATGAAAGTTACAA ATATTGGGAATCAGCAAATTGACAAAGTTTTTAACAACAT TGGAGCAGACCTTCTGACTGGCAGTGAGTCCGAAAATAAA GAGGACGGGTTACAGAATAAACATAAAAGAGCATCACTTA CACTTGAAGAAAAACAAAAATTAGCAAAAGAACAAGAGCA GGCACAGAAGCTGAAAAGCCAGCAGCCTCTTAAACCCCAA GTGCACACACCTGTTGCTACTGTTAAACAGACTAAGGACT TGACAGACACACTGATGGATAATATGTCATCCTTGACCAG CCTTTCTGTTAGTACCCCTAAATCTTCTGCTTCAAGTACT TTCACTTCTGTTCCTTCCATGGGCATTGGTATGATGTTTT CTACACCAACTGATAATACAAAGAGAAATTTGACAAATGG CCTAAATGCCAATATGGGCTTTCAGACTTCAGGATTCAAC ATGCCCGTTAATACAAACCAGAACTTCTACAGTAGTCCAA GCACAGTTGGAGTGACCAAGATGACTCTGGGAACACCTCC CACTTTGCCAAACTTCAATGCTTTGAGTGTTCCTCCTGCT GGTGCAAAGCAGACCCAACAAAGACCCACAGATATGTCTG CCCTTAATAATCTCTTTGGCCCTCAGAAACCCAAAGTTAG CATGAACCAGTTATCACAACAGAAACCAAATCAGTGGCTT AATCAGTTTGTACCTCCTCAAGGTTCTCCAACTATGGGCA GTTCAGTAATGGGGACACAGATGAACGTGATAGGACAATC TGCTTTTGGTATGCAGGGTAATCCTTTCTTTAACCCACAG AACTTTGCACAGCCACCAACTACTATGACCAATAGCAGTT CAGCTAGCAATGATTTAAAAGATCTTTTTGGGTGAGGTGT CTTACTTCTATTTTGAAGGATTATTTCAGTTTCAATCATG GGTGAGCTGATTTACATCTTTATATAGTTGGCTTGGAGGA AGTACTTCTATGGGAAAGTGAACAGTTCTGTGACAGGAAA CATCTCTGTCCATGCCAGCATAGTAGTTGTATGGACTTCT AACCAGTTGAGTTTTTTAAAGCATTGAGGATTTTTTCCTC TTACCAACTCCTCTTCAGGTTTTTAAAGACCCAGCCCTTC CCAATCTCAAAGAGAAAAAGGAAACTGAGTTATCTTGAAT AACATAACTTTTTAATCAAATGTTTATTTTGGCTTGTGGA TCTTGGTGTTATTTAAAAAATTGAGGTGATGGTCATTGCA AGCTCATCTATTAAGTACTATATGGTACACAGTCTATGAG TCATTAGTCTTCATTTTAATATGTAAAAAATCTTGATGCT GTATTGATTTGTTTGCATTTAAGATGACAGTGAGAAAATG ATAAGCATAAAGAGAAGTATCAGGTTATTTGCTTTTTCCA AACTTTTCAGATGAACTATTGTTTAGTACAGAGACTGAGC AAATACTACAAAATTCAACTTAACCTTCATTTCATTGGTT TAAATGCGTTATTAACCATCTTAAGTGCAAACTAATCATT GTAAATTATATTTTAGCATGGTCTGCCTCAAATAGTAATG TATTTTTCTGCATTCACTTGGATATATTTAGAATCACTTT TTTCCTCCTGTATCAAGGAAGAGGTATGTGCTGATTTGTT TGGATATTTGACAAGGCACTCTGATGTGACTTCCCTGACT ACTACCTTCATATTTCATTTCAAATTCAAACTTCTGAGGT TGCAGCATATATGAATTGCATTTTCAAAAGAAGATTTGTA AGAATTAAACTATATTTATGAGTAAACTTTTGAGGTTTCT GCTGTATTGTTTCAAATGTAATAAACTTTACTTCTGTAAA AATTGAGCAGTTGTATCTTCTGACCACCAACAGATTTTCA GCTTGCCATGATAGTCTGACCTCATTAATTACTGCTACTG AAGTTCAATTTTTTTCTAGGAATTTTAGGAACCTTTTGTT TAAATATTTTAATTTCTATTAGCCATTTTTAGGAAGGAAA GAATCAATTCTCTTAACAGGAAACATGCTTTATTTTTCAA AACCTTTCTCTGATATTTTTCTTTAATTTGCTGATTATTC AACCACAGAGCCTTATGCTATAAATGTCATTTGTATTTTA AAAAATAATATTCCACTCATAAAACTTTAAAACCATCTTT CAACGAACTATATATGTATTATAGTTGCTGCCATAGAGTT GATGGTTTTTAATTATCTGGAACCAGCAATCATTTAAAAT AAACCATATTAAGTTTAGTATGCTGGTATTGTTTATTCAT TTTATATGAATATTCATTGAAAATATATACACAATATATG TAATACACAGCACTTGATTACAAAATGTAATTTAATTATA TTATTGCTGGCAGCATTCAGTTAAGAGGGTACTTTAAAAA ATAGAAGTCAGCTTTCACATCTGATTTCTGTATGGGCTGT ACTTGGTTAACTTGATTTTAGAAAAAGGACTAACAGAATT GCTAAAGAAATGCATCCAATAAATGAAAAACAGTAGGAAG ATCAAATGTTTTTGTCAAATATATTCACAACTTGACCAGA TTAGCTGTCCTGTTTGTAATGCAATATTAATATGTCTTTT GGGAAAAAGCCTACATATGGAATAAAATAAGTATTGAAGA ATTTTTCTTTGTAACAATTTAGTAGTCACTGTTTATTGAG AAATTGTTTTTTATTTTGTAAAATAACATGATGTTAGTGT TGAACTCTTAAACAGAAAGAAAGCTTAATATAACAGCTTA TAGAACTTGAACTACTAAATATGAAAATAAGTCATTTGAA AAAAATACAGTATGTAAAATTTGTTCATTCGTTGAGGTAA TGGTGCTATGTTTTTACAAAATTGTTCCTACACCTTTTTT CTACTTCAGGTATTTTATTTCAACCATTTCCATCAATTGA ACTGTTACCATTGCCTTTTTCTGTTGAGAAATTGCCTCTG AAAAATAGTGCTATTTTTCAGCTTAAGTGTTCTTAAGTGA ATGAAATTTTCAAAGTACTAGATCACCTTAAAATTATTTC ACGTACTGAAGACAATTAAGTCCGTTATGTTTAGAGTAGA AAATGTTTAGGTTAAAGAGCATCTGTCAACAGAATCTACA AAAAAGATTCCCTTGCATTTGAATTAGTTCTCTATTCTCC TATTGCTAAATGTGTGATATATAGAGAGGATGTATAAAAG GAAATGGAAATAGACTATGTACTTGTCTGGTTTTTGTTTG TTTTTATTTTGGAATGCTTATAAGCCTCCTTTACACTGAA TAAGGAAGTAGTTTTTGTTTTCTTTTGACCTGTAAAATAC CTCACATGGTTGTTTTTACACATGAAAGAAAAAGGTATAT GCGAACATACCTGATATCAAGAGGAGTATGCACCAAATAA ATTTTAGCTTTGATAAAACTTTCCATAAAAAAAAAA SMARCD2 NM_001098426.1 GTTGGGCGGGGCAGGGAGTTCGTAGCCGCCTCTGGGTAAC 19 TCGACTCGGGCGGCCAAACCTCCGGAGGCCGGGGACGGAA GGCGGGCCCGCAGCAGATCCTGGATCCGGAATCTCCCGGG CAGGAGCGGAATCTGTCCCGAACCGGGTCTGTGAGGAACT CGCGAACTTGGATTAGGAAATCCCGGAGCCCGGATCGACA AATCCCGGAACCCGGAATTAAGATCGCCAAGTCCCGGATC GCGGAGCACAGAGCACGGAGTGGACTCGACGCGGAGCCCG GAGTCCGGATCGCGGCACCGCGGGACGGGACGGAGCGATG TCGGGCCGAGGCGCGGGCGGGTTCCCGCTGCCCCCGCTAA GCCCTGGCGGCGGCGCCGTGGCTGCGGCCCTGGGAGCGCC GCCTCCCCCCGCGGGACCCGGCATGCTGCCCGGACCGGCG CTCCGGGGACCGGGTCCGGCAGGAGGCGTGGGGGGCCCCG GGGCCGCCGCCTTCCGCCCCATGGGCCCCGCGGGCCCCGC GGCGCAGTACCAGCGACCTGGCATGTCACCAGGGAACCGG ATGCCCATGGCTGGCTTGCAGGTGGGACCCCCTGCTGGCT CCCCATTTGGTGCAGCAGCTCCGCTTCGACCTGGCATGCC ACCCACCATGATGGATCCATTCCGAAAACGCCTGCTTGTG CCCCAGGCGCAGCCTCCCATGCCTGCCCAGCGCCGGGGGT TAAAGAGGAGGAAGATGGCAGATAAGGTTCTACCTCAGCG AATCCGGGAGCTTGTTCCAGAGTCTCAGGCGTACATGGAT CTCTTGGCTTTTGAGCGGAAGCTGGACCAGACCATTGCTC GCAAGCGGATGGAGATCCAGGAGGCCATCAAAAAGCCTCT GACACAAAAGCGAAAGCTTCGGATCTACATTTCCAATACG TTCAGTCCCAGCAAGGCGGAAGGCGATAGTGCAGGAACTG CAGGGACCCCTGGGGGAACCCCAGCAGGGGACAAGGTGGC TTCCTGGGAACTCCGAGTGGAAGGAAAACTGCTGGATGAT CCTAGCAAACAGAAGAGGAAGTTTTCTTCATTCTTTAAGA GCCTCGTCATTGAGCTGGACAAGGAGCTGTACGGGCCTGA CAATCACCTGGTGGAGTGGCACCGGATGCCCACCACCCAG GAGACAGATGGCTTCCAAGTAAAACGGCCTGGAGACCTCA ACGTCAAGTGCACCCTCCTGCTCATGCTGGATCATCAGCC TCCCCAGTACAAATTGGACCCCCGATTGGCAAGGCTGCTG GGAGTGCACACGCAGACGAGGGCCGCCATCATGCAGGCCC TGTGGCTTTACATCAAGCACAACCAGCTGCAGGATGGGCA CGAGCGGGAGTACATCAACTGCAACCGTTACTTCCGCCAG ATCTTCAGTTGTGGCCGACTCCGTTTCTCCGAGATTCCCA TGAAGCTGGCAGGGTTGCTGCAGCATCCAGACCCCATTGT CATCAACCATGTCATTAGTGTCGACCCTAACGACCAGAAG AAGACAGCCTGTTACGACATCGATGTGGAGGTGGACGACC CACTGAAGGCCCAAATGAGCAATTTTCTGGCCTCTACCAC CAATCAGCAGGAGATCGCCTCCCTTGATGTCAAGATCCAT GAGACCATTGAGTCCATCAACCAGCTGAAGACCCAGAGAG ATTTCATGCTCAGTTTTAGCACCGACCCCCAGGACTTCAT CCAGGAATGGCTCCGTTCCCAGCGCCGAGACCTCAAGATC ATCACTGATGTGATTGGAAATCCTGAGGAGGAGAGACGAG CTGCTTTCTACCACCAGCCCTGGGCCCAGGAAGCAGTAGG CAGGCACATCTTTGCCAAGGTGCAGCAGCGAAGGCAGGAA CTGGAACAGGTGCTGGGAATTCGCCTGACCTAACTGCTCA GGGATCTTTCTTCCCAGCCCTGGAGCCTGGAGGGAGACCA CCCTCTGGGTCCTTGCTGGGGCCGCAGACACGTAGGCTGG GGTGAGGAGTGTCTGCTGTCACCCTCTACTCTCCAGCTTT AGTCTTATAAATGTAGTGATAGGATTCCTTGTTGCTTGGT CCCCAAAGCCTTATACTTTTTGCATTGGCTTTAATTGGGT TCAGCAGATGCCTCCTCTGCCCCCCTGCAGGCAGGCCCAA GTAGGACTGCTGGAGGCTGTGCTTTGACATTGTAAGACAT TTCCGAACCAAAGGCTGCTGGGTTTGCATGTTTACAGACT CCCCCTGGGGCGAGGGTCAGAGCTGGCTCTGGGGAGCTGG GCTAGGAAGAGGAGGTGCAGCCCAGACTCTTCCTAGCCTT TCTAAACCAAAGTTCTTTGCCATTCCTACAAGCCCAGCCT TGCTGCTGGTTTTTTCCTTTCCTTTGGGTATTTGCACTAT TTTGGGAGCAAGTTTTCTATGTGGGAGCCACTTTTTTTGT ACAGGGGTAAGTTGGGGGTTTTCAGGGAGCCTGTTAGGTG CCTCCTTCTTTTCTTTCCTCAATCTATGCAAGCGGCTCTG GCCGCCATCATCTCCTGGGATGCCAGAGGGCTGCCTCTCC AGCGGCTTGGGCCGGGGAGGGGACACTCCAGTTCTCTAGC ATGGCCTGAGGTATGGGGTATGTGCATGTGGAGGCCAGGG TAAGGTGAATGGGGAGGCTGGGAGGACTGGTGTTGCCCTT TGGAGCTTGGTGAGGAGGGTGGGCCTAGGGCTTGGCGAGT GCCACATCTGGCAGGTTTGGAAATTTCCAAATAAATCCTT TTGTCTATTG SP1 NM_001251825.1 GTCCGGGTTCGCTTGCCTCGTCAGCGTCCGCGTTTTTCCC 20 GGCCCCCCCCAACCCCCCCGGACAGGACCCCCTTGAGCTT GTCCCTCAGCTGCCACCATGAGCGACCAAGATCACTCCAT GGATGAAATGACAGCTGTGGTGAAAATTGAAAAAGGAGTT GGTGGCAATAATGGGGGCAATGGTAATGGTGGTGGTGCCT TTTCACAGGCTCGAAGTAGCAGCACAGGCAGTAGCAGCAG CACTGGAGGAGGAGGGCAGGGTGCCAATGGCTGGCAGATC ATCTCTTCCTCCTCTGGGGCTACCCCTACCTCAAAGGAAC AGAGTGGCAGCAGTACCAATGGCAGCAATGGCAGTGAGTC TTCCAAGAATCGCACAGTCTCTGGTGGGCAGTATGTTGTG GCTGCCGCTCCCAACTTACAGAACCAGCAAGTTCTGACAG GACTACCTGGAGTGATGCCTAATATTCAGTATCAAGTAAT CCCACAGTTCCAGACCGTTGATGGGCAACAGCTGCAGTTT GCTGCCACTGGGGCCCAAGTGCAGCAGGATGGTTCTGGTC AAATACAGATCATACCAGGTGCAAACCAACAGATTATCAC AAATCGAGGAAGTGGAGGCAACATCATTGCTGCTATGCCA AACCTACTCCAGCAGGCTGTCCCCCTCCAAGGCCTGGCTA ATAATGTACTCTCAGGACAGACTCAGTATGTGACCAATGT ACCAGTGGCCCTGAATGGGAACATCACCTTGCTACCTGTC AACAGCGTTTCTGCAGCTACCTTGACTCCCAGCTCTCAGG CAGTCACGATCAGCAGCTCTGGGTCCCAGGAGAGTGGCTC ACAGCCTGTCACCTCAGGGACTACCATCAGTTCTGCCAGC TTGGTATCATCACAAGCCAGTTCCAGCTCCTTTTTCACCA ATGCCAATAGCTACTCAACTACTACTACCACCAGCAACAT GGGAATTATGAACTTTACTACCAGTGGATCATCAGGGACC AACTCTCAAGGCCAGACACCCCAGAGGGTCAGTGGGCTAC AGGGGTCTGATGCTCTGAACATCCAGCAAAACCAGACATC TGGAGGCTCATTGCAAGCAGGCCAGCAAAAAGAAGGAGAG CAAAACCAGCAGACACAGCAGCAACAAATTCTTATCCAGC CTCAGCTAGTTCAAGGGGGACAGGCCCTCCAGGCCCTCCA AGCAGCACCATTGTCAGGGCAGACCTTTACAACTCAAGCC ATCTCCCAGGAAACCCTCCAGAACCTCCAGCTTCAGGCTG TTCCAAACTCTGGTCCCATCATCATCCGGACACCAACAGT GGGGCCCAATGGACAGGTCAGTTGGCAGACTCTACAGCTG CAGAACCTCCAAGTTCAGAACCCACAAGCCCAAACAATCA CCTTAGCCCCAATGCAGGGTGTTTCCTTGGGGCAGACCAG CAGCAGCAACACCACTCTCACACCCATTGCCTCAGCTGCT TCCATTCCTGCTGGCACAGTCACTGTGAATGCTGCTCAAC TCTCCTCCATGCCAGGCCTCCAGACCATTAACCTCAGTGC ATTGGGTACTTCAGGAATCCAGGTGCACCCAATTCAAGGC CTGCCGTTGGCTATAGCAAATGCCCCAGGTGATCATGGAG CTCAGCTTGGTCTCCATGGGGCTGGTGGTGATGGAATACA TGATGACACAGCAGGTGGAGAGGAAGGAGAAAACAGCCCA GATGCCCAACCCCAAGCCGGTCGGAGGACCCGGCGGGAAG CATGCACCTGCCCCTACTGTAAAGACAGTGAAGGAAGGGG CTCGGGGGATCCTGGCAAAAAGAAACAGCATATTTGCCAC ATCCAAGGCTGTGGGAAAGTGTATGGCAAGACCTCTCACC TGCGGGCACACTTGCGCTGGCATACAGGCGAGAGGCCATT TATGTGTACCTGGTCATACTGTGGGAAACGCTTCACACGT TCGGATGAGCTACAGAGGCACAAACGTACACACACAGGTG AGAAGAAATTTGCCTGCCCTGAGTGTCCTAAGCGCTTCAT GAGGAGTGACCACCTGTCAAAACATATCAAGACCCACCAG AATAAGAAGGGAGGCCCAGGTGTAGCTCTGAGTGTGGGCA CTTTGCCCCTGGACAGTGGGGCAGGTTCAGAAGGCAGTGG CACTGCCACTCCTTCAGCCCTTATTACCACCAATATGGTA GCCATGGAGGCCATCTGTCCAGAGGGCATTGCCCGTCTTG CCAACAGTGGCATCAACGTCATGCAGGTGGCAGATCTGCA GTCCATTAATATCAGTGGCAATGGCTTCTGAGATCAGGCA CCCGGGGCCAGAGACATATGGGCCATACCCCTTAACCCCG GGATGCAAGGTAGCATGGGTCCAAGAGACATGGAAGAGAG AGCCATGAAGCATTAAAATGCATGGTGTTGAGAAGAATCA GGAGAGGGATACAAGAGAGGAGATGGGGTCCCGGCACCCA TCTGTATCATCAGTGCCTCTTTGAAGGTGGGAAACATTAG TGAAAATTCTGTTGGTGCCACGCTTTGATGAGCATTTGTT TGACCCCAGTTTCTTCTTACACTTCTTACCCCAGCCTACC CTTCCTGCATTTCTCTTCTCAGCTCTTCCATGATGGATTC CCCCCCCTTTCCTAAAGCCATCATGCCTTGATAAATATAT ATGATCATTGAAATACTTTTTAACAAAAAACAGATTCTAT ATTATTATATATATATATATATATATAAAGATATATAGAG ATGCATTCACAGGGGTTGGCTGGGAGGAGGAAGACCATTC TGTGACCAAAATACCTTGGTCATTTTTTTTATATTGCCTT ATTTCCCTATGGCTGAGCCTTGTTGTGACACATCAAGCTT TTCTGTAGATGTTGTCTTGGCTTCCCACCAGCTTAAGCGT TCATATGCTCTGCTTTTAGTTCATATATACATACATAATG TTTTTCCTTTCTTAATTTTGTCTTTTTGTTTGGGATCAGC TTCTTGCACTCCTTCCCTAACTCAACTGTTGCCGTCTCAT CTTCTCTCATCTGATCACTTCATGTTTTGTTTTTGTTACT GCCTGGATGAGGCACTTCTGTCAATTTTTTCAGGACCTTA GTTCCAGCAGCAGAATGGAAAAATCCTTGAAGCCCAGGCT GATGCTTGAAGTAACTGTGGAGGGAGTGTTCAAAATACTA CTGACGCAGGCACCTTCTTGGCGCTGGAGAGTCAAAGGCA TCTCCCTTCATTAGCTGCTCTGAGCATCAAGAATTAGAAG TCTTTCAGTGGAATTGTACAAGAGTCCCTTTGAAGATAAT AATCTTGGCTCAGTTTGTATAAACTGTCAAATTTTCAAAT AATAGGTAGGGGGCTTTCACTAGGAAAATCATGTGCTCAG AAGAGGAAATGACTCGTAGTCAGGTTCAGGAGTTAGTGGA GTATTTGGACTTTGGTACTGCTGTCTTCCAAGGTAGCTCT AAGTTTTGATGTGTGGGCTTCTGAGTTTATATTCTGAAAG GAAATACACTTCTTTTGAACATCCCCACTAGGTTCTTTTC CATTGTCAATAAGGAGCATCAGCCAGTGAATCTGTTTCAG GTTTCCATTCTGCAGAACTCCTCCAAAGCATGTGCTAGTG GCAAGACAGTGGTTCTTATGATGTTTTCCCTTAACTTTTC CTTGTATGTTCTTGGGTGGTTCCTAAGGGAAAGGGAAGCA CATGATCATGGGAATGATAGCCCAGAACAAAAAGAAATCT TGTCTTACCACAGTGTTTTATAGGAGAGATTGGGAGAAAT CATCCTGTTTTCTCTGTGACCTGATTTCAGAAGAGACTGA TCCAAAAATTATAACGGCAGGGAACCTAGTGCATTTGGCA CTGAGATTTAAATGCAACCAGAATTGTCCTCAAGGCCCAG CCATAAAAGCATTGTCTCTCTCGACCTTCTGGTATCTTGT TAGAGAGCTTTTCACTGTGAGGAAGTGTGGAAAAATAGCT CTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTAA TCTGTTAGGTTGGGGATAGGTTTTCTGCTAGCCAATATTA AAAGAGACCTGCAATAAAAAAATTACCCTGATCTGATAGA AAGCAAGTGTTTTTGTATGTGTGGGTGAATGTGTGTTCAT GCCCGTATATGTCTACACACAGATGACAAATTATATTTGA AATCGTTGGAAAATAAATTCAGATCAAAATGCCTTTCAGG CCCATTACCTAGAAATCTATCTTAAAACCTGGGTATGTTC CTAAGGTCATTTCTTTGCTTATGCTAAATTAATTACAATT ATGAATGGAGGATATTCTACTGTACTTTTTTAAAAAGAAA CTATTTTTGTGTTTGAAAGTGAAACCAACATCCAGATCTA TAGCAGAGTCCTTATTCTTCTCATAAATCTTTTTACTTTG GCTACAAATAGATGATGGTATGATTCTATTATATATTTTA TATAAAATCCATCCAAATTAAGTTTTGGGTAAGTGTGTTG TTTAATCTGAACTATAGTAACTTAATACTCTAAACAATAG TTCACTCCATTTGGTCCTTTCTCCACAGATGTAATTATGT TTTCAACTCAGGAACTATGGCAAGGAACTTTCCCCAGATC AAATTCTATTAACGCTGAGATACAAGTCATCCATGCACAG CCACTATCATACCCTTTATTCTCACTGAAAGGCAGAACTC AGAACCTGTTATTTTATGTCTGTAATCATGTACTTTGGCA TCTTTTGGAGGAAAGGGGCAGGATAACTCACTGGAATGTA CAGTATTTTGCTAGTGCATTTCAAGGAATGGAATCTTCTC CAGTATGAAATTACCAGATATAAAATAATGTAATGATGCT GAGGATATAAGCTTTTAGAAGGTAATTTGATGGTATTTCT TTCTCGAATGAAAAGCTGCTGGTTTACCCTCAACCCTATT CATTAGCATTACCATGAGTGAATTTATATCTAATTATTTC CACTTGCCCTGTTCTCTTCACACCAAGGAAGCTCCAGATC CAGTATCTTGTTTGGCCTCAAAACAGAAGCAGCTTCTTTT GTCTCCCAGCAGTAGTGAGCCACTCAGTCTCTTCCACAGG AAGTTTGGAGCCTACATTCCTTGAGTCAGGAGCTTATTAC AGAAAAACCCCGTTTCCCTGAACTTTTGGCTAACAGAAAT TAATTTAACTGACATGCATATTGATTCTGAAATTTTTTTC CTAAGTTTTTTTCATTTTTTTGAATGAGTTTTTTAAATTT TTTAGATGACCAAAACTTGCAGGGCAGGGGATGCCCAGAA GAGTGGTGAGATAGTAAAACACTTATTCCCTCATCCTTTC AGGTTTTCAGGTTGCCCATTTATATTCATTTACATGTCAT TTGACTGTCTCACTTTTTACCCAGAACAGTAACAACCCAC ACCGTCTTCCTTCAGGGATTTCCAACTGGCACTCTGTGGG TGCTACACAGAATGCAATTTAATGGATATTTCTCAGCCTG GTTCAGAATAAATTGATCCTTTGATCCCAGAAAGTATATA CTGAAGTGTGGGATAAAGATTATGATTAGGGGAGGGTTGG AGACAAAAGCTGTAAATTACTATGGCTGATTTATTTCTAC TATATACATATATATTTTTTGCTTTTGTATATCCTATATA GGAAACTAAGCATTGTATTTTTTTTAACAAATCTAAAAAA GCACTATGAACTACAGGTGTTTGACTTTCAAAATATATTT TGTATTGTTAATATCTTCACATTGTGTGAATACTGGAAGC TGCAGATCTTTGCTAGGACGCAATAAATTTATATACTTTT TGAGGGGTTCTTCTGGGGTGCTAATCAGGCCCCTGTTATG CTTAGGGGGAGCCCTGGTGCTACTTGCTTGAAGTTTTCAG TGTAAGTACCCTGATGCCTTTTGGACCTTGGGATCAGATC AAGAGTTTTGGAGATCAGGTACCAAGGAAATAAGGACAGT CTAGCTGCCTCAAGTGAGGGGCCCTTTGCATAGCTCTCCT TCCCCCTCACTGAAGCTGGGTAGCCTATTGGGGTTGAGAG GGAAAATGTGAAATCTCAGAATTTATCTCCCTTAGAAGAG AGCCAGTAACTTATGTACAAGGATGAAAGAAAGGTCGCAG CAGTAGCTTTGGGGAAAGGGAGGAAGATATGGCACTTCTC CAACCCCGGAAAACATTGCTTTTGAAAACTGCTGATAAAA TATGAGCCGGTTATTACTTCTGTTTGGGAGACTGTGCTCT CTGTGGTGCCTCTCTTGGCTCTACTCCACAGATACCAGAC CTCTTCTAAGAGGATGAGCAGACCAGCTTTGAGGTTGACC TGTTTCTCTTTGTCTGCCTTCCCAAAACACCAGCCCCCAG GAAGACATTAAGCAGCCTTAAGCTTAAATTCCTACTCCCT CTTCCAAATTTGGCTCACTTGCCTTAGATCCAAGGCAGGG AAAGGAAAAGAAGGGGGGTCTCTGGCTTTATTACTCCCCT AAGTCTTTACTCTGACTTCCCCAAACCCAGAAAGATTTTC TCCACAGTGTTCATTTGAAAGAGGAGTATTTTGTCCCATT TTCCCCTTCCTCATTATCAAACAGCCCCAGTCTTCCTTGT CTCTGCTAAGAAAGTAGAGGCATGATGATCTGCCTCTCAA CTGCCCTAAGTCCTAGCTAAGTATCAGGGGAAAAAAAAAA AAAAAAAGCCTAACAAATGGGATTAGACTAGGGCTGCAAG TAGTGAGGATTTTGTTGATACCTCTGCTGGGATGTGTGCT TTCCCATATCTTGCCTTCAGGAATTACACTGTGCCTTTTC CCCAGGGATATGGGCTCTGTCTACCCAGTGCTCCAGTTTC CCGGTAACTGCTCTTGAACATTGTGGACAAGGGCAGGTCT TCATATTTTTGATCATCCCTTTCTCCCAGTGAAATCCCAT AGCCCTTACCTAGAGTCTAGGGCACAAAGACTTCGGGGAA GATACACTGAGATTGACCTGAGGAGACATCTACACACACC AGTGGCAGCTGCCCCAGGGCCTGCTTCCCCTTCCTAAGTC TGTCATCCTCTGGAAGGGATGGGTGGTGCTCCAATCTCTG GTGCCTAAAAACCCAAGTTTATTTCTCTCTTAACACTGGC AATAACCAGTCCACACCACTGTTGCCTTTTAAAACCTCTT AATAATCTCATGCTGTGTTTGTTTTGATTCCAATCCAATT ATCACCAGGGCTGTGTGGGTAAATGCTTTTAAATGCTCTC TCATCTTGTTCTTCCCCCTCACCCCCCACTCTTAGGTATG TATGATGCTAATCTTGTCCCTAAGTAAGTTTCTTCCTGCT CCTTTTGTATCTTCCTTTCTTGTCTTTCCTCCTACCTTTT GTCTCTTGGTGTTTTGGGACTTTTTTTTTTTTTTTTTTGG CCTTTTGTACAAAGATTAGTTTCAATGTAGTCTGTAGCCT CCTTTGTAAACCAATTAAAAAGTTTTTTAATAAAAAAAAA AAA SRSF5 NM_001039465.1 ATTTTGTGGAGCGCCAGAGCTGCTAAGTGCGTCAGTTGTG 21 GAGTGGCGTAGACGAGTTAAGTCCTGGTCTGCGTGGAGGT CGACGACTCCGTCGCAGACTACGGACCTGTCTGGGTCTCA GCCGCCAAAGACCCCGTCCGGTAGGTGAGTGGCTCACTTT GAGGGCAAGCCTTCTCGGATCGAGGCTTCTTCATGGCCGC TCAGATCGTGAGCGGCCGGGGCTGCTCTCTTTGCGGAGGA TGGCGTCTAATGAGCGCAGTTGATTCGAGGAAGTACTAGC CGGACATCATGAGTGGCTGTCGGGTATTCATCGGGAGACT AAATCCAGCGGCCAGGGAGAAGGACGTGGAAAGATTCTTC AAGGGATATGGACGGATAAGAGATATTGATCTGAAAAGAG GCTTTGGTTTTGTGGAATTTGAGGATCCAAGGGATGCAGA TGATGCTGTGTATGAGCTTGATGGAAAAGAACTCTGTAGT GAAAGGGTTACTATTGAACATGCTAGGGCTCGGTCACGAG GTGGAAGAGGTAGAGGACGATACTCTGACCGTTTTAGTAG TCGCAGACCTCGAAATGATAGACGAAATGCTCCACCTGTA AGAACAGAAAATCGTCTTATAGTTGAGAATTTATCCTCAA GAGTCAGCTGGCAGGATCTCAAAGATTTCATGAGACAAGC TGGGGAAGTAACGTTTGCGGATGCACACCGACCTAAATTA AATGAAGGGGTGGTTGAGTTTGCCTCTTATGGTGACTTAA AGAATGCTATTGAAAAACTTTCTGGAAAGGAAATAAATGG GAGAAAAATAAAATTAATTGAAGGCAGCAAAAGGCACAGT AGGTCAAGAAGCAGGTCTCGATCCCGGACCAGAAGTTCCT CTAGGTCTCGTAGCCGATCCCGTTCCCGTAGTCGCAAATC TTACAGCCGGTCAAGAAGCAGGAGCAGGAGCCGGAGCCGG AGCAAGTCCCGTTCTGTTAGTAGGTCTCCCGTGCCTGAGA AGAGCCAGAAACGTGGTTCTTCAAGTAGATCTAAGTCTCC AGCATCTGTGGATCGCCAGAGGTCCCGGTCCCGATCAAGG TCCAGATCAGTTGACAGTGGCAATTAAACTGTAAATAACT TGCCCTGGGGGCCTTTTTTTAAAAAACAAAAACCACAAAA ATTCCCAAACCATACTTGCTAAAAATTCTGGTAAGTATGT GCTTTTCTGTGGGGGTGGGATTTGGAAGGGGGGTTGGGTT GGGCTGGATATCTTTGTAGATGTGGACCACCAAGGGGTTG TTGAAAACTAATTGTATTAAATGTCTTTTGATAAGCCTTC TGCTCACATTTTTGTGAATGTCTGAAGTATATAGTTTGTG TATATTGACAGAGCTCTTTTATAACTAAAGCAAATTTAAT TTTTTTGTACTAGAAAAAAATTTGAACATTTTAGTTCTTG GTTATAAAAATGTTAATTCAGAATTAGTTTAATGCCTTAA TTAAACTAATTAATAGCTTTGGACACTTAAAAGAGCTCTA AATTTGCTTGTACATAAAGGCTTAATTTGTTTTCCTTGTT AGGGTCAAGGGTGTCCTCCACTCTTTAACAGCTGCTGGAC AGACACATTAGAGCAGCTGTTTGTTATTGATAATAAAATA TTATAAAACTA TAGAP NM_001278733.1 ATACTATTGACCACATTATGCGGCCAACGATACCCATTTT 22 CTTACCTGGATCTTTGCTTCTTAACACTGTAGTCTAATTT TTCTCGTTGCCTTGTTTTCTTGGCTGTAGAAGTTAAGAAG AGAAAGAAGGTGCTGTCCTGGCCCTTTCTCATGAGAAGGC TCTCCCCTGCATCAGATTTTTCTGGGGCTTTGGAGACAGA CTTGAAAGCATCGCTATTTGATCAGCCCTTGTCAATTATC TGCGGTGACAGTGACACACTCCCCAGACCCATCCAGGACA TTCTCACTATTCTATGCCTTAAAGGCCCTTCAACGGAAGG GATATTCAGGAGAGCAGCCAACGAGAAAGCCCGTAAGGAG CTGAAGGAGGAGCTCAACTCTGGGGATGCGGTGGATCTGG AGAGGCTCCCCGTGCACCTCCTCGCTGTGGTCTTTAAGGA CTTCCTCAGAAGTATCCCCCGGAAGCTACTTTCAAGCGAC CTCTTTGAGGAGTGGATGGGTGCTCTGGAGATGCAGGACG AGGAGGACAGAATCGAGGCCCTGAAACAGGTTGCAGATAA GCTCCCCCGGCCCAACCTCCTGCTACTCAAGCACTTGGTC TATGTGCTGCACCTCATCAGCAAGAACTCTGAGGTGAACA GGATGGACTCCAGCAATCTGGCCATCTGCATTGGACCCAA CATGCTCACCCTGGAGAATGACCAGAGCCTGTCATTTGAA GCCCAGAAGGACCTGAACAACAAGGTGAAGACACTGGTGG AATTCCTCATTGATAACTGCTTTGAAATATTTGGGGAGAA CATTCCAGTGCATTCCAGTATCACTTCTGATGACTCCCTG GAGCACACTGACAGTTCAGATGTGTCGACCCTGCAGAATG ACTCAGCCTACGACAGCAACGACCCTGATGTGGAATCCAA CAGCAGCAGTGGCATCAGCTCTCCCAGCAGGCAGCCCCAG GTGCCCATGGCCACAGCTGCTGGCTTGGATAGCGCGGGCC CACAGGATGCCCGAGAGGTCAGCCCAGAGCCCATTGTGAG CACCGTGGCCAGGCTGAAAAGCTCCCTCGCACAGCCCGAT AGGAGATACTCAGAGCCCAGCATGCCATCCTCCCAGGAGT GCCTCGAGAGCCGGGTGACAAACCAAACACTAACAAAGAG TGAAGGGGACTTCCCCGTGCCCCGGGTAGGCTCTCGTTTG GAAAGTGAGGAGGCTGAAGACCCATTTCCAGAGGAGGTCT TCCCTGCAGTGCAAGGCAAAACCAAGAGGCCGGTGGACCT GAAGATCAAGAACTTGGCCCCGGGTTCGGTGCTCCCGCGG GCACTGGTTCTCAAAGCCTTCTCCAGCAGCTCGCTGGACG CGTCCTCTGACAGCTCGCCCGTGGCTTCTCCTTCCAGTCC CAAAAGAAATTTCTTCAGCAGACATCAGTCTTTCACCACA AAGACAGAGAAAGGCAAGCCCAGCCGAGAAATTAAAAAGC ACTCCATGTCTTTCACCTTTGCCCCTCACAAAAAAGTGCT GACCAAAAACCTCAGCGCGGGCTCTGGGAAATCGCAAGAC TTTACCAGGGACCACGTCCCGAGGGGTGTCAGAAAGGAAA GCCAGCTTGCCGGCCGAATCGTGCAGGAAAATGGGTGTGA AACCCACAACCAAACAGCCCGCGGCTTCTGCCTGAGACCC CACGCCCTCTCGGTGGATGATGTGTTCCAGGGAGCTGACT GGGAGAGGCCTGGAAGCCCACCCTCTTATGAAGAGGCCAT GCAGGGCCCGGCAGCCAGACTAGTGGCCTCCGAGAGCCAG ACCGTGGGGAGCATGACGGTGGGGAGCATGAGGGCGAGGA TGCTGGAGGCGCACTGCCTCCTACCCCCTCTTCCACCTGC TCACCACGTAGAGGACTCAAGACACAGGGGCAGCAAAGAG CCACTCCCTGGCCACGGACTCTCTCCCCTGCCTGAGCGAT GGAAACAGAGCAGAACTGTCCATGCTTCTGGGGACTCTCT GGGGCACGTGTCTGGCCCAGGGAGACCTGAGCTCCTCCCG CTGAGGACCGTCTCCGAGTCCGTGCAGAGGAATAAGCGGG ACTGTCTCGTGCGACGATGTAGCCAGCCGGTCTTTGAGGC TGACCAATTCCAATATGCCAAAGAATCGTATATTTAGGAG GGAGGCCATACGCCATGCCATAGCTTGTGCTATCTGTAAA TATGAGACTTGTAAAGAACTGCCTGTAGATTGTTTTTAAA AGGTCTTGAATAAGCTCCTTGAGAAAGTTGTGGAAAGCCC TCCTCAGTGAGGATAGCTACACCATGGCCATGGCGCATCA GATAGTCTCTGTGTACCTGGATTTGTGCAATATGTAAAAA TGTATCAAATGTATTATAGATAAGGTGTTAGGTGCAAAGG ATGTCTAATAATCCCTGCACACGTTTTGAACTTGCAGTGA AGTACACTGCTGTTCCTTGCTTCCTGGGGCACTTTTCTCT TGGTTAGTGTTTAAAAATTATCTTCGCTTTTTTAATGTGG CCTCAAATGTCATGCCAATTTTCACATCTTCCACAAACTC CATTTAGGGAGAAATGTTTAAATCTCTGGTATAAGTTTAC TCCATACCAGAGTAAACTATATATTACTCTATATAAGCAG TCTTGCAATAACTAATCACCACCATAGAAGAAAGAAACAG ACTGCAAGGAACAGAGTTGAGTGTCTGGAGTCATCAAAGG CATTAAAAACTCCAGTAAAAGCTGGGGCCGTAGCAAAAAT CATGAAAAACACTTCAACGTGTCCTTTCAATCATCCAATT AAATGTGGGTAGATTAATGAAAATGTATTACATCAATATT AACTCATCTATAGCACTTTGAGTATCTTTGTAGTTCATGA TATCCTATCCTATAATGTGGAGGTAAATGATTTTATATGC ATTGGGGGTCATATATAAAACTTCAATGTAATTTCACTAC AATAAATTGCCTTCCTTATTTGAAAGTAAAAATGTTCTTT TTTTATTGACATGTTAACTCCTTTCCCTCAATTAATAGAA ATCCACTAAGAAAATCATTCACATATTGGTTCACTCAACA AGCATTTATTAAATATATATTCACTATTCTAGACTAATAG CAAGACCGGGGATCTTGTTTAGGAAGAAGCAGTCCCTGTT CTCCAGAATTTGCAAAACCATTAAAAAAGCACCTACTTTA AGCCATTTTTTTTCAGCAAGGAGTCATTCTGCCAGAAAAA TGTAGTACACAAATACAGGATAATATAACAAATGTAAAAT TTCTCATTTCTAGTGAATTAAACTTTCCAGTAATTTTACA TCTCACCTCATTCTTATGATGCTCAGTTTGCTTAATTATT GGCAAACATAATGGTAAAATGTTTGTACTGTATTAGAGCT TTACTGTTCGATTATTAAGATATTTATCCAGTATCTTAGA GATGCTGGACTTCAATTTTCCTTATTTTATCTTTTTAAAA TAAAATATCATGCATGCTTCTGATTTGTTATAGAAA TANK NM_001199135.1 ACTCGGCCAGGCGCCGGCGACCTGAGGGGAGAGGGAACGC 23 AGCTGAAAGCGTGAACTGTACCTGTCATTTACTCCATCCT TTATAGTGATGCTACAGGACGAAGAGGAATGGATAAAAAC ATTGGCGAGCAACTCAATAAAGCGTATGAAGCCTTCCGGC AGGCATGCATGGATAGAGATTCTGCAGTAAAAGAATTACA GCAAAAGACTGAGAACTATGAGCAGAGAATACGTGAACAA CAGGAACAGCTGTCACTTCAACAGACTATTATTGACAAGC TAAAATCTCAGTTACTTCTTGTGAATTCCACTCAAGATAA CAATTATGGCTGTGTTCCTCTGCTTGAAGACAGTGAAACA AGAAAGAATAATTTGACTCTTGATCAGCCACAAGATAAAG TGATTTCAGGAATAGCAAGAGAAAAACTACCAAAGGTAAG AAGACAAGAGGTTTCTTCTCCTAGAAAAGAAACTTCAGCA AGGAGTCTTGGCAGTCCTTTGCTCCATGAAAGGGGTAATA TAGAGAAGACTTTCTGGGATCTGAAAGAAGAATTTCATAA AATATGCATGCTAGCAAAAGCACAGAAAGACCACTTAAGC AAACTTAATATACCAGACACTGCAACTGAAACACAGTGCT CTGTGCCTATACAGTGTACGGATAAAACAGATAAACAAGA AGCGCTGTTTAAGCCTCAGGCTAAAGATGATATAAATAGA GGTGCACCATCCATCACATCTGTCACACCAAGAGGACTGT GCAGAGATGAGGAAGACACCTCTTTTGAATCACTTTCTAA ATTCAATGTCAAGTTTCCACCTATGGACAATGACTCAACT TTCTTACATAGCACTCCAGAGAGACCCGGCATCCTTAGTC CTGCCACGTCTGAGGCAGTGTGCCAAGAGAAATTTAATAT GGAGTTCAGAGACAACCCAGGGAACTTTGTTAAAACAGAA GAAACTTTATTTGAAATTCAGGGAATTGACCCCATAGCTT CAGCTATACAAAACCTTAAAACAACTGACAAAACAAAGCC CTCAAATCTCGTAAACACTTGTATCAGGACAACTCTGGAT AGAGCTGCGTGTTTGCCACCTGGAGACCATAATGCATTAT ATGTAAATAGCTTCCCACTTCTGGACCCATCTGATGCACC TTTTCCCTCACTCGATTCCCCGGGAAAAGCAATCCGAGGA CCACAGCAGCCCATTTGGAAGCCCTTTCCTAATCAAGACA GTGACTCGGTGGTACTAAGTGGCACAGACTCAGAACTGCA TATACCTCGAGTATGTGAATTCTGTCAAGCAGTTTTCCCA CCATCCATTACATCCAGGGGGGATTTCCTTCGGCATCTTA ATTCACACTTCAATGGAGAGACTTAAGACACATTTGAAAA CAGACATATCAAGTTCTATGTGATGATTTTGGGTTTTTAA TACTATAAATACTTGATTGTAAACTAAATTCAAGATCATT TATAGGAAAATCTAGTTTCACAGCTATTTGAATTTTTTTC TGGATTTACTATATAACTCTTATTTTTTAAAAGATCATTC TGTTCTTTCAAGGAGAAATAAGCCTAAAAGAAGAAAAACA AAAAAAATTCTGTATAAAACTGTAATCCTTTGTATTCATG TTTACAGTGCTATTACTATAATTCAAAATTATGTATGTGA CTTAGAGTTATATAATCATAATTTATGTTTATTTCAAATA TCTAAGTTTATTGCTTGGATTTCTAGTGAGAGCTGTTGAA TTTGGTGATGTCAAATGTTTCTAGGGTTTTTTTAGTTTGT TTTTATTGAAAAATTTAATTATTTATGCTATAGGTGATAT TCTCTTTGAATAAACCTATAATAGAAAATAGCAGACAACA TAAACATCTTTGTAAATATCAAACCTAATACATTTCTTGT CCAGTGATAAAACAACTGGTAGAATTATTTAAACACTTTA GATTTTTAAATAATATACATGGCTTTAATTTTTACTGTGT GTATAGCTACATGATGAAATTAATTAAATATTAAGAGGTA AAAATAAAAAAAAAAAAAAA TLE4 NM_001282748.1 GGAGAGCTCGCCAGAGCGCTCGCATGGCGGGCCGGTGATT 24 GTAGTCAATCTGGCCGTATTCTCAGGCAGGGTCGCCCGGG GCGGACTACATCTCCCGGGATGCTGCGCGGCCGCCCCGCG GAAGATTGTGAATATGTATCAGAATGTTAATGATTAGCTG CTGCTAAATTTGGTCAAAGAAGTCACCTACACAGAGCGTG TTGTTAGAGCTGTGCTGAGCGGGTGTTTGGGTTGTTGGCT GCTTTCTTCCCCCTTTCTCACACACTTGTATATTATTTTG AGGTGGTGTTCGCAGAGTTTGAAAGGAGAGAGAATTAAAA AAAAAAGCCGCAAGCGTTTCACTCTTTTATTTTTATAATC CCCTTCAATTTGGGGTTAAAAAAAAGACAAGAAAACAGGA AGGAAGAGAAATAAGGAAATGAGATGTGGTAAAAGAAGCT AAAAGGTGCCTTTTAAAAGATCGTTGCTGTGAAGTGAAAA AAATCTCCAGAGAAACCAAAAAGCACCGCCGAGACCTCTT CCGAACCAAAGGAGTTTGTGTTTGCTTTTAGGGAAGAAGA AAGATCATTCATTCGGAGGAATAACAACCAATTAAAAGAC AAATAAAAAAAGTTTGGAGTGGGACGCAGAGCGAGCGAGA GGAGCTGCCGGCGGGCGGTGGGGCGCGGAGCCCGCACTTT CCCGGCCGGGTGAGCGGCGGCCGCGGCGCCGGGCTCGGCG GGTGCGCCTCGGCGGAGCGAACGTCGGAGCGTTGCCTTGG GAGACGCGCGCCGGACAATGCCCGCGGCGGGCCAGTGACG CCCGCGGGGAATGCGGAGCGGCCCGGCAGCCGGCACCCAG CCGCCGCCGCGCGTTCCTGCCGCCCGTGTCACGCGAGACC CGGCGGGGGCCGGGACCGCCCGAGCCGCCCCTCAGACCGA GCCGGCCGCCTCCGCTGCCGCGGCCGCCTCCTCTTCGGGG TCATTAAAGCCAATGAGCCGCGCGCCTCTGCCGAGCGCAG CCAACTAAATCGGCTTGGATGATTCGCGACCTGAGCAAGA TGTACCCGCAGACCAGACACCCGGCACCGCATCAGCCTGC TCAACCCTTTAAATTTACAATTTCCGAATCCTGTGATCGG ATTAAGGAAGAGTTTCAGTTTTTACAGGCTCAATACCACA GTCTGAAGCTGGAATGTGAGAAACTCGCCAGTGAGAAGAC AGAGATGCAGCGGCATTATGTCATGTATTATGAAATGTCC TATGGGTTGAATATAGAAATGCACAAGCAGGCAGAGATTG TCAAGAGGCTGAATGCTATCTGTGCACAAGTCATTCCTTT CCTGTCCCAAGAGCACCAGCAACAAGTGGTGCAGGCTGTG GAACGGGCCAAGCAGGTGACCATGGCAGAACTGAACGCCA TCATTGGGCAACAACTCCAGGCCCAGCATTTATCACATGG ACATGGTCTCCCCGTACCTCTGACTCCACACCCTTCAGGG CTCCAGCCCCCTGCCATTCCACCCATCGGTAGCAGTGCCG GGCTTCTGGCCCTCTCCAGTGCTCTAGGAGGTCAGTCCCA TCTTCCAATTAAAGATGAGAAGAAGCACCATGACAATGAT CACCAAAGAGACAGAGACTCCATCAAGAGCTCTTCAGTAT CCCCATCAGCCAGTTTCCGAGGTGCTGAGAAGCACAGAAA CTCCGCAGACTACTCCTCAGAGAGCAAAAAGCAGAAAACT GAAGAAAAGGAAATTGCAGCTCGTTATGACAGCGATGGTG AGAAAAGTGATGACAACTTGGTGGTTGACGTTTCCAATGA GGATCCATCTTCCCCTCGAGGGAGCCCAGCACATTCCCCC AGAGAGAATGGCCTAGACAAGACACGCCTGCTCAAGAAAG ATGCCCCGATTAGTCCAGCCTCTATTGCATCTTCCAGCAG TACTCCCTCCTCCAAATCCAAAGAACTTAGCCTTAAGAGG GATATGGGGAAATTGAGTGAAACACGTCTTAGCGAAGATG AACAATGCACATTGGGGTTACAGAGATGGTTTTGTCGCCT GTGGTTTATGAATGAAAAATCTACTACTCCCGTCTCAAAG TCCAATACCCCTACTCCACGAACTGATGCGCCCACCCCAG GCAGTAACTCTACTCCCGGATTGAGGCCTGTACCTGGAAA ACCACCAGGAGTTGACCCTTTGGCCTCAAGCCTAAGGACC CCAATGGCAGTACCTTGTCCATATCCAACTCCATTTGGGA TTGTGCCCCATGCTGGAATGAACGGAGAGCTGACCAGCCC CGGAGCGGCCTACGCTGGGCTCCACAACATCTCCCCTCAG ATGAGCGCAGCTGCTGCCGCCGCCGCTGCTGCTGCTGCCT ATGGGAGATCACCAGTGGTGGGATTTGATCCACACCATCA CATGCGTGTGCCAGCAATACCTCCAAACCTGACAGGCATT CCAGGAGGAAAACCAGCATACTCCTTCCATGTTAGCGCAG ATGGTCAGATGCAGCCTGTCCCTTTTCCACCCGACGCCCT CATCGGACCTGGAATCCCCCGGCATGCTCGCCAGATCAAC ACCCTCAACCACGGGGAGGTGGTGTGCGCGGTGACCATCA GCAACCCCACGAGACACGTGTACACGGGTGGGAAGGGCTG CGTCAAGGTCTGGGACATCAGCCACCCAGGCAATAAGAGT CCTGTCTCCCAGCTCGACTGTCTGAACAGGGATAACTACA TCCGTTCCTGCAGATTGCTCCCTGATGGTCGCACCCTAAT TGTTGGAGGGGAAGCCAGTACTTTGTCCATTTGGGACCTG GCGGCTCCAACCCCACGCATCAAGGCAGAGCTGACATCCT CGGCCCCCGCCTGCTATGCCCTGGCCATCAGCCCCGATTC CAAGGTCTGCTTCTCATGCTGCAGCGACGGCAACATCGCT GTGTGGGATCTGCACAACCAGACCTTGGTGAGGCAATTCC AGGGCCACACAGATGGAGCCAGCTGTATTGACATTTCTAA TGATGGCACCAAGCTCTGGACAGGTGGTTTGGACAACACG GTCAGGTCCTGGGACCTGCGCGAGGGGCGGCAGCTGCAGC AGCACGACTTCACCTCCCAGATCTTTTCTCTGGGCTACTG CCCAACTGGAGAGTGGCTTGCAGTGGGGATGGAGAACAGC AATGTGGAAGTTTTGCATGTCACCAAGCCAGACAAATACC AACTACATCTTCATGAGAGCTGTGTGCTGTCGCTCAAGTT TGCCCATTGTGGCAAATGGTTTGTAAGCACTGGAAAGGAC AACCTTCTGAATGCCTGGAGAACACCTTATGGGGCCAGTA TATTCCAGTCCAAAGAATCCTCATCGGTGCTTAGCTGTGA CATCTCCGTGGACGACAAATACATTGTCACTGGCTCTGGG GATAAGAAGGCCACAGTTTATGAAGTTATTTATTAAAGAC AAATCTTCATGCAGACTGGACTTCTCCTCCTGGTAGCACT TTGCTCTGTCATCCTTTTTGTTCACCCCCATCCCCGCATC TAAAACCAAGGATTTCAGATACTCATTGCAGTTGTGGAGT TTAATCCCCTTTCTTAACCTCACTTCCCACTTGCTATTGA ATTGTGAATAGTCATTAAAAACCTGTGATACCAAATCTTC AGCTGTCTACTTGGAAGAACATGGAATAAGCATACTTAAC AGTGAAAAGAATCTTTAATTATGTATTATATCTGTAATAT ATTTATTTTGTTTAAAGAAGGCTTTCTAACAATGACTGAC TAAATAAAGCTGTCTGCTCCTGCATTGATAATGAAGGTGC GTTGTATTTGATACCCCTCCCCCCCTTTTTTTGGCAAAGG AGGGGAAAGGAAGGTTTAAAATAATTGATTTAAAATGTCA CTAAGTGTAGACTGATGACTGTATAGAGATGTGAAATGTA TAATTACACATGGAAGCAATATGTTGCTGTGTTGTTATTA GGTTTTTTTTGTTTTTGTTTTCTACATCTTTTAAAGACTT TTGGAAATTTGGCTGAACAATTAGAACACAACAGGCCAAC TCATACTCATTTGGATCTATTTAGACAACGTTAACCAATA TATCTATAGCTTTAGATTATATTCGATAAAAGTAATTGGA CTTTTTTTCTTTTTTTGACTCGTTGACAAGTGTCTTTGTA ATATGTTTTTAGTTCCCTTTTTTTGTTGTATTATAGGCAG ATGAACAAATTAAATTTGGCCTCAAAGAGAGAACTTACTC CCTTCTGGATATTTTTGCCACATTTCTTTGCAAAAGGAGA TATATATATCTTTAGTCAGTTTTGTTGTTATGAGAAATTA TGGGTTATTTTGTGGCATGCTCTTTGGGAGCTGCACAGTT ATGGGGAGGACTCCCACTGCTGTGCAAGTTAAGTCTTTTA CAAAACAAGGACAGCAGAGGAGGGTTTGCAGAGACCTCCC TCTGAAAAACACAAAGAATGGACTCTCTCCTGGGATGAGG ACTTGCTTTCTTTACCTCCGGTTCTTTCCATGTCTTAGTT GGATGTCCCTGAAATGGACACAGGCTGTGCCATTGTGCCA GAAACATTGTGTTATCTTTTATGTTGTTGTTGTTGCTGTT AAACTATAATATGTGACTTCTTTTTTTATTATTTTTTGTT TGAATGCTTTAAAAATCTTTTAAGTCTGTGGATCTGCTGA TGTACAGTGCCTTTGCTGCTATGGATCAAAATCAAAAGAA CCGTGTAGATATACTTTATTGTATAAGTAGAAAATTACTT AATTTCATACTAGAAATGGATGGATGCTGCAAGTTGAAAT GGACTGTCCATTGACGTTCCTAATGTGGTAGCAGAAAAAA AAAAATGGTGTCTTAAGTGCTTAGTGTTTGATGTCATTAA CAGTTTCGTAAAACTCTACAGTGTAGAAAGATTTTGATAC TAAACTGTGCGTTGTACATAGTTCTAATGCATTGTATTGA CCACCAGTACTTCTATAATGGTAGATTGTTTGTGAATTCA GACTTTTAAGCATTAAACATAAATAACTTCTAGTATGCTT ATTTTTCTAATTCTTTGTCTTGATGACATTAGTTTATTTT TTATCTTTGGCTGTGCCACTCCTATATATTAAAAATGCCT AGTTTTTTCAAGGGAGATTGTTGTTAAAGTAAAGTGGTTT TTTTTGTTGTTAAA TPT1 NM_001286272.1 CTTCGTGCCACGTCACCGCCTGCGTCGCTTCCGGAGGCGC 25 AGCGGGCGATGACGTAGAGGGACGTGCCCTCTATATGAGG TTGGGGAGCGGCTGAGTCGGCCTTTTCCGCCCGCTCCCCC CTCCCCCCGAGCGCCGCTCCGGCTGCACCGCGCTCGCTCC GAGTTTCAGGCTCGTGCTAAGCTAGCGCCGTCGTCGTCTC CCTTCAGTCGCCATCATGATTATCTACCGGGACCTCATCA GCCACGATGAGATGTTCTCCGACATCTACAAGATCCGGGA GATCGCGGACGGGTTGTGCCTGGAGGTGGAGGGGAAGATG GTCAGTAGGACAGAAGGTAACATTGATGACTCGCTCATTG GTGGAAATGCCTCCGCTGAAGGCCCCGAGGGCGAAGGTAC CGAAAGCACAGTAATCACTGGTGTCGATATTGTCATGAAC CATCACCTGCAGGAAACAAGTTTCACAAAAGAAGCCTACA AGAAGTACATCAAAGATTACATGAAATCAATCAAAGGGAA ACTTGAAGAACAGAGACCAGAAAGAGTAAAACCTTTTATG ACAGGGGCTGCAGAACAAATCAAGCACATCCTTGCTAATT TCAAAAACTACCAGTTCTTTATTGGTGAAAACATGAATCC AGATGGCATGGTTGCTCTATTGGACTACCGTGAGGATGGT GTGACCCCATATATGATTTTCTTTAAGGATGGTTTAGAAA TGGAAAAATGTGATGCAAAAGAAAGAAATCCCTGCGCTTT CTGTCTGTCTTTGTGGCGGCCCAGATTGAATTGGGGAATA CATCTTTAGCCTGGAAATGTAGGCTGCATGTTAATGGTAA TGTAACTTTTGCAGTGTAATGTTTGAAAAATATTAATGTA GTTTTTGCTTTTACAGTAACAAATGTGGCAATTATTTTGG ATCTATCACCTGTCATCATAACTGGCTTCTGCTTGTCATC CACACAACACCAGGACTTAAGACAAATGGGACTGATGTCA TCTTGAGCTCTTCATTTATTTTGACTGTGATTTATTTGGA GTGGAGGCATTGTTTTTAAGAAAAACATGTCATGTAGGTT GTCTAAAAATAAAATGCATTTAAACTCATTTGAGAGAATG CCTTTTAGTTTAATGCATATTTAAACTAAATTGATCCTGT AGTGTTCCTGGAGAAGCTAGAGCCTGATTGTAGGCTACTA CTCATCAATTAACTTCTACAGTGGAGACTACTTCTGGGAC TGGAATATAAAAAAGAATCAAAGGTTCTGATTTTGAGTTG CAATAAAGGGAAAGACCATGCTCATAGCAGTGCCAACATC TGAAGTGTGGAGCCTTACCCATTTCATCACCTACAACGGA AGTAGTTAACTGGAAGAGATTACCAAGAGAATAAAAAGAG ACTCATTCAGTGGAAGCAACTTTGTCTCAGCTTATTTCAC ATAAAGAGAGCGAAGTCTTTTGGGATGAATGTTAATTAAA CTCCCTGGTAACTAGAACAGGGACTGGCAAACTAGCCTAT CTGACCACCTGTTTTGTACACTTTAAGGTGGTTGGTTGCC TTTTTAAATGGTTGAGGGGAAAAGAATACCTTGTGGGATA TGGAATTTAAGTTCGAGTCCAGTTTTATTGGAACGTGGCT ATGCTTATTCATTTATGGATTGACTGTGGCTGTTGTCAGT GCATGAGCAGAGTTGTGTCTAACAGACTAGAGCCTGCAAG TTTGCCAGCCCCTGATTTAAAAGATGAAGGTACACAGAAT GTGGGCTGGCTGGTGGGCAAAGGGGTAAAAATGTTCTCTA TATTGTATCTGAAAAGATGGGGTGTCTGAATAAGAAAATG CATCTATTTGACAGACCTGGAGCAGTTGCTATCTGCTGCT ATGGTTTCCACCACAGATGCAAGAAGAACATGTCCTTGCG CTTTCCGTCTGTCTAATTGTGGCAGCTGAGATTGAATAGA GGAATACAGGAGGAAAAAAAGCGGGAAGAGTTTTTGAGGC AGGTCGGTCACCCAGGCTTGTAGTGCAGTGGCACAAGCAA CTCACTGCATTCTCTGCATCCTGTGCTCAAGCCATTTTCC CACCTCAGTCTCACTAGTTGCTGGGACTGCAGGCATGCAC CCCTATGCCCAGCTAATTTTTGTAGAGACCGAGTATCGCT TAGTTGCCCAGGGTGGTCTCAACTCCTGGGCTCAAGGAGA TCTGCCCACCTCAGCCTCCCAAAGTGCAGGCCTAGCCTGG GAGGGGAATTTTCAAAACGTGAGTTTTGGGAAATAGTCTA TCAGCCTTACCTGGTTGATTACACTTGTAAAAGAAAGATT AAAAGCAGGCCAGTGACTCTGGTCTGCTTGAACATGTGAA TGTAGTGGTTTGAGCAATCTGGAGTTTGCCCTAGTGTCAA ATTCCAGACTGTCCATAGTGTCCAAAACCTGAGGCAGATA CTAATGTTAACCCCCAGCACCCCGTGATTGGAAACAAACC TAAATACGTATTGGGAACTTAATAGCAATTTTAAGCATTC TGATAGATTTTTTGTAGGGATGGGGTCATGCCATGTGGCC CAGGCTGGTCTGAAAACTCTGGCCTCAAGTGATCTCAAGC TTTGGCCTTCTAAAGTGTTGGGATTACAGGTGTGAGGCAT TGCACCTGGCTTAGCGTTCTGATTTGACATTGTAATGAAA AGTGTGAGTCTCATCTACAGGGCCTTTTGTCCTCTGAAAT GATAGCAGGAAGGGAATTTTCAGGCAGTGGTCAAAGCTGG GGAAACCAGGATAGTGAAGAAGGCCTTGAGGTGAGAGATG GAAGCTAATTGGTGAACTAGCCTTGGAAGCCTGAAACAGA CAAGTAGCAATTCAGAGACTTTGTGGGCTCCACTGCTCCA ACTTGTTTTGAAGATTTTCAGTTCTGCAGAAGAGGTATTT CCCCAGTTGTCCTTTCAGTGCTCTTAGCTGTTTTCCCAAC ATCCAGATCCAATCAAGGCTGGGACATAGCATTTTATCAT GTCTATTTAAGTCAGAAGTGATGAACCCCAGCTGTTTACC TCATGGTAAACCTTTGAAGATTCCAGGTAGAATCTTCTCA GACTTTGAAGACTGTCTCATTTTATATCTTTTTCTCGTTA TTCCTAGGGTCAAGACGTTTTGGGCAAGAATAAGGATGTG AACATCAGAAAGCTCATAACATTTTGTTTTTGATGCTAAG TTTAACAAAGGCATGCTTTAGTAGCCTGTGGGCCCTAGGG TTTGTTAAAGTGTGGAGAACAACTGAGTGGAGCAAGAGGA CTTTTCTAGGAAGGTCCTTGTAATGTGACATTTGAAAACA AATGAAGGTGTGGAAGTAGGCCATGTGGATATCAGGACAA ACCATTCCAGGCCAAGACAACAGCAGTTAGTCTGGAGTGT GATGTGTTCTGGGAAAAAAGTGGCCACTTTGCTAACCCAA GAAGACAGGAAGGGTTGTAAAGCAGTGGGAGTGTGCAAGG AAGGAAGACCAGACCTCAAGGAAACCACAGGCGCTCTGAG CAGAAGAGTTACATGATATGACTCAAATTTTTAAAGGATC ACTTTGGCTGCCAGGTGGCAGGGTAAAAGCATAGAATAAT TGTGTATAATGTGTTTTTAAGGCAAAGATAGTGGCTTAGT CTAGGGTAGTAGACTGAGGTGGTAGGAAATGAAGATAGAG ACAACAGGATATGCTGGTGGGTGAGGATGGATTTAATGTT GATACAAGTATTTTGGTCTGAGCGTTTGGAAGAAAGTTGG CACTGAGGTGGGAAGTCGAGTTTAGTTTTGTTAGTTTTGG ATGTGTTAAGTTTGAGATGCTGATTCTTCAGAGAAGTCTA AGCTGGAGAACTATATAGAGAGTGGAAAGATAACAATAGA CATTGAAAGCCATGATACAGGATAAGGTCATTTGGAGAGA GGATAGACTGCATTCCAACATGAGATTGGTTGACAAAGAG AAACCAACAAAGGTAATTAAGAGGTGCTCCCACTGCACTT GTACTCAGAAGGCTGAGGTAGGATTGTTAGAGGCCAGCCT GGGCACCACAGGGAGACCCCATCTCTAAAATTTAGCCAGG AACCATGGCTCATGCCTGTAGCCCCAGGAATTTGGGAGGC TGAGTGGGGAGGATCGCTTGAGGTCAGGAGTTTGAGACCA GCCTGGGCAACATAGGGAGACCTAAAAAAATTAATTGGGC ATCTGTAGTCCCAGCTACTCAGGCGGCTGAGCTGAGAGGA TGGCTTGAGTCCGAGAGATTGAGGGTGCAGTGAGCTGTGA TCATACCACTGCACTCCAGCCTGGGCGGCAGTGAGACACT ATCTGAAAAAAGTTTAAAAATTTTAAAAAAGAAGGAACTG CCCCTGAGGTAAGAACCAAGGGAGGGCCTCCCAGAGGTCA GGTGGAAAAAGTTTTAGGAAGGAGGAAGTAGTCAACAGGG TTACCTGTTGCAAAGTACTTAAGTAATATGAGGCCTGATA GTGGTAAACTTGACTACCGTTGGATTTCACTAGTGGGAAA GGAAGTCTAATTAAAATGCACTCAAGAGACTAACAGTCGC AGGCATGAAATACAATACAGGTACATGGTTTTTTATTATG TGTGCATCTGCTTCAGTAATAGGTGTGAATTACTCATTTG GATCATTAGGAGTTTCAAAATCTAGTTAAATGACTAGATT TTTGTTGATGTAAATTCTGTCATTCTGAACTGCAGGGATT GTCAGTAACTTAACTGCAAACTAAACTGGTGATAATTATG GTAAAATTGCAAGACGAGCAATAAATCTCAACCAACTTGA GAGAACACTGATAA TSC22D3 NM_001015881.1 CGCCGTGAAAACCAGCTGCTGCAGCCGCAGAGGCAGCCGG 26 AGGCAGAGGGGCGGCGGGCAGGACCAGACAGGGCTGGGCA GGGGGCTGGCCGAGCGCCGTGCGCCGCTTGGGAGAAGGCC GGAAGCTTACCAGCCGAGAAGGAATTCCTAGCTAGCTTCA GAGCCGGTGCCTCCGGAGCCAGCGTGGTGGCCATAGACAA CAAGATCGAACAGGCCATGGATCTGGTGAAGAATCATCTG ATGTATGCTGTGAGAGAGGAGGTGGAGATCCTGAAGGAGC AGATCCGAGAGCTGGTGGAGAAGAACTCCCAGCTAGAGCG TGAGAACACCCTGTTGAAGACCCTGGCAAGCCCAGAGCAG CTGGAGAAGTTCCAGTCCTGTCTGAGCCCTGAAGAGCCAG CTCCCGAATCCCCACAAGTGCCCGAGGCCCCTGGTGGTTC TGCGGTGTAAGTGGCTCTGTCCTCAGGGTGGGCAGAGCCA CTAAACTTGTTTTACCTAGTTCTTTCCAGTTTGTTTTTGG CTCCCCAAGCATCATCTCACGAGGAGAACTTTACACCTAG CACAGCTGGTGCCAAGAGATGTCCTAAGGACATGGCCACC TGGGTCCACTCCAGCGACAGACCCCTGACAAGAGCAGGTC TCTGGAGGCTGAGTTGCATGGGGCCTAGTAACACCAAGCC AGTGAGCCTCTAATGCTACTGCGCCCTGGGGGCTCCCAGG GCCTGGGCAACTTAGCTGCAACTGGCAAAGGAGAAGGGTA GTTTGAGGTGTGACACCAGTTTGCTCCAGAAAGTTTAAGG GGTCTGTTTCTCATCTCCATGGACATCTTCAACAGCTTCA CCTGACAACGACTGTTCCTATGAAGAAGCCACTTGTGTTT TAAGCAGAGGCAACCTCTCTCTTCTCCTCTGTTTCGTGAA GGCAGGGGACACAGATGGGAGAGATTGAGCCAAGTCAGCC TTCTGTTGGTTAATATGGTATAATGCATGGCTTTGTGCAC AGCCCAGTGTGGGATTACAGCTTTGGGATGACCGCTTACA AAGTTCTGTTTGGTTAGTATTGGCATAGTTTTTCTATATA GCCATAAATGCGTATATATACCCATAGGGCTAGATCTGTA TCTTAGTGTAGCGATGTATACATATACACATCCACCTACA TGTTGAAGGGCCTAACCAGCCTTGGGAGTATTGACTGGTC CCTTACCTCTTATGGCTAAGTCTTTGACTGTGTTCATTTA CCAAGTTGACCCAGTTTGTCTTTTAGGTTAAGTAAGACTC GAGAGTAAAGGCAAGGAGGGGGGCCAGCCTCTGAATGCGG CCACGGATGCCTTGCTGCTGCAACCCTTTCCCCAGCTGTC CACTGAAACGTGAAGTCCTGTTTTGAATGCCAAACCCACC ATTCACTGGTGCTGACTACATAGAATGGGGTTGAGAGAAG ATCAGTTTGGGCTTCACAGTGTCATTTGAAAACGTTTTTT GTTTTGTTTTGTAATTATTGTGGAAAACTTTCAAGTGAAC AGAAGGATGGTGTCCTACTGTGGATGAGGGATGAACAAGG GGATGGCTTTGATCCAATGGAGCCTGGGAGGTGTGCCCAG AAAGCTTGTCTGTAGCGGGTTTTGTGAGAGTGAACACTTT CCACTTTTTGACACCTTATCCTGATGTATGGTTCCAGGAT TTGGATTTTGATTTTCCAAATGTAGCTTGAAATTTCAATA AACTTTGCTCTGTTTTTCTAAAAATAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAA UBE2J1 NM_016021.2 GCGGCCGCGGCAGGGCTGGGCCTGCGACTACCCGAGGAGG 27 CTGACCTCCAGCCCGGGCGCCCGGTTCAGCGCCGCCCCGG CCGGCGCCGGTGCCTGCCAGGCACTCAGGGAGGCGGGGGC GCAGTGGAGGAGGCGGCGCCATCGCGAAGCGAGCGCCTCG CCCGCACTCAGCCTTGCCACCCCGCCCGCAGTCCAGGCTG GACTGGGCGGCATTTGCCGAGGCTCCTCGGCCAGGCCCCG TCCGCCCGAGCCGCGCTGAGACCCGGGCAGCGGCCGCGTG GAGAGGAGGTGGCAGCGGCCCGGGAGGCCGGAGCCAAGCC AGCGACCCACCATGGAGACCCGCTACAACCTGAAGAGTCC GGCTGTTAAACGTTTAATGAAAGAAGCGGCAGAATTGAAA GATCCAACAGATCATTACCATGCGCAGCCTTTAGAGGATA ACCTTTTTGAATGGCACTTCACGGTTAGAGGGCCCCCAGA CTCCGATTTTGATGGAGGAGTTTATCACGGGCGGATAGTA CTGCCACCAGAGTATCCCATGAAACCACCAAGCATTATTC TCCTAACGGCTAATGGTCGATTTGAAGTGGGCAAGAAAAT CTGTTTGAGCATCTCAGGCCATCATCCTGAAACTTGGCAG CCTTCGTGGAGTATAAGGACAGCATTATTAGCCATCATTG GGTTTATGCCAACAAAAGGAGAGGGAGCCATAGGTTCTCT AGATTACACTCCTGAGGAAAGAAGAGCACTTGCCAAAAAA TCACAAGATTTCTGTTGTGAAGGATGTGGCTCTGCCATGA AGGATGTCCTGTTGCCTTTAAAATCTGGAAGCGATTCAAG CCAAGCTGACCAAGAAGCCAAAGAACTGGCTAGGCAAATA AGCTTTAAGGCAGAAGTCAATTCATCTGGAAAGACTATCT CTGAGTCAGACTTAAACCACTCTTTTTCACTAACTGATTT ACAAGATGATATACCTACAACATTCCAGGGTGCTACGGCC AGTACATCGTACGGACTCCAGAATTCCTCAGCAGCATCCT TTCATCAACCTACCCAACCTGTAGCTAAGAATACCTCCAT GAGCCCTCGACAGCGCCGGGCCCAGCAGCAGAGTCAGAGA AGGTTGTCTACTTCACCAGATGTAATCCAGGGCCACCAGC CAAGAGACAACCACACTGATCATGGTGGGTCAGCTGTACT GATTGTCATCCTGACTTTGGCATTGGCAGCTCTTATATTC CGACGAATATATCTGGCAAACGAATACATATTTGACTTTG AGTTATAATATGGTTTTGTGACTTATGAGCTGTGACTCAA CTGCTTCATTAAACATTCTGCATTGGGTATAATCTAAGAA TTGTTTACAAAAAGATTATTTTGTATTTACCCTTCATTCC TTTTTTTGATCCTTGTAAGTTTAGTATAAATATATCTAGA CATTCAGACTGTGTCTAGCAGTTACGTCCTGCTTAAAGGG ACTAGAAGTCAAAGTTCCTTGTCTCACTATTTGATCTGCT TTGCAGGGAAATAACTTGTTTTTTCTCATGTTTCATCTTC TTTTTATGTAAATTTGTAATACTTTCCTATATTGCCCTTT GAAATTTTTGGATAAAAGATGATGTTTTAAGTTCCAATGA GTATTACTAGTTACTCAATACCACTTATTGAGTACTCTGT TTCTACGTATGTAGAATGTATAGGGATAGAAGAGTTGAAA AGGGAAAGCAAAACTCCTCAAGTAGCTTCCTTAAAATGTC ATTCATAGGAGATGTACTGGAATTGCTCATTCTGTGACTT TATTTGTGTCCTAAACATTCTTCAGTGAAAATAATTTTAT TTCAGTCAAACATTTATGAGGAAATGAGATCACATCTTTG TCACTGGATGCTACTTGAAGAGGGAGTACTTTGTAACCAC TTTGATATGCTGTTATCACCACCCCCTGCCCTCTGCTGCC ATAATCACACAAATTTAAAAAGAAAGAAAACAGTCTTCCA TAGATTTTTAAGGAAGAAAGGGCCCAAGCCAGGAGATCGC TTGGTTTTCTTCCAGAAGTTAAATGGGGGGATCTGAAGAT TTGAATGTTTGGTCTGCTTTGAAATGTATGTCTTTTGGGA TGTATTATATGCCTAGCTTTATAATCAGTATAAATTTTAA TTATTCCAGGAATATGCATAATATTGAAATATTTCATGTC CTATTTTAATAGAAAACCTCAGGGCCCAAGTAACAGTGAT AGAAGTTAGAAAAACCTTTACTTAGAATTGTCCACCTAGT CAGAGCCCAAGAAAGAATTTTCAGTGGAAAAATCAATATA TAACTTAGTGCTAGCTAGCGCCACAGACTCTAGTAGATAA TATTATCATCATAATGGCTGGTGAAACCATATAATCACAG AAAAACATTGCCTTCAGCATGTTCAGTTCGCAGCACTGAG GGCACTCTTGAGGGTGTTGTTAATGAAGATTTAATTTTTA AATACAGGTGGTTCCAAGCTTTCAAATAGGTTATGCTCCA AAAGTGTTATTTGTAAGTTAATTTTTTTACAAGTCAAACA ATGTTGGAAGTGGTATTTAGGTTCTAGATCGGTCCACGAA AGTTAGCCCATATGTATATCTTGAATAGTATAGGGGAGGG TATTCATAAAGTCCTTATGTGGTTTTAACTAAGTGAAATT ATGGACAAGAGAAATAATTGTAAAATCGTCTTAAAGGAAA ATTTAATTTTTACTCCTGTTTATGGGACATTCGTTCTATT AACTGTCAGACACAATTTCTGTTTTCATCTGAGAGCCAGT TTTCCTTTATTTCTACATCTAAAATAAGAACATATTGTAC ACTATTATATAATACAGAATTGTCTTAAACTTTAATAAAT TCGCATTTTAAAGGTGTTTACAGATTATTTTTTATATCTG TAGCTGAATTTGTTAAAGTCTAAAAAGCTCAAGGACTTTA TGAAGATCTCATTATATGAGGAAAATCATAGGTTACCATT TTATAACTCTATTGCCATAAGAAAATACACTCTAAAATCT TGATTTGAAACATATTAGAAACCTTGATTCAGTGCTCAGT GGTCTCCTAGTAAGAAGTCACCGACGGTAGCGTCATATGA GAAGAAAGAAATCCCCACCACCTCAACCTCTGCTGAGATT GTGTGCTAGGAACAGCCTTCCCTCCGTTTCCCCTCAGTCA AACTTGAGCCAGCCTCTGGATCGATGTGATCTTATTGCAT GTTTCCATGGGGTGTACCTATACTTTAAGCCAATCCTGCT GCATTCACTGCTAAGTTAAATAAAAAGCCAAGAAGATTTT GCACTGTGCAGATCCTTTGCTATCTGACTTGCATCTCTTC CCCCACCTGTCAGCTAGCCACCTGCTTGTTTGTGTTGGGA TATTTTTTAGCACCTGAAGCACCATCTGAAAGGGGCACCA TTTTCTTCTTCCCTTTGATCTCACATATGCTCCCTAAAAA TCCTTAAGTTGTCAATCTGATCCCCAGTGTGAGGTTAATG AGCAAAATTGGTCTTTGGGGCCCTTTTTGTCCAAGCCCCA CTGAAAGGCCTCTTCAGAAAACTATTATCTTTAAAGCCCT ACTTTAACTCCTTAATTCCAGCATACAGCTAAAACTGGAT GTATATTCTGGCAAGTAAAGGCTGAGGACTCCTCTTTAAT CCTCAGATCTAGATAACTCATGACATTTTATTTGACCAAC ATAGCACATGATGAGATATCAAGGTAATTAAAATAGCATG CTTGAAAAAAAAATACGTAATCTGTTTCACCTGTAACTGT TTAAGCCAATAAACTTTTCAAAATTTATGTAATGTGGGGC TTTTATGTAGCACTTTACGTTTTCATGCTGCTTATTGTTT TATTCTACTGAAAAAAATGAATTTCAAGATTCTCAACTTT TTTAATTTCAAAAATTGTTTATTGTTTTGACTATAGGAAT ACAAAATTTCCTATTTTGGGAGAATAAGAACTCTTTTTGT CATTTTTGGCTATGAATAAACTTTCTGGTCTTTTGAGACC ACCCATTTTTATAGATCAGAATCAGAAAACAGGTAAACCT CACTCACACATTTGGACTCATTTGAACAAAAATCTAGGCC AAAATACTGAAAAGCCTATGTGTTTTTTTAATTGGAAGTA TATGTAAGGTTAATGCATTTAGTGAACGTGACTAACAAAG ACTAATGTGCACATTAACAGATGTACTTTTTAAGGTTTTA TGGGAGGCTGTGCATTGCTCAAAAGCTGTTGGGAACGCCT TCTGAACAGTTGCCTTCAGAACTAGTTTGAGCTGCTCAAT AAAACCAGTGACTTTACTCATAAAAAAAAAAAAAAAAAAA ALG9 NM_001077690.1 GTCTTTTGTCCCTCGGCGGACACCGTTTGCCAGCCAAAGC 28 TATGTCTGCGCGCTCACCGACTTCATAGGGTGCCGAATTC TTTTTTCCCCAGGCTTGCCATGGCTAGTCGAGGGGCTCGG CAGCGCCTGAAGGGCAGCGGGGCCAGCAGTGGGGATACGG CCCCGGCTGCGGACAAGCTGCGGGAGCTGCTGGGCAGCCG AGAGGCGGGCGGCGCGGAGCACCGGACCGAGTTATCTGGG AACAAAGCAGGACAAGTCTGGGCACCTGAAGGATCTACTG CTTTCAAGTGTCTGCTTTCAGCAAGGTTATGTGCTGCTCT CCTGAGCAACATCTCTGACTGTGATGAAACATTCAACTAC TGGGAGCCAACACACTACCTCATCTATGGGGAAGGGTTTC AGACTTGGGAATATTCCCCAGCATATGCCATTCGCTCCTA TGCTTACCTGTTGCTTCATGCCTGGCCAGCTGCATTTCAT GCAAGAATTCTACAAACTAATAAGATTCTTGTGTTTTACT TTTTGCGATGTCTTCTGGCTTTTGTGAGCTGTATTTGTGA ACTTTACTTTTACAAGGCTGTGTGCAAGAAGTTTGGGTTG CACGTGAGTCGAATGATGCTAGCCTTCTTGGTTCTCAGCA CTGGCATGTTTTGCTCATCATCAGCATTCCTTCCTAGTAG CTTCTGTATGTACACTACGTTGATAGCCATGACTGGATGG TATATGGACAAGACTTCCATTGCTGTGCTGGGAGTAGCAG CTGGGGCTATCTTAGGCTGGCCATTCAGTGCAGCTCTTGG TTTACCCATTGCCTTTGATTTGCTGGTCATGAAACACAGG TGGAAGAGTTTCTTTCATTGGTCGCTGATGGCCCTCATAC TATTTCTGGTGCCTGTGGTGGTCATTGACAGCTACTATTA TGGGAAGTTGGTGATTGCACCACTCAACATTGTTTTGTAT AATGTCTTTACTCCTCATGGACCTGATCTTTATGGTACAG AACCCTGGTATTTCTATTTAATTAATGGATTTCTGAATTT CAATGTAGCCTTTGCTTTGGCTCTCCTAGTCCTACCACTG ACTTCTCTTATGGAATACCTGCTGCAGAGATTTCATGTTC AGAATTTAGGCCACCCGTATTGGCTTACCTTGGCTCCAAT GTATATTTGGTTTATAATTTTCTTCATCCAGCCTCACAAA GAGGAGAGATTTCTTTTCCCTGTGTATCCACTTATATGTC TCTGTGGCGCTGTGGCTCTCTCTGCACTTCAGAAATGTTA CCACTTTGTGTTTCAACGATATCGCCTGGAGCACTATACT GTGACATCGAATTGGCTGGCATTAGGAACTGTCTTCCTGT TTGGGCTCTTGTCATTTTCTCGCTCTGTGGCACTGTTCAG AGGATATCACGGGCCCCTTGATTTGTATCCAGAATTTTAC CGAATTGCTACAGACCCAACCATCCACACTGTCCCAGAAG GCAGACCTGTGAATGTCTGTGTGGGAAAAGAGTGGTATCG ATTTCCCAGCAGCTTCCTTCTTCCTGACAATTGGCAGCTT CAGTTCATTCCATCAGAGTTCAGAGGTCAGTTACCAAAAC CTTTTGCAGAAGGACCTCTGGCCACCCGGATTGTTCCTAC TGACATGAATGACCAGAATCTAGAAGAGCCATCCAGATAT ATTGATATCAGTAAATGCCATTATTTAGTGGATTTGGACA CCATGAGAGAAACACCCCGGGAGCCAAAATATTCATCCAA TAAAGAAGAATGGATCAGCTTGGCCTATAGACCATTCCTT GATGCTTCTAGATCTTCAAAGCTGCTGCGGGCATTCTATG TCCCCTTCCTGTCAGATCAGTATACAGTGTACGTAAACTA CACCATCCTCAAACCCCGGAAAGCAAAGCAAATCAGGAAG AAAAGTGGAGGTTAGCAACACACCTGTGGCCCCAAAGGAC AACCATCTTGTTAACTATTGATTCCAGTGACCTGACTCCC TGCAAGTCATCGCCTGTAACATTTGTAATAAAGGTCTTCT GACATGAATACTGGAATCTGGGTGCTCTGGGCTAGTCAAA GTCTATTTCAAAGTCTAATCAAAGTCACATTTGCTCCCTG TGTGTGTCTCTGTTCTGCATGTAAACTTTTTGCAGCTAGG CAGAGAAAGGCCCTAAAGCACAGATAGATATATTGCTCCA CATCTCATTGTTTTTCCTCTGTTCAATTATTTACTAGACC GGAGAAGAGCAGAACCAACTTACAGGAAGAATTGAAAATC CTGGTACTGGATGGCTGTGATAAGCTGTTCTCCACACTCT GGCCTGGCATCTGAGAACTAGCAAGCCTCTCTTAGGCCAT ATGGGCTTCTCCACCAAAGCTGTTTGGCAGCTCCTAGCAG ACCTTCTTATTGAAATCCTCATGCTGAAAATGAACACAGC CTAGTTGCCAACCCACATGTCCTTTTCACCTCCAGCAAGA CTAAGCTTCTTTAAAGCACTTCACAGGACTAGGACCCTGT CCTGGAGCTATCTCAGGAAAAAGGTGACCATTTGAGGAAC TGTGACCTAATTTTATTATAATGATGCCTCTAATTTTCAT TTCCTTTACAACCAACTGTAACTATAAGGTTGTATTGCTT TTTTGTTCAGTTTTAGCATGCTATTTTTTGAATTCTAGAC TCCTCCATGTGAAGATATCAACAGACAAAACTACAACTGT ATAGGACATATTTGGAGAAAATTCTATCAATTGATACATT TGGATGACATCACATTTTTAAGTAATGTAATCTGAGGCCA TTGCTGAGGAAATTAAGAATTTTCCTTTTTTTTTAACCAC CCCCAGTGAAAAGGATCAGTGTATATTTATAGCACCTATT TTTTAGTTCTGTCTGTTGTGAGGCACATCCTGCATGGGGC ACTTCTAGTCAAATAGGCAATGATAAGGACCTAATTAAAA TGTGATAAGTGTATACTATTACTTTAAAAGCCTTTACAGT CAGTACTTCAGTTTACAAGGCACTTTCACAGCATCTCGTT TGATCCTCACAGTCACAACATGTGGTAGACAAGGCAGGTG ATTTTTATCCCCATTTTACAGATAAGGAAACAGGCTGCGG GTGGGGAGTGAGGGGAGGTAAAGATAGTTAGTTGCCTAAG GTCACACAGCCAGTAAGTAATAGAGCTGGGACTGGAACCC AGGTTTCCTTACTCTCATCTATTGCTCCTCCATATTCCTC ACTCAACCATGAAAACATTACTTGAAAGGACTGATGAGGT TAACCAGAGACCTAACTGATATTGTAACTTTCTATTTTAA GGAAGAATTGTGTCTGTATTTGAGTTCTTTGGAGCCTCCA GTCTGCCTGTGTGTTAGACCAGCACAGCAGTGCTGTGTGA TGCAGCCTGACCTGTGGCAGGAAAGTAGTGCTTCTGTTTG GAAGTCATGTTCTTTTGCAGCCACACAGGATCCAAATATC AGTACTATTCCTGTAGTCAATCTGGGGTCACATTATAGGT GCCTTATTTCCCTAAGGGTAACTGATCTGAATATCTGCAA ATAGGATGAATCTATTTTTCAGAAGTTCCATCTTTCATTT TTCTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCGCCCA TGCTGGAGTGCAGTGGCGCGATCTCGGCTCGCTGCAACCT CTGCCTCCCAGGTTGAAGCAATTCTCATGCCTCAGCCACC CGAGTAGCTGGGATTACAGGCATGCGCCATCATGCCCAGC TAATTTATGTATTTTTAGTAGAGTTGGAGTTTCACCATGT TGGCCAGGCTGGTCTTGGACTCCTGACCTCAGGTCATCCA CCCGCCTCAGCCTCCCAAAGTGCTGGTATTACAGGCGTGA GCCACCGCACCCAGCCCCATCTTTCATTTTCAAAGAGAAG GGCATTCTAATAGGAACTGGTGCCAAGAGAGAAGAAAAGA AGTGATAACAGAAGAAATGGCTAGTTACAATATTAAAAAG CTCCTCTTTGAGATCTCCTCTGCAGGAATATCAGAGACGG AGTTGAAGCGCTGGAGAGGTAATAGGTCTAGACAGTACAG AACAATAACTGGGGAGTGTGTGAGGATAGACTGGGCTCCC CCTTGCTTGAAAGATCTCTGGCATTTAATTCTCAATTCTT GATTACTATTTTCCAGTGTAAAACTAGCACATATGATCTG ACTACAGGACAGAGAATTTTAAGTGAAACATTTGCCTTAC TTGCAGTAATAATGTGCTGTTCTTCACAGTAGCTAAGGCC CTCTATGTTTCCCAGAGGTAAATAAGAATCCAGGAATGGA GGTCCATCTGTGATGAATGGCTTTTTTCTAATCAAAGTAG TATAATGCTGTTTTATCTGTTTTGTCATCTTGTTTTTTTT TTTTTTTAAAAAAACAAAACCTTAATTATAATATAGCGCA AAGAAAGGCCAGGACTGATGCAGGGATTCCTTGGAAATAT CAGTTCCTATCACTTTTAAAACCTGATTTTGGATCTCTCT GTTCTATGTATGTCTTTAGTGAGAGCACAATACATGGCAG AACGCTGTGCCAAATGTTATAGGTAAGGAATATAGAAATG AATGTTTTTTGTTGTGAAGGTGTTTTCATGTGATATTTTA TAAACACATTTTAAAAAATCTCCATCACTTTTTAGTATAG GAAGGATAGCTTTGCCTGGGAAAAACAGTTTCAACACACC TGCTCAGAGTAGCAGTTCTCCCTCAAAAAAGCAGTGTTCA GCCTGCACTGACTGTTCTGCTTGCCAAAAGGAGGAAGCAT GCAAGATACTTATTTCTCCATAGATTGTGGAGTATAGAGG GATGTGGGACTACAGATTATTATTTTTTTTCCCCGAGACA GAGTCTTGCTCTGTCGCCCAGGTTGGAACACAATGGCACG ACCTCAGCTCACTGCAACCTCTGTCTCCCGGGTTCAAGCA ATTCTCCTGCTTCAGCCTCCTGAGTAGCTGGGATTACAGG CACACACCACCACCGCACTCAGCTAATTTTTGTATTTTTA GTAGAGGTGGGGTTTTACCATGTTGGCCAGGCTGGTCTTA AACTCCTGACCTTGTAATCATCCCGCCTCGGCCTCCTAAA GTGCTAGGATTACAGGCATGAGCCACCGCACCCGGCCCAG ATAATTTTTAATAGCCTTTGATCATGGGGTGAGTGAGGGA GTAGGTATACTTGGCAAATGCATGGTTCTCTGATTTCTAG CTCTAAAGCAGCCTTATCTGAATCCCCAAATCTTGTGATG CTGAGTACCATTACTGAACCAGTCTGCACGGTAGGCATCT GCTACCAAAATTTACCTCCTACCTGGTAGGTGTCATCTGA TAAGAAAGAAGACAGGTTATTTTAATTTTTTGAGATAATC ACAGAAAATTGCAGCCCATACTCTTTATTACCGAATTCAA GTTTGGAAATAGACCCTTTGTTTTAAATCATGATGGGTCT TTATCCCAATCATTTATCTGGGTCATTTTTCCAACTTTGG AGTTCTAGGAAAGAACCTTGAAAACCTGATATGATTCTGC AGCATGAGGTCTACGGTGACCATTTGGGCAAAGCTCCAGT GGCAATCATTTATTGTGTTTTGCATTTCCTGGGATTTATT GAAATAAGAATTCACTGTGATTATGTAGTCTTCTGGCTAG TATCAGGCAGCTCTGCTTTTAATTTGGTTAATTTTATTTT CTCTGAAGAGGGAGAAGAGGTACAATTTAATCTTGGCCTC CACAAGCATATTAAAGCTCACGTGTTAATCAGTGCATTCT TATGCTCCTACATTAAATGCCTTGGGTAAATGGATAAATG GACATGTGCCCAGCTTTAATTTTTTTTGCAACAGAAAGAT CAGACTTCCGTATGGCATCGTTGGATTTCAGAGGCTTTCT GGTGTATCTGTAAATCTGAATGTTGCCTTCTGCCAGTCTG TATAACCAGGTGATTCATGCTGCAAATGAAATCAGGAAGC AGTAAAGTGTTAAAGCAAGAGTATTGTCCAATTCACTTGT CTTCCTGATCCTTGTACTTTATTTCACGTGTCGGTGTTTA CATTACATACTTATATTTCCTGTGAAAGAAAGAGTTAAAT AAATTGTAGCAGTTTGA SEPN NM_031475.2 AGCGGAGCGCCAGGCAGCGCGGAGCGGAGGCCAGGCCCAC 29 AGCCGCTCCGCCTCCCGGCCCGCAGATCCCCGACGGCCGC ACCGCGGGCTCCTCTGGCCCGCAAGAACACGTGCATGGCG TCCTGGGGAAGGCGCTGAGTGCGGAGTCGCGGCGCCGCAC GCGGCACCATGGCCCTGGAGCAGGCGCTGCAGGCGGCGCG GCAGGGCGAGCTGGACGTGCTGAGGTCGCTGCACGCCGCA GGCCTCCTGGGGCCCTCGCTGCGCGACCCGCTGGACGCGC TGCCCGTGCACCACGCGGCCCGCGCTGGGAAGCTGCACTG TCTGCGCTTCCTGGTGGAGGAAGCCGCCCTCCCCGCCGCG GCCCGCGCCCGCAACGGCGCCACACCGGCCCACGACGCCT CCGCCACCGGCCACCTCGCCTGCCTGCAGTGGCTGCTGTC GCAGGGCGGCTGCAGAGTGCAGGACAAAGACAATTCTGGT GCCACAGTCTTGCATCTGGCTGCCCGCTTCGGCCACCCCG AGGTGGTGAACTGGCTCTTGCATCATGGCGGTGGGGACCC CACCGCGGCCACAGACATGGGCGCCCTGCCTATCCACTAC GCTGCCGCCAAAGGAGACTTCCCCTCCCTGAGGCTTCTCG TCGAGCACTACCCTGAGGGAGTGAATGCCCAAACCAAGAA CGGTGCCACGCCCCTGTACCTGGCGTGCCAGGAGGGCCAC CTGGAGGTGACCCAGTACCTGGTGCAGGAATGCGGCGCAG ACCCGCACGCGCGCGCCCACGACGGCATGACCCCGCTGCA CGCCGCGGCGCAGATGGGCCACAGCCCAGTCATCGTGTGG TTGGTGAGCTGCACCGACGTGAGCCTGTCCGAGCAGGACA AAGACGGCGCCACCGCCATGCACTTCGCGGCGAGCCGCGG CCACACCAAGGTGCTCAGCTGGCTGCTGCTGCACGGCGGG GAGATCTCGGCTGACCTGTGGGGCGGGACCCCGCTGCACG ACGCCGCCGAGAACGGGGAGCTAGAGTGCTGCCAGATCCT GGTAGTGAACGGCGCGGAGCTGGACGTCCGCGACCGCGAC GGGTACACGGCCGCCGACCTGTCGGACTTCAACGGCCACA GCCACTGCACCCGCTACCTGCGCACGGTGGAGAACCTGAG CGTGGAGCACCGCGTGCTTTCCCGGGATCCATCCGCAGAG CTGGAGGCTAAGCAGCCGGATTCAGGCATGTCCTCACCCA ATACCACGGTGTCGGTCCAGCCGCTGAACTTTGACCTCAG CTCGCCTACCAGCACCCTCTCCAACTACGACTCCTGCTCC TCCAGCCACTCCAGCATCAAGGGCCAGCACCCTCCATGTG GGCTTTCCAGCGCTAGAGCTGCAGACATACAGAGCTACAT GGACATGCTGAACCCGGAGCTGGGCCTGCCTCGGGGCACG ATTGGGAAGCCCACACCCCCACCACCCCCACCCAGCTTCC CCCCGCCACCCCCGCCCCCAGGCACCCAACTGCCCCCACC CCCACCTGGCTACCCAGCTCCCAAGCCTCCTGTAGGACCA CAGGCAGCTGACATCTACATGCAGACCAAGAACAAACTCC GCCACGTGGAGACAGAGGCCCTCAAGAAGGAGCTGAGCTC CTGTGACGGCCACGACGGGCTGCGGAGGCAGGACTCCAGC CGCAAGCCCCGCGCCTTCAGCAAGCAGCCCAGCACGGGGG ACTACTACCGGCAGCTGGGCCGCTGCCCCGGCGAGACGCT GGCCGCACGCCCGGGCATGGCGCACAGCGAGGAGGTGCGT GCCCGCCAGCCCGCGCGCGCCGGCTGCCCGCGCCTCGGCC CTGCCGCCCGCGGCTCACTCGAAGGCCCCTCCGCTCCCCC GCAGGCGGCGCTGCTTCCTGGGAACCATGTTCCTAACGGC TGCGCCGCGGACCCCAAGGCGTCCAGGGAGCTGCCACCGC CGCCCCCACCGCCGCCGCCGCCCCTGCCGGAGGCCGCGAG TTCGCCACCGCCGGCCCCGCCTCTGCCCCTCGAGAGCGCT GGCCCTGGCTGCGGGCAGCGCCGCTCCTCCTCGTCCACCG GCAGCACCAAGTCTTTCAACATGATGTCCCCGACGGGCGA CAACTCGGAGCTACTGGCTGAGATTAAGGCAGGCAAGAGC CTGAAGCCGACGCCCCAGAGCAAGGGGCTGACCACAGTGT TCTCAGGCATCGGGCAGCCGGCCTTCCAGCCCGATTCGCC GCTGCCTTCTGTGTCACCTGCACTGTCACCAGTCCGGAGC CCCACACCGCCAGCTGCGGGGTTTCAGCCGCTGCTCAATG GAAGCTTGGTTCCCGTGCCGCCCACTACTCCTGCGCCGGG AGTGCAGCTGGACGTGGAGGCTCTCATCCCCACGCACGAT GAGCAGGGCCGGCCCATCCCCGAGTGGAAGCGCCAGGTGA TGGTGCGCAAGATGCAGCTGAAGATGCAGGAGGAGGAGGA GCAGAGGCGGAAGGAGGAGGAGGAGGAGGCCCGGCTGGCC AGCATGCCCGCCTGGAGGCGGGACCTCCTGCGGAAGAAGC TGGAAGAAGAGAGGGAGCAGAAGCGGAAAGAGGAGGAGCG ACAGAAGCAGGAGGAGCTGCGGCGGGAGAAGGAACAGTCA GAGAAGCTGCGGACGCTGGGCTACGATGAGAGCAAGCTGG CGCCCTGGCAGCGACAGGTCATCCTGAAGAAGGGGGACAT CGCTAAGTACTAGAGGCCGCAGACTCCTGTCCGCAGCCTC GCAGCTCCGTGGGGCCCTCCGCCCCAGCCCCAGCCAGCCA GGCCCTGGTGGAAAGGCTGGGAGCCGCACAGCCCTCCCCT CCTGCGCTGGAAACCCTCCCTGACCCCCACCCTGGCCCCC CGTATCCCCAGCCCTTGGCAACACTGGAGTGCACACGCCG CCACGGTTGCCCAGAAAAAGTGCCCAAGCTGCTGACGCAA ACAACAACAAATGCTGCTTATTTGCATGCCGACTTACATA TATTTGCATGTTCGTTGACTATCAAAGAGTGCAGAGCTCT CCCCAGCCCCGTGGGTGGTGACTTTGTTTTCCTGCGGGGC TCAGCCCCCTCCAGGATGCAGCCCCCTCCCCCGCACCCCG GAACCGGCGTCGCTGGCGCATCCTGGGTGGAGGCAGGCCC CGAGCTCGGGGAAGGGGTTTTCCCTTCCTCTCTGACCCAG ATCTGCGCGCGGCCTAGCCCGGGCCTCATTTCTTATCCCC GCCAAGGGTTTCCTCTCAGTCATTTGTTTACCAGAAACAT GAAAACTGCCTGTCTGGCCGGGCCGCACTTGTGGCCCCCG GGACCCCACCTCTGGCCCCACCTCCCTCAAGTCTGCGCCC CGTCCCCAGCCAGACCCACTCGCTGCCGGGACCCTTTCAC TGCCCCGGTGGAGTGAATAGAGGATGAGGGGCCCTGACCC TGTGTCTCCAACTGCTGCACCCCATCCCGACCCTGTCTCC GCCACCTCGCAGCCCCATTAAAGCGCTCTCATCTGGGCTC CGGTTCACTCA YWHAQ NM_006826.3 TTGGGCGGTGGACCGCCCCTCGGCCCCGGGGTAGGCTGAC 30 ACGGGAGGGTCCTCAGCTAAAGCCAAAAGCAGATCAAAGT GGTGGGACTCGCGTCGCGGCCGCGGAGACGTGAAGCTCTC GAGGCTCCTCCCGCTGCGGGTCGGCGCTCGCCCTCGCTCT CCTCGCCCTCCGCCCCGGCCCCGGCCCCGCGCCCGCCATG GAGAAGACTGAGCTGATCCAGAAGGCCAAGCTGGCCGAGC AGGCCGAGCGCTACGACGACATGGCCACCTGCATGAAGGC AGTGACCGAGCAGGGCGCCGAGCTGTCCAACGAGGAGCGC AACCTGCTCTCCGTGGCCTACAAGAACGTGGTCGGGGGCC GCAGGTCCGCCTGGAGGGTCATCTCTAGCATCGAGCAGAA GACCGACACCTCCGACAAGAAGTTGCAGCTGATTAAGGAC TATCGGGAGAAAGTGGAGTCCGAGCTGAGATCCATCTGCA CCACGGTGCTGGAATTGTTGGATAAATATTTAATAGCCAA TGCAACTAATCCAGAGAGTAAGGTCTTCTATCTGAAAATG AAGGGTGATTACTTCCGGTACCTTGCTGAAGTTGCGTGTG GTGATGATCGAAAACAAACGATAGATAATTCCCAAGGAGC TTACCAAGAGGCATTTGATATAAGCAAGAAAGAGATGCAA CCCACACACCCAATCCGCCTGGGGCTTGCTCTTAACTTTT CTGTATTTTACTATGAGATTCTTAATAACCCAGAGCTTGC CTGCACGCTGGCTAAAACGGCTTTTGATGAGGCCATTGCT GAACTTGATACACTGAATGAAGACTCATACAAAGACAGCA CCCTCATCATGCAGTTGCTTAGAGACAACCTAACACTTTG GACATCAGACAGTGCAGGAGAAGAATGTGATGCGGCAGAA GGGGCTGAAAACTAAATCCATACAGGGTGTCATCCTTCTT TCCTTCAAGAAACCTTTTTACACATCTCCATTCCTTATTC CACTTGGATTTCCTATAGCAAAGAAACCCATTCATGTGTA TGGAATCAACTGTTTATAGTCTTTTCACACTGCAGCTTTG GGAAAACTTCATTCCTTGATTTGTGTTTGTCTTGGCCTTC CTGGTGTGCAGTACTGCTGTAGAAAAGTATTAATAGCTTC ATTTCATATAAACATAAGTAACTCCCAAACACTTATGTAG AGGACTAAAAATGTATCTGGTATTTAAGTAATCTGAACCA GTTCTGCAAGTGACTGTGTTTTGTATTACTGTGAAAATAA GAAAATGTAGTTAATTACAATTTAAAGAGTATTCCACATA ACTTCTTAATTTCTACATTCCCTCCCTTACTCTTCGGGGG TTTCCTTTCAGTAAGCAACTTTTCCATGCTCTTAATGTAT TCCTTTTTAGTAGGAATCCGGAAGTATTAGATTGAATGGA AAAGCACTTGCCATCTCTGTCTAGGGGTCACAAATTGAAA TGGCTCCTGTATCACATACGGAGGTCTTGTGTATCTGTGG CAACAGGGAGTTTCCTTATTCACTCTTTATTTGCTGCTGT TTAAGTTGCCAACCTCCCCTCCCAATAAAAATTCACTTAC ACCTCCTGCCTTTGTAGTTCTGGTATTCACTTTACTATGT GATAGAAGTAGCATGTTGCTGCCAGAATACAAGCATTGCT TTTGGCAAATTAAAGTGCATGTCATTTCTTAATACACTAG AAAGGGGAAATAAATTAAAGTACACAAGTCCAAGTCTAAA ACTTTAGTACTTTTCCATGCAGATTTGTGCACATGTGAGA GGGTGTCCAGTTTGTCTAGTGATTGTTATTTAGAGAGTTG GACCACTATTGTGTGTTGCTAATCATTGACTGTAGTCCCA AAAAAGCCTTGTGAAAATGTTATGCCCTATGTAACAGCAG AGTAACATAAAATAAAAGTACATTTTATAAACCATTTACT ATGGCTTTGTAACAATTGCATACCCATATTTTAAGGGACA GGTGAATTTACTACTTTCTAAAGTTTATTGATACTTCCCT TTTATGTAAAATGTAGTAGTGATACCTATATTTCCACATT GTGCATTGTGACACACTTGTCTAGGGATGCCTGGAAGTGT ATAAAATTGGACTGCATTTCTTAGAGTGTTTTACTATAGA TCAGTCTCATGGGCCATCTCTTCCTCAGATGTAAATGATA TCTGGTTAAGTGTTATATGGAATAAAGTGGACATTTTAAA ACTAGCAAAGTTAAAAAAAAAAAAAAAAAAAA VPS37A NM_001145152.1 GCAGAGGGGGCGGAGAGCGCCCCCGGGGGCGGGGCACGCA 31 AGTGACGGCGGCGCGGGTGGTGGAGCGCTGGGCGGCCAGG CTCCCTGGCTGGCCGGTTTGGGCGTCTGGGCCGTGAAGGT GGGACCTCCTGTTCCGGGCCGCAAGTTTCCCTCTCCAGCC GCCCGCCGTTCGTAGCATGTCCCCCAGAACTCGGGGAGCG CAGGCAGGACAGGCTTAGAGAAGACGCGGTCCCCAGCGCT TGGGCCACGGACGTCCCACCCCGCTCCTCTGTCGCTGGAG AACCGCCGGGCCGAGCCACTGGGAGAAGCAGGCCAGAGCC TTCCAGGGCCTCCGGCCCGTGGACCCGAGGAGGATGAGCT GGCTTTTTCCCCTGACCAAGAGCGCCTCCTCCTCCGCGGC TGGGTCCCCCGGTGGCCTCACCAGCCTCCAGCAGCAGAAG CAGCGCCTGATCGAGTCCCTCCGGAACTCACACTCCAGAT TGCTTCCTCCACAGTTTCCTCAGGAAAAACCAGTGATCAG TGTTTATCCACCAATACGACATCACTTAATGGATAAACAA GGAGTGTATGTTACCTCTCCATTAGTAAACAATTTTACAA TGCACTCAGATCTTGGAAAAATTATTCAGAGTCTGTTGGA TGAGTTTTGGAAGAATCCTCCAGTTTTAGCTCCTACTTCA ACAGCATTTCCTTATCTATACAGTAACCCAAGTGGGATGT CTCCTTATGCTTCTCAGGGTTTTCCATTTCTTCCTCCATA TCCTCCACAAGAAGCAAACAGGAGTATCACTTCTTTATCT GTTGCTGACACTGTTTCTTCTTCAACAACAAGTCATACCA CAGCCAAGCCTGCCGCTCCTTCATTTGGTGTCCTTTCAAA TCTGCCATTACCCATTCCCACAGTGGATGCTTCAATACCG ACAAGCCAAAATGGTTTTGGGTACAAGATGCCAGATGTCC CTGATGCATTTCCAGAACTCTCAGAACTAAGTGTGTCACA ACTCACAGATATGAATGAACAAGAGGAGGTATTACTAGAA CAGTTTCTGACTTTGCCTCAACTAAAACAAATTATTACCG ACAAAGATGACTTAGTAAAAAGTATTGAGGAACTAGCAAG AAAAAATCTCCTTTTGGAGCCCAGCTTGGAAGCCAAAAGA CAAACTGTTTTAGATAAGTATGAATTACTTACACAGATGA AGTCCACTTTCGAAAAGAAGATGCAAAGGCAGCATGAACT TAGTGAGAGCTGTAGTGCAAGTGCCCTTCAGGCAAGATTG AAAGTAGCTGCACATGAAGCTGAGGAAGAATCTGATAATA TTGCAGAAGACTTCTTGGAGGGAAAGATGGAAATAGATGA TTTTCTCAGTAGCTTCATGGAAAAGAGAACAATTTGCCAC TGTAGAAGAGCCAAGGAAGAGAAACTTCAGCAGGCGATAG CAATGCACAGCCAATTTCATGCTCCACTATAGATTTTCCT GGAAACATGAACTGCCAAGAGAGGAATGGGACACAAAACC AAACACTGTTTTATATTTATGGTTTGCAAACTGGCATTTC ATCAGTGGCTAAATTCACAGATATCCTATATAGATTGTAT ACAGAACTGAGACTGATTTTGTACCGATTAGAATGATTGC TATGATCTTTGAGAAATTTTTCTGCACTATTTGCACTGAA ATGTTTATTTATTGTTGATAAATTGTATCATATTTAAGTT CCACTGCTGTTCCTCTTACCTTGATTAAATGCCTATGCAT GTACTTTTAGCTAGTTTTTAATATTTTATAAAACTTCATT TAAATTTGTATTTTTAACTTGAAGTTCCATTTCTTTATCA AGGATGGTATTTAGATTTTTTTCCTCTTAACCTTTTTTCA AAAACTATTTTCAACTGTGAGGAAACCCTTATTTTTCTTT CTTTGTGGATAAAACTTTCAAAAGCAATTTAAGATATTCA TAGTGTTAGGAAACACCAAACCTGCCTATGTGCCATCTCA CAAAAGAAACTTTTAATACCTACAATAAATCAAAAGAATA AACCAGCTGTTCTTATATATTGTTTCATTTTTAAAACTAA AGATGCATTTAAGAAGCAATACAAGTAAATATTTTACCTA ATAGGAAAAAAAAAAGTTGCCTTTCATTTAAACCATTCCA ACAGAAATTCTTATGCTAATTTAAAACATATATATATCTG GTAGGTTTGTGGTTGGATAGGTTTTCTAAATTCCTAATGT TAAAAACAATCTTTATGTTAATATACACTAAATCTATACA CAAAAAAAGTCAGTGAACTTTTCTGACCTTTACTGTGAGT TACCTTTTCCTAAGAGGAAAGCTATAGTAATAAGTAAAAT TTAATTTTTAGGCAATCCTGATTTTTAATGAATTTAATTG AGTGTTCTTGTATACTACATTGAGCAGTTTGCTTCTATAC CGTGTCACAAAATTCATGTATTTCTTGAGAAGCCCTAAAA GCTCATAAAGGAAAATGCCGTGAACTATGTAGCTCAGGCT TGGTAAGGTGCCATCTAAATTACAAAACAAACTAATGCAT AATTTTGCTTAAATTTCATCCCAGTATGATTGTCTTCCCA ACACCAGCATATAGTATAGATTGTCTGTCTTTTTTATATT TTTTAGTTCTTCCTGTACATGTTTTTGGCAATAAAGTTAT AGGAAGAACAAAATTATTTTGTTAGAATTAAAACATGCTT AATATTTAGTCTGTTTGTGGAGGGCAGGTATTCACGTGGA CTGAGATACAATGTTGGATACAGAAAATAACTTTCATTGT CTTCCTGACACTGTGCTAAGGACATGCTGTTAAAGCTTCA AAGTGACCAGATGAGGAAGGAATAATTAATTATTACTCCT GATTTGTAGATAACTGAGGTAAGAGTGTTTCAAATTTATG ATAGTCTTTTGGGTATTCAGAAACCTTTCCTTATACTGCA CTGGCCACCAGAGCTTAATTTTCCCAGCAGTTACAGCAAT GGGAGATAGAACAGTCTCAATCTTTTGCCAACCATCAGGT TCCTAGAAACCAGGTAGGTGTATCCCATAACAAGGGAGGA GCATACCACAGCCCCTCATTTGATTAATTCATTTGATCTA TCTATGTTATTAAGTACCTACTAGGAATAAGGCATTGTGG AAATACTATACAAAGATAAACATTGTTTAGATGCTTATCT ACTTTCCTTTTCACCAGAAAAACAGAAAAAAAAGAAACAT TTTCTTACAGAGTAAAAATGTTCTACATAATCACATGAGT AGTTCATCTCAGTGTTTTTTATTCTTTAAAGTTGAACTAT CCCAGTTTCATTCTATACCATTCATTGGATAACCTTGTTA CAACCCAGTCATGAAACAGAGCAGTGTGATCAGTTATCTG CATTTAACAAATAGACAAATCAGTTTACATAAAGGTTATG TATGTCACCCACGATGAAAAGAATCTGCATTTGAATATGC CCGTATGAATGTGGGTTCTGTTTTTGCAACAGAGATTAAG TGACCATTTTTTCTAATTTTATGGCTATATATTTTCTTCA TAAAAATTGGTCACATCGGAGAAGCAGTGCCACAGGAAAA ATGAAATGCATGTGAAAGTTTGTATTCTGATTTTACAAGA TGAGATAGAAATCAGAATTAAAGAGGAATACTTAGGAGTT ACTAGGCTAATCAGTGTACGAATTTGTCATAGGTAGAGAT TTAAAGGTTAATATCTTAAAATAGAAGAAAATTCTAAATC AATCAATCAGTGAGATATAAACTAAACAGACCCACTTCAA AGTTGAAAGAAATTTCTAGGCATAAATTGAGACTAGGAAA TTTATATCAGAATAGAGGGTGCTTGACACATATATATGCT TAAATTGAAGGACAGCTCAGATTCATTTTTAGGAGAAGAA AGTAAACTAATGTGCTCTTAAAGAATAAAAATTTATTCTA TGGTTTCTGTCTCTGATCATCACCTTCCATTCTATAAAAA GCTCAGTTACTGATTTGCTGGGTCATGGTCAAAATTCTTA CCTATTTATTTCATATCAACTTTAAAAAATAAATTACTTG CATTCTATATATTACTAATTGGGAAGTAATATGCCTCAAA TCAGTTTTATACTGGATTATTCCCTATGCTTTAAACCACT GCTCTCAATAAAACACTTCCTGATTAATGTTTGATTATTA GATATTTTAGTCTTGTTGGGGATATTTTAGTCTTGTTGGG TTAGCCATGCTCTGAAGAATCTGTGAAAGTACAGTAAAGT TTTAATAAGCAATAAATGTAACCTTTTATATAAATCTCAG TGCTAGGTTAACTTCTAATAAGCAGACGAACATGTTACAT AAATTATAATGTCTGTCTTGTAAAAAAGTTGAGGGGACTA AAAGTTTATGACTCTGATATGGAAGTTGTCATATTAAAAA ACTACATTTTAAAACATCAAATATTTATACTATTTGCTTT TCAAATAAAAGCATAGTGCTGTTTGGCATA PRRC2B NM_013318.3 GCAGATCGGGAGCGGTGCCGAGAAAAATTTCCTTACTAGA 32 TGACATTTCATCGCAATGTCCGATCGTTTGGGGCAAATTA CCAAGGGCAAGGATGGGAAAAGCAAGTACTCGACTCTCAG CCTGTTTGATAAGTATAAAGGAAAATCAGTAGACGCGATT AGATCCTCAGTTATTCCTAGACATGGCTTACAGAGTCTTG GGAAAGTTGCTGCAGCCCGGCGCATGCCACCGCCTGCAAA CCTGCCAAGCTTGAAGTCTGAAAACAAAGGAAACGACCCC AACATCGTGATAGTACCCAAGGACGGGACGGGATGGGCAA ACAAGCAGGATCAGCAAGACCCAAAGAGTTCCAGTGCGAC GGCCTCTCAGCCGCCGGAGTCGCTGCCGCAGCCGGGTTTG CAGAAATCTGTCTCCAATTTGCAGAAACCGACACAGTCAA TCAGTCAGGAGAATACAAATTCAGTGCCAGGTGGACCAAA GTCATGGGCACAGCTGAATGGAAAGCCAGTAGGACACGAA GGTGGTTTAAGGGGCTCAAGCCGACTGTTATCCTTCTCTC CCGAGGAATTTCCGACGCTGAAAGCAGCTGGAGGGCAGGA CAAGGCTGGCAAAGAAAAGGGCGTCTTAGATCTGTCGTAT GGGCCAGGACCAAGCCTCCGCCCTCAGAATGTGACAAGCT GGAGGGAGGGCGGTGGGCGACACATAATTTCTGCCACGTC TCTGAGCACCTCCCCAACTGAGCTGGGCAGCAGGAACTCG AGTACGGGAGATGGAGCCCCCTCCTCGGCATGTACCAGCG ATTCTAAGGACCCCTCTCTCCGCCCGGCTCAGCCTGTCCG AAAAGGGGCTTCACAGTTCATGGGAAATGTATACCACCCA CCTACATACCATGACATGCTTCCTGCTTTTATGTGTTCGC CGAAGTCATCAGAAAACCAGGGTACAGTGGAACGAGGCTC TTTTCCCCTTCCTCAGCTCCGCCTTGAACCTCGAGTTCCT TTTAGACAGTTCCAGATGAATGACCAAGACGGAAAAGAAA ACAGGCTGGGATTGTCTCGCCCACTCCGCCCACTAAGGCA GCTGGTGGAGCGGGCACCACGGCCCACCATTATCAATGCG GAAAACCTGAAGGGCCTTGACGATCTGGACGCCGATGCCG ATGATGGCTGGGCAGGCCTCCATGAAGAAGTGGACTATTC TGAGAAACTGAAGTTCAGTGATGATGAAGAGGAGGAAGAA GTTGTGAAGGACGGCAGGCCAAAGTGGAACAGTTGGGACC CTAGGAGGCAGCGGCAGTTGTCAATGAGCTCTGCAGACAG TGCGGACGCTAAGCGGACTCGAGAGGAAGGGAAGGACTGG GCTGAAGCAGTGGGTGCGTCCCGTGTGGTCCGAAAGGCGC CAGACCCTCAGCCACCGCCCAGGAAGCTTCATGGCTGGGC ACCAGGCCCTGACTACCAGAAGTCATCAATGGGCAGCATG TTCCGGCAACAGTCCATCGAGGACAAGGAGGACAAGCCCC CACCAAGGCAGAAGTTCATTCAGTCAGAGATGTCCGAGGC GGTGGAGCGAGCCCGAAAGCGCCGGGAAGAAGAGGAGCGC CGAGCCCGGGAGGAGAGGCTGGCCGCCTGTGCTGCCAAAC TCAAGCAGCTGGACCAGAAGTGTAAGCAGGCACGAAAGGC AGGTGAGGCCCGGAAGCAGGCAGAGAAGGAAGTGCCCTGG TCTCCAAGTGCTGAGAAGGCATCTCCCCAGGAAAACGGCC CTGCTGTCCACAAAGGCTCCCCAGAATTCCCTGCCCAAGA GACCCCCACCACATTCCCAGAAGAGGCACCCACAGTGTCC CCAGCAGTGGCACAGAGCAACAGCAGTGAGGAAGAGGCCA GAGAGGCTGGGTCCCCTGCACAGGAGTTCAAGTATCAGAA GTCCCTTCCTCCCCGATTCCAGCGCCAGCAGCAGCAACAA CAGCAGGAGCAGCTGTACAAGATGCAGCACTGGCAGCCGG TGTACCCCCCGCCGTCCCACCCCCAGCGCACCTTTTACCC ACACCACCCCCAGATGTTGGGCTTCGATCCCAGGTGGATG ATGATGCCTTCCTACATGGACCCACGTATCACGCCCACTC GGACCCCGGTGGACTTCTACCCCTCCGCCCTGCATCCCTC AGGACTGATGAAGCCCATGATGCCCCAGGAGTCCCTCAAT GGGACAGGCTGTCGCTCTGAGGATCAGAACTGTGTGCCCC CACTCCAAGAAAGAAAAGTGACCCCCATCGACTCACCCCC TGTGTGGAGCCCAGAGGGCTACATGGCACTGCAGAGCAAG GGCTACCCGCTCCCGCACCCGAAGTCGAGTGACACCTTGG CTATGGACATGCGTGTCAGGAATGAAAGCTCTTTCTCTGC CTCACTCGGAAGGGCAGGGGGCGTAAGTGCTCAGCGCGAT CTCTTTGAGGAGAGAGGGGAGGAGTACTTGAGTGCTTTTG ACAAGAAGGCCCAAGCAGACTTTGACAGCTGTATCTCTTC TCAAAGAATAGGCCAGGAGCTTTTGTTTCCACCCCAAGAA AATGTTCAGGATGCAGGTGCTCCTGGGGGTCACACCCAAA ACCTCAGGTGTTCCCCATTGGAGCCTGACTTTGTCCCAGA TGAGAAAAAGCCAGAGTGTGGCAGTTGGGATGTTAGCCAC CAGCCAGAGACCGCTGACACAGCCCATGGTGTTGAGCGGG AGACACCCCGGGAGGGGACGGCCTTTAACATCTCCTCCTG GGACAAGAACGGGAGCCCCAACAAACAGCCATCCTCGGAG CCTGAATGGACTCCCGAGCCCCGGAGCTCCAGCAGCCAGC ACCCGGAGCAGACGGGCAGGACCCGGAGGTCGGGACCCAT CAAGAAACCAGTCCTGAAAGCCCTCAAGGTGGAAGACAAG GAGAAGGAGCTTGAGAAGATTAAGCAGGAGCTAGGGGAGG AGAGTACCCGGCTGGCCAAGGAGAAGGAGCAGAGCCCCAC GGCAGAAAAGGATGAGGACGAAGAGAACGATGCCTCTCTG GCCAACTCCTCCACCACCACTTTGGAGGACAAAGGCCCTG GCCATGCCACTTTTGGCCGCGAGGCCACCAAATTTGAAGA GGAGGAGAAACCTGACAAGGCCTGGGAAGCCAGACCCCCA CGAGAGTCCAGCGATGTTCCCCCCATGAAGAGAAATAACT GGATCTTTATTGATGAGGAGCAAGCCTTTGGGGTCAGAGG ACAGGCCCGGGGCCGGGGCCGTGGTTTCAGAGAGTTCACT TTTCGTGGTCGGCCTGCTGGCGGAAATGGGAGCGGCCTCT GTGGTGGGGGGGTCCTGGGGGCCCGCAGCATCTACTGCAG CAGTCAGCGCAGCGGCCGTGGCCGGGGCCTGCGAGAGTTT GCGCGGCCAGAGGACTGCCCCAGAGCCAAGCCCCGACGGA GAGTTGCCAGTGAGACCCATAGCGAGGGCTCAGAGTATGA AGAACTTCCCAAGCGCCGCCGGCAGAGGGGCTCCGAGAAC GGGAATGAAGGCTCGCTCCTGGAGAGGGAGGAGAGCACCT TGAAGAAGGGCGACTGCAGAGATTCTTGGCGGTCCAACAA GGGGTGCTCTGAGGACCACAGCGGTCTAGATGCCAAGAGC CGAGGCCCTCGGGCCTTTGGGCGAGCCCTCCCTCCCCGGC TGAGCAATTGCGGGTATGGACGGAGAACCTTCGTCTCCAA AGAGTCACCCCACTGGCAGAGCAAAAGTCCAGGCAGCTCT TGGCAGGAATATGGCCCTTCCGACACATGCGGATCCCGGC GACCTACAGACAGAGACTATGTCCCAGATTCCTACAGACA CCCTGACGCATTTGGTGGCCGGGGCTTTGAGGACAGCCGC GCGGAGGACAAGAGATCCTTCTTCCAAGATGAACACGTGG CAGATTCTGAAAATGCAGAGAACCGGCCCTTCAGGAGAAG GCGCCCCCCACGCCAAGATAAGCCCCCTCGATTCCGGCGC CTCCGGCAAGAGCGGGAGTCCCTGGGCCTGTGGGGACCCG AGGAGGAGCCCCACCTGCTGGCAGGTCAGTGGCCAGGCAG GCCCAAACTGTGTTCTGGGGACAAGAGTGGCACTGTGGGC CGCAGGTCCCCTGAGCTCTCCTACCAGAACTCCTCCGATC ACGCCAATGAGGAGTGGGAGACGGCCTCCGAAAGCAGCGA CTTCAGCGAGCGGCGGGAGCGGCGGGAAGGCCCTGGGTCC GAGCCCGACTCCCAGGTGGATGGTGGCCTGTCGGGGGCTA GTTTGGGTGAGAAGAAGGAGCTGGCCAAGAGGAGCTTCTC CAGTCAGAGACCCGTGGTTGACAGACAGAGCCGAAAGCTG GAGCCGGGAGGGTTTGGGGAGAAGCCCGTTAGGCCAGGTG GTGGTGACACCTCCCCTCGCTATGAGAGCCAACAGAATGG GACGCCTTTGAAAGTGAAAAGATCCCCAGACGAGGCCTTG CCTGGAGGTCTTAGTGGCTGCAGCAGTGGGAGTGGCCACT CCCCCTATGCCCTGGAGCGGGCAGCCCATGCCAGTGCTGA CCTTCCCGAAGCCTCCAGTAAAAAGGCAGAGAAGGAGGCC AAGTTGGCTGCTCCGAGGGCAGGTGAACAGGGAGAGGCCA TGAAACAGTTTGACCTGAACTATGGAAGTGCCATCATTGA AAATTGCGGGTCCAGCCCCGGGGAGGAGAGTGAGGTGGGT TCTATGGTGGGCGAAGGCTTCATCGAAGTCCTGACCAAGA AGCAGCGCCGCCTGCTGGAGGAAGAGAGAAGAAAGAAGGA GCAGGCCGTGCAGGTGCCTGTCAAAGGTCGAGGCCTTTCC TCCCGTATTCCTCCTCGATTTGCAAAAAAGCAGAACAACT TATGTCTGGAGCAAGGTGACGTGACCGTGCCTGGCAGCAG CCTGGGCACTGAGATCTGGGAGAGCAGCAGCCAGGCTCTC CCTGTGCAGGCCCCAGCCAACGACTCCTGGAGGAAAGCTG TCACTGCCTTCAGCAGCACCGAGACTGGCTCTGCGGAGCA GGGTTTTAAGAGCAGCCAGGGAGATAGTGGCGTTGACTTG AGTGCCGAGTCTCGGGAGTCGTCTGCGACCTCCTCGCAGC GCAGCTCCCCATATGGGACTCTGAAGCCAGAGGAGATGAG CGGGCCCGGCCTGGCGGAACCCAAGGCCGACAGCCACAAG GAGCAGGCTCCAAAGCCATCTGAGCAGAAGGATTCAGAAC AAGGCTCTGGACAGAGCAAGGAGCACAGACCAGGACCCAT CGGCAACGAGCGTTCTCTGAAAAACAGAAAGGGCTCGGAG GGGGCCGAGCGGCTGCAAGGGGCTGTCGTCCCGCCTGTTA ACGGGGTGGAGATTCACGTGGACTCCGTGCTGCCTGTGCC ACCCATTGAATTTGGAGTCAGTCCAAAAGACTCCGATTTC AGCTTGCCACCTGGTTCTGCCTCTGGTCCTACTGGGAGTC CAGTTGTTAAACTTCAGGATGCCTTGGCCAGTAATGCAGG GTTAACACAGAGTATCCCCATCCTGCGGCGGGACCATCAC ATCCAGAGGGCCATCGGTCTCTCCCCAATGTCCTTCCCCA CCGCCGACCTTACTCTGAAGATGGAGTCTGCGCGCAAGGC TTGGGAAAACTCCCCCAGTTTGCCGGAGCAGAGCTCTCCA GGCGGCGCTGGCTCAGGCATCCAGCCTCCATCCTCTGTGG GTGCCTCCAGCGGGGTCAACTACAGCTCCTTCGGTGGAGT GTCCATGCCACCCATGCCTGTGGCCTCTGTAGCACCTTCT GCTTCTATGCCAGGCAGCCACCTCCCGCCCCTGTACCTGG ATGGCCATGTGTTTGCAAGTCAGCCCCGGCTGGTTCCTCA AACGATACCTCAGCAGCAGAGTTACCAACAGGCCGCCGCT GCCCAGCAGATCCCGATCTCCCTTCACACATCTCTGCAGG CACAAGCTCAGCTTGGACTGAGGGGTGGGCTTCCTGTGTC CCAGTCCCAGGAGATCTTCAGCTCCTTGCAGCCCTTCAGA TCTCAGGTGTACATGCACCCCAGCCTGTCACCGCCCAGCA CCATGATCCTCTCTGGGGGCACAGCCTTGAAGCCTCCATA CTCGGCGTTCCCAGGCATGCAGCCCTTGGAGATGGTGAAG CCGCAGTCTGGCTCACCCTACCAGCCCATGAGCGGGAACC AAGCCCTGGTCTACGAGGGCCAGCTCAGCCAGGCTGCTGG CCTGGGTGCCTCCCAGATGTTGGACTCCCAGCTCCCACAG CTGACCATGCCACTGCCTCGGTACGGCTCCGGGCAGCAGC CACTGATCCTGCCCCAGTCTATTCAGCTGCCACCTGGGCA GAGCCTCTCCGTTGGGGCCCCCCGAAGGATTCCTCCGCCC GGGTCCCAGCCGCCAGTCCTGAACACCAGCAGAGAGCCCT CTCAGATGGAGATGAAAGGCTTCCACTTTGCCGACAGTAA ACAGAATGTCCCTTCAGGAGGCCCCGTGCCATCGCCACAG ACCTACAGGCCTAGCTCTGCTAGCCCCAGTGGGAAGCCCT CTGGATCAGCAGTTAACATGGGCTCTGTGCAGGGACACTA CGTGCAACAGGCAAAACAACGAGTGGATGAGAAACCCAGC CTGGGAGCCGTGAAGCTGCAGGAGGCCCCCTCGGCTGCCT CCCAGATGAAGCGAACCGGAGCGATCAAGCCTCGGGCTGT CAAAGTGGAGGAGAGTAAGGCCTGACAGTGCCTGGCTGCC ACCTCGCCTCTCCCTACTGAGGACGGTGCCGCCATGCGGC CTCGACACAGCCGACACTCGGGAGCCTCACCAGATCCACC GTCCAAATGCGTGGCCCAGACTGAGAGACCTCCCTCCTCT CCACTCCCGAAAGCTCCGTTGTCAACCAGCTTGCACCCGT GGATATATGGCATTGACCCGCTTGCTTTGATACGAAACAA AAAAGCAGACGACTCCTTCATCCCATCTGCTCCTACCGTG ACTGTGGAGTGACGCCTCCTGTGCAGTGCAGATTTGCCCT CCCTGCCTCCTCCCTGTCCTGCCGCGCAGCCAGGGCGCCT TCTCAGCAGTGCTTCCGGCCCAGCCGCCCATCCCTAGGCA CAGTGATTTGGCAGCAGGGTCATTTTACTTTGAGGCTTTT TGTTTTAAAATGTAGCCAAGGTTTTTACAAAGGGGAAAGG AAAAGAAAACAAAAACGCAAGCTCCATGTGTATAGCTGAA CTTTTATATGTTTCTTGCCAGCCCCTCCGCTCCCTTCCAT CTCTAGCCTCTGTCCTGTTTAGTTTGATACGTCACTGCAG TACCTTAAGAGGTGACTCTTAAGAATGCATCCCCTCCTGA TTCCTCAGCTGGTTCACCCTTGAGGTTATTTGCAAAAAGA AAAGGAGGTTCTTGAGGGCACCGATTGCGAGCATTCTGGT GCCTGGCTCCCCGCCTGGGAAGCGATGGGGTGCTCAGAGC AGCAGGCAGGTTGGGGGAGGGGGGGGGTCATAGTTGGGTT CCAGCTCCTGGCTTGATGAGCCCAGGGCGCTTACAGGCAG CCCATGAAGTTGATGACAGTTTTAGCATGAGAATCACACA GGGTCCCTGTCCTGGGCTCCTCTAAAGCCAGTGGATGTGC TGGGCACCAGAGACAAATCATGGAGATGGCTGCTGGTGGC TCCCAGGTTGGCCCAGATGGGGTGAGCTGACATACCACAG GCCCATCCCAGGCCCCGTGGGCTCTGCTTCTGGGGCTCCA TACCCTGCCCTGCAGGGGTGCTGTGTTTTTCACACATTTC TTTCCCTGAAGCCTTCTGTAACCTGTCATTTTCCTTCCTT CCTCTTCCGGAGCCTGCTGCTTTCTCTGGACCTGTCTCCA CCTCCCACACAGCTCATCGTGAACACCACTTGGTGATGGA GGGAGTGGACCCGTGTGTGGTCCCCAAGTGAGGCCACTGG GAGTTTGTCCTTTTCCTCCTTTGCTTCACTCCCAGCAGCA GACCCAGGTTGTCAGGACAGGAGGGCCTGAGCTAAGCAGT AGGCATCAGTCTCGTTTGTCTTCAGACGGCGGGGGCAGGT CCAGGGTGAGGCTGGGTGGAGGGCTGACCAAGGTCCAAAG GGCCTGCGCAGCCTCCGGGAGGGCAGCTTCTCCAGCCAGA GGCTTGTGTGAGCCATCGTGTGCTGGGCTTGTTTTTAAGT AAGAAACAAGGAAATCACTCCAGATTCTGTCATTCCAAGG AAAGGGAAGGGGACAGTTCAGGTTTCTCAGCTGTTCTTAG GGGTCACTGAGCGTCTACCTCCTCCTCCAGAGGAGGCTGG CTCAGAACACCTAGAGGAGGGGGCCGGGGATGCACCCCCC ACCAGAGGCTGCCTTCAGCGTCTCACGGGTGCAGGACAGC GCTCAGGCTTGGGCTCTAAGCTCTGTGTCTAGTGTAGAAC ATGGGGAAGGAGCATCTTAGGAACTGCTGAAGTAACTTCT TACTGCTCTCACAATTCTAAGGAAGCGGGAGAACGGCCTC CTACCAACAGCGCCCACCCCAGAGCTGCCTGGGAAAGGGC AGTTTTACTGAAAGGTGCTTTACTGTTCACCTGCATCTTT CAGCAGCTCCCCTCCTGCCCTCACCTGGTCTTTTCCCTCT TTATCCCAAGCCTTTATGCTTGAGTCCCTTCCCCAGGGGC TGCCCACCCGACAGTTCCAGGCATTCCCTACCTGAGCTTC TTGTCTGCTTTTCCTTCTCCCACTGCAAGCGGCTGCTTGT GGGGCCTGGGATGAGCCCTCTCTGTCCCCACCGGCCCTCC TTGCCAAGCCATTCCTGGGTGAGTTCAGGCCTGCGGGAGC CACACATTCATCTCCACCTGGACACTTGAGCCGCATGGCC AGACCCCTCCCACCTGATGCGGTGGTGCGTGTGATTTGTC AAAAGAAAGCCTTCTGGATGCTGTTAAGATGTACCCTTCA GGTGAACCTGGTATCAGACCCACAGTACTTGCTGTTTGAG AAAAAATAAAAACAAAAAGGTCACCTGTTCTCCAGCCCTT TTCTCTTACCTGGTATTTCCTTCCTTTCTCCTCCCCCACC CCAAATAAAAAAACAAAAAACACTAGAATTTATTTATATG TATTGATGTTGTAGGTCTAGGTGAAAAAAAAAGAAGTAAA TGTTTCACTGCTCTATTTATATATAATGTCTGAATTAATT CTGTGCAGGAAAGGCCAGGAAATTGCATGTGAAGTTCGGT GCAGTCACCACCTGTGTGTGACCTGAGCTGCAGTCTCTTC GCTGAGATGCAGGTTTTAAATGAGACTTGGGGGGCTGAGG GCAGGCCTCAGGCCTCCCAGCGCCCCAACCCCTCCTTGGT CTAATGAAATGCAGTTCTTAGTGCAGAGATGTTTTAAGGT GCAATATATCTCTTCCTTTCCCGTGGTTTTAGAGCCAAGC TCAAGGTAGTAGGACGTAGGGTCTTATTTTGTTTTCAAAC CCCCATCCTCAGAGCGCAGATACATGCAGAGGCTTCTGCC AGGATACCACGGGGCCTTAGTGGGAACAGGTGGAGACCAG CACTTCCCTTTCCTGCTGCTGAGGTAGGGATTGGGGGGTC AGAACCCACTCACTTTTGCCTGTTAAAGTTGCCCTCCTGA CGCTGGCAGCTCTGCCTTGGTCACTGGGGATGCGGCTCGT TGCTCAGCCACCAGTGGCCTTGCGGTATTGTCCACCATCC ACTAGAGTGGGATGAAGTCCAGAGTGTGGGTATACATCTC AGATGCCCATCTACCCACTGGGGACTTCAATGCCAGCTGC ATTTGGTTTGGTTTTCTTAACTGTTGGCTTCTCCCCACAG CGTTTTTTGTTTTTTTTTAAACATTCATATTGTTTTCAAA CTTGGAATTCATAGACACTCTGGCTCTAGGTTCCTTAAGG GGGAAAACAAAAGATGACTTTATTTCACATTCAAGAAAAT CAGTTCAGTTCCAAAGCTGTGGTCCTTCCAGCCACTTCTA GGGACACTGGGGAACCTTGTTAAACGTTGACATCAGTGCT CTCCAGCCGTGCTGTCACCCTCCTATCTTCTGGATCTGCC TTCGCGATGGTCAGTGACAGCTTCTGGAAGCTGAGCACAC ACAGGTGCACAGCCATGCTGTGGTCTGGCCTGCTACGGCA GCATGGCAGCTCTGGTGGAGCCTTCTCCCTTGCCATTTGG TTCCCCTGTGCCAAGTAGCTGCAGGCTGCCCCTCAAATCT TCATTTGTCCCTTTTCACTTCCTGCAGAACAAGCCTGGGT TAGAGGGTCTGCTGGAAATGGCCTTTGAAGACCAAGGATA CCAGGATGTGTGCACTCTGTCGTGTTCTGTGATGAATGGG AAACGTAGGCTTCCAGAAAGCCAGCTCTCTTCTGAAATGT GACGGACCTAAGCAGGAAGTCATCCAGGACAGGAGTGGCT CAGTGTTGGGGATGGACGCTGTCGCCCAGCCATGCTCCAC CAGGGCCACCAATGTGTAGTTGGCTGGTGGTCTTCGGGCA TGTGAGACCTGCTCTTCACTGTTTCCACCCCACTTGGTGG CCTCCAGGATGGTAGTGGCACCCTCAGAGCCCCATCTTCA GCATGTTCTGAAGCCTCAGAGTGGAAATTCCTGCTAAGGC TCTGTGTGGACGCCTTTCTCCCGTGATCTAAAGGGGACAC TGTACTCAAGCTTTTGACCTCATGCCTTGTGTAGTAAAAA AGGATTTGGGGGTTTTGTTTGGTTCCTGAGAGGGTTGTGT TTTGTTTTTGTTTCCTTTTGTTTATGTTTTGGCCTTTCCT CTTTGTCTTTCCATGTAGACCAGATATTTGAAAGGGCAGA CGATGGCTAGAGGTGTAATGTGCAGCTTGTTTATACGGTA TTTTGGGAAACTTACCTTGGATGGGAAATCGAATCGTGGA TTCACCAGGCCGGTGCTGGCACACTCACCCTCGCCCTTTC CCTCCGGTTCAGTACCTATTGTTTCTCCTTTCAAATATGT GATTGTACTAGCTCTTTCCATATGAAAGAATTCTCCTTAT TTAAATAAAAAAAGTTTAAAAA DOPEY2 NM_005128.3 TCCCACAGTGCCTGGCCCAGAAGCCTTGCTAAATATTTGA 33 ACAGGATTGCCCAATACTTTTCTGCTGTGAGAATGTAAGA TGGATCCAGAAGAGCAGGAGCTCTTAAATGATTACAGATA CAGAAGCTACTCTTCAGTGATTGAAAAGGCTTTGAGAAAT TTTGAGTCCTCGAGTGAATGGGCGGATCTCATATCTTCAC TTGGCAAACTCAACAAGGCTCTTCAGAGTAACCTGAGGTA CTCCTTGTTGCCAAGACGGCTCCTCATCAGCAAAAGATTA GCTCAGTGTTTGCACCCTGCCCTGCCCAGTGGTGTCCACT TAAAAGCTCTGGAAACCTACGAGATTATCTTTAAAATCGT GGGGACCAAATGGCTGGCCAAGGACTTGTTTCTGTACAGC TGCGGGTTATTTCCTCTCCTGGCACACGCGGCGGTGTCGG TGAGGCCGGTGCTGCTCACCCTGTACGAGAAGTACTTCCT CCCACTGCAGAAGCTGCTCCTGCCCAGTCTGCAGGCCTTC ATCGTGGGCCTGCTGCCCGGCCTTGAAGAGGGCTCCGAGA TCTCCGACAGAACGGATGCTCTGCTCCTGAGACTGTCGCT GGTGGTTGGCAAAGAGGTGTTTTACACCGCCCTCTGGGGG AGCGTCCTGGCCAGCCCGTCCATCCGCCTCCCTGCCTCAG TCTTCGTGGTGGGCCACATCAACAGGGATGCCCCCGGCCG GGAGCAGAAGTACATGCTGGGGACCAATCACCAACTCACG GTGAAGTCTTTGCGTGCCTCCCTGTTGGACTCAAATGTTC TTGTGCAAAGAAATAATCTGGAAATCGTTCTGTTTTTCTT CCCATTTTATACCTGTCTGGATTCCAATGAGAGAGCCATC CCCCTCCTCAGATCTGACATCGTGCGCATTCTCTCAGCCG CCACCCAGACCCTACTGAGAAGGGACATGTCCCTGAACAG AAGACTGTATGCATGGTTACTAGGCTCAGACATAAAAGGA AATACCGTTGTGCCAGAATCTGAAATCTCAAATTCTTATG AAGACCAGTCGTCTTATTTTTTTGAAAAATACTCCAAGGA TCTTTTAGTTGAGGGTTTGGCTGAGATATTGCATCAGAAG TTCATAGATGCTGACGTGGAGGAACGCCATCATGCATACC TGAAGCCTTTTCGCGTCCTCATCAGTCTGCTTGACAAGCC AGAAATAGGGCCTCAAGTGGTTGGGAATTTGTTTCTCGAA GTCATCAGGGCCTTTTATTCTTACTGCAGAGATGCCCTTG GCTCTGATCTTAAACTTAGCTACACCCAGAGTGGAAATTC GCTGATAAGTGCAATCAAGGAAAACAGAAATGCCTCTGAG ATTGTCAAAACGGTAAATTTGCTGATAACTTCTCTAAGCA CAGACTTTCTCTGGGATTATATGACAAGGTGTTTTGAGGA ATGCTTTAGACCAGTGAAGCAGCGTTACAGCGTGAGGAAC AGCGTCAGCCCTCCCCCCACGGTCTCGGAGCTCTGCGCCC TCCTGGTCTTCCTGCTGGATGTCATTCCTTTGGAACTTTA CTCTGAGGTGCAAACCCAGTATCTCCCTCAGGTGCTCGGC TGCCTGGTGCAGCCTCTTGCTGAGGACATGGAGGCCTTAA GTTTACCTGAACTCACGCATGCCTTGAAGACGTGTTTCAA GGTGCTCAGCAAAGTCCAGATGCCTCCTTCCTACCTCGAC ACGGAGTCCACCAGCGGAACCTCGAGTCCAGTAAAAGGTG AAAACGGCAAAATAATTTTGGAAACAAAGGCAGTGATTCC CGGTGACGAAGATGCTTCGTTTCCCCCTCTGAAGTCTGAG GACAGTGGGATCGGGCTCAGTGCCTCGTCACCGGAGCTCT CTGAGCACTTGAGGGTTCCTCGAGTTTCTCTGGAAAGGGA CGACGTTTGGAAGAAGGGCGGGAGCATGCAGAGGACGTTT CTTTGCATCCAAGAGCTAATCGCCAACTTTGCCAGCAAGA ACATTTTTGGAGTACAGCTGACAGCGTCAGGAGAAGAAAG CAAGTCCGAGGAGCCTGCAGGGAAGAGGGACAGGGATGGG ACGCAGAGCCTGGCAGCCAATGATTCCAGCAGGAAGAACT CTTGGGAGCCCAAGCCCATCACTGTGCCTCAGTTCAAGCA GATGCTGTCAGACTTGTTCACAGCACGAGGGTCTCCATTC AAGACAAAAAGTTCAGAGTCACCATCGTCTTCGCCCAGCA GCCCTGCCAGGAAAAACGGGGGAGAATGGGATGTTGAGAA GGTGGTCATTGACCTGGGGGGTTCCAGGGAGGAACGCAGG GAGGCCTTTGCCGCCGCCTGCCACCTGCTGCTGGATTGTG CCACTTTCCCTGTCTACCTGTCCGAGGAAGAGACCGAGCA GCTCTGTGCAACGCTCTTCCAGCTGCCAGGAGCCGGTGAT TCCAGTTTTCCATCTTGGCTGAAGTCCCTCATGACTATTT GCTGCTGTGTGACTGACTGCTACCTCCAGAACGTGGCCAT TTCCACTCTGCTGGAAGTGATAAACCATTCCCAGTCCCTG GCGCTTGTCATTGAAGACAAGATGAAACGCTATAAGAGCT CTGGACACAACCCTTTTTTTGGCAAGCTGCAGATGGTGAC GGTTCCTCCCATTGCTCCAGGGATATTGAAAGTCATTGCA GAGAAAACAGATTTCTATCAGAGGGTGGCTCGTGTGCTTT GGAATCAGCTGAACAAAGAGACCCGGGAGCATCACGTCAC CTGCGTAGAATTGTTCTACCGGCTGCACTGCCTGGCCCCT ACGGCCAACATCTGCGAGGACATCATCTGCCATGCCCTCC TGGACCCTGACAAGGGAACAAGGCTGGAAGCTCTGTTTAG ATTTTCCGTGATCTGGCATCTGACAAGAGAGATCCAAGGC AGTCGAGTAACATCTCACAATCGCTCCTTTGATAGGTCCT TGTTTGTCGTGCTGGACAGCCTGGCCTGCACGGATGGTGC CATCGGTGCGGCAGCCCAGGGCTGGCTGGTGCGTGCGCTC TCCCTCGGGGACGTGGCTCGCATCCTCGAACCCGTGCTCC TGCTGCTGCTGCAGCCAAAAACCCAGAGAACCTCCATCCA CTGCCTCAAGCAGGAGAACTCGGCCGATGACTTGCACCGT TGGTTTAACAGGAAGAAAACCTCTTTCAGAGAGGCATGCG CAGTGCCCGAGCCTCAGGAGAGCGGCTCTGAAGAGCACCT GCCTCTGAGCCAGTTCACCACAGTGGACCGTGAAGCCATT TGGGCCGAAGTGGAGAAGGAGCCCGAGAAGTACCCGCTGC GAGGCGAGCTGAGCGAGGAAGAGCTGCCCTACTACGTGGA GCTTCCAGACAGGACGGCCCACGGCGCCCCGGACAGCAGC GAGCACACCGAGTCTGCAGATACAAGCTCCTGCCACACGG ACAGCGAGAACACGTCCTCCTTCTCCTCCCCTTCCCACGA CCTGCAGGAGCTGAGCAACGAAGAGAACTGCTGTGCACCC ATCCCCATGGGGGGCAGGGCGTACCCCAAGCGCTCGGCCC TGCTGGCGGCCTTCCAGTCAGAAAGCTTCAAGGCTGGGGC CAAGTTAAGCCTGGTGCGGGTGGACTCGGACAAGACGCAG GCTTCTGAGTCGTTCTCCAGCGACGAGGAGGCGGACTTGG AGCTCCAGGCCCTCACCACATCCAGGCTGCTAAAGCAGCA GCGGGAAAGGCAGGAGGCCGTCGAGGCCTTGTTCAAGCAC ATCCTGCTCTACCTGCAGCCCTACGACTCTCGGCGGGTCC TCTATGCCTTCTCGGTGCTGGAGGCTGTGCTCAAAACCAA CCCTAAGGAATTCATCGAGGCTGTGTCCAGGACTAGCATG GATACCAGCTCCACCGCGCACCTCAACCTCATCTCCAACC TCCTCGCTCGCCACCAGGAGGCCCTCATTGGCCAGAGTTT CTACGGAAAGCTCCAGACCCAGGTCCCCAACGTGTGCCCC CACTCTCTGCTCCTGGAGCTGCTCACCTACCTCTGCCTGA GCTTCCTGCGCTCCTACTACCCTTGCTATTTGAAGGTCTC GCACCGAGACATTCTCGGCAACCGGGACGTGCAGGTCAAA AGTGTCGAGGTTTTGATCAGGATAATGATGCAGCTGGTCT CAGTGGCCAAGTCTTCGGAAGGGAAGAACGTGGAGTTCAT CCACAGCTTGCTGCAGAGGTGCAAAGTTCAGGAGTTTGTC CTGCTCTCCCTGTCGGCGTCCATGTACACGAGCCAGAAGC GCTACGGGCTGGCCACCGCCCACCACGGCAGGGCCCTGCC AGAGGACAGCCTCTTTGAGGAGAGTCTCATTAACTTGGGT CAGGACCAGATCTGGAGTGAGCACCCGCTGCAGATTGAGC TGCTGAAGCTGCTGCAGGTGCTGATTGTCTTGGAACACCA CCTGGGTCGGGCCCATGAGGAGGCGGAAAACCAGCCCGAC CTGTCCCGGGAGTGGCAGAGAGCCCTGAACTTCCAGCAGG CCATCAGCGCCCTGCAGTACGTGCAGCCCCACCCCCTCAC CTCCCAGGGTCTTCTGGTCTCTGCGGTGGTGAGGGGTCTG CAGCCCGCCTACGGTTACGGCATGCATCCGGCCTGGGTGA GCTTGGTCACGCATTCCTTGCCCTACTTCGGAAAGTCCCT GGGCTGGACGGTGACACCCTTTGTTGTCCAGATTTGCAAA AACTTGGATGACTTGGTCAAGCAGTATGAAAGCGAATCTG TGAAGCTCTCTGTCAGCACAACCTCCAAGAGGGAAAACAT TTCTCCAGATTATCCACTCACCCTTCTAGAAGGTCTAACG ACCATTAGTCATTTTTGTCTTTTGGAACAAGCCAACCAAA ACAAAAAGACCATGGCTGCAGGTGATCCTGCCAACTTGAG GAATGCCAGAAATGCCATTTTGGAAGAGCTGCCTCGAACT GTTAACACCATGGCCCTTCTCTGGAATGTTCTCAGAAAGG AGGAGACTCAAAAGAGACCTGTCGATCTCCTAGGGGCCAC GAAGGGATCCTCTTCCGTTTACTTTAAAACCACCAAAACC ATAAGACAAAAAATTTTAGACTTCTTAAACCCCTTGACGG CCCATCTTGGGGTTCAGTTGACAGCGGCTGTTGCGGCAGT GTGGAGCAGAAAGAAAGCCCAGCGTCACAGTAAGATGAAG ATTATCCCAACGGCAAGTGCATCCCAGCTAACCCTTGTCG ACTTGGTGTGTGCACTCAGCACCCTGCAGACTGACACGCT GCTGCACCTGGTGAAGGAGGTGGTGAAGAGGCCACCCCAA GTCAAAGGGGGTGATGAGAAATCGCCCCTAGTGGACATTC CTGTGTTGCAGTTTTGCTATGCTTTTCTCCAAAGGCTCCC AGTACCAGCCTTGCAAGAGAACTTTTCTTCACTGTTGGGA GTATTGAAAGAGTCTGTACAGTTGAATCTAGCCCCACCTG GGTATTTTCTGCTTCTCAGCATGCTGAATGACTTTGTAAC AAGAACTCCCAACCTGGAAAACAAGAAGGACCAAAAAGAC CTGCAGGAAATCACTCAGAAAATCCTAGAAGCTGTGGGGA ACATTGCCGGCTCTTCCTTGGAGCAAACCAGCTGGCTAAG CAGAAACCTGGAAGTGAAGGCCCAACCTCAGGCCTCTCTA GAAGAATCTGATGCTGAGGAGGACCTGTATGATGCTGCTG CAGCTTCAGCAATGGTGTCTTCATCCGCCCCGTCGGTGTA CAGCGTGCAAGCCCTCTCTCTCCTGGCAGAGGTACTGGCT TCCCTCCTGGACATGGTTTATCGAAGTGATGAGAAGGAGA AAGCTGTGCCGTTAATCTCCCGTCTGCTTTACTATGTTTT TCCATACTTACGCAACCACAGTGCCTACAATGCTCCCAGC TTCCGGGCTGGCGCTCAGCTGCTGAGCTCCCTGAGTGGCT ATGCCTACACAAAGCGAGCCTGGAGGAAGGAGGTCCTGGA GCTGTTTCTCGACCCCGCTTTCTTTCAGATGGATACTTCC TGTGTTCATTGGAAGTCCATTATTGACCATCTTTTGACTC ATGAGAAAACAATGTTTAAGGATTTAATGAACATGCAGAG CAGTTCTTTGAAACTATTCTCAAGTTTTGAACAGAAAGCC ATGCTGTTAAAGCGCCAGGCTTTTGCTGTCTTCAGTGGAG AACTTGATCAATACCACCTTTACCTTCCACTGATACAAGA ACGCCTGACAGACAATCTCAGAGTTGGACAGACATCCATA GTTGCTGCTCAGATGTTTCTTTTTTTCAGAGTTTTGCTGC TAAGAATATCTCCTCAACATTTGACTTCATTGTGGCCAAT AATGGTCTCTGAATTGATTCAGACATTCACACAGCTTGAA GAAGATCTAAAAGATGAAGATGAGTCATTGAGAAGCACCA ACAAAGTAAACAGAACGAAAGTTTCAGTCCCGGATGCAAA TGGACCCTCAGTGGGGGAGATACCCCAGAGTGAACTCATC TTGTATTTATCAGCTTGCAAATTCTTGGACACAGCGCTTT CTTTTCCACCTGACAAGATGCCATTATTTCAAATTTATAG GTGGGCATTTATTCCAGAAGTGGACACAGAGGGCCCTGCC TTCCTGTCGGATGTAGAGGAGAATCACCAAGAATGCAAAC CCCACACTGTCAGGATTCTAGAACTTCTAAAATTAAAGTT TGGGGAAATCAGTAGCTCTGATGAGATCACCATGAAGAGT GAATTCCCGCTTCTGCGCCAACATTCTGTTTCCAGCATCA GGCAGTTGATGCCATTCTTCATGACTCTAAATGGTGCATT TAAGACCCAGAGACAGCTGCCTGCTGATAGCCCAGGAACT CCATTCTTGGACTTTCCTGTCACAGATAGCCCAAGGATCT TAAAACAACTGGAAGAATGCATCGAATATGATTTTCTGGA ACATCCAGAATGTTAACCATGTGAGAGAGAATATGTTTAA TCCATGTATTGGTACTTTACTGAAAACCAGGTTATATTCT AAAGAAGAAAGAAGGCAGGATAGTGCTTTTGAACAAGCCT ATTTCCATTTTGAAAGTAGATTTCAGGCTAGGTGCGGTGG CTCACACCTGTAATCTCAGCACTTTGGGAGGCCAAGGCAG GCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGACC AACATGGTGAGACCCTGTCTCTACTAAAAATACAAAAATT AGCTGGGTGTGGTGGCGGCGCCTGTAATCCCAGCTACTTG GGAGGCTAAGGCATGAGAATTGCTTGAACCCAGGAGGTGG AGGCTGCAGTGAGCCGAGATCACGACACTGCACTCCAGCT GTGTGACAGAATGAGACCATCTCCAAAAAAAAAAAAAAGT AGATTTCAGATAATTTACTGTTCAGCAACAGGACACACCT CCCTAAATGCCTTGTAATATATTTGAATCTGATTCTGCAT TTCTTCCTCAATTTATGTAATGAAAATAAAATTAATATAT CATCTAACAGTAGCACAAAATTTGTAATATGAAGTAAAGT ATGAAGATAATGAAGAAGTTGTTTTCTTTGTTGAAGCAGT TATATGGGTCTTTCTCAGTATATTTCTCTTTTCTCTAAAA GTTTAAACTTATTAAAAGAATGTTATTTTTAACCTTTCAA AAAAAAAAA NDUFB11 NM_019056.6 GCTCTGGCCGGCCCCGGCGATTGGTCACCGCCCGCTAGGG 34 GACAGCCCTGGCCTCCTCTGATTGGCAAGCGCTGGCCACC TCCCCACACCCCTTGCGAACGCTCCCCTAGTGGAGAAAAG GAGTAGCTATTAGCCAATTCGGCAGGGCCCGCTTTTTAGA AGCTTGATTTCCTTTGAAGATGAAAGACTAGCGGAAGCTC TGCCTCTTTCCCCAGTGGGCGAGGGAACTCGGGGCGATTG GCTGGGAACTGTATCCACCCAAATGTCACCGATTTCTTCC TATGCAGGAAATGAGCAGACCCATCAATAAGAAATTTCTC AGCCTGGCCGAAAATGGTTGGCCCCACGAAGCCACGACAA CTGGAGGCAAAGAGGGTTGCTCAACGCCCCGCCTCATTGG AAAACCAAATCAGATCTGGGACCTATATAGCGTGGCGGAG GCGGGGCGATGATTGTCGCGCTCGCACCCACTGCAGCTGC GCACAGTCGCATTTCTTTCCCCGCCCCTGAGACCCTGCAG CACCATCTGTCATGGCGGCTGGGCTGTTTGGTTTGAGCGC TCGCCGTCTTTTGGCGGCAGCGGCGACGCGAGGGCTCCCG GCCGCCCGCGTCCGCTGGGAATCTAGCTTCTCCAGGACTG TGGTCGCCCCGTCCGCTGTGGCGGGAAAGCGGCCCCCAGA ACCGACCACACCGTGGCAAGAGGACCCAGAACCCGAGGAC GAAAACTTGTATGAGAAGAACCCAGACTCCCATGGTTATG ACAAGGACCCCGTTTTGGACGTCTGGAACATGCGACTTGT CTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGC ACCTTTGTGGCCTATCTGCCTGACTACAGGTGCACAGGGT GTCCAAGAGCGTGGGATGGGATGAAAGAGTGGTCCCGCCG CGAAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGC CTTCCCATCATGGAATCCAACTGCTTCGACCCCAGCAAGA TCCAGCTGCCAGAGGATGAGTGACCAGTTGCTAAGTGGGG CTCAAGAAGCACCGCCTTCCCCACCCCCTGCCTGCCATTC TGACCTCTTCTCAGAGCACCTAATTAAAGGGGCTGAAAGT CTGAAAAAAAAAAAAAAA ND4 NC_012920.1 ATGCTAAAACTAATCGTCCCAACAATTATATTACTACCACTGAC 35 ATGACTTTCCAAAAAACACATAATTTGAATCAACACAACCACCC ACAGCCTAATTATTAGCATCATCCCTCTACTATTTTTTAACCAAA TCAACAACAACCTATTTAGCTGTTCCCCAACCTTTTCCTCCGACC CCCTAACAACCCCCCTCCTAATACTAACTACCTGACTCCTACCC CTCACAATCATGGCAAGCCAACGCCACTTATCCAGTGAACCACT ATCACGAAAAAAACTCTACCTCTCTATACTAATCTCCCTACAAA TCTCCTTAATTATAACATTCACAGCCACAGAACTAATCATATTT TATATCTTCTTCGAAACCACACTTATCCCCACCTTGGCTATCATC ACCCGATGAGGCAACCAGCCAGAACGCCTGAACGCAGGCACAT ACTTCCTATTCTACACCCTAGTAGGCTCCCTTCCCCTACTCATCG CACTAATTTACACTCACAACACCCTAGGCTCACTAAACATTCTA CTACTCACTCTCACTGCCCAAGAACTATCAAACTCCTGAGCCAA CAACTTAATATGACTAGCTTACACAATAGCTTTTATAGTAAAGA TACCTCTTTACGGACTCCACTTATGACTCCCTAAAGCCCATGTC GAAGCCCCCATCGCTGGGTCAATAGTACTTGCCGCAGTACTCTT AAAACTAGGCGGCTATGGTATAATACGCCTCACACTCATTCTCA ACCCCCTGACAAAACACATAGCCTACCCCTTCCTTGTACTATCC CTATGAGGCATAATTATAACAAGCTCCATCTGCCTACGACAAAC AGACCTAAAATCGCTCATTGCATACTCTTCAATCAGCCACATAG CCCTCGTAGTAACAGCCATTCTCATCCAAACCCCCTGAAGCTTC ACCGGCGCAGTCATTCTCATAATCGCCCACGGGCTTACATCCTC ATTACTATTCTGCCTAGCAAACTCAAACTACGAACGCACTCACA GTCGCATCATAATCCTCTCTCAAGGACTTCAAACTTACTCCCAC TAATAGCTTTTTGATGACTTCTAGCAAGCCTCGCTAACCTCGCC TTACCCCCCACTATTAACCTACTGGGAGAACTCTCTGTGCTAGT AACCACGTTCTCCTGATCAAATATCACTCTCCTACTTACAGGAC TCAACATACTAGTCACAGCCCTATACTCCCTCTACATATTTACC ACAACACAATGGGGCTCACTCACCCACCACATTAACAACATAA AACCCTCATTCACACGAGAAAACACCCTCATGTTCATACACCTA TCCCCCATTCTCCTCCTATCCCTCAACCCCGACATCATTACCGGG TTTTCCTCTT MORF4L1 NM_001265603.1 CGGCGTGCCCTGGGGCGGCGCGGGCGCAGGGGCGCGTGCG 36 CGGCGGGCTGTCGTTGGCTGGAGCAGCGGCTGCGCGGGTC GCGGTGCTGTGAGGTCTGCGGGCGCTGGCAAATCCGGCCC AGGATGTAGAGCTGGCAGTGCCTGACGGCGCGTCTGACGC GGAGTTGGGTGGGGTAGAGAGTAGGGGGCGGTAGTCGGGG GTGGTGGGAGAAGGAGGAGGCGGCGAATCACTTATAAATG GCGCCGAAGCAGGACCCGAAGCCTAAATTCCAGGAGGTTG GGATGAATGGGTTCCGGAGAGCAGAGTACTCAAATACGTG GACACCAATTTGCAGAAACAGCGAGAACTTCAAAAAGCCA ATCAGGAGCAGTATGCAGAGGGGAAGATGAGAGGGGCTGC CCCAGGAAAGAAGACATCTGGTCTGCAACAGAAAAATGTT GAAGTGAAAACGAAAAAGAACAAACAGAAAACACCTGGAA ATGGAGATGGTGGCAGTACCAGTGAGACCCCTCAGCCTCC TCGGAAGAAAAGGGCCCGGGTAGATCCTACTGTTGAAAAT GAGGAAACATTCATGAACAGAGTTGAAGTTAAAGTAAAGA TTCCTGAAGAGCTAAAACCGTGGCTTGTTGATGACTGGGA CTTAATTACCAGGCAAAAACAGCTCTTTTATCTTCCTGCC AAGAAGAATGTGGATTCCATTCTTGAGGATTATGCAAATT ACAAGAAATCTCGTGGAAACACAGATAATAAGGAGTATGC GGTTAATGAAGTTGTGGCAGGGATAAAAGAATACTTCAAC GTAATGTTGGGTACCCAGCTACTCTATAAATTTGAGAGAC CACAGTATGCTGAAATTCTTGCAGATCATCCCGATGCACC CATGTCCCAGGTGTATGGAGCGCCACATCTCCTGAGATTA TTTGTACGAATTGGAGCAATGTTGGCTTATACACCTCTGG ATGAGAAGAGCCTTGCTTTATTACTCAATTATCTTCACGA TTTCCTAAAGTACCTGGCAAAGAATTCTGCAACTTTGTTC AGTGCCAGCGATTATGAAGTGGCTCCTCCTGAGTACCATC GGAAAGCTGTGTGAGAGGCACTCTCACTCACTTATGTTTG GATCTCCGTAAACACATTTTTGTTCTTAGTCTATCTCTTG TACAAACGATGTGCTTTGAAGATGTTAGTGTATAACAATT GATGTTTGTTTTCTGTTTGATTTTAAACAGAGAAAAAATA AAAGGGGGTAATAGCTCCTTTTTTCTTCTTTCTTTTTTTT TTTCATTTCAAAATTGCTGCCAGTGTTTTCAATGATGGAC AACAGAGGGATATGCTGTAGAGTGTTTTATTGCCTAGTTG ACAAAGCTGCTTTTGAATGCTGGTGGTTCTATTCCTTTGA CACTACGCACTTTTATAATACATGTTAATGCTATATGACA AAATGCTCTGATTCCTAGTGCCAAAGGTTCAATTCAGTGT ATATAACTGAACACACTCATCCATTTGTGCTTTTGTTTTT TTTTATGGTGCTTAAAGTAAAGAGCCCATCCTTTGCAAGT CATCCATGTTGTTACTTAGGCATTTTATCTTGGCTCAAAT TGTTGAAGAATGGTGGCTTGTTTCATGGTTTTTGTATTTG TGTCTAATGCACGTTTTAACATGATAGACGCAATGCATTG TGTAGCTAGTTTTCTGGAAAAGTCAATCTTTTAGGAATTG TTTTTCAGATCTTCAATAAATTTTTTCTTTAAATTTCAAA GAACAAAAAAAAAAAAAAA MRPL19 NM_014763.3 GTAGTCTTGACGTGAGCTAGCTGGCATGGCGGCCTGCATT 37 GCAGCGGGGCACTGGGCTGCAATGGGCCTAGGCCGGAGTT TCCAAGCCGCCAGGACTCTGCTCCCCCCGCCGGCCTCTAT CGCCTGCAGGGTCCACGCGGGGCCTGTCCGGCAGCAGAGC ACTGGGCCTTCCGAGCCCGGTGCGTTCCAACCGCCGCCGA AACCGGTCATCGTGGACAAGCACCGCCCCGTGGAACCGGA ACGCAGGTTCTTGAGTCCTGAATTCATTCCTCGAAGGGGA AGAACAGATCCTCTGAAATTTCAAATAGAAAGAAAAGATA TGTTAGAAAGGAGAAAAGTACTCCACATTCCAGAGTTCTA TGTTGGAAGTATTCTTCGTGTTACTACAGCTGACCCATAT GCCAGTGGAAAAATCAGCCAGTTTCTGGGGATTTGCATTC AGAGATCAGGAAGAGGACTTGGAGCTACTTTCATCCTTAG GAATGTTATCGAAGGACAAGGTGTCGAGATTTGCTTTGAA CTTTATAATCCTCGGGTCCAGGAGATTCAGGTGGTCAAAT TAGAGAAACGGCTGGATGATAGCTTGCTATACTTACGAGA TGCCCTTCCTGAATATAGCACTTTTGATGTGAATATGAAG CCAGTAGTACAAGAGCCTAACCAAAAAGTTCCTGTTAATG AGCTGAAAGTAAAAATGAAGCCTAAGCCCTGGTCTAAACG CTGGGAACGTCCAAATTTTAATATTAAAGGAATCAGATTT GATCTTTGTTTAACTGAACAGCAAATGAAAGAAGCTCAGA AGTGGAATCAGCCATGGCTTGAATTTGATATGATGAGGGA ATATGATACTTCAAAAATTGAAGCTGCAATATGGAAGGAA ATTGAAGCGTCGAAAAGGTCTTGATTCTGAGAATGAATTT GGTTAGTTGCAGAAGATACATTGGCTCTAAGAGGATATAT TTTGAGACCAATTTAATTTCATTTATAAGAACATAGTAAT TAAGTGAACTAAGCATTCATTGTTTTATTAATACTTTTTT TCTAAAATAAAACTTGTACACCAGTTTATTACTCTAAAAA GAGAATTACACATGCCAAATGGACCAATGTCCATTTGCTT ATTGGAGGCAAAGCTACAATAGAAGTCAGAGCATCACCAG AATGGTCTTTAATGAGCATGGAACCTGAGCAAAGGGAATA GGTGGGATGAATTTTTTTTTTAATTGTGAAACAATTCATA AGCACAATATGATTTACAGAATAATAAACATTCATGTACC CACTATCAGGTTAAGAAATAGAACATTTATTAATATGTAG GAATGTTAAGAAATAAAACATTTAATAAGATCTCAGAAGA CTCCAGTAAATCTGCAATTGTATCTCTCTCCTTTTTAAAT GTAAATATCATCTTGACTTGTTAATTATTCCCTTGCATTT CTTTTAGTTTACTGCCAACACATATATTCTTCAACAATAT ATTTAATTTTGAAAAACCTGAAAAAAAAAACCTGTTAGCA AGTATAAAGGGGCAGTATTACTATTATTGCATGAAGGCTT CAAGGGAAACGTTACAGTCTTTGGGTCATAGTCTGGCTTC AGCTTCCTCTGAGAGTTTACAGAGGCCAATTTTGAGCAAA TTCATGGCTAAGGTTATGAGTGAGTTCTGCTAAACAGAAG GCTCACCACAAGGTATCTGGCAGGATTATACTGGGTAGCT GGATGTTGCAGAAATGTGGTTAGAGGAAGTAAACTGTTTT TTGATGCTCACAGCATGATGAATCAAACTCTGTATCTTAG GATTAGGTTAAAACAATACCTTTGGTATGATATGAGTGTT GTTGCTGATCCATGCAGCATGGATTGGAAAGCTGGGGTAT AAGCACACATGCTAAAGAAAAACATGTAATTTGGTCCATA CTCACCTGGATATACTGTTCCTCAGGTTAAAAAATACAGT ACTATCCTAAATCTTGAAGGCAACTCTCAGCCTATCCATT GAGTTACCTTCAGATCTGCCCTCTGGTTCCTAGCTGTCTT GGGACTAACTTCTTTCCTGCGCTCAGCTGTTTTCTGGATT CCATGTTTTCCATTTTATTGAGTACTAACTTGTTTTGCTG CAGCACATCCTTTGGTAGCTTCTAGAGGAAGTTTGTGTGG AGGTAAAATTTTTGAGACCTTGCATGTCTCATGTTTGATT GATACTTTATACGTTTAGGTAGGAGGTAATTTTCCTTCAG GACTTTAAAAATATTGTTGCTCCATTTTCTTTGTTTCTAT TGTTGTATTGAGAAATCCAATGCCATTTTGATTTCCCCAT CATAAATTTCATGATGATGTGTCTTGGTGTGGGTCTATAT TTATCCATTGTATTGGGTTTTAGGTGAACCCTTCCAGATA GTAACTCATTTCTGTCAGTTCTGGGAAACACTTAGCATTG GTTGATGATTTATTCTCTGCTGCTTTGTTCTCCCAACTAT TATTTGGATGTTGGATATCCAGCACTGGGTATCTATTTTC TTACCTCCCTCCCTTGACCCCAGTCTCTGTTTTTTAGCTC TTTAGCTCAATCTTCCAACTCTTTGCTATTGTATTTTAAA ATCTTAAGACCCCTTCTTGATTTGTAGAAGTTCCTTTTCT TACAACCAAAAAGCCTTTATCTATGGATTTGTTCACAGAT AAGGGGTATTCAATATAGTGTATTTTTTTTTCATTTAAAA TTGTTTGCGCATCTATTTCCTCCAAATTTCTTTCTGTATT TATTTTTTGTTGTCTATATTTCAGACTTTTCCAGGATATC TGATAATCTTTGGCTGTCTTCTTATGGTTGAAAGAGGGAC TAAAAAGCTTGGAAAGCCTTTGGGTTGTGGGAAGGGGCTG TCTTTAGGATTATCTGAATGGGCTTTTTTGGGAGTCCCCT CCTCCACATGAATATTTTGGTTTTGTCAGATTCCCTAGAA TAGAGGCTTCCAATCTCCTTCCTGGAGGGGTCTGTCCAGG AAGGAGATTGTCTAGGGGTCTGTCAGACAGCAGCTTTCAG CTACTTCCTTGATCTTTTTCACTAATGATTATATAGTCAT CTAACTACTGTCAACAAGTAATAGATATCCTATCCTTCAC TTGTTTAGATTATTTGCTGAGATAACCTCTCAAAAGAACC TCTCAAAATAAAAGGTTAACAAGAGCCTATATCTTATATT TTTCTTCTCTTTATCTTGTTAGAAGATAGCTATTAAAACC TGTTCTTTTTCTGTCTTGATAAACACACTTCAATCTTGGT AGAATGGTAGATGGGACAGTATATTTTAGGACCTAAAGCT CTGCAAATGTATGATCAGCTTGTAAGTACAGGTGCTCAAA AACATGTAAACAATCATGCTTTTTACTCTGTAGGAATATC TTTAAAATTCTTGTGAATTTTTCCCCAGAAGTAAAGCAAA TCTTCCCCCAGAAATAAAATTAAATGTGCATAATCTAAAG CTTTTTTTTTTTATTGTGGTAGGATATATATATAAAACAT AATTTGCCATTGTAAACATTTTAAATTTACAAGTCAGAGG CATTAATTACATCACAATGTTGTGAAATTATTACTACTAT TTCCAAAATTTTCTCATCACCCCAAACTGAAACTCTGTAA CTGTTGAGCAATAACCTCATTCCTGTATCTCTCCCAACCC CAGGTAACCTCAAATCTTTCTTTTTATCTTTGAGACAAGG TCTCATTCTATCACTCAGGTAGGAGTGCAGTGGTGTGATC ATAGCTCATTGCAGCCTCAAAATCCTGGGCTCAAGCAATC CTCCTTGAGTAGCTAAGACTATAGGCACACATTAACTGCG CCTGGCTGATTTTGTTTTTTGTAGAGATGTGGTCTTGCTA TGTTTCCCATGCTGGTCTTGAGTTCCTGGCCTCAAGCAGT CCTTAAGATTCATCCATGTTGTGGCATGTGTCAGAATTTC ATTTGTTTTTATGACTAAATAATATTCCATTGTATGTATA TACATTTTGTTCATCCATCTTCTGATGAACACTGGGATAT GTCTACCTTTTGGCTATTGTGAATAATGCTGCAGTAAACA TTGACATAACAAGTATGTATTTGATTGCCTGTTTCTAAGT TCTTTTGGGTATACATCTTGAGTAGAATTGCTAGATAATG TCATGTTTTATTTCTCTTGTGATTTCTTCTTCGATCCCCT GGTTGAGTGTGTTAATTTCTACATGTTTATGAATTTCCCA CTGTTTTTTTGTTATTGATTTCCAAGTTCATTCCATTGTG ATTAGAGAAGATACTTAGTATGATTTTAATGTTTTTGAGA ATTGGTGTGTGGCCTGATAGATGGTCTGTCCTGGAGAATG TTCCTCATACACTTGAGCAAAATATTTATCATGCTATTGT TGACTGTAGTTTTCTATATGTCTCTTAGGTCAAGGTGGTT TACAATGTGTTAAGGTTCTCTTTTTTTAAAAAAATTTTTG CACAGAGTATCTTTTTCTATGTGTTCCATGTATTTGTGTC TTTGGAGCTATAGTCTCTTGTAGACAGCATATCACTATCT TGTTTTGTTTTGTTTTTTCTGTCCATTCTGCCAATTTCTG CCTTTTGATTGGAAAATTTAATCCATTTGCATTTAAAGTA ATTAAGGAAGGACTTTCTTCTACCATTTAACACTTCTTCT ATATGTCATATACTTTTTTGGCCCCTCATTTCCTCTTTAT GGCCTTCTTTTCTGTTTTTTTGTAGTGAACTAGTCTGATT CTCTTTCCACTCCCCTTTGTGTATATTTGTTAGATGTTTT ATTTGTGGTTGCTATGGGGATTATAGTTAACATCCTACAC TTAAAACAATCTAATTTAAACTGATACCAATTTACCTTCA ATAGCATACAAAATCTCTACTCCTGTAAAGCTCTGCCCCT GCCCCCCTTATGTTATTGATGGCACAAATTGCCTAATAAA TAATTTATAGTTATTTGTATGAGTTTGTCTTTTAAATCAT TTAGGAAATAAAAAGTGGAGTTAGAAAACAGTATGATAGT AATACTGACTTTTATATTTGTCAATATATTTATCTTATTT TGGATCCTTATTTCATTATATAGATTTGAGTTACTGTCTA GTGCCCTTCCATTTCGGCCCAAAGGATTCCCTTATGCATT TCTTGCAGGGCAAGTCTAATTGTAATAAACTCCCTCAGCT TTTGTTTTATCTGAGAATGTCTTGATTTCTCCCTTATTTT TGATGGATAATTTTGCCAGATACATGAATTTTTGGTAACA GTATTTTTCTTTCAGCACTTTAAATATGTCATCCCACTAC CTTCTGACTTCATGGTTTCTCATGAGATATTAGATGTTAT AAAATTTGAGGATTCCTCATTCTTGATGAGTCAGTTCTGT CTTATTGCTTTTCGGATTTGCTCAGCTTTTGTCTTTTGAC AGTTTGATTATAACGCGGCTCAGTGTGGGTCTCTGAGTTT ATCCCACTTAGAGTTTGTTGAGTTTCTTGGAGTCATAGAT TTATGTCTTTTATCAAATTTTGGACATATTTGGCTATTAT TTCTTCAATTTTTTTCACTGCTTCTTTCTTTTCCTTCTGA AATATTCTTAATGTATATGTTGGTCTGTTTGATGCTGTCT CACCAGTTTCTTAGGCTGTGTTCTCTTTTGTTCCTCAGAC TTGATTATTGCAGTTGCCCTTCTTTTTATTTTTTTCAAGT TTGTTGATTCTTCTCCCTGTTCAGATCAACTGTTGAACTC CTCTAGTGAATTTATTTCAGTTACTGTACTTTTCAGCTCC AAGATTTATCTTTGGTTCCTTTTTATAACGTCTGTGTCTT TATTGATATTCTCATTTTGTTCATATGTCTCTTTCTTCCT TTAGTTCTTTGTCCATGTTTTCCTTTAGCTCTTTGGGCTT ATTTAAGACAATTGTTTAAAGTCTTTGCATAGTAAGTCCA ATGTCTGTGTTTCTTCAGGGATGGTTTTCATTATTTTGTT TTCAATGAGCCATACTTTCCTGTGTCTTTGTATGCTGTCT TTTTGTTGTTGAAAACTGTATGTTTGAACATCATAACGTG GTGGCCCTGAAAATCAGATATTCCCCCCTTCCTGAGAGTT AGTTTTATTTTTATTATTGAAGATTGTAGCAGTCTATTGC TACATGTGCAGTCATTTCCAAACTATTTTTGCAAAGACTG TATTCCTTCTGTGTGTCATCACTGAAGTCTCTGTTCCTTA GTTTGTGTTTAATAGTTTGACATAGATTTCCTTGAAAGGA GTTAAAACTAGCAGAAAAATCTCTCTCCCAGTCTTTCCAG TCTTTGTAGATTGGTTCTGTGCTGGGCTTTTCCATTAATA CTTAGCCAGGCTTGTACTGAGCCTAACAATCAGGCCCAAA AGCGTAGGGTCTTTGCAGATCTTGTCTGAGCATGCTTCTT GCTGTGTATGCACGTAGTTTTCTAAATCTCCCTGTATGTG CTGTTGAATATTCTAATTTCCCAAAGAAACTCCTTTGCAG CTTTTTCTCACAGAACATAGATGGTTTTTTGGATATCTTG ACCATAGTCTTTCGACCCAGGTGTTTGCGGTTGTTAGTTC ACCTTACACTTTTTTCAAGCATTGCCTACTGCTTACGATG AGTGCTCTGTCAATCCTTTAAGTAGCCCCAGACAGGCTAC CAGAGACTTAAACAAGAATTTGTAAGTTCTGCTCAGCTTC CTCTAGAAATGGGGATCAGGGTCCAAGACAGAATGCAGTT GCTGATTTCAAGACTGCTGCAACACCAGGGAGCTTGTGGG GGAAGGGCAAGCAGAAATGTCACAAAGCTTTCTTGCCATT TTAAAGTTGCCTGTTCTTGACTCAGCATTTGCTTCATTGC TATAAACTTTTTACTGTTTTTCAGAGTTCTGATAAAATTG GCTATGCCTGTTCCTGCTTTAAAAAATATATATATATTTT TTAGGGATTGGGGTCTCACTATACTGACCAGGCTGGTCTT GAACTTCTGGCCTCAAGCCATCCTCTCATTTCAGCTTCCC AAAGTGCTGCAATTACACGCGTGAACCACCACACCCAGCC CCTGCTTGTTTTTCAATGTGCCTACTCCACCATGTTGCTC AAGTATGTATATTTTCTAAACTACCTTGTAGTGTTGTGAT GGGAAATAAATCCCTGAGCCTTTTGAATAACTCAGAGAGA TCAAAAACTTAGTTTATCCTATTCGAAGGATTAGAAAAAT GATATATCTTTCACTTTTTCAGGGATAGGCTCCTCATTAG AAGGCTCCTATGTGCCGATGCTGTACAAGACATTTCATTT CTCTTAATGTTTACAACAAGCTTGTTGCCAAGGCTGATCT TGAACTCCTGGCCTCAAACGATCCTCCCAGCTCAGTCTCA CAAAGTGTTGGGATGTCTGGCCAACTAATGACTATCTTAA CTCTTGTGTTTCAATGTTTATGCCTTCTTTTATCTTGACT GATTGTATGACTATGTCTTCTAGAACAATGTTGAACAGAA ATGGTGAGAGCAGACATCCTTGCTTTAATATTTCACCATT ATATATGATGTTAGGTATAGATTTTTCTCACAGATGCCTT TTATCAGATTGAGGAATTTATATTCCTACTTTGCCGAAAG GTTTTTGTAGTATGAGGGGGTGCTGAATTTTGTCAAACAC TTTTTCGGTAATAATTGAGATGATTGGTTCTGCAGTCATC GAGATGTGGATTTTCTCCTTTATTCTGTTCGTGAGTGATT ACACTGGTTGACTAATGTTAAAACAACCTTACTTTCCAGG AATAAACCCTATTATCTTTTTTATACA PSMC4 NM_153001.2 TGCGGGTACGGACAGCGCATGAGCTTATGTTGAGGGCGGA 38 GCCCAGACCAGCCCTTCGTCCTATCCTGCCCTTCCAGCAC CTCTCAGCCGTAACTTAAACTACACTTCCCAGAAGCCTCC TCAGCCAGGGACTTCCGTTGTCGTCAGCGGAAGCGGTGAC AGATCATCCCAGGCCACACAGAGGCCGGCTTGGTCACTAT GGAGGAGATAGGCATCTTGGTGGAGAAGGCTCAGGATGAG ATCCCAGCACTGTCCGTGTCCCGGCCCCAGACCGGCCTGT CCTTCCTGGGCCCTGAGCCTGAGGACCTGGAGGACCTGTA CAGCCGCTACAAGGAGGAGGTGAAGCGAATCCAAAGCATC CCGCTGGTCATCGGACAATTTCTGGAGGCTGTGGATCAGA ATACAGCCATCGTGGGCTCTACCACAGGCTCCAACTATTA TGTGCGCATCCTGAGCACCATCGATCGGGAGCTGCTCAAG CCCAACGCCTCAGTGGCCCTCCACAAGCACAGCAATGCAC TGGTGGACGTGCTGCCCCCCGAAGCCGACAGCAGCATCAT GATGCTCACCTCAGACCAGAAGCCAGATGTGATGTACGCG GACATCGGAGGCATGGACATCCAGAAGCAGGAGGTGCGGG AGGCCGTGGAGCTCCCGCTCACGCATTTCGAGCTCTACAA GCAGATCGGCATCGATCCCCCCCGAGGCGTCCTCATGTAT GGCCCACCTGGCTGTGGGAAGACCATGTTGGCAAAGGCGG TGGCACATCACACAACAGCTGCATTCATCCGGGTCGTGGG CTCGGAGTTTGTACAGAAGTATCTGGGTGAGGGCCCCCGC ATGGTCCGGGATGTGTTCCGCCTGGCCAAGGAGAATGCAC CTGCCATCATCTTCATAGACGAGATTGATGCCATCGCCAC CAAGAGATTCGATGCTCAGACAGGGGCCGACAGGGAGGTT CAGAGGATCCTGCTGGAGCTGCTGAATCAGATGGATGGAT TTGATCAGAATGTCAATGTCAAGGTAATCATGGCCACAAA CAGAGCAGACACCCTGGATCCGGCCCTGCTACGGCCAGGA CGGCTGGACCGTAAAATTGAATTTCCACTTCCTGACCGCC GCCAGAAGAGATTGATTTTCTCCACTATCACTAGCAAGAT GAACCTCTCTGAGGAGGTTGACTTGGAAGACTATGTGGCC CGGCCAGATAAGATTTCAGGAGCTGATATTAACTCCATCT GTCAGGAGAGTGGAATGTTGGCTGTCCGTGAAAACCGCTA CATTGTCCTGGCCAAGGACTTCGAGAAAGCATACAAGACT GTCATCAAGAAGGACGAGCAGGAGCATGAGTTTTACAAGT GACCCTTCCCTTCCCTCCACCACACCACTCAGGGGCTGGG GCTTCTCTCGCACCCCCAGCACCTCTGTCCCAAAACCTCA TTCCCTTTTTTCTTTACCCAGGATTGGTTTCTTCAATAAA TAGATAAGATCGAATCCATTTAATTTCTTCTTAGAAGTTT AACTCCTTTGGAGAATGTGGGCCTTGAATAGGATCCTCTG GGTCCCTCTTAATCTGACAGATGAGCAGACGAGGTGCATG GCCTGGGTTGCAGCTTGAGAGAACCAAAATATTCAAACCA GATGACTTCCAAAATGTGGGGAAAGGGATGGAAAATGAAC CTGAGATGGAGTCCTTAATCACGGGATAAAGCCCTGTGCA TCTCCCTCATTTCCTACAGGTAAAAGACAGTAAAGAAATT CAGGTCACAGGCCTTGGGAGTTCATAGGAAGGAGATGTCC AGTGCTGTCCAGTAGAACTTT SF3A1 NM_005877.5 GGTCCCGGAAGTGCGCCAGTCGTACCTTCGCGGCCGCAAC 39 TCGCTCGGCCGCCGCCATCTTGCGAGCTCGTCGTACTGAC CGAGCGGGGAGGCTGTCTTGAGGCGGCACCGCTCACCGAC ACCGAGGCGGACTGGCAGCCCTGAGCGTCGCAGTCATGCC GGCCGGACCCGTGCAGGCGGTGCCCCCGCCGCCGCCCGTG CCCACGGAGCCCAAACAGCCCACAGAAGAAGAAGCATCTT CAAAGGAGGATTCTGCACCTTCTAAGCCAGTTGTGGGGAT TATTTACCCTCCTCCAGAGGTCAGAAATATTGTTGACAAG ACTGCCAGCTTTGTGGCCAGAAACGGGCCTGAATTTGAAG CTAGGATCCGACAGAACGAGATCAACAACCCCAAGTTCAA CTTTCTGAACCCCAATGACCCTTACCATGCCTACTACCGC CACAAGGTCAGCGAGTTCAAGGAAGGGAAGGCTCAGGAGC CGTCCGCCGCCATCCCCAAGGTCATGCAGCAGCAGCAGCA GACCACCCAGCAGCAGCTGCCCCAGAAGGTCCAAGCCCAA GTAATCCAAGAGACCATCGTGCCCAAAGAGCCTCCTCCTG AGTTTGAGTTCATTGCTGATCCTCCCTCTATCTCAGCCTT CGACTTGGATGTGGTGAAGCTGACGGCTCAGTTTGTGGCC AGGAATGGGCGCCAGTTTCTGACCCAGCTGATGCAGAAAG AGCAGCGCAACTACCAGTTTGACTTTCTCCGCCCACAGCA CAGCCTCTTCAACTACTTCACGAAGCTAGTGGAACAGTAC ACCAAGATCTTGATTCCACCCAAAGGTTTATTTTCAAAGC TCAAGAAAGAGGCTGAAAACCCCCGAGAAGTTTTGGATCA GGTGTGTTACCGAGTGGAATGGGCCAAATTCCAGGAACGT GAGAGGAAGAAGGAAGAAGAGGAGAAGGAGAAGGAGCGGG TGGCCTATGCTCAGATCGACTGGCATGATTTTGTGGTGGT GGAAACAGTGGACTTCCAACCCAATGAGCAAGGGAACTTC CCTCCCCCCACCACGCCAGAGGAGCTGGGGGCCCGAATCC TCATTCAGGAGCGCTATGAAAAGTTTGGGGAGAGTGAGGA AGTTGAGATGGAGGTCGAGTCTGATGAGGAGGATGACAAA CAGGAGAAGGCGGAGGAGCCTCCTTCCCAGCTGGACCAGG ACACCCAAGTACAAGATATGGATGAGGGTTCAGATGATGA AGAAGAAGGGCAGAAAGTGCCCCCACCCCCAGAGACACCC ATGCCTCCACCTCTGCCCCCAACTCCAGACCAAGTCATTG TCCGCAAGGATTATGATCCCAAAGCCTCCAAGCCCTTGCC TCCAGCCCCTGCTCCAGATGAGTATCTTGTGTCCCCCATT ACTGGGGAGAAGATCCCCGCCAGCAAAATGCAGGAACACA TGCGCATTGGACTTCTTGACCCTCGCTGGCTGGAGCAGCG GGATCGCTCCATCCGTGAGAAGCAGAGCGATGATGAGGTG TACGCACCAGGTCTGGATATTGAGAGCAGCTTGAAGCAGT TGGCTGAGCGGCGTACTGACATCTTCGGTGTAGAGGAAAC AGCCATTGGTAAGAAGATCGGTGAGGAGGAGATCCAGAAG CCAGAGGAAAAGGTGACCTGGGATGGCCACTCAGGCAGCA TGGCCCGGACCCAGCAGGCTGCCCAGGCCAACATCACCCT CCAGGAGCAGATTGAGGCCATTCACAAGGCCAAAGGCCTG GTGCCAGAGGATGACACTAAAGAGAAGATTGGCCCCAGCA AGCCCAATGAAATCCCTCAACAGCCACCGCCACCATCTTC AGCCACCAACATCCCCAGCTCGGCTCCACCCATCACTTCA GTGCCCCGACCACCCACAATGCCACCTCCAGTTCGTACTA CAGTTGTCTCCGCAGTACCCGTCATGCCCCGGCCCCCAAT GGCATCTGTGGTCCGGCTGCCCCCAGGCTCAGTGATCGCC CCCATGCCGCCCATCATCCACGCGCCCAGAATCAACGTGG TGCCCATGCCTCCCTCGGCCCCTCCTATTATGGCCCCCCG CCCACCCCCCATGATTGTGCCAACAGCCTTTGTGCCTGCT CCACCTGTGGCACCTGTCCCAGCTCCAGCCCCAATGCCCC CTGTGCATCCCCCACCTCCCATGGAAGATGAGCCCACCTC CAAAAAACTGAAGACAGAGGACAGCCTCATGCCAGAGGAG GAGTTCCTGCGCAGAAACAAGGGTCCAGTGTCCATCAAAG TCCAGGTGCCCAACATGCAGGATAAGACGGAATGGAAACT GAATGGGCAGGTGCTGGTCTTCACCCTCCCACTCACGGAC CAGGTCTCTGTCATTAAGGTGAAGATTCATGAAGCCACAG GCATGCCTGCAGGGAAACAGAAGCTACAGTATGAGGGTAT CTTCATCAAAGATTCCAACTCACTGGCTTACTACAACATG GCCAATGGCGCAGTCATCCACCTGGCCCTCAAGGAGAGAG GCGGGAGGAAGAAGTAGACAAGAGGAACCTGCTGTCAAGT CCCTGCCATTTTGCCTCTCCTGTCTCCCACCCCCTGCCCC AGACCCAGGAGCCCCCCTGAGGCTTTGCCTTGCCTGCATA TTTGTTTCGCTCTTACTCAGTTTGGGAATTCAAATTGTCC TGCAGAGGTTCATTCCCCTGACCCTTTCCCCACATTGGTA AGAGTAGCTGGGTTTTCTAAGCCACTCTCTGGAATCTCTT TGTGTTAGGGTCTCGATTTGAGGACATTCATTTCTTCAGC AGCCCATTAGCAACTGAGAGCCCAGGGATGTCCTACAGGA TAGTTTCATAGTGACAGGTGGCACTTGGCTAATAGAATAT GGCTGATATTGTCATTAATCATTTTGTACCTTGACATGGG TTGTCTAATAAAACTCGGACCCTTCTTGTGAAATCAGTTA AATAAGACTTGTCTCGGTCACCTGTGCCCTGTCCAGACTC GAGGCAGTGGTAACACTGCACAGTGCTATGTGGCTTCTCT TTGAGGATTTTTGGGTTTTGTAACTAAATTCTTGCTGCCC TCATACTTTTTATGTATTAGAATCATATTCGTATTGCCCT TTTAAAACATTGGGATCCTCCAAAGGCCTGCCCCATGTAT TTAACAGTAATACAGGAAGCATGGCAGGCACCATGCAAAC CAAGGATGGATGGTGCAGTCCCTGTGTCAGTGGGCGGTGG TTTCCTGCTGGCCTGGAATCACTCATCACCTGATTGATTG GCTCTGTGGTCCTGGGCAGGTGCCTCATAGGTGTGTGGAT ATGATGACGTTTCTTTAAAATGTATGTATTTAACAAATAC TTAATTGTATTAAGGTCATGTACCAAGGATTTGATAAAGT TTAAATAATTTACTCTCTACTTTTATCCATTTTATCCATT TTAACTCATGTAATCCTCATGTGAGTATTCCTGTTTAACA CTTGAGTAAACTGAGGCACAGAGAACATAAGTTGCATGCC ATAGTCACACACTGTGAAAGTGAAAAGAGAATGTGTGCAA AACACGTCACAGTCCTGGTTTCTGAGTAAAGGCAGGCTGT TATCTTTAGAATCAAGCTATCACAGGGAGATAGGCAATGC TGTGGGTGTTGGAGGAAGGTGAGAGCCTGTTGCTAACAAT TTCCTGGTTTTAAAGCTAAGGCTGATTTTATTGGGAAGAT CTCACATGTGTGTGGCCCCTGAGAGTTCCCAGTGCCTTTT ATTTGCAGTCCTTCCATTTGGACCTCCTAGCTGCCCCATC AGGTCATCTCCAGGGCTCAGAGGGGTGAGACCATTTCCCA AGGTCACAGAACCAGCTCTCTAGTCACCACCCTGCCTCTC CCTCTCACCCAGAGTCAGTACCAGTTTTATGGCTTTATTA CAAACTGCTGGGTCCCTCCCATTTTCAACTTGATTGATGG GATGTCATCCCTTATCCTGTCTGACATTTGCCTCTGGCCT GGTTGCTAGAAGTTTGCCCCAGGGGCAAGAGTTGAAATTT GGCTTCCTGAGGTGGGCTTTGTGGTTTGCGTCCCTAAAGT GAGCCCACTACTGGTTGCTTGTCCATGGCCAACACCAGAA ATCCCCTGAGCACTACCTGGGTCTCATTCCAAGAAGGAAG AGGGTCAGGAGACCTGGGGAGTCTCATATTCCAAGTTCTT CTTTCTTTCTGGGAGCAGTGGGCAGTTCATGGTGTTAGGG CACTCACCCCCACAGACTGGCAAACCCTGCAGGACTTCCG TGGCTGAGGCTGTGACCGGAGGCCAGGAATGCCGTTGGGT GGATTGTGAGTGAATGGGCCCTTTGAGCTGCCCTCTAGAG AGCAAATCCAGTTTCCTGGAGCTCCTGAATGAATATCTGT ACTGGCTCGCTCAGATGCAGAAGCTCCATTGACCATGAGG CCTTGTGAACATCAGTGGCCACAGGCCCAGTGTGCTGCTT GGCACTGCACTAGTTTAGGACCTGCAGCATGTAGGTAGCG TCCTAGTGTTTATAATACAAAGCTGCTCTGCACAGCTTTT CTGATTCTTCTTGCAATCTCCTGAGGATTATCTGCCCCAT TTTTAAAACGAGGTGGAATACCCAAGGTCATGTAGCCAGT GAGTGCTCTGGAAAGCCAAAGCAGCTCATCCCTTCCTGGG GACCACACTGCTCTGCTCCACCAGACCACACTATGAAATA GGAATAAGTGCTCCTGTTGCAGGACTGCTGGGAAAACAGG TGGTGTGGGACTTAAGTCACCATAATTTTGAAGACTTGCA TGCAGAGGGCTCCAGGAATTGTAGACATTAAGGAATTTCA CTTTCAGTTCTACCCACTACTTAAGTACTTGTCATGTACT CTTAGAGGAGGCCAGTAATGATCAGAACCATTTTACTTTA AAATTAATAATATTGTATTAGAGAATATATTAAATGGTTA TATTGGGTTATGTTAGGATATATACTTGAATGGAAATACA TGTACTATTAGCAATCATATTTCATTTATCCCTGTAATTA GACAAGAAAGCATAATATAGCTCTACTCATGGGTACACAT ACCAGTGTATAAGATTTTTAGAAGTTTACTTTTTAAAAAT AAAAGCAAAATGTAAGATCTTAAAAAAAAAAAAAAAAAA PUM1 NM_001020658.1 AGTGGGCCGCCATGTTGTCGGAGTGAAAGGTAAGGGGGAG 40 CGAGAGCGCCAGAGAGAGAAGATCGGGGGGCTGAAATCCA TCTTCATCCTACCGCTCCGCCCGTGTTGGTGGAATGAGCG TTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGA CTCTTTCAGCCCCCACCTGAAACATCACCCTCAAGAACCA GCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAG GGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAGGCTCT TGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATA GGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACT ACTTCTTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGG AGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGA TGGCCTACTGGGGATAACATTCATGCAGAACATCAGGTGC GTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGC TCTGGAGGGAAGAGCGATGGGAGAGCAGCTCTTGCCAGGT AAAAAGTTTTGGGAAACAGATGAATCCAGCAAAGATGGAC CAAAAGGAATATTCCTGGGTGATCAATGGCGAGACAGTGC CTGGGGAACATCAGATCATTCAGTTTCCCAGCCAATCATG GTGCAGAGAAGACCTGGTCAGAGTTTCCATGTGAACAGTG AGGTCAATTCTGTACTGTCCCCACGATCGGAGAGTGGGGG ACTAGGCGTTAGCATGGTGGAGTATGTGTTGAGCTCATCC CCGGGCGATTCCTGTCTAAGAAAAGGAGGATTTGGCCCAA GGGATGCAGACAGTGATGAAAACGACAAAGGTGAAAAGAA GAACAAGGGTACGTTTGATGGAGATAAGCTAGGAGATTTG AAGGAGGAGGGTGATGTGATGGACAAGACCAATGGTTTAC CAGTGCAGAATGGGATTGATGCAGACGTCAAAGATTTTAG CCGTACCCCTGGTAATTGCCAGAACTCTGCTAATGAAGTG GATCTTCTGGGTCCAAACCAGAATGGTTCTGAGGGCTTAG CCCAGCTGACCAGCACCAATGGTGCCAAGCCTGTGGAGGA TTTCTCCAACATGGAGTCCCAGAGTGTCCCCTTGGACCCC ATGGAACATGTGGGCATGGAGCCTCTTCAGTTTGATTATT CAGGCACGCAGGTACCTGTGGACTCAGCAGCAGCAACTGT GGGACTTTTTGACTACAATTCTCAACAACAGCTGTTCCAA AGACCTAATGCGCTTGCTGTCCAGCAGTTGACAGCTGCTC AGCAGCAGCAGTATGCACTGGCAGCTGCTCATCAGCCGCA CATCGGTTTAGCTCCCGCTGCGTTTGTCCCCAATCCATAC ATCATCAGCGCTGCTCCCCCAGGGACGGACCCCTACACAG CTGGATTGGCTGCAGCAGCGACACTAGGCCCAGCTGTGGT CCCTCACCAGTATTATGGAGTTACTCCCTGGGGAGTCTAC CCTGCCAGTCTTTTCCAGCAGCAAGCTGCCGCTGCCGCTG CAGCAACTAATTCAGCTAATCAACAGACCACCCCACAGGC TCAGCAAGGACAGCAGCAGGTTCTCCGTGGAGGAGCCAGC CAACGTCCTTTGACCCCAAACCAGAACCAGCAGGGACAGC AAACGGATCCCCTTGTGGCAGCTGCAGCAGTGAATTCTGC CCTTGCATTTGGACAAGGTCTGGCAGCAGGCATGCCAGGT TATCCGGTGTTGGCTCCTGCTGCTTACTATGACCAAACTG GTGCCCTTGTAGTGAATGCAGGCGCGAGAAATGGTCTTGG AGCTCCTGTTCGACTTGTAGCTCCTGCCCCAGTCATCATT AGTTCCTCAGCTGCACAAGCAGCTGTTGCAGCAGCCGCAG CTTCAGCAAATGGAGCAGCTGGTGGTCTTGCTGGAACAAC AAATGGACCATTTCGCCCTTTAGGAACACAGCAGCCTCAG CCCCAGCCCCAGCAGCAGCCCAATAACAACCTGGCATCCA GTTCTTTCTACGGCAACAACTCTCTGAACAGCAATTCACA GAGCAGCTCCCTCTTCTCCCAGGGCTCTGCCCAGCCTGCC AACACATCCTTGGGATTCGGAAGTAGCAGTTCTCTCGGCG CCACCCTGGGATCCGCCCTTGGAGGGTTTGGAACAGCAGT TGCAAACTCCAACACTGGCAGTGGCTCCCGCCGTGACTCC CTGACTGGCAGCAGTGACCTTTATAAGAGGACATCGAGCA GCTTGACCCCCATTGGACACAGTTTTTATAACGGCCTTAG CTTTTCCTCCTCTCCTGGACCCGTGGGCATGCCTCTCCCT AGTCAGGGACCAGGACATTCACAGACACCACCTCCTTCCC TCTCTTCACATGGATCCTCTTCAAGCTTAAACCTGGGAGG ACTCACGAATGGCAGTGGAAGATACATCTCTGCTGCTCCA GGCGCTGAAGCCAAGTACCGCAGTGCAAGCAGCGCCTCCA GCCTCTTCAGCCCGAGCAGCACTCTTTTCTCTTCCTCTCG TTTGCGATATGGAATGTCTGATGTCATGCCTTCTGGCAGG AGCAGGCTTTTGGAAGATTTTCGAAACAACCGGTACCCCA ATTTACAACTGCGGGAGATTGCTGGACATATAATGGAATT TTCCCAAGACCAGCATGGGTCCAGATTCATTCAGCTGAAA CTGGAGCGTGCCACACCAGCTGAGCGCCAGCTTGTCTTCA ATGAAATCCTCCAGGCTGCCTACCAACTCATGGTGGATGT GTTTGGTAATTACGTCATTCAGAAGTTCTTTGAATTTGGC AGTCTTGAACAGAAGCTGGCTTTGGCAGAACGGATTCGAG GCCACGTCCTGTCATTGGCACTACAGATGTATGGCTGCCG TGTTATCCAGAAAGCTCTTGAGTTTATTCCTTCAGACCAG CAGGTAATTAATGAGATGGTTCGGGAACTAGATGGCCATG TCTTGAAGTGTGTGAAAGATCAGAATGGCAATCACGTGGT TCAGAAATGCATTGAATGTGTACAGCCCCAGTCTTTGCAA TTTATCATCGATGCGTTTAAGGGACAGGTATTTGCCTTAT CCACACATCCTTATGGCTGCCGAGTGATTCAGAGAATCCT GGAGCACTGTCTCCCTGACCAGACACTCCCTATTTTAGAG GAGCTTCACCAGCACACAGAGCAGCTTGTACAGGATCAAT ATGGAAATTATGTAATCCAACATGTACTGGAGCACGGTCG TCCTGAGGATAAAAGCAAAATTGTAGCAGAAATCCGAGGC AATGTACTTGTATTGAGTCAGCACAAATTTGCAAGCAATG TTGTGGAGAAGTGTGTTACTCACGCCTCACGTACGGAGCG CGCTGTGCTCATCGATGAGGTGTGCACCATGAACGACGGT CCCCACAGTGCCTTATACACCATGATGAAGGACCAGTATG CCAACTACGTGGTCCAGAAGATGATTGACGTGGCGGAGCC AGGCCAGCGGAAGATCGTCATGCATAAGATCCGGCCCCAC ATCGCAACTCTTCGTAAGTACACCTATGGCAAGCACATTC TGGCCAAGCTGGAGAAGTACTACATGAAGAACGGTGTTGA CTTAGGGCCCATCTGTGGCCCCCCTAATGGTATCATCTGA GGCAGTGTCACCCGCTGTTCCCTCATTCCCGCTGACCTCA CTGGCCCACTGGCAAATCCAACCAGCAACCAGAAATGTTC TAGTGTAGAGTCTGAGACGGGCAAGTGGTTGCTCCAGGAT TACTCCCTCCTCCAAAAAAGGAATCAAATCCACGAGTGGA AAAGCCTTTGTAAATTTAATTTTATTACACATAACATGTA CTATTTTTTTTAATTGACTAATTGCCCTGCTGTTTTACTG GTGTATAGGATACTTGTACATAGGTAACCAATGTACATGG GAGGCCACATATTTTGTTCACTGTTGTATCTATATTTCAC ATGTGGAAACTTTCAGGGTGGTTGGTTTAACAAAAAAAAA AAGCTTTAAAAAAAAAAGAAAAAAAGGAAAAGGTTTTTAG CTCATTTGCCTGGCCGGCAAGTTTTGCAAATAGCTCTTCC CCACCTCCTCATTTTAGTAAAAAACAAACAAAAACAAAAA AACCTGAGAAGTTTGAATTGTAGTTAAATGACCCCAAACT GGCATTTAACACTGTTTATAAAAAATATATATATATATAT ATATATATATAATGAAAAAGGTTTCAGAGTTGCTAAAGCT TCAGTTTGTGACATTAAGTTTATGAAATTCTAAAAAATGC CTTTTTTGGAGACTATATTATGCTGAAGAAGGCTGTTCGT GAGGAGGAGATGCGAGCACCCAGAACGTCTTTTGAGGCTG GGCGGGTGTGATTGTTTACTGCCTACTGGATTTTTTTCTA TTAACATTGAAAGGTAAAATCTGATTATTTAGCATGAGAA AAAAAAATCCAACTCTGCTTTTGGTCTTGCTTCTATAAAT ATATAGTGTATACTTGGTGTAGACTTTGCATATATACAAA TTTGTAGTATTTTCTTGTTTTGATGTCTAATCTGTATCTA TAATGTACCCTAGTAGTCGAACATACTTTTGATTGTACAA TTGTACATTTGTATACCTGTAATGTAAATGTGGAGAAGTT TGAATCAACATAAACACGTTTTTTGGTAAGAAAAGAGAAT TAGCCAGCCCTGTGCATTCAGTGTATATTCTCACCTTTTA TGGTCGTAGCATATAGTGTTGTATATTGTAAATTGTAATT TCAACCAGAAGTAAATTTTTTTCTTTTGAAGGAATAAATG TTCTTTATACAGCCTAGTTAATGTTTAAAAAGAAAAAAAT AGCTTGGTTTTATTTGTCATCTAGTCTCAAGTATAGCGAG ATTCTTTCTAAATGTTATTCAAGATTGAGTTCTCACTAGT GTTTTTTTAATCCTAAAAAAGTAATGTTTTGATTTTGTGA CAGTCAAAAGGACGTGCAAAAGTCTAGCCTTGCCCGAGCT TTCCTTACAATCAGAGCCCCTCTCACCTTGTAAAGTGTGA ATCGCCCTTCCCTTTTGTACAGAAGATGAACTGTATTTTG CATTTTGTCTACTTGTAAGTGAATGTAACATACTGTCAAT TTTCCTTGTTTGAATATAGAATTGTAACACTACACGGTGT ACATTTCCAGAGCCTTGTGTATATTTCCAATGAACTTTTT TGCAAGCACACTTGTAACCATATGTGTATAATTAACAAAC CTGTGTATGCTTATGCCTGGGCAACTATTTTTTGTAACTC TTGTGTAGATTGTCTCTAAACAATGTGTGATCTTTATTTT GAAAAATACAGAACTTTGGAATCTGAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAA ACTB NM_001101.4 GAGTGAGCGGCGCGGGGCCAATCAGCGTGCGCCGTTCCGA 41 AAGTTGCCTTTTATGGCTCGAGCGGCCGCGGCGGCGCCCT ATAAAACCCAGCGGCGCGACGCGCCACCACCGCCGAGACC GCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGATC CGCCGCCCGTCCACACCCGCCGCCAGCTCACCATGGATGA TGATATCGCCGCGCTCGTCGTCGACAACGGCTCCGGCATG TGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCG TCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGT GATGGTGGGCATGGGTCAGAAGGATTCCTATGTGGGCGAC GAGGCCCAGAGCAAGAGAGGCATCCTCACCCTGAAGTACC CCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGA GAAAATCTGGCACCACACCTTCTACAATGAGCTGCGTGTG GCTCCCGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCC TGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCAT GTTTGAGACCTTCAACACCCCAGCCATGTACGTTGCTATC CAGGCTGTGCTATCCCTGTACGCCTCTGGCCGTACCACTG GCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGT GCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTG CGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCA TGAAGATCCTCACCGAGCGCGGCTACAGCTTCACCACCAC GGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTG TGCTACGTCGCCCTGGACTTCGAGCAAGAGATGGCCACGG CTGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCC TGACGGCCAGGTCATCACCATTGGCAATGAGCGGTTCCGC TGCCCTGAGGCACTCTTCCAGCCTTCCTTCCTGGGCATGG AGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCAT GAAGTGTGACGTGGACATCCGCAAAGACCTGTACGCCAAC ACAGTGCTGTCTGGCGGCACCACCATGTACCCTGGCATTG CCGACAGGATGCAGAAGGAGATCACTGCCCTGGCACCCAG CACAATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAG TACTCCGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGT CCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGA CGAGTCCGGCCCCTCCATCGTCCACCGCAAATGCTTCTAG GCGGACTATGACTTAGTTGCGTTACACCCTTTCTTGACAA AACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGC TTTATTTGTTTTTTTTGTTTTGTTTTGGTTTTTTTTTTTT TTTTGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAG GTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCA CAATGTGGCCGAGGACTTTGATTGCACATTGTTGTTTTTT TAATAGTCATTCCAAATATGAGATGCGTTGTTACAGGAAG TCCCTTGCCATCCTAAAAGCCACCCCACTTCTCTCTAAGG AGAATGGCCCAGTCCTCTCCCAAGTCCACACAGGGGAGGT GATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTT TTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATT TTGAATGATGAGCCTTCGTGCCCCCCCTTCCCCCTTTTTT GTCCCCCAACTTGAGATGTATGAAGGCTTTTGGTCTCCCT GGGAGTGGGTGGAGGCAGCCAGGGCTTACCTGTACACTGA CTTGAGACCAGTTGAATAAAAGTGCACACCTTAAAAATGA GGAAAAAAAAAAAAAAAAAA GAPD NM_002046.6 GCTCTCTGCTCCTCCTGTTCGACAGTCAGCCGCATCTTCT 42 TTTGCGTCGCCAGCCGAGCCACATCGCTCAGACACCATGG GGAAGGTGAAGGTCGGAGTCAACGGATTTGGTCGTATTGG GCGCCTGGTCACCAGGGCTGCTTTTAACTCTGGTAAAGTG GATATTGTTGCCATCAATGACCCCTTCATTGACCTCAACT ACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAA ATTCCATGGCACCGTCAAGGCTGAGAACGGGAAGCTTGTC ATCAATGGAAATCCCATCACCATCTTCCAGGAGCGAGATC CCTCCAAAATCAAGTGGGGCGATGCTGGCGCTGAGTACGT CGTGGAGTCCACTGGCGTCTTCACCACCATGGAGAAGGCT GGGGCTCATTTGCAGGGGGGAGCCAAAAGGGTCATCATCT CTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGT GAACCATGAGAAGTATGACAACAGCCTCAAGATCATCAGC AATGCCTCCTGCACCACCAACTGCTTAGCACCCCTGGCCA AGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCAT GACCACAGTCCATGCCATCACTGCCACCCAGAAGACTGTG GATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGCGGGG CTCTCCAGAACATCATCCCTGCCTCTACTGGCGCTGCCAA GGCTGTGGGCAAGGTCATCCCTGAGCTGAACGGGAAGCTC ACTGGCATGGCCTTCCGTGTCCCCACTGCCAACGTGTCAG TGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATA TGATGACATCAAGAAGGTGGTGAAGCAGGCGTCGGAGGGC CCCCTCAAGGGCATCCTGGGCTACACTGAGCACCAGGTGG TCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTT TGACGCTGGGGCTGGCATTGCCCTCAACGACCACTTTGTC AAGCTCATTTCCTGGTATGACAACGAATTTGGCTACAGCA ACAGGGTGGTGGACCTCATGGCCCACATGGCCTCCAAGGA GTAAGACCCCTGGACCACCAGCCCCAGCAAGAGCACAAGA GGAAGAGAGAGACCCTCACTGCTGGGGAGTCCCTGCCACA CTCAGTCCCCCACCACACTGAATCTCCCCTCCTCACAGTT GCCATGTAGACCCCTTGAAGAGGGGAGGGGCCTAGGGAGC CGCACCTTGTCATGTACCATCAATAAAGTACCCTGTGCTC AACCAGTTAAAAAAAAAAAAAAAAAAAAA GUSB NM_000181.3 GTCCTCAACCAAGATGGCGCGGATGGCTTCAGGCGCATCA 43 CGACACCGGCGCGTCACGCGACCCGCCCTACGGGCACCTC CCGCGCTTTTCTTAGCGCCGCAGACGGTGGCCGAGCGGGG GACCGGGAAGCATGGCCCGGGGGTCGGCGGTTGCCTGGGC GGCGCTCGGGCCGTTGTTGTGGGGCTGCGCGCTGGGGCTG CAGGGCGGGATGCTGTACCCCCAGGAGAGCCCGTCGCGGG AGTGCAAGGAGCTGGACGGCCTCTGGAGCTTCCGCGCCGA CTTCTCTGACAACCGACGCCGGGGCTTCGAGGAGCAGTGG TACCGGCGGCCGCTGTGGGAGTCAGGCCCCACCGTGGACA TGCCAGTTCCCTCCAGCTTCAATGACATCAGCCAGGACTG GCGTCTGCGGCATTTTGTCGGCTGGGTGTGGTACGAACGG GAGGTGATCCTGCCGGAGCGATGGACCCAGGACCTGCGCA CAAGAGTGGTGCTGAGGATTGGCAGTGCCCATTCCTATGC CATCGTGTGGGTGAATGGGGTCGACACGCTAGAGCATGAG GGGGGCTACCTCCCCTTCGAGGCCGACATCAGCAACCTGG TCCAGGTGGGGCCCCTGCCCTCCCGGCTCCGAATCACTAT CGCCATCAACAACACACTCACCCCCACCACCCTGCCACCA GGGACCATCCAATACCTGACTGACACCTCCAAGTATCCCA AGGGTTACTTTGTCCAGAACACATATTTTGACTTTTTCAA CTACGCTGGACTGCAGCGGTCTGTACTTCTGTACACGACA CCCACCACCTACATCGATGACATCACCGTCACCACCAGCG TGGAGCAAGACAGTGGGCTGGTGAATTACCAGATCTCTGT CAAGGGCAGTAACCTGTTCAAGTTGGAAGTGCGTCTTTTG GATGCAGAAAACAAAGTCGTGGCGAATGGGACTGGGACCC AGGGCCAACTTAAGGTGCCAGGTGTCAGCCTCTGGTGGCC GTACCTGATGCACGAACGCCCTGCCTATCTGTATTCATTG GAGGTGCAGCTGACTGCACAGACGTCACTGGGGCCTGTGT CTGACTTCTACACACTCCCTGTGGGGATCCGCACTGTGGC TGTCACCAAGAGCCAGTTCCTCATCAATGGGAAACCTTTC TATTTCCACGGTGTCAACAAGCATGAGGATGCGGACATCC GAGGGAAGGGCTTCGACTGGCCGCTGCTGGTGAAGGACTT CAACCTGCTTCGCTGGCTTGGTGCCAACGCTTTCCGTACC AGCCACTACCCCTATGCAGAGGAAGTGATGCAGATGTGTG ACCGCTATGGGATTGTGGTCATCGATGAGTGTCCCGGCGT GGGCCTGGCGCTGCCGCAGTTCTTCAACAACGTTTCTCTG CATCACCACATGCAGGTGATGGAAGAAGTGGTGCGTAGGG ACAAGAACCACCCCGCGGTCGTGATGTGGTCTGTGGCCAA CGAGCCTGCGTCCCACCTAGAATCTGCTGGCTACTACTTG AAGATGGTGATCGCTCACACCAAATCCTTGGACCCCTCCC GGCCTGTGACCTTTGTGAGCAACTCTAACTATGCAGCAGA CAAGGGGGCTCCGTATGTGGATGTGATCTGTTTGAACAGC TACTACTCTTGGTATCACGACTACGGGCACCTGGAGTTGA TTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAA GAAGTATCAGAAGCCCATTATTCAGAGCGAGTATGGAGCA GAAACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGT TCACTGAAGAGTACCAGAAAAGTCTGCTAGAGCAGTACCA TCTGGGTCTGGATCAAAAACGCAGAAAATACGTGGTTGGA GAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAGT CACCGACGAGAGTGCTGGGGAATAAAAAGGGGATCTTCAC TCGGCAGAGACAACCAAAAAGTGCAGCGTTCCTTTTGCGA GAGAGATACTGGAAGATTGCCAATGAAACCAGGTATCCCC ACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTT TACTTGAGCAAGACTGATACCACCTGCGTGTCCCTTCCTC CCCGAGTCAGGGCGACTTCCACAGCAGCAGAACAAGTGCC TCCTGGACTGTTCACGGCAGACCAGAACGTTTCTGGCCTG GGTTTTGTGGTCATCTATTCTAGCAGGGAACACTAAAGGT GGAAATAAAAGATTTTCTATTATGGAAATAAAGAGTTGGC ATGAAAGTGGCTACTGAAAAAAAAAAAAAAAAAAAAAAAAA RPLP0 NM_001002.3 GTCTGACGGGCGATGGCGCAGCCAATAGACAGGAGCGCTA 44 TCCGCGGTTTCTGATTGGCTACTTTGTTCGCATTATAAAA GGCACGCGCGGGCGCGAGGCCCTTCTCTCGCCAGGCGTCC TCGTGGAAGTGACATCGTCTTTAAACCCTGCGTGGCAATC CCTGACGCACCGCCGTGATGCCCAGGGAAGACAGGGCGAC CTGGAAGTCCAACTACTTCCTTAAGATCATCCAACTATTG GATGATTATCCGAAATGTTTCATTGTGGGAGCAGACAATG TGGGCTCCAAGCAGATGCAGCAGATCCGCATGTCCCTTCG CGGGAAGGCTGTGGTGCTGATGGGCAAGAACACCATGATG CGCAAGGCCATCCGAGGGCACCTGGAAAACAACCCAGCTC TGGAGAAACTGCTGCCTCATATCCGGGGGAATGTGGGCTT TGTGTTCACCAAGGAGGACCTCACTGAGATCAGGGACATG TTGCTGGCCAATAAGGTGCCAGCTGCTGCCCGTGCTGGTG CCATTGCCCCATGTGAAGTCACTGTGCCAGCCCAGAACAC TGGTCTCGGGCCCGAGAAGACCTCCTTTTTCCAGGCTTTA GGTATCACCACTAAAATCTCCAGGGGCACCATTGAAATCC TGAGTGATGTGCAGCTGATCAAGACTGGAGACAAAGTGGG AGCCAGCGAAGCCACGCTGCTGAACATGCTCAACATCTCC CCCTTCTCCTTTGGGCTGGTCATCCAGCAGGTGTTCGACA ATGGCAGCATCTACAACCCTGAAGTGCTTGATATCACAGA GGAAACTCTGCATTCTCGCTTCCTGGAGGGTGTCCGCAAT GTTGCCAGTGTCTGTCTGCAGATTGGCTACCCAACTGTTG CATCAGTACCCCATTCTATCATCAACGGGTACAAACGAGT CCTGGCCTTGTCTGTGGAGACGGATTACACCTTCCCACTT GCTGAAAAGGTCAAGGCCTTCTTGGCTGATCCATCTGCCT TTGTGGCTGCTGCCCCTGTGGCTGCTGCCACCACAGCTGC TCCTGCTGCTGCTGCAGCCCCAGCTAAGGTTGAAGCCAAG GAAGAGTCGGAGGAGTCGGACGAGGATATGGGATTTGGTC TCTTTGACTAATCACCAAAAAGCAACCAACTTAGCCAGTT TTATTTGCAAAACAAGGAAATAAAGGCTTACTTCTTTAAA AAGTAAAAAAAAAAAAAAAAAAAAAAAAA TFRC NM_003234.3 AGAGCGTCGGGATATCGGGTGGCGGCTCGGGACGGAGGAC 45 GCGCTAGTGTGAGTGCGGGCTTCTAGAACTACACCGACCC TCGTGTCCTCCCTTCATCCTGCGGGGCTGGCTGGAGCGGC CGCTCCGGTGCTGTCCAGCAGCCATAGGGAGCCGCACGGG GAGCGGGAAAGCGGTCGCGGCCCCAGGCGGGGCGGCCGGG ATGGAGCGGGGCCGCGAGCCTGTGGGGAAGGGGCTGTGGC GGCGCCTCGAGCGGCTGCAGGTTCTTCTGTGTGGCAGTTC AGAATGATGGATCAAGCTAGATCAGCATTCTCTAACTTGT TTGGTGGAGAACCATTGTCATATACCCGGTTCAGCCTGGC TCGGCAAGTAGATGGCGATAACAGTCATGTGGAGATGAAA CTTGCTGTAGATGAAGAAGAAAATGCTGACAATAACACAA AGGCCAATGTCACAAAACCAAAAAGGTGTAGTGGAAGTAT CTGCTATGGGACTATTGCTGTGATCGTCTTTTTCTTGATT GGATTTATGATTGGCTACTTGGGCTATTGTAAAGGGGTAG AACCAAAAACTGAGTGTGAGAGACTGGCAGGAACCGAGTC TCCAGTGAGGGAGGAGCCAGGAGAGGACTTCCCTGCAGCA CGTCGCTTATATTGGGATGACCTGAAGAGAAAGTTGTCGG AGAAACTGGACAGCACAGACTTCACCGGCACCATCAAGCT GCTGAATGAAAATTCATATGTCCCTCGTGAGGCTGGATCT CAAAAAGATGAAAATCTTGCGTTGTATGTTGAAAATCAAT TTCGTGAATTTAAACTCAGCAAAGTCTGGCGTGATCAACA TTTTGTTAAGATTCAGGTCAAAGACAGCGCTCAAAACTCG GTGATCATAGTTGATAAGAACGGTAGACTTGTTTACCTGG TGGAGAATCCTGGGGGTTATGTGGCGTATAGTAAGGCTGC AACAGTTACTGGTAAACTGGTCCATGCTAATTTTGGTACT AAAAAAGATTTTGAGGATTTATACACTCCTGTGAATGGAT CTATAGTGATTGTCAGAGCAGGGAAAATCACCTTTGCAGA AAAGGTTGCAAATGCTGAAAGCTTAAATGCAATTGGTGTG TTGATATACATGGACCAGACTAAATTTCCCATTGTTAACG CAGAACTTTCATTCTTTGGACATGCTCATCTGGGGACAGG TGACCCTTACACACCTGGATTCCCTTCCTTCAATCACACT CAGTTTCCACCATCTCGGTCATCAGGATTGCCTAATATAC CTGTCCAGACAATCTCCAGAGCTGCTGCAGAAAAGCTGTT TGGGAATATGGAAGGAGACTGTCCCTCTGACTGGAAAACA GACTCTACATGTAGGATGGTAACCTCAGAAAGCAAGAATG TGAAGCTCACTGTGAGCAATGTGCTGAAAGAGATAAAAAT TCTTAACATCTTTGGAGTTATTAAAGGCTTTGTAGAACCA GATCACTATGTTGTAGTTGGGGCCCAGAGAGATGCATGGG GCCCTGGAGCTGCAAAATCCGGTGTAGGCACAGCTCTCCT ATTGAAACTTGCCCAGATGTTCTCAGATATGGTCTTAAAA GATGGGTTTCAGCCCAGCAGAAGCATTATCTTTGCCAGTT GGAGTGCTGGAGACTTTGGATCGGTTGGTGCCACTGAATG GCTAGAGGGATACCTTTCGTCCCTGCATTTAAAGGCTTTC ACTTATATTAATCTGGATAAAGCGGTTCTTGGTACCAGCA ACTTCAAGGTTTCTGCCAGCCCACTGTTGTATACGCTTAT TGAGAAAACAATGCAAAATGTGAAGCATCCGGTTACTGGG CAATTTCTATATCAGGACAGCAACTGGGCCAGCAAAGTTG AGAAACTCACTTTAGACAATGCTGCTTTCCCTTTCCTTGC ATATTCTGGAATCCCAGCAGTTTCTTTCTGTTTTTGCGAG GACACAGATTATCCTTATTTGGGTACCACCATGGACACCT ATAAGGAACTGATTGAGAGGATTCCTGAGTTGAACAAAGT GGCACGAGCAGCTGCAGAGGTCGCTGGTCAGTTCGTGATT AAACTAACCCATGATGTTGAATTGAACCTGGACTATGAGA GGTACAACAGCCAACTGCTTTCATTTGTGAGGGATCTGAA CCAATACAGAGCAGACATAAAGGAAATGGGCCTGAGTTTA CAGTGGCTGTATTCTGCTCGTGGAGACTTCTTCCGTGCTA CTTCCAGACTAACAACAGATTTCGGGAATGCTGAGAAAAC AGACAGATTTGTCATGAAGAAACTCAATGATCGTGTCATG AGAGTGGAGTATCACTTCCTCTCTCCCTACGTATCTCCAA AAGAGTCTCCTTTCCGACATGTCTTCTGGGGCTCCGGCTC TCACACGCTGCCAGCTTTACTGGAGAACTTGAAACTGCGT AAACAAAATAACGGTGCTTTTAATGAAACGCTGTTCAGAA ACCAGTTGGCTCTAGCTACTTGGACTATTCAGGGAGCTGC AAATGCCCTCTCTGGTGACGTTTGGGACATTGACAATGAG TTTTAAATGTGATACCCATAGCTTCCATGAGAACAGCAGG GTAGTCTGGTTTCTAGACTTGTGCTGATCGTGCTAAATTT TCAGTAGGGCTACAAAACCTGATGTTAAAATTCCATCCCA TCATCTTGGTACTACTAGATGTCTTTAGGCAGCAGCTTTT AATACAGGGTAGATAACCTGTACTTCAAGTTAAAGTGAAT AACCACTTAAAAAATGTCCATGATGGAATATTCCCCTATC TCTAGAATTTTAAGTGCTTTGTAATGGGAACTGCCTCTTT CCTGTTGTTGTTAATGAAAATGTCAGAAACCAGTTATGTG AATGATCTCTCTGAATCCTAAGGGCTGGTCTCTGCTGAAG GTTGTAAGTGGTCGCTTACTTTGAGTGATCCTCCAACTTC ATTTGATGCTAAATAGGAGATACCAGGTTGAAAGACCTTC TCCAAATGAGATCTAAGCCTTTCCATAAGGAATGTAGCTG GTTTCCTCATTCCTGAAAGAAACAGTTAACTTTCAGAAGA GATGGGCTTGTTTTCTTGCCAATGAGGTCTGAAATGGAGG TCCTTCTGCTGGATAAAATGAGGTTCAACTGTTGATTGCA GGAATAAGGCCTTAATATGTTAACCTCAGTGTCATTTATG AAAAGAGGGGACCAGAAGCCAAAGACTTAGTATATTTTCT TTTCCTCTGTCCCTTCCCCCATAAGCCTCCATTTAGTTCT TTGTTATTTTTGTTTCTTCCAAAGCACATTGAAAGAGAAC CAGTTTCAGGTGTTTAGTTGCAGACTCAGTTTGTCAGACT TTAAAGAATAATATGCTGCCAAATTTTGGCCAAAGTGTTA ATCTTAGGGGAGAGCTTTCTGTCCTTTTGGCACTGAGATA TTTATTGTTTATTTATCAGTGACAGAGTTCACTATAAATG GTGTTTTTTTAATAGAATATAATTATCGGAAGCAGTGCCT TCCATAATTATGACAGTTATACTGTCGGTTTTTTTTAAAT AAAAGCAGCATCTGCTAATAAAACCCAACAGATACTGGAA GTTTTGCATTTATGGTCAACACTTAAGGGTTTTAGAAAAC AGCCGTCAGCCAAATGTAATTGAATAAAGTTGAAGCTAAG ATTTAGAGATGAATTAAATTTAATTAGGGGTTGCTAAGAA GCGAGCACTGACCAGATAAGAATGCTGGTTTTCCTAAATG CAGTGAATTGTGACCAAGTTATAAATCAATGTCACTTAAA GGCTGTGGTAGTACTCCTGCAAAATTTTATAGCTCAGTTT ATCCAAGGTGTAACTCTAATTCCCATTTTGCAAAATTTCC AGTACCTTTGTCACAATCCTAACACATTATCGGGAGCAGT GTCTTCCATAATGTATAAAGAACAAGGTAGTTTTTACCTA CCACAGTGTCTGTATCGGAGACAGTGATCTCCATATGTTA CACTAAGGGTGTAAGTAATTATCGGGAACAGTGTTTCCCA TAATTTTCTTCATGCAATGACATCTTCAAAGCTTGAAGAT CGTTAGTATCTAACATGTATCCCAACTCCTATAATTCCCT ATCTTTTAGTTTTAGTTGCAGAAACATTTTGTGGTCATTA AGCATTGGGTGGGTAAATTCAACCACTGTAAAATGAAATT ACTACAAAATTTGAAATTTAGCTTGGGTTTTTGTTACCTT TATGGTTTCTCCAGGTCCTCTACTTAATGAGATAGTAGCA TACATTTATAATGTTTGCTATTGACAAGTCATTTTAACTT TATCACATTATTTGCATGTTACCTCCTATAAACTTAGTGC GGACAAGTTTTAATCCAGAATTGACCTTTTGACTTAAAGC AGAGGGACTTTGTATAGAAGGTTTGGGGGCTGTGGGGAAG GAGAGTCCCCTGAAGGTCTGACACGTCTGCCTACCCATTC GTGGTGATCAATTAAATGTAGGTATGAATAAGTTCGAAGC TCCGTGAGTGAACCATCATTATAAACGTGATGATCAGCTG TTTGTCATAGGGCAGTTGGAAACGGCCTCCTAGGGAAAAG TTCATAGGGTCTCTTCAGGTTCTTAGTGTCACTTACCTAG ATTTACAGCCTCACTTGAATGTGTCACTACTCACAGTCTC TTTAATCTTCAGTTTTATCTTTAATCTCCTCTTTTATCTT GGACTGACATTTAGCGTAGCTAAGTGAAAAGGTCATAGCT GAGATTCCTGGTTCGGGTGTTACGCACACGTACTTAAATG AAAGCATGTGGCATGTTCATCGTATAACACAATATGAATA CAGGGCATGCATTTTGCAGCAGTGAGTCTCTTCAGAAAAC CCTTTTCTACAGTTAGGGTTGAGTTACTTCCTATCAAGCC AGTACGTGCTAACAGGCTCAATATTCCTGAATGAAATATC AGACTAGTGACAAGCTCCTGGTCTTGAGATGTCTTCTCGT TAAGGAGATGGGCCTTTTGGAGGTAAAGGATAAAATGAAT GAGTTCTGTCATGATTCACTATTCTAGAACTTGCATGACC TTTACTGTGTTAGCTCTTTGAATGTTCTTGAAATTTTAGA CTTTCTTTGTAAACAAATGATATGTCCTTATCATTGTATA AAAGCTGTTATGTGCAACAGTGTGGAGATTCCTTGTCTGA TTTAATAAAATACTTAAACACTGAAAAAAAAAAA 18S X03205.1 TACCTGGTTGATCCTGCCAGTAGCATATGCTTGTCTCAAA 46 GATTAAGCCATGCATGTCTAAGTACGCACGGCCGGTACAG TGAAACTGCGAATGGCTCATTAAATCAGTTATGGTTCCTT TGGTCGCTCGCTCCTCTCCCACTTGGATAACTGTGGTAAT TCTAGAGCTAATACATGCCGACGGGCGCTGACCCCCTTCG CGGGGGGGATGCGTGCATTTATCAGATCAAAACCAACCCG GTCAGCCCCTCTCCGGCCCCGGCCGGGGGGCGGGCGCCGG CGGCTTTGGTGACTCTAGATAACCTCGGGCCGATCGCACG CCCCCCGTGGCGGCGACGACCCATTCGAACGTCTGCCCTA TCAACTTTCGATGGTAGTCGCCGTGCCTACCATGGTGACC ACGGGTGACGGGGAATCAGGGTTCGATTCCGGAGAGGGAG CCTGAGAAACGGCTACCACATCCAAGGAAGGCAGCAGGCG CGCAAATTACCCACTCCCGACCCGGGGAGGTAGTGACGAA AAATAACAATACAGGACTCTTTCGAGGCCCTGTAATTGGA ATGAGTCCACTTTAAATCCTTTAACGAGGATCCATTGGAG GGCAAGTCTGGTGCCAGCAGCCGCGGTAATTCCAGCTCCA ATAGCGTATATTAAAGTTGCTGCAGTTAAAAAGCTCGTAG TTGGATCTTGGGAGCGGGCGGGCGGTCCGCCGCGAGGCGA GCCACCGCCCGTCCCCGCCCCTTGCCTCTCGGCGCCCCCT CGATGCTCTTAGCTGAGTGTCCCGCGGGGCCCGAAGCGTT TACTTTGAAAAAATTAGAGTGTTCAAAGCAGGCCCGAGCC GCCTGGATACCGCAGCTAGGAATAATGGAATAGGACCGCG GTTCTATTTTGTTGGTTTTCGGAACTGAGGCCATGATTAA GAGGGACGGCCGGGGGCATTCGTATTGCGCCGCTAGAGGT GAAATTCTTGGACCGGCGCAAGACGGACCAGAGCGAAAGC ATTTGCCAAGAATGTTTTCATTAATCAAGAACGAAAGTCG GAGGTTCGAAGACGATCAGATACCGTCGTAGTTCCGACCA TAAACGATGCCGACCGGCGATGCGGCGGCGTTATTCCCAT GACCCGCCGGGCAGCTTCCGGGAAACCAAAGTCTTTGGGT TCCGGGGGGAGTATGGTTGCAAAGCTGAAACTTAAAGGAA TTGACGGAAGGGCACCACCAGGAGTGGAGCCTGCGGCTTA ATTTGACTCAACACGGGAAACCTCACCCGGCCCGGACACG GACAGGATTGACAGATTGATAGCTCTTTCTCGATTCCGTG GGTGGTGGTGCATGGCCGTTCTTAGTTGGTGGAGCGATTT GTCTGGTTAATTCCGATAACGAACGAGACTCTGGCATGCT AACTAGTTACGCGACCCCCGAGCGGTCGGCGTCCCCCAAC TTCTTAGAGGGACAAGTGGCGTTCAGCCACCCGAGATTGA GCAATAACAGGTCTGTGATGCCCTTAGATGTCCGGGGCTG CACGCGCGCTACACTGACTGGCTCAGCGTGTGCCTACCCT ACGCCGGCAGGCGCGGGTAACCCGTTGAACCCCATTCGTG ATGGGGATCGGGGATTGCAATTATTCCCCATGAACGAGGA ATTCCCAGTAAGTGCGGGTCATAAGCTTGCGTTGATTAAG TCCCTGCCCTTTGTACACACCGCCCGTCGCTACTACCGAT TGGATGGTTTAGTGAGGCCCTCGGATCGGCCCCGCCGGGG TCGGCCCACGGCCCTGGCGGAGCGCTGAGAAGACGGTCGA ACTTGACTATCTAGAGGAAGTAAAAGTCGTAACAAGGTTT CCGTAGGTGAACCTGCGGAAGGATCATTA PPIA NM_021130.4 GGGGCCGAACGTGGTATAAAAGGGGCGGGAGGCCAGGCTC 47 GTGCCGTTTTGCAGACGCCACCGCCGAGGAAAACCGTGTA CTATTAGCCATGGTCAACCCCACCGTGTTCTTCGACATTG CCGTCGACGGCGAGCCCTTGGGCCGCGTCTCCTTTGAGCT GTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGT GCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTT CCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGG TGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCC ATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAA AGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGG ACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCC AAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCA AAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCG CTTTGGGTCCAGGAATGGCAAGACCAGCAAGAAGATCACC ATTGCTGACTGTGGACAACTCGAATAAGTTTGACTTGTGT TTTATCTTAACCACCAGATCATTCCTTCTGTAGCTCAGGA GAGCACCCCTCCACCCCATTTGCTCGCAGTATCCTAGAAT CTTTGTGCTCTCGCTGCAGTTCCCTTTGGGTTCCATGTTT TCCTTGTTCCCTCCCATGCCTAGCTGGATTGCAGAGTTAA GTTTATGATTATGAAATAAAAACTAAATAACAATTGTCCT CGTTTGAGTTAAGAGTGTTGATGTAGGCTTTATTTTAAGC AGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAAT TCTACACAGTACTTAGATTTTTTTTACTTTCCAGTCCCAG GAAGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAG GCAGCAACTGGGCATGGTGGCTCACTGTCTGTAATGTATT ACCTGAGGCAGAAGACCACCTGAGGGTAGGAGTCAAGATC AGCCTGGGCAACATAGTGAGACGCTGTCTCTACAAAAAAT AATTAGCCTGGCCTGGTGGTGCATGCCTAGTCCTAGCTGA TCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTAGAGTG AGCTATTATCATGCCACTGTACAGCCTGGGTGTTCACAGA TCTTGTGTCTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGG AGCCAGAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCA TGCATTTAGAGGTGTTCTTCAAGATGACTAATGTCAAAAA TTGAGACATCTGTTGCGGTTTTTTTTTTTTTTTTTTCCCC TGGAATGCAGTGGCGTGATCTCAGCTCACTGCAGCCTCCG CCTCCTGGGTTCAAGTGATTCTAGTGCCTCAGCCTCCTGA GTAGCTGGGATAATGGGCGTGTGCCACCATGCCCAGCTAA TTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTTGA CCAGGCTGGTCTCAAACTCTTGACCTCAGCTGATGCGCCT GCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCC ACCGCACCCTACCTCATTTTCTGTAACAAAGCTAAGCTTG AACACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTA GGCTGTAGGTCAAGTTTATACATCTTAATTATGGTGGAAT TCCTATGTAGAGTCTAAAAAGCCAGGTACTTGGTGCTACA GTCAGTCTCCCTGCAGAGGGTTAAGGCGCAGACTACCTGC AGTGAGGAGGTACTGCTTGTAGCATATAGAGCCTCTCCCT AGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAACCTGAC CAATTTAAGCCATAAGATCTGGTCAAAGGGATACCCTTCC CACTAAGGACTTGGTTTCTCAGGAAATTATATGTACAGTG CTTGCTGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAA AACCCCTTCTCTGCCCACCTTAACAGACCTCTAGGGTTCT TAACCCAGCAATCAAGTTTGCCTATCCTAGAGGTGGCGGA TTTGATCATTTGGTGTGTTGGGCAATTTTTGTTTTACTGT CTGGTTCCTTCTGCGTGAATTACCACCACCACCACTTGTG CATCTCAGTCTTGTGTGTTGTCTGGTTACGTATTCCCTGG GTGATACCATTCAATGTCTTAATGTACTTGTGGCTCAGAC CTGAGTGCAAGGTGGAAATAAACATCAAACATCTTTTCAT TATCCCTA PGK1 NM_000291.3 GAGAGCAGCGGCCGGGAAGGGGCGGTGCGGGAGGCGGGGT 48 GTGGGGCGGTAGTGTGGGCCCTGTTCCTGCCCGCGCGGTG TTCCGCATTCTGCAAGCCTCCGGAGCGCACGTCGGCAGTC GGCTCCCTCGTTGACCGAATCACCGACCTCTCTCCCCAGC TGTATTTCCAAAATGTCGCTTTCTAACAAGCTGACGCTGG ACAAGCTGGACGTTAAAGGGAAGCGGGTCGTTATGAGAGT CGACTTCAATGTTCCTATGAAGAACAACCAGATAACAAAC AACCAGAGGATTAAGGCTGCTGTCCCAAGCATCAAATTCT GCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGAGCCA CCTAGGCCGGCCTGATGGTGTGCCCATGCCTGACAAGTAC TCCTTAGAGCCAGTTGCTGTAGAACTCAAATCTCTGCTGG GCAAGGATGTTCTGTTCTTGAAGGACTGTGTAGGCCCAGA AGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTC ATCCTGCTGGAGAACCTCCGCTTTCATGTGGAGGAAGAAG GGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGA GCCAGCCAAAATAGAAGCTTTCCGAGCTTCACTTTCCAAG CTAGGGGATGTCTATGTCAATGATGCTTTTGGCACTGCTC ACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCACA GAAGGCTGGTGGGTTTTTGATGAAGAAGGAGCTGAACTAC TTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGG CCATCCTGGGCGGAGCTAAAGTTGCAGACAAGATCCAGCT CATCAATAATATGCTGGACAAAGTCAATGAGATGATTATT GGTGGTGGAATGGCTTTTACCTTCCTTAAGGTGCTCAACA ACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGC CAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGAAGAAT GGTGTGAAGATTACCTTGCCTGTTGACTTTGTCACTGCTG ACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGT GGCTTCTGGCATACCTGCTGGCTGGATGGGCTTGGACTGT GGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTC GGGCTAAGCAGATTGTGTGGAATGGTCCTGTGGGGGTATT TGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATG GATGAGGTGGTGAAAGCCACTTCTAGGGGCTGCATCACCA TCATAGGTGGTGGAGACACTGCCACTTGCTGTGCCAAATG GAACACGGAGGATAAAGTCAGCCATGTGAGCACTGGGGGT GGTGCCAGTTTGGAGCTCCTGGAAGGTAAAGTCCTTCCTG GGGTGGATGCTCTCAGCAATATTTAGTACTTTCCTGCCTT TTAGTTCCTGTGCACAGCCCCTAAGTCAACTTAGCATTTT CTGCATCTCCACTTGGCATTAGCTAAAACCTTCCATGTCA AGATTCAGCTAGTGGCCAAGAGATGCAGTGCCAGGAACCC TTAAACAGTTGCACAGCATCTCAGCTCATCTTCACTGCAC CCTGGATTTGCATACATTCTTCAAGATCCCATTTGAATTT TTTAGTGACTAAACCATTGTGCATTCTAGAGTGCATATAT TTATATTTTGCCTGTTAAAAAGAAAGTGAGCAGTGTTAGC TTAGTTCTCTTTTGATGTAGGTTATTATGATTAGCTTTGT CACTGTTTCACTACTCAGCATGGAAACAAGATGAAATTCC ATTTGTAGGTAGTGAGACAAAATTGATGATCCATTAAGTA AACAATAAAAGTGTCCATTGAAACCGTGATTTTTTTTTTT TTCCTGTCATACTTTGTTAGGAAGGGTGAGAATAGAATCT TGAGGAACGGATCAGATGTCTATATTGCTGAATGCAAGAA GTGGGGCAGCAGCAGTGGAGAGATGGGACAATTAGATAAA TGTCCATTCTTTATCAAGGGCCTACTTTATGGCAGACATT GTGCTAGTGCTTTTATTCTAACTTTTATTTTTATCAGTTA CACATGATCATAATTTAAAAAGTCAAGGCTTATAACAAAA AAGCCCCAGCCCATTCCTCCCATTCAAGATTCCCACTCCC CAGAGGTGACCACTTTCAACTCTTGAGTTTTTCAGGTATA TACCTCCATGTTTCTAAGTAATATGCTTATATTGTTCACT TCTTTTTTTTTTATTTTTTAAAGAAATCTATTTCATACCA TGGAGGAAGGCTCTGTTCCACATATATTTCCACTTCTTCA TTCTCTCGGTATAGTTTTGTCACAATTATAGATTAGATCA AAAGTCTACATAACTAATACAGCTGAGCTATGTAGTATGC TATGATTAAATTTACTTATGTAAAAAAAAAAAAAAAAAA RPL13A NM_012423.3 CACTTCTGCCGCCCCTGTTTCAAGGGATAAGAAACCCTGC 49 GACAAAACCTCCTCCTTTTCCAAGCGGCTGCCGAAGATGG CGGAGGTGCAGGTCCTGGTGCTTGATGGTCGAGGCCATCT CCTGGGCCGCCTGGCGGCCATCGTGGCTAAACAGGTACTG CTGGGCCGGAAGGTGGTGGTCGTACGCTGTGAAGGCATCA ACATTTCTGGCAATTTCTACAGAAACAAGTTGAAGTACCT GGCTTTCCTCCGCAAGCGGATGAACACCAACCCTTCCCGA GGCCCCTACCACTTCCGGGCCCCCAGCCGCATCTTCTGGC GGACCGTGCGAGGTATGCTGCCCCACAAAACCAAGCGAGG CCAGGCCGCTCTGGACCGTCTCAAGGTGTTTGACGGCATC CCACCGCCCTACGACAAGAAAAAGCGGATGGTGGTTCCTG CTGCCCTCAAGGTCGTGCGTCTGAAGCCTACAAGAAAGTT TGCCTATCTGGGGCGCCTGGCTCACGAGGTTGGCTGGAAG TACCAGGCAGTGACAGCCACCCTGGAGGAGAAGAGGAAAG AGAAAGCCAAGATCCACTACCGGAAGAAGAAACAGCTCAT GAGGCTACGGAAACAGGCCGAGAAGAACGTGGAGAAGAAA ATTGACAAATACACAGAGGTCCTCAAGACCCACGGACTCC TGGTCTGAGCCCAATAAAGACTGTTAATTCCTCATGCGTT GCCTGCCCTTCCTCCATTGTTGCCCTGGAATGTACGGGAC CCAGGGGCAGCAGCAGTCCAGGTGCCACAGGCAGCCCTGG GACATAGGAAGCTGGGAGCAAGGAAAGGGTCTTAGTCACT GCCTCCCGAAGTTGCTTGAAAGCACTCGGAGAATTGTGCA GGTGTCATTTATCTATGACCAATAGGAAGAGCAACCAGTT ACTATGAGTGAAAGGGAGCCAGAAGACTGATTGGAGGGCC CTATCTTGTGAGTGGGGCATCTGTTGGACTTTCCACCTGG TCATATACTCTGCAGCTGTTAGAATGTGCAAGCACTTGGG GACAGCATGAGCTTGCTGTTGTACACAGGGTATTTCTAGA AGCAGAAATAGACTGGGAAGATGCACAACCAAGGGGTTAC AGGCATCGCCCATGCTCCTCACCTGTATTTTGTAATCAGA AATAAATTGCTTTTAAAGAAAAAAAAAAAAAAAAAA B2M NM_004048.2 AATATAAGTGGAGGCGTCGCGCTGGCGGGCATTCCTGAAG 50 CTGACAGCATTCGGGCCGAGATGTCTCGCTCCGTGGCCTT AGCTGTGCTCGCGCTACTCTCTCTTTCTGGCCTGGAGGCT ATCCAGCGTACTCCAAAGATTCAGGTTTACTCACGTCATC CAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGT GTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTG AAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACT TGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTA CACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGC CGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTA AGTGGGATCGAGACATGTAAGCAGCATCATGGAGGTTTGA AGATGCCGCATTTGGATTGGATGAATTCCAAATTCTGCTT GCTTGCTTTTTAATATTGATATGCTTATACACTTACACTT TATGCACAAAATGTAGGGTTATAATAATGTTAACATGGAC ATGATCTTCTTTATAATTCTACTTTGAGTGCTGTCTCCAT GTTTGATGTATCTGAGCAGGTTGCTCCACAGGTAGCTCTA GGAGGGCTGGCAACTTAGAGGTGGGGAGCAGAGAATTCTC TTATCCAACATCAACATCTTGGTCAGATTTGAACTCTTCA ATCTCTTGCACTCAAAGCTTGTTAAGATAGTTAAGCGTGC ATAAGTTAACTTCCAATTTACATACTCTGCTTAGAATTTG GGGGAAAATTTAGAAATATAATTGACAGGATTATTGGAAA TTTGTTATAATGAATGAAACATTTTGTCATATAAGATTCA TATTTACTTCTTATACATTTGATAAAGTAAGGCATGGTTG TGGTTAATCTGGTTTATTTTTGTTCCACAAGTTAAATAAA TCATAAAACTTGATGTGTTATCTCTTA YWHAZ NM_003406.3 CTTTCTCCTTCCCCTTCTTCCGGGCTCCCGTCCCGGCTCA 51 TCACCCGGCCTGTGGCCCACTCCCACCGCCAGCTGGAACC CTGGGGACTACGACGTCCCTCAAACCTTGCTTCTAGGAGA TAAAAAGAACATCCAGTCATGGATAAAAATGAGCTGGTTC AGAAGGCCAAACTGGCCGAGCAGGCTGAGCGATATGATGA CATGGCAGCCTGCATGAAGTCTGTAACTGAGCAAGGAGCT GAATTATCCAATGAGGAGAGGAATCTTCTCTCAGTTGCTT ATAAAAATGTTGTAGGAGCCCGTAGGTCATCTTGGAGGGT CGTCTCAAGTATTGAACAAAAGACGGAAGGTGCTGAGAAA AAACAGCAGATGGCTCGAGAATACAGAGAGAAAATTGAGA CGGAGCTAAGAGATATCTGCAATGATGTACTGTCTCTTTT GGAAAAGTTCTTGATCCCCAATGCTTCACAAGCAGAGAGC AAAGTCTTCTATTTGAAAATGAAAGGAGATTACTACCGTT ACTTGGCTGAGGTTGCCGCTGGTGATGACAAGAAAGGGAT TGTCGATCAGTCACAACAAGCATACCAAGAAGCTTTTGAA ATCAGCAAAAAGGAAATGCAACCAACACATCCTATCAGAC TGGGTCTGGCCCTTAACTTCTCTGTGTTCTATTATGAGAT TCTGAACTCCCCAGAGAAAGCCTGCTCTCTTGCAAAGACA GCTTTTGATGAAGCCATTGCTGAACTTGATACATTAAGTG AAGAGTCATACAAAGACAGCACGCTAATAATGCAATTACT GAGAGACAACTTGACATTGTGGACATCGGATACCCAAGGA GACGAAGCTGAAGCAGGAGAAGGAGGGGAAAATTAACCGG CCTTCCAACTTTTGTCTGCCTCATTCTAAAATTTACACAG TAGACCATTTGTCATCCATGCTGTCCCACAAATAGTTTTT TGTTTACGATTTATGACAGGTTTATGTTACTTCTATTTGA ATTTCTATATTTCCCATGTGGTTTTTATGTTTAATATTAG GGGAGTAGAGCCAGTTAACATTTAGGGAGTTATCTGTTTT CATCTTGAGGTGGCCAATATGGGGATGTGGAATTTTTATA CAAGTTATAAGTGTTTGGCATAGTACTTTTGGTACATTGT GGCTTCAAAAGGGCCAGTGTAAAACTGCTTCCATGTCTAA GCAAAGAAAACTGCCTACATACTGGTTTGTCCTGGCGGGG AATAAAAGGGATCATTGGTTCCAGTCACAGGTGTAGTAAT TGTGGGTACTTTAAGGTTTGGAGCACTTACAAGGCTGTGG TAGAATCATACCCCATGGATACCACATATTAAACCATGTA TATCTGTGGAATACTCAATGTGTACACCTTTGACTACAGC TGCAGAAGTGTTCCTTTAGACAAAGTTGTGACCCATTTTA CTCTGGATAAGGGCAGAAACGGTTCACATTCCATTATTTG TAAAGTTACCTGCTGTTAGCTTTCATTATTTTTGCTACAC TCATTTTATTTGTATTTAAATGTTTTAGGCAACCTAAGAA CAAATGTAAAAGTAAAGATGCAGGAAAAATGAATTGCTTG GTATTCATTACTTCATGTATATCAAGCACAGCAGTAAAAC AAAAACCCATGTATTTAACTTTTTTTTAGGATTTTTGCTT TTGTGATTTTTTTTTTTTTGATACTTGCCTAACATGCATG TGCTGTAAAAATAGTTAACAGGGAAATAACTTGAGATGAT GGCTAGCTTTGTTTAATGTCTTATGAAATTTTCATGAACA ATCCAAGCATAATTGTTAAGAACACGTGTATTAAATTCAT GTAAGTGGAATAAAAGTTTTATGAATGGACTTTTCAACTA CTTTCTCTACAGCTTTTCATGTAAATTAGTCTTGGTTCTG AAACTTCTCTAAAGGAAATTGTACATTTTTTGAAATTTAT TCCTTATTCCCTCTTGGCAGCTAATGGGCTCTTACCAAGT TTAAACACAAAATTTATCATAACAAAAATACTACTAATAT AACTACTGTTTCCATGTCCCATGATCCCCTCTCTTCCTCC CCACCCTGAAAAAAATGAGTTCCTATTTTTTCTGGGAGAG GGGGGGATTGATTAGAAAAAAATGTAGTGTGTTCCATTTA AAATTTTGGCATATGGCATTTTCTAACTTAGGAAGCCACA ATGTTCTTGGCCCATCATGACATTGGGTAGCATTAACTGT AAGTTTTGTGCTTCCAAATCACTTTTTGGTTTTTAAGAAT TTCTTGATACTCTTATAGCCTGCCTTCAATTTTGATCCTT TATTCTTTCTATTTGTCAGGTGCACAAGATTACCTTCCTG TTTTAGCCTTCTGTCTTGTCACCAACCATTCTTACTTGGT GGCCATGTACTTGGAAAAAGGCCGCATGATCTTTCTGGCT CCACTCAGTGTCTAAGGCACCCTGCTTCCTTTGCTTGCAT CCCACAGACTATTTCCCTCATCCTATTTACTGCAGCAAAT CTCTCCTTAGTTGATGAGACTGTGTTTATCTCCCTTTAAA ACCCTACCTATCCTGAATGGTCTGTCATTGTCTGCCTTTA AAATCCTTCCTCTTTCTTCCTCCTCTATTCTCTAAATAAT GATGGGGCTAAGTTATACCCAAAGCTCACTTTACAAAATA TTTCCTCAGTACTTTGCAGAAAACACCAAACAAAAATGCC ATTTTAAAAAAGGTGTATTTTTTCTTTTAGAATGTAAGCT CCTCAAGAGCAGGGACAATGTTTTCTGTATGTTCTATTGT GCCTAGTACACTGTAAATGCTCAATAAATATTGATGATGG GAGGCAGTGAGTCTTGATGATAAGGGTGAGAAACTGAAAT CCCAAACACTGTTTTGTTGCTTGTTTTATTATGACCTCAG ATTAAATTGGGAAATATTGGCCCTTTTGAATAATTGTCCC AAATATTACATTCAAATAAAAGTGCAATGGAGAAAAAAAA AAA SDHA NM_004168.3 ACTGCAGCCCCGCTCGACTCCGGCGTGGTGCGCAGGCGCG 52 GTATCCCCCCTCCCCCGCCAGCTCGACCCCGGTGTGGTGC GCAGGCGCAGTCTGCGCAGGGACTGGCGGGACTGCGCGGC GGCAACAGCAGACATGTCGGGGGTCCGGGGCCTGTCGCGG CTGCTGAGCGCTCGGCGCCTGGCGCTGGCCAAGGCGTGGC CAACAGTGTTGCAAACAGGAACCCGAGGTTTTCACTTCAC TGTTGATGGGAACAAGAGGGCATCTGCTAAAGTTTCAGAT TCCATTTCTGCTCAGTATCCAGTAGTGGATCATGAATTTG ATGCAGTGGTGGTAGGCGCTGGAGGGGCAGGCTTGCGAGC TGCATTTGGCCTTTCTGAGGCAGGGTTTAATACAGCATGT GTTACCAAGCTGTTTCCTACCAGGTCACACACTGTTGCAG CACAGGGAGGAATCAATGCTGCTCTGGGGAACATGGAGGA GGACAACTGGAGGTGGCATTTCTACGACACCGTGAAGGGC TCCGACTGGCTGGGGGACCAGGATGCCATCCACTACATGA CGGAGCAGGCCCCCGCCGCCGTGGTCGAGCTAGAAAATTA TGGCATGCCGTTTAGCAGAACTGAAGATGGGAAGATTTAT CAGCGTGCATTTGGTGGACAGAGCCTCAAGTTTGGAAAGG GCGGGCAGGCCCATCGGTGCTGCTGTGTGGCTGATCGGAC TGGCCACTCGCTATTGCACACCTTATATGGAAGGTCTCTG CGATATGATACCAGCTATTTTGTGGAGTATTTTGCCTTGG ATCTCCTGATGGAGAATGGGGAGTGCCGTGGTGTCATCGC ACTGTGCATAGAGGACGGGTCCATCCATCGCATAAGAGCA AAGAACACTGTTGTTGCCACAGGAGGCTACGGGCGCACCT ACTTCAGCTGCACGTCTGCCCACACCAGCACTGGCGACGG CACGGCCATGATCACCAGGGCAGGCCTTCCTTGCCAGGAC CTAGAGTTTGTTCAGTTCCACCCTACAGGCATATATGGTG CTGGTTGTCTCATTACGGAAGGATGTCGTGGAGAGGGAGG CATTCTCATTAACAGTCAAGGCGAAAGGTTTATGGAGCGA TACGCCCCTGTCGCGAAGGACCTGGCGTCTAGAGATGTGG TGTCTCGGTCCATGACTCTGGAGATCCGAGAAGGAAGAGG CTGTGGCCCTGAGAAAGATCACGTCTACCTGCAGCTGCAC CACCTACCTCCAGAGCAGCTGGCCACGCGCCTGCCTGGCA TTTCAGAGACAGCCATGATCTTCGCTGGCGTGGACGTCAC GAAGGAGCCGATCCCTGTCCTCCCCACCGTGCATTATAAC ATGGGCGGCATTCCCACCAACTACAAGGGGCAGGTCCTGA GGCACGTGAATGGCCAGGATCAGATTGTGCCCGGCCTGTA CGCCTGTGGGGAGGCCGCCTGTGCCTCGGTACATGGTGCC AACCGCCTCGGGGCAAACTCGCTCTTGGACCTGGTTGTCT TTGGTCGGGCATGTGCCCTGAGCATCGAAGAGTCATGCAG GCCTGGAGATAAAGTCCCTCCAATTAAACCAAACGCTGGG GAAGAATCTGTCATGAATCTTGACAAATTGAGATTTGCTG ATGGAAGCATAAGAACATCGGAACTGCGACTCAGCATGCA GAAGTCAATGCAAAATCATGCTGCCGTGTTCCGTGTGGGA AGCGTGTTGCAAGAAGGTTGTGGGAAAATCAGCAAGCTCT ATGGAGACCTAAAGCACCTGAAGACGTTCGACCGGGGAAT GGTCTGGAACACGGACCTGGTGGAGACCCTGGAGCTGCAG AACCTGATGCTGTGTGCGCTGCAGACCATCTACGGAGCAG AGGCACGGAAGGAGTCACGGGGCGCGCATGCCAGGGAAGA CTACAAGGTGCGGATTGATGAGTACGATTACTCCAAGCCC ATCCAGGGGCAACAGAAGAAGCCCTTTGAGGAGCACTGGA GGAAGCACACCCTGTCCTATGTGGACGTTGGCACTGGGAA GGTCACTCTGGAATATAGACCCGTGATCGACAAAACTTTG AACGAGGCTGACTGTGCCACCGTCCCGCCAGCCATTCGCT CCTACTGATGAGACAAGATGTGGTGATGACAGAATCAGCT TTTGTAATTATGTATAATAGCTCATGCATGTGTCCATGTC ATAACTGTCTTCATACGCTTCTGCACTCTGGGGAAGAAGG AGTACATTGAAGGGAGATTGGCACCTAGTGGCTGGGAGCT TGCCAGGAACCCAGTGGCCAGGGAGCGTGGCACTTACCTT TGTCCCTTGCTTCATTCTTGTGAGATGATAAAACTGGGCA CAGCTCTTAAATAAAATATAAATGAACAAACTTTCTTTTA TTTCCAAATCCATTTGAAATATTTTACTGTTGTGACTTTA GTCATATTTGTTGACCTAAAAATCAAATGTAATCTTTGTA TTGTGTTACATCAAAATCCAGATATTTTGTATAGTTTCTT TTTTCTTTTTCTTTTCTTTTTTTTTTTTGAGACAGGATCG GTGCAGTAGTACAATCACAGCTCACTGCAGCCTCAAACTC CTGGGCAGCTCAGGTGATCTTCCTGACTCAGCCTTCTGAG TAGTTGGGGCTACAGGTGTGCACCACCATGCCCAGCTCAT TTATTTTGTAATTGTAGGGACAGGGTCTCACTGTGTTGCC TAGGCTGGTCTCAAGTGATCCTCCCTCCTTGGCCTCCCAA GGTGCTGGAATTATAGGTGTGAACAAACCAAAAAAAAAAA AAA HPRT1 NM_000194.2 GGCGGGGCCTGCTTCTCCTCAGCTTCAGGCGGCTGCGACG 53 AGCCCTCAGGCGAACCTCTCGGCTTTCCCGCGCGGCGCCG CCTCTTGCTGCGCCTCCGCCTCCTCCTCTGCTCCGCCACC GGCTTCCTCCTCCTGAGCAGTCAGCCCGCGCGCCGGCCGG CTCCGTTATGGCGACCCGCAGCCCTGGCGTCGTGATTAGT GATGATGAACCAGGTTATGACCTTGATTTATTTTGCATAC CTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATTCC TCATGGACTAATTATGGACAGGACTGAACGTCTTGCTCGA GATGTGATGAAGGAGATGGGAGGCCATCACATTGTAGCCC TCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGACCT GCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGA TCCATTCCTATGACTGTAGATTTTATCAGACTGAAGAGCT ATTGTAATGACCAGTCAACAGGGGACATAAAAGTAATTGG TGGAGATGATCTCTCAACTTTAACTGGAAAGAATGTCTTG ATTGTGGAAGATATAATTGACACTGGCAAAACAATGCAGA CTTTGCTTTCCTTGGTCAGGCAGTATAATCCAAAGATGGT CAAGGTCGCAAGCTTGCTGGTGAAAAGGACCCCACGAAGT GTTGGATATAAGCCAGACTTTGTTGGATTTGAAATTCCAG ACAAGTTTGTTGTAGGATATGCCCTTGACTATAATGAATA CTTCAGGGATTTGAATCATGTTTGTGTCATTAGTGAAACT GGAAAAGCAAAATACAAAGCCTAAGATGAGAGTTCAAGTT GAGTTTGGAAACATCTGGAGTCCTATTGACATCGCCAGTA AAATTATCAATGTTCTAGTTCTGTGGCCATCTGCTTAGTA GAGCTTTTTGCATGTATCTTCTAAGAATTTTATCTGTTTT GTACTTTAGAAATGTCAGTTGCTGCATTCCTAAACTGTTT ATTTGCACTATGAGCCTATAGACTATCAGTTCCCTTTGGG CGGATTGTTGTTTAACTTGTAAATGAAAAAATTCTCTTAA ACCACAGCACTATTGAGTGAAACATTGAACTCATATCTGT AAGAAATAAAGAGAAGATATATTAGTTTTTTAATTGGTAT TTTAATTTTTATATATGCAGGAAAGAATAGAAGTGATTGA ATATTGTTAATTATACCACCGTGTGTTAGAAAAGTAAGAA GCAGTCAATTTTCACATCAAAGACAGCATCTAAGAAGTTT TGTTCTGTCCTGGAATTATTTTAGTAGTGTTTCAGTAATG TTGACTGTATTTTCCAACTTGTTCAAATTATTACCAGTGA ATCTTTGTCAGCAGTTCCCTTTTAAATGCAAATCAATAAA TTCCCAAAAATTTAAAAAAAAAAAAAAAAAAAAAA TOX4 NM_001303523.1 AGCAGAGAGAACACACGTCCTTGCGGAAGTGACGGCAGTT 54 CCGAGTCCAGTGGGGGCGGTGGGAGCGATGAGGGTCTGAG ACGGTGGGAGCGGTTGTGTGAAGATGGAGACATTCCATAC ACCAAGCTTGGGTGATGAGGAATTTGAAATCCCACCTATC TCCTTGGATTCTGATCCCTCATTGGCTGTCTCAGATGTGG TTGGCCACTTTGATGACCTGGCAGACCCTTCCTCTTCACA GGATGGCAGTTTTTCAGCCCAGTATGGGGTCCAGACATTG GACATGCCTGTGGGCATGACCCATGGCTTGATGGAGCAGG GCGGGGGGCTCCTGAGTGGGGGCTTGACCATGGACTTGGA CCACTCTATAGGAACTCAGTATAGTGCCAACCCACCTGTT ACAATTGATGTACCAATGACAGACATGACATCTGGCTTGA TGGGGCATAGCCAGTTGACCACCATTGATCAGTCAGAACT GAGTTCCCAGCTGGGTTTGAGCCTAGGGGGTGGCACCATC CTGCCACCTGCCCAGTCACCTGAAGATCGTCTTTCAACCA CCCCTTCACCTACTAGTTCACTTCACGAGGATGGTGTTGA GGATTTCCGGAGGCAACTTCCCAGCCAGAAGACAGTCGTG GTGGAAGCAGGGAAAAAGCAGAAGGCCCCAAAGAAGAGAA AAAAGAAAGATCCTAATGAACCTCAGAAACCAGTTTCAGC ATATGCTTTATTCTTTCGTGATACACAGGCTGCCATCAAG GGACAGAATCCTAATGCCACTTTTGGTGAGGTTTCAAAAA TTGTGGCCTCCATGTGGGATAGTCTTGGAGAGGAGCAAAA ACAGGTATATAAGAGGAAAACTGAGGCTGCCAAGAAAGAG TATCTGAAGGCACTGGCTGCTTACAAAGACAACCAGGAGT GTCAGGCCACTGTGGAAACAGTGGAATTGGATCCAGCACC ACCATCACAAACTCCTTCTCCACCTCCTATGGCTACTGTT GACCCAGCATCTCCAGCACCAGCTTCAATAGAGCCCCCTG CCCTGTCCCCATCCATTGTTGTTAACTCCACCCTTTCATC CTATGTGGCAAACCAGGCATCTTCTGGAGCTGGGGGTCAG CCCAATATCACCAAGTTGATTATTACCAAACAAATGTTGC CCTCTTCTATTACTATGTCTCAAGGAGGGATGGTTACTGT TATCCCAGCCACAGTGGTGACCTCCCGGGGGCTCCAACTA GGCCAAACCAGTACAGCTACTATCCAGCCCAGTCAACAAG CCCAGATTGTCACTCGGTCAGTGTTGCAGGCAGCAGCAGC TGCTGCTGCTGCTGCTTCTATGCAACTGCCTCCACCCCGA CTACAGCCCCCTCCATTACAACAGATGCCACAGCCCCCGA CTCAGCAGCAAGTTACCATTCTGCAGCAGCCTCCTCCACT CCAGGCCATGCAACAGCCTCCACCTCAGAAAGTTCGAATC AATTTACAGCAACAGCCTCCTCCTCTGCAGATCAAGAGTG TGCCTCTACCCACTTTGAAAATGCAGACTACCTTAGTCCC ACCAACTGTGGAAAGTAGTCCTGAGCGGCCTATGAACAAC AGCCCTGAGGCCCATACAGTGGAGGCACCTTCTCCTGAGA CTATCTGTGAGATGATCACAGATGTAGTTCCTGAGGTTGA GTCTCCTTCTCAGATGGATGTTGAATTGGTGAGTGGGTCT CCTGTGGCACTCTCACCCCAGCCTCGATGTGTGAGGTCTG GTTGTGAGAACCCTCCCATTGTGAGTAAGGACTGGGACAA TGAATACTGCAGCAATGAGTGTGTGGTGAAGCACTGCAGG GATGTATTCTTGGCCTGGGTAGCCTCTAGAAATTCAAACA CAGTGGTGTTTGTGAAATAGTCCTTCCTGTTCTCCAAGCC AGTGAAGAGTTATCTGCTGGGAAAGTGTCCAAGAGCCTGT TTTTGAAACACAAGCTGGGCTTCTGGTAGTGCCTCATCAC AACCCATGATGGCTGTTCATGTTTCACCCCTTTTCTTCCT TCAGCAGAGGCCAGGCTATGGAGCAGGGCCACTGAATTTG CTGTAATCTGGAGATGCTTTTTACTTTCAACCATAAGCGG TAATAGCAGAGGAAAGGGTGAAGGGAGTCTGGGCAAGCAA AGCATAGAGATGGTGGGGTGGTGGTGGGGTTGAAGAAACT TGTTGGTATAATTGTCATAGGACTTGCCTAAAATATTATT AAAATTACGGGAGTGTACTCAGCTTTGAGCCTAGGAGAAA ATGCCACTGTGTGCATCCATTTTAAAGGGTTCCCTCATAA AAAAATGTTATTCCCCATTATCACATCAGTACACTGCTTT GAAAACAAAACTTTTCAACATGGGCATACTGGGCTACATG GAAAATGACATCACCCAGGAGTGATTTCTCTTTATATATA TTATTTCTGCAGTTACCATCCTTATCTGAGTTATCACAGT TCATGAATCTAAGAGGCGGAACTCTACATCATTAGTAAGA GGTTCCACCAAAGTCTAAAGTTGTATTCACTTGTGTTTGA TGAACTATCTTTAAAAGACCATAGGTCTATCATTATTTCT TAGACATAATCTAAAGAAAAACAGACTAGAGAAGCCACCT GGTTGTAACAGAATAAGCAGAAGTTTACAGCATGATAGTC CAAGTGGTGATAACTTTAAATAAAACTCAAATTTTTACTG TTTGTAGACAGGAATGCTGTCCTAGAGAACCTCCTCCTCA ACCAGCTACGTACATAGTTTTATCCTATGCATTCCTGTTT TCTGTGTGTTTTTTGTTTTTTTTTTTTTTTTTTTTTTTTG AGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTG GTGCGACCTCAGCTCACTGAAACCTCTGCCTCCCGGGTTC AAGCGATTCTCCTGCATCAGCCTCCCGAGTAGCTAGGATT ACAGGCGCCCGCCACTACGCCCAGCTAATTTGTGGTATTT TTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTC TCGAACTCCTGACCTCATGATCCGCCCGCCTTGACCTCCC AAAGTGCTGGGATTACAGGCATGAGCCACCGCACCCAGCC TGCATTCCTGTTTTTTTAATGGTTTTGGAGGGTAGCAGTA GAGATGGGGTCTCACTATGTTGCCCAGTCTAGTCTTGAAC TCCTGGGCTACAGTTACCCTCCTACCTCGGCTTCCCAAAG TGCTCGGATTACAGGTGTGAGCCACTGTGCCTAGCCTATA ATGATCATTTTAATGTTTCCCATGCACTCATTTAGTTTGA ACCTTCACAGCAACCCAATGAGGTAATACTCCCATTTCAC ATATAATACTGAGAGATGAGTTGCACAAGATTATACACTG TTAAGTAGCAGAGCCAGAATGGACTTCAGAATCCCAACTA CAATACAAATGTTTATTTAAATAAAGAAGAAAGCTATTGT ACAAATATCACTCTTCAGGTTTAGCTTACAGAGCCATGGC TATGGATTCTTAGCTCTGTAAGGAAGTGCTTCTATAAATT CTTAGGTTTAGAGATGATACCATCTGGGTACCTTTGCTTG AACCGTGCAACCACATCTGGGTCTAGTAGGTGGATCCCAT CCAGTTGGTTTCCAAGGGTGATCCTGAAACAGTGTAAAAG GAGGGGCAAACCAGAAATCCTGGAATTAGAGGGTTTAATA TTGTTAAAAAATGCATACCAAATGAAGACTGCCTATCATC ATATCAAATATGCCAATTCTAAAAAGAGCTTAACATTAGA ATAGTATATGGTAGAATTACTAGTTCAGAATTGGCATAGA TTCTGGTGTTAAAATAGACTGGATCTGTATTATCTGAGGG TTAGTAACTAATGCTTAGCCAGGCCTGCTTCACAGAGTTG CTACCAGGGAGTATTCTTTGGATAAGCAAAATGCTAGCAG CATGTGTTTTAAGCTCTGTTAAGGGGTGAAAGATGTAATT ATTGACAGATTAAATAGATAACTTCGTAACCACCAGGGGG CAGATTCAATACATCACAGAATGGCTGAGGAAGATCCTTG GGTTGTGAAGAGAGTAGAAACCCTAGGGAGCAGTGCTTTT GGGTCCTAGAACCTGTTGAGTTTCTAATGAATATTTGTAG AATCTCATAAAACAGTTTAAATACAAGCTTAAGTGGCTTA TGAATCCTGTGAAGCTCATTTATGGACTAGTGTAAAACAA TGTGAAGCTCTACTAAGTTCTGTCCTTAATCATAAATAAT AGCCCCTTGAGGACTAGCCTGTTCTCTGGTCACCTTACCA GTTGGGTTGCACATTGTGTGGTCGTCCAAATAACTCAATC TTGCGAGTGCCAGGAGATAGTCTTTCAATCATGCCATAGA TTTCATCTGGTTTATGACTGGTGGAACGAACCTAGGAAAT AAAAACTAGCTGCTTTTTAAGTTACACAAGAAAAAA

Definitions

[0071] The articles a and an are used in this disclosure to refer to one or more than one (i.e., to at least one) of the grammatical object of the article. By way of example, an element means one element or more than one element.

[0072] The term and/or is used in this disclosure to mean either and or or unless indicated otherwise.

[0073] As used herein, the terms polynucleotide and nucleic acid molecule are used interchangeably to mean a polymeric form of nucleotides of at least 10 bases or base pairs in length, either ribonucleotides or deoxynucleotides or a modified form of either type of nucleotide, and is meant to include single and double stranded forms of DNA. As used herein, a nucleic acid molecule or nucleic acid sequence that serves as a probe in a microarray analysis preferably comprises a chain of nucleotides, more preferably DNA and/or RNA. In other embodiments, a nucleic acid molecule or nucleic acid sequence comprises other kinds of nucleic acid structures such as for instance a DNA/RNA helix, peptide nucleic acid (PNA), locked nucleic acid (LNA) and/or a ribozyme. Hence, as used herein the term nucleic acid molecule also encompasses a chain comprising non-natural nucleotides, modified nucleotides and/or non-nucleotide building blocks which exhibit the same function as natural nucleotides.

[0074] As used herein, the terms hybridize, hybridizing, hybridizes, and the like, used in the context of polynucleotides, are meant to refer to conventional hybridization conditions, such as hybridization in 50% formamide/6SSC/0.1% SDS/100 g/ml ssDNA, in which temperatures for hybridization are above 37 degrees centigrade and temperatures for washing in 0.1SSC/0.1% SDS are above 55 degrees C., and preferably to stringent hybridization conditions.

[0075] As used herein, the term normalization or normalizer refers to the expression of a differential value in terms of a standard value to adjust for effects which arise from technical variation due to sample handling, sample preparation, and measurement methods rather than biological variation of biomarker concentration in a sample. For example, when measuring the expression of a differentially expressed protein, the absolute value for the expression of the protein can be expressed in terms of an absolute value for the expression of a standard protein that is substantially constant in expression. In some embodiments, normalizing the expression level of a gene to the expression level of a housekeeping gene means dividing the expression level of the gene by the expression level of the housekeeping gene.

[0076] The terms diagnosis and diagnostics also encompass the terms prognosis and prognostics, respectively, as well as the applications of such procedures over two or more time points to monitor the diagnosis and/or prognosis over time, and statistical modeling based thereupon. Furthermore, the term diagnosis includes: a. prediction (determining if a patient will likely develop aggressive disease (hyperproliferative/invasive)), b. prognosis (predicting whether a patient will likely have a better or worse outcome at a pre-selected time in the future), c. therapy selection, d. therapeutic drug monitoring, and e. relapse monitoring.

[0077] The term providing as used herein with regard to a biological sample refers to directly or indirectly obtaining the biological sample from a subject. For example, providing may refer to the act of directly obtaining the biological sample from a subject (e.g., by a blood draw, tissue biopsy, lavage and the like). Likewise, providing may refer to the act of indirectly obtaining the biological sample. For example, providing may refer to the act of a laboratory receiving the sample from the party that directly obtained the sample, or to the act of obtaining the sample from an archive.

[0078] Accuracy refers to the degree of conformity of a measured or calculated quantity (a test reported value) to its actual (or true) value. Clinical accuracy relates to the proportion of true outcomes (true positives (TP) or true negatives (TN) versus misclassified outcomes (false positives (FP) or false negatives (FN)), and may be stated as a sensitivity, specificity, positive predictive values (PPV) or negative predictive values (NPV), or as a likelihood, odds ratio, among other measures.

[0079] The term biological sample as used herein refers to any sample of biological origin potentially containing one or more biomarkers. Examples of biological samples include tissue, organs, or bodily fluids such as whole blood, plasma, serum, tissue, lavage or any other specimen used for detection of disease.

[0080] The term subject as used herein refers to a mammal, preferably a human.

[0081] Treating or treatment as used herein with regard to a condition may refer to preventing the condition, slowing the onset or rate of development of the condition, reducing the risk of developing the condition, preventing or delaying the development of symptoms associated with the condition, reducing or ending symptoms associated with the condition, generating a complete or partial regression of the condition, or some combination thereof.

[0082] Biomarker levels may change due to treatment of the disease. The changes in biomarker levels may be measured by the present disclosure. Changes in biomarker levels may be used to monitor the progression of disease or therapy.

[0083] Altered, changed or significantly different refer to a detectable change or difference from a reasonably comparable state, profile, measurement, or the like. Such changes may be all or none. They may be incremental and need not be linear. They may be by orders of magnitude. A change may be an increase or decrease by 1%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 99%, 100%, or more, or any value in between 0% and 100%. Alternatively, the change may be 1-fold, 1.5-fold, 2-fold, 3-fold, 4-fold, 5-fold or more, or any values in between 1-fold and five-fold. The change may be statistically significant with a p value of 0.1, 0.05, 0.001, or 0.0001.

[0084] The term stable disease refers to a diagnosis for the presence of a plasma cell dyscrasia, however the myeloma has been treated and remains in a stable condition, i.e. one that that is not progressive, as determined by imaging data and/or best clinical judgment.

[0085] The term progressive disease refers to a diagnosis for the presence of a highly active state of a plasma cell dyscrasia, i.e. one has not been treated and is not stable or has been treated and has not responded to therapy, or has been treated and active disease remains, as determined by imaging data and/or best clinical judgment.

EXAMPLES

[0086] The disclosure is further illustrated by the following examples, which are not to be construed as limiting this disclosure in scope or spirit to the specific procedures herein described. It is to be understood that the examples are provided to illustrate certain embodiments and that no limitation to the scope of the disclosure is intended thereby. It is to be further understood that resort may be had to various other embodiments, modifications, and equivalents thereof which may suggest themselves to those skilled in the art without departing from the spirit of the present disclosure and/or scope of the appended claims.

Example 1. Derivation of a 32-Marker Gene Panel

[0087] Raw probe intensities (n=1,354,896 features) from n=15 peripheral blood mononuclear cell samples were used to identify genes that best discriminated between controls and multiple myeloma using the transcriptional profile of GSE7116. Following removal of outliers, a total of 31 target transcripts (26 genes, 5 splice variants) and one house-keeping gene was identified in an unbiased manner as potential markers of myeloma (Table 2; FIG. 1A and FIG. 1B). These genes were demonstrated to be expressed in multiple myeloma cell lines, IM-9 (normal diploid karyotype) and MMIR (dexamethasone-resistant), identifying they are produced by transformed B-lymphoblasts.

[0088] Then an artificial intelligence model of myeloma disease dynamics was built using normalized gene expression of these 31 markers (normalized to the housekeeping gene, TPT1) in whole blood from Controls (n=45), Responders/Stable (n=24: stable disease), and Newly Diagnosed/Relapsed (n=66: progressive disease) samples. The dataset was randomly split into training and testing partitions for model creation and validation respectively. Twelve algorithms were evaluated (XGB, RF, glmnet, cforest, CART, treebag, knn, nnet, SVM-radial, SVM-linear, NB and mlp) with accuracies ranging from 0.7-0.85). The top performing algorithm (XGB-gradient boosting) best predicted the training data. In the test set, XGB produced probability scores that predicted the sample. Each probability score reflects the certainty of an algorithm that an unknown sample belongs to either Stable Disease or Progressive class. For example, an unknown sample S1 can have the following probability vector [Control=0.2, Progressive=0.8]. This sample would be considered a myeloma sample that exhibited progressive disease, given a score of 0.8. If the sample came from a patient with MRD or who was under treatment, the score would identify either they are exhibiting progressive disease (will relapse) or are failing the therapy. MyelomX scores>0.2 are considered indicative the sample is from a myeloma patient.

TABLE-US-00002 TABLE 2 Multiple Myeloma Biomarker or Housekeeping Genes NCBI Chromosome UniGene Amplicon Exon Assay Symbol Name location ID RefSeq length Boundary Location ASXL1 additional sex combs like 1, Chr.20: Hs.374043 NM_001164603.1 95 1-2 484 transcriptional regulator 32358062-32439319 BHLHE40 Basic helix-loop-helix family, Chr.3: Hs.744856 NM_003670.2 66 4-5 683 member e40 4979412-4985181 BTG2 BTG anti-proliferation factor 2 Chr.1: Hs.519162 NM_006763.2 86 1-2 215 203305536-203309602 COPA coatomer protein complex, Chr.1: Hs.162121 NM_001098398.1 82 6-7 892 subunit alpha 160288587-160343564 FBXW7 F-box and WD repeat domain Chr.4: Hs.561245 NM_001013415.1 76 3-4 548 containing 7, E3 ubiquitin 152321258-152536095 protein ligase GNA13 Guanine nucleotide binding Chr.17: Hs.515018 NM_006572.5 70 1-2 496 protein (G protein), alpha 13 65009289-65056802 IL8 Interleukin 8 Chr.4: Hs.624 NM_000584.3 101 1-2 222 74606223-74609433 JMJD1C Jumonji domain containing 1C Chr.10: Hs.413416 NM_001282948.1 115 21-22 7309 63167221-63522075 LARS2 leucyl-tRNA synthetase 2, Chr.3: Hs.526975 NM_015340.3 83 2-3 164 mitochondrial 45388561-45548842 MALAT1 metastasis associated lung Chr.11: Hs.621695 NR_002819.2 117 1-1 4952 adenocarcinoma transcript 1 65497679-65504494 (non-protein coding) MBNL1 muscleblind-like splicing Chr.3: Hs.201858 NM_001314057.1 55 4-5 981 regulator 152243656-152465780 MCL1 myeloid cell leukemia sequence Chr.1: Hs.632486 NM_001197320.1 89 3-4 682 1 (BCL2-related) 150574551-150579738 NFKBIZ nuclear factor of kappa light Chr.3: Hs.319171 NM_001005474.2 62 and .sup.6-7 and 1322 and polypeptide gene enhancer in 101827990-101861025 86 12-13 2087 B-cells inhibitor, zeta NR4A1 nuclear receptor subfamily 4, Chr.12: Hs.524430 NM_001202233.1 79 and .sup.3-4 and 1107 and group A, member 1 52022832-52059507 87 7-8 1767 PDE4B phosphodiesterase 4B, Chr.1: Hs.198072 NM_001037339.2 72 8-9 1429 cAMP-specific 65792510-66374579 P1AS2 protein inhibitor of Chr:18: Hs.57769 NM_001324046.1 72 12-13 1716 activated STAT, 2 46803224-46920167 PRKAA1 protein kinase, AMP-activated, Chr.5: Hs.43322 NM_006251.5 93 and .sup.2-3 and 275 and alpha 1 catalytic subunit 40759379-40798195 75 5-6 606 SCYL2 SCY1-like 2 (S. cerevisiae) Chr.12: Hs.506481 NM_001317784.1 151 and .sup.2-3 and 463 and 100267137-100341724 67 8-9 1381 SMARCD2 SWI/SNF related, matrix Chr.17: Hs.250581 NM_001098426.1 63 4-5 885 associated, actin 63832081-63842991 dependent regulator of chromatin, subfamily d, member 2 SP1 Sp1 transcription factor Chr.12: Hs.620754 NM_001251825.1 62 and .sup.3-4 and 1631 and 53380195-53416446 72 5-6 2002 SRSF5 serine/arginine-rich splicing Chr.14: Hs.632326 NM_001039465.1 102 5-6 651 factor 5 69767087-69772005 TAGAP T-cell activation RhoGTPase Chr.6: Hs.529984 NM_001278733.1 99 3-4 552 activating protein 159034468-159045152 TANK TRAF family member-associated Chr.2: Hs.132257 NM_001199135.1 89 2-3 210 NFKB activator 161136955-161236176 TLE4 transducin-like enhancer of Chr.9: Hs.444213 NM_001282748.1 89 2-3 1162 split 4 (E(sp1) homolog, 79571773-79726882 Drosophila TPT1 tumor protein, translationally- Chr.13: Hs.374596 NM_001286272.1 131 3-3 377 (housekeeping controlled 1 45333471-45341284 gene) TSC22D3 TSC22 domain family, member 3 Chr.X: Hs.522074 NM_001015881.1 77 2-3 220 107713221-107777329 UBE2J1 Ubiquitin-conjugating Chr.6: Hs.163776 NM_016021.2 61 3-4 568 enzyme E2, J1 89326625-89352917

Example 2. Diagnosis: Identification of Samples as Myeloma

[0089] In the test set 1, the data for the utility of the test to differentiate patients with active myeloma disease (n=57) from controls (n=23) are included in Table 3. The receiver operator cuver analysis and metrics are included in FIG. 2B. The score exhibited an area under the curve (AUC) of 0.99. The metrics are: sensitivity>95%, specificity 100%, PPV 100%, NPV 88.5%. The overall accuracy is 96%. The tool can therefore differentiate between controls and aggressive and stable myeloma disease.

[0090] Specific evaluation of the MGUS identified significant differences between this plasma cell dyscrasia (n=18; MyelomX=399) and controls (n=155, 128, p<0.0001) (FIG. 3A). The AUC for differentiating MGUS from controls 0.97 (FIG. 3B).

[0091] Specific evaluation of the multiple myeloma sub-groups identified significant differences between newly diagnosed patients (n=53; MyelomX=7525), clinically stable disease (n=56, 3120, p<0.0001) and refractory disease (n=26, 9217) (FIG. 4A). The AUC for differentiating stable from refractory disease was 0.97 (FIG. 4B).

[0092] The test was evaluated in a second test set (test set 2) that included 155 healthy controls and 81 myeloma patients, the majority of whom exhibited stable disease including those with MRD. The mean MyelomX score in this myeloma group was 4714 versus 128 in the control group (FIG. 5A). The receiver operator cuver analysis demonstrated the score exhibited an area under the curve (AUC) of 0.97 (FIG. 5B) and the metrics were 89-99% (FIG. 5C).

TABLE-US-00003 TABLE 3 Confusion matrix showing classification accuracy of the XGB-algorithm that determines whether a sample is a myeloma or a control in blood samples Reference Predicted Myeloma Control Control 3 20 Myeloma 55 2 Sensitivity 96% Specificity 87% Positive Predictive 95% Value Negative Predictive 81% Value Accuracy 94%

Example 3. Identification of Minimal Residual Disease

[0093] Effective therapy (n=40), decreased the score from 5914 to 3512 which was associated with complete remissions (FIG. 6). Evaluation of the MRD group identified ten patients all with high scores (>40) who relapsed at an early time point (within one year). The MyelomX score can therefore biochemically define MRD and identify those who have progressive disease and will relapse at an early time-point.

Example 4. Differentiating Treatment Responders from Refractory Disease

[0094] In the therapy series (n=23), treatment with bortemozib (a proteasome inhibitor-PI) for 3 months significantly decreased the MyelomX scores from 649 to 2312 (p<0.0001) in treatment responders but was unchanged in those refractory to PI-treatment (609, p=NS) (FIG. 7). This indicates that the MyelomX score can be used to measure the efficacy of proteasome inhibitor therapy in myeloma, that a decrease in score correlates with response to therapeutic intervention and non-responders can accurately be identified.

Example 5. Use of MyelomX Score to Diagnose Myeloma, Demonstrate MRD and Define Therapy Response

[0095] A confusion matrix identifying the accuracy of the MyelomX score in both data sets is included in Table 4. As a diagnostic, the score is 97% accurate for identifying active disease. For determining MRD it is overall 75% accurate, but is 100% accurate for those who do not recur within one year. For treatment responders, the score is 87% accurate for identifying responders and 97% for those who are failing therapy or are refractory.

TABLE-US-00004 TABLE 4 Confusion matrix showing classification accuracy of the XGB-model algorithm and score cut-offs for defining the dynamic state of myeloma disease in blood samples Reference Control Intermediate MMx (MMx Score MMx Score Score Predicted 20) 21 to 39 40 Accuracy Control (n = 47) 45 2 0 96% Multiple myeloma 2 13 50 97% (No MRD) (n = 65) New Diagnosed 1 1 29 97% (n = 31) MRD (n = 24) 2 16 6 75% Treatment 26 8 5 87% Responder (n = 39) Refractory Disease 1 0 33 97% (n = 34)

[0096] We confirmed that myeloma was the source for the blood-based gene expression assay by evaluating expression in different myeloma cell lines and in FAC-sorted multiple myeloma tumors form patients.

[0097] All 32 genes were highly expressed in all 3 myeloma cell lines. Scores ranged from 869 (RPMI-8226) to 7610 (IM9) to 609 (MM-1R) (FIG. 8A).

[0098] Spike-in experiments using these 3 cell lines and normal whole blood demonstrated that gene expression scores were detected when as few as 1 cell was spiked into 1 ml of blood. One single myleoma cell was detectable. Scores ranged from 307 (RPMI-8226) to 417 (IM9) to 213 (MM-1R) (FIG. 8B). Scores were significantly elevated compared to control blood (no spike-in; p<0.0001).

[0099] We then evaluated gene expression in tumor tissue (FAC sorted CD138+ cells). All 32 genes (and variants) were highly expressed in myeloma and scores were consistent with values from whole blood samples (FIG. 9A). We also compared gene expression in tumor tissue and matched whole blood from the same patient. Gene expression was highly concordant (Pearson r: 0.87-0.95, median: 0.92) identifying gene expression in tumor tissue and blood was concordant (FIG. 9B).

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EQUIVALENTS

[0135] While the present invention has been described in conjunction with the specific embodiments set forth above, many alternatives, modifications and other variations thereof will be apparent to those of ordinary skill in the art. All such alternatives, modifications and variations are intended to fall within the spirit and scope of the present invention.