The present disclosure relates to a splitable introducer sheath assembly and the method of manufacturing the same. The splitable introducer sheath assembly includes a sheath tube, a hub portion, and at least two anchors. The sheath tube includes anchor tabs separately extending from the proximal sheath end. In one embodiment. The anchors secure the respective anchor tabs within the respective first and second hub halves. Alternatively, the hub halves may include a base having a first mating surface and a cap having a second mating surface; the anchor tabs extends within the corresponding one of the base with a proximal end of the anchor tab extending beyond the first mating surface; and the first mating surface of the cap is secured to the second mating surface of the base with the proximal end of the corresponding anchor tab secured therebetween.

A pharmaceutical product including a housing that defines a cavity, wherein the cavity stores a pharmaceutical material, and wherein the housing comprises a material configured to dissolve based on contact with a fluid, an ingestible device to encode information in a current signature, wherein the ingestible device is positioned within the housing, and a protective material that encompasses the ingestible device. The ingestible device may be attached to a flexible component, wherein the flexible component is configured to releasably secure the ingestible device within the housing.

An aperture plate is manufactured by plating metal around a mask of resist columns having a desired size, pitch, and profile, which yields a wafer about 60 μm thickness. This is approximately the full desired target aperture plate thickness. The plating is continued so that the metal overlies the top surfaces of the columns until the desired apertures are achieved. This needs only one masking/plating cycle to achieve the desired plate thickness. Also, the plate has passageways formed beneath the apertures, formed as an integral part of the method, by mask material removal. These are suitable for entrainment of aerosolized droplets exiting the apertures.

Intravascular blood pumps systems and methods of use. The blood pump system includes a catheter portion having a distal blood pump with one or more distal collapsible impellers. The system can include a clean purge fluid pathway to carry clean fluid distally to the blood pump and a purge fluid return pathway to carry return fluid proximally into an external motor and out a proximal end of the motor, and optionally to a waste reservoir.

A container having a barrier layer is provided. The container may be of thermoplastic and the barrier may inhibit materials from leaching from the thermoplastic material or from extraction of compounds from medicants by the thermoplastic. A process is also described that allows for molding thin barrier layers as container lines and for forming thermoplastic containers with barrier liners.

The present disclosure relates to a drug delivery device, having a longitudinal axis and comprising a plunger movable along the longitudinal axis and a guide curve adapted to engage at least one part of the plunger so as to guide the plunger when the plunger is being released to move along the longitudinal axis.

An all-in-one insulin pen includes a handheld housing that houses a glucose testing module, an insulin delivery module, a wireless communication module, and a microcontroller. The glucose testing module tests a one-time glucose concentration of a patient. The insulin delivery module automatically administers an insulin bolus to the patient based at least in part on the one-time glucose concentration.

A microneedle structure has one or more microneedles (104) projecting from the major surface (102) of a substrate (100). The microneedle has a penetrating tip (106) formed at an intersection between upright surfaces (108) and an inclined surface (110) corresponding to a (1 1 1) crystallographic plane. The microneedle has an expanding portion bounded by a continuation of the upright surfaces (108) and inclined surface (110), and a constant cross-section portion bounded by a continuation of the upright surfaces and a slicing plane (112) extending from an edge (114) of inclined surface (110) towards, and perpendicular to, major surface (102) of the substrate. A width W of inclined surface (110) increases monotonically from penetrating tip (106) to edge (114).

The present invention provides a connector for push-connecting a cartridge containing vaporizable material, such as a 510-cartridge, to a power-supplying device. The connector includes a housing containing electrical contacts, a cartridge-receiving end for receiving a conductive end of the cartridge, and a flexible, preferably silicone, ring connected to the cartridge receiving end of the housing for retaining the conductive end of the cartridge inserted therethrough against the electrical contacts. The ring is preferably part of a silicon boot that houses the housing.

The invention relates to the providing of hydrophobic and hydrophilic polymer-based hollow fiber membranes containing a water-insoluble antioxidant; in particular, the invention relates to the providing of hollow fiber membranes for the extracorporeal treatment of blood, wherein the hollow fiber membranes have improved biocompatibility relative to treatment blood, in particular improved complement activation and lower platelet loss vis-à-vis treatment blood. At the same time, the elution of hydrophilic polymers from the lumen of the hollow fiber membrane is reduced.