The present disclosure relates to compositions and therapeutic methods for activating an immune response in a patient in need thereof. In a preferred embodiment, the subject methods and compositions are able to antagonize the activity of VISTA, a naturally occurring “checkpoint” protein which contributes to immune tolerance, optionally in combination with an antagonist of a second checkpoint pathway such as PD-1. For example, such methods and compositions may be suitable for preventing and treating colon cancer or another cancer. An exemplary VISTA antagonist, specifically, an anti-VISTA antibody, is demonstrated herein to activate an immune response against cancer cells in vitro and in vivo, thereby conferring protective anti-tumor immunity which decreased tumor burden. Additionally, an additive benefit was observed when a VISTA antagonist was used in combination with a second checkpoint protein antagonist, specifically, an antibody against PD-1 ligand (PD-L1).

The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements Y, Q.sup.1, Q.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals. ##STR00001##

Prooxidative chain-transfer agents for use in the treatment of a malignant tumour disease, or infectious disease. The prooxidative chain-transfer agents are selected from lipophilic thiols, lipophilic trithiocarbonates, lipophilic, aromatic dithioesters, and lipophilic, aromatic thiols. The compounds amplify the prooxidative activity at the target site and are therefore highly efficient and specific for their targets.

The present invention relates to compounds of Formulae (I) and (II) as defined herein, and salts and solvates thereof. ##STR00001##
The present invention also relates to pharmaceutical compositions comprising compounds of Formulae (I) and (II), and to the use of compounds of Formulae (I) and (II) in the treatment or prevention of filarial worm infection, as well as other diseases or conditions in which filarial worm infection is implicated.

The present invention relates to compounds of formula I, ##STR00001##
wherein the variables are defined as given in the description and claims. The invention further relates to uses, processes and composition for compounds I.

An object of the present invention is to develop and provide a novel agricultural and horticultural insecticidal and acaricidal agent due to the emergence of resistant pests against existing drugs and the like in crop production in the fields of agriculture, horticulture and the like, where damages caused by pests and the like have been still serious.

The present invention provides a benzimidazole compound represented by the general formula (1)

##STR00001##

wherein R is an alkyl group or the like, Y.sup.1, Y.sup.2, Y.sup.3, and Y.sup.4 are a hydrogen atom or the like, Q is a 5-membered heterocyclic group optionally having a substituent such as a substituted imidazole bound at a nitrogen atom and a substituted pyrazole bound at a nitrogen atom, or a salt thereof, an agricultural and horticultural insecticidal and acaricidal agent having the compound or a salt thereof as an active ingredient, and a method for using the same.

Biocide and biopesticide compositions are provided. The compositions include mixtures of essential oils and carriers, the combined effect of which provides repelling and/or killing effects against arthropod pests and internal parasites. Methods of controlling and treating for arthropod pests and internal parasites using the disclosed compositions are also provided.

Methods for treating eye diseases associated with inflammation and/or vascular proliferation in subjects are disclosed. The methods include administering therapeutically effective amounts of a tranilast compound, in particular (E)-2-[[3-(3-Methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or (E)-2-[[3,4-Bis(difluoromethoxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or pharmaceutically acceptable salts or solvates thereof.

The present invention relates to a combination of a flexible container of the type with a brush and a tube enclosing a homogeneous suspension composed of an aqueous phase and of an oily phase which has at least one active principle, characterized in that the container has an applicator consisting of friction members suitable for applying said suspension at the outlet of an orifice onto a zone of the body of a subject to be treated, said suspension having a suitable viscosity allowing it to be distributed homogeneously via said members of said applicator.

This invention relates to compositions for combating ectoparasites and endoparasites in animals, comprising eprinomectin and praziquantel in combination with a pharmaceutically acceptable carrier, and optionally an antioxidant. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.