A pre-loaded container and a method of manufacturing a preloaded vial is provided wherein one or more active agents is lyophilized within the vial cap and the vial cap is then sealed onto a vial retaining a suitable diluent to form the pre-loaded vial. Lyophilizing the one or more active agents within the vial cap ensures that the one or more active agents are retained in sterile conditions, that the lyophilized one or more active agents and the diluent may be stored efficiently, and that the one or more active agents may be solubilized in a sterile and efficient manner.

A method for producing prick test single use sterile vials for use in a prick test is provided. The method comprises providing at least one allergen source including therewithin allergen extract, providing a plurality of single dose vials, connecting a tube to the at least one allergen source, connecting a metering device to the tube, drawing by the tube an amount of the allergen extract from one of the at least one allergen source, receiving the amount of allergen extract at the metering device, and dispensing by the metering device a volume of allergen extract into one of the plurality of single dose vials.

A method for the filling of containers with autologous fresh blood components, comprising the following phases of: a) providing an equipment (1) defining a transit channel (3) having at least a first gap (3a) associated with an empty syringe (4) or the like, at least a second gap (3b) associated with a bag (5) or the like containing an autologous fresh blood component and at least a third gap (3c) connected to a plurality of containers (6) to be filled; b) insulating the second gap (3b) from the third gap (3c) and placing in communication the first gap (3a) with the third gap (3c); c) suctioning the air contained in the containers (6) to be filled by means of said syringe (4) so as to define a vacuum inside them; d) insulating the first gap (3a) from the third gap (3c) and placing in communication the latter with the second gap (3b), the containers suctioning the contents of the bag (5) due to the effect of the vacuum defined inside them.

A pharmaceutical product includes a delivery syringe comprising a plastic receptacle and an oxygen-tight envelope which envelopes the delivery syringe in an oxygen-tight manner, wherein the plastic receptacle is filled with an oxygen-sensitive active pharmaceutical ingredient fluid and an inner surface of the plastic receptacle is siliconized at least in sections.

A method is described for shaping the bottom of hot-filled containers, in which the bottoms of the containers are forced inwardly from a state bulged outwardly, in particular as they cool down. Complex mechanisms for forcing the bottom inwardly are dispensable for the reason that the bottoms are forced inwardly by at least one fluid jet and/or fluid pressure wave. In addition, shaping the bottom can advantageously be carried out in a production region immediately downstream of a closer.

A method is described for shaping the bottom of hot-filled containers, in which the bottoms of the containers are forced inwardly from a state bulged outwardly, in particular as they cool down. Complex mechanisms for forcing the bottom inwardly are dispensable for the reason that the bottoms are forced inwardly by at least one fluid jet and/or fluid pressure wave. In addition, shaping the bottom can advantageously be carried out in a production region immediately downstream of a closer.

The invention relates to a tubular bag machine and to a method for operating a tubular bag machine (01) for the continuous production of tubular bags (20), which are filled with a mixture of liquid and solid filling components (29, 30). A formatting device (18), by means of which the bag shape of the tubular bag (20) open at the top seal is formatted, is disposed below the wiper device (16), the formatting device (18) comprising at least two formatting elements (19), which are contacted on the outer side of the film tube (34) and are displaced between an open position and a formatting position. The horizontal distance between the formatting elements (19) is larger in the open position than in the formatting position. The formatting elements (19) are moved to the open position before and/or while filling the tubular bag (20) with filling material (29, 30). The formatting elements (19) are moved to the formatting position while and/or after filling the tubular bag (20) with filling material (29, 30) and before producing the top seam to remove air from the air bubble (32) in the top area of the tubular bag (20) via filling material components (29, 30).

Various aspects of the subject disclosure relate to a compounder system having a cartridge that includes fluid pathways controllable by valves of the cartridge. A pump component within the cartridge is actuable to move fluid through the controllable fluid pathways. The cartridge includes a backpack for management of tubing to couple the cartridge to a receiving container. A disposable waste container is contained by the cartridge and the backpack. A syringe holder is provided for use of a syringe as a receiving container to receive a compounded medication.

A package that is configured to store and dispense fluids. The package includes a container and a dosing dispenser for closing an opening to the container. The dosing dispenser includes a body portion having a syringe receiver that is configured to receive a syringe to remove fluid from the container.

Embodiments herein describe tools, instruments and methods for aseptic loading, dispensing and/or delivering cells into an implantable device and aseptically and selectively sealing a device inside a sterile package as well as and storing and preparing for shipment the cell-filled device.