Disclosed herein are novel procedures, systems and excipient solutions for in situ provision of a contrast media at a user defined concentrations. An automated procedure according to embodiments of the current invention provides increased user safety, flexibility and user friendliness.

Disclosed herein are novel procedures, systems and excipient solutions for in situ provision of a contrast media at a user defined concentrations. An automated procedure according to embodiments of the current invention provides increased user safety, flexibility and user friendliness.

The present invention relates to a magazine having a plurality of solution bags for dialysis received therein, wherein the plurality of solution bags are identical; wherein the plurality of solution bags are fixed in a stationary manner in an identical orientation at different, but identically designed holding positions of the magazine; and wherein the holding positions are configured such that the solution bags can be removed from the magazine. The invention furthermore relates to a method of filling the solution bags.

A blister assembly comprises at least one collapsible blister adapted, as it is collapsed, to eject a liquid contained therein. The blister assembly comprises a first layer (130) having at least one blister chamber (150) and a second layer (131) sealed to the first layer at least around a periphery of the at least one blister chamber such that a liquid is contained between the first layer and the second layer. The seal between the first and second layers comprises a first planar portion having a first peel strength and a second planar portion having a second peel strength, wherein the first peel strength is greater than the second peel strength, such that when pressure is applied to the blister, the second portion of the seal breaks to release the liquid contained within the chamber into the liquid inlet. The blister assembly further comprises at least one discontinuity (142) formed in the first and second layers in the region of the first portion of the seal, such that a shear force is required to delaminate the first and second layers in that region.

An implantable and/or injectable device made of biodegradable material which comprises two hollow volumes where said device comprises a cylinder, which comprises a top portion and a bottom portion, where the top end and bottom end of said cylinder are open and via said openings on said top and bottom ends a first hollow volume and a second hollow volume are respectively accessed, where said first hollow volume and second hollow volume are separated from each other by a partition and are characterized in that the side wall of said first hollow volume has a thickness which is smaller than the thickness of the side wall of said second hollow volume. A method for manufacturing, filling with at least one active agent and closing said device and the use of the said device filled with at least one active agent for the treatment and/or the prevention of pathologies which require repeated and programmed administration over time.

Systems and methods permit gloveless filling containers with a product. A filling arm is disposed within the chamber. An optical sensor is configured to locate and target openings of the containers within the chamber. Locations of the openings are used to guide the filling arm to fill the containers with a product.

The system of the invention involves a gloveless aseptic processing system. The automated system is for filling nested pharmaceutical containers with a pharmaceutical fluid substance. A closed sterilizable gloveless isolator chamber is capable of maintaining an aseptic condition, having a sterilization system. The container filling system has a dispensing head for filling the containers, and a container closing system disposed within the gloveless isolator chamber with rams for pushing closures into openings of the nested containers. The container manipulation mechanism is disposed within the gloveless isolator chamber and is capable of positioning the nested pharmaceutical containers within the gloveless isolator chamber including operably disposing the nested pharmaceutical containers with the container filling system and the container closing system. Container tubs sealed by removable covers and contain a container nest bearing a plurality of pre-sterilized pharmaceutical containers.

The disclosure relates to processes for producing lightweight polyethylene terephthalate articles such as bottles that retain good batTier properties against the permeation of oxygen, carbon dioxide and/or water vapor. The use of relatively small amounts of polytrimethylene furandicm.Math.boxylate during the formation of the PET bottles can produce a bottle having the required barrier properties and result in the use of less material.

The present disclosure is directed to a vessel having a lumen defined at least in part by a wall, the wall having an interior surface facing the lumen, and the interior surface comprising a coating. The coating is configured to prevent the leaching of metal ions from the vessel wall into a fluid contained within the lumen and stored in contact with the coating. The vessels are used to store an aqueous drug product, typically an aqueous drug product containing an active agent and one or more excepients, such as a polysorbate stabilizer. The coated vessels are effective to reduce degradation of the active agent and/or one or more excipients, e.g. a polysorbate stabilizer.

An injector may include a container having a wall with an interior surface defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a sterile container needle that is in fluid communication with the container in a delivery state, but may or may not be in fluid communication with the container in a storage state. Further, the injector may include an actuator that is adapted to move the container needle from the storage state to the delivery state.