The present invention provides methods for disrupting biofilms and/or preventing the formation of biofilms along with medical items that contain a coating or covering made of compositions for achieving such disruption or prevention. In particular, the compositions of the present invention provide random-sequence peptide mixtures for use in disrupting bacterial biofilms; the random-sequence peptides having hydrophobic and/or cationic amino acids, wherein the ratio of the total hydrophobic and cationic amino acids in the mixture is predefined.

The present invention provides methods for disrupting biofilms and/or preventing the formation of biofilms along with medical items that contain a coating or covering made of compositions for achieving such disruption or prevention. In particular, the compositions of the present invention provide random-sequence peptide mixtures for use in disrupting bacterial biofilms; the random-sequence peptides having hydrophobic and/or cationic amino acids, wherein the ratio of the total hydrophobic and cationic amino acids in the mixture is predefined.

Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.

Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.

A device is for sterilization by electron beam irradiation of flexible bags, in particular flexible bags of the type that can contain solutions of human plasma proteins for therapeutic use. A sterilization method includes irradiating flexible bags by electron beam irradiation. An in-line method for filling flexible can use the sterilization device and method.

The invention proposes a treatment method for the sterilization by irradiation of containers made of thermoplastic material. The method comprises at least an initial step of modification of the pitch consisting in selectively varying the initial pitch between two consecutive containers to increase the irradiation time of each container. The method also comprises an irradiation step consisting in irradiating each container from the outside with an electron beam emitted by at least one emitter of a sterilization device.

A system for and method of shipping items is provided. The method includes adhering a package to an inner surface of a shipping case, thereby inhibiting movement of the package relative to the shipping case. The method includes wrapping one or more item with a sacrificial layer, such as shrink wrap, stretch wrap, paper, or the like, thereby creating a tight barrier of the package. The system includes one or more conveyor system and one or more adhesive applicator for automating the methods of the present invention. After adhesive is applied to at least one of a first surface of the package and the inner surface of the shipping case, the package is placed into the shipping case and the shipping case is moved to a closed configuration, thereby defining a void surrounding all but the first surface of the package.

A packaged article is composed of a bulk bag having a top end and a bottom end. Further included is a pallet having a first side and a second side. Also included are an outer bag having a first closed end and a first open end and a heatshrink bag having a second closed end and a second open end. The first closed end of the outer bag is between the bottom end of the bulk bag and the first side of the pallet. The first open end of the outer bag is gathered over the top end of the bulk bag to enclose the bulk bag within the outer bag. The second closed end of the heatshrink bag is proximate to the top end of the bulk bag and the second open end contacts the second side of the pallet.

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs).

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs).