Provided is a device for granulating, agglomerating, pelletising, drying and/or coating, the device including a swirl chamber, a distribution chamber, wherein the swirl chamber is separated from the distribution chamber by a base and wherein a powder to be granulated or a powder mixture to be granulated is presented in the swirl chamber, the device further including at least one agitator for thoroughly mixing the powder to be granulated or the powder mixture to be granulated and at least one addition device for a liquid, wherein the base is designed in several parts and at least one base part is horizontally and/or vertically displaceable, with the result that that the base becomes a distributor plate. Also provided is a method for granulating, agglomerating, pelletising, drying and/or coating using such a device and a base suitable for use as a distributor plate in a convective drying apparatus.

A modular system for producing dosage-form bulk material in the form of dosage-form base materials or dosage forms. The system includes at least one processing unit (2) which includes a plurality of process stations, at least one container for receiving dosage-form bulk material, and at least one handling system, the at least one handling system transferring the containers between process stations. Also described is a method for producing dosage-form bulk material.

A continuous granulation system for obtaining conditioned granules is disclosed. The system comprises a processor configured to produce a continuous flow of granules at an outlet of the processor. The system also comprises a collection chamber positioned downstream from the processor and configured to collect the granules from the outlet. Further, the system comprises an air displacement device coupled to the collection chamber and configured to create a unidirectional flow of air at the outlet in a direction of the granules exiting the processor and away from the outlet. The unidirectional flow of air conditions the granules obtained in the collection chamber. A continuous granulation method and a continuous granule collection system for obtaining the conditioned granules is also disclosed.

A tool for dry mixing and coating of powder mixtures comprising includes a fixing shaft and an approximately disc-shaped element fixed thereto and of a diameter d, having an upper surface, a lower surface and a peripheral surface connecting the upper and lower surfaces. The disc-shaped element has a plurality of grooves extending parallel to the shaft axis. Each groove has two groove walls extending from the peripheral surface to a groove bottom. A tooth is formed between two grooves. In order to provide a tool which is suitable for particularly low contamination dry mixing, dry dispersing and coating of powder mixtures, the disc-shaped element has a base portion and at least one wear element fixed to the base portion, wherein at least one portion of each groove wall, that adjoins the peripheral surface, is formed by the wear element.

A coating apparatus and a method are disclosed for coating tablets in a rotating drilled container at the outlet of which a rotating annular element operates that is coaxial with the container, in which in an initial transition phase the annular element rotates in a direction that is opposite the rotation direction of the container to retain the tablets inside the container, forming a bed of tablets until a desired level is reached, and in a stationary phase the annular element rotates in a direction that is the same as the rotation of the container to permit the exit of the tablets, until the quantity of tablets entering the container is the same that the quantity exiting.

Pitch granules including a core made up of a first composition including at least one pitch, the composition having a penetrability at 25° C. of 0 to 45 1/10 mm, a ring-and-ball softening temperature (TBA) of 55° C. to 175° C., understanding the penetrability as measured according to standard EN 1426 and the TBA as measured according to standard EN 1427, and a layer encapsulating at least one portion of the surface of the core, the layer being made up of a coating composition including at least one anti-caking agent.

Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to form a coacervate domain of the first component within each of the droplets to form the liquid coacervate particles. The self-assembled nano, meso, micro and macro liquid coacervate particles and related coated substrates can have utility in drug delivery, bioanalytical systems, controlled cell culture, tissue engineering, biomanufacturing and drug discovery.

Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to form a coacervate domain of the first component within each of the droplets to form the liquid coacervate particles. The self-assembled nano, meso, micro and macro liquid coacervate particles and related coated substrates can have utility in drug delivery, bioanalytical systems, controlled cell culture, tissue engineering, biomanufacturing and drug discovery.

Methods, systems, and apparatuses for coating a material by contacting the material with a coating material and a solvent are disclosed herein. The coated material can be obtained by evaporating the solvent: by heating the coated material directly or indirectly with electromagnetic radiation; by heating with heat generated from a heat source that heats an internal container for the material to be coated and/or coated material; and/or in an interior volume of a coating container having a side wall, by heating a portion of the side wall of the coating container and/or internal container with a heat source that is positioned outside of the interior volume of the coating container.

A granular coating conveyor system for coating granular particles carried in compartments along a tubular conveyor member. Coating fluid is fed over the granular particles through radial nozzles located inside a co-axial rotating blender with tubular member upstream discharge port and tubular member downstream return ingress port for the granular particles. The blender is a drum having a helicoidal spiral screw integrally mounted to an interior peripheral wall face of the drum and extending therealong radially outwardly of the tubular member mixing in the drum in tumbling fashion the granular particles with coating fluid and guiding same therealong, so as to dynamically form a kidney shape mass of granular particles.