Provided is process for the synthesis of at least one functionalized organic polysulfide.

The present invention generally relates to the field of biotechnology as it applies to the production of aryl sulfates using recombinant host cells. More particularly, the present invention pertains to recombinant host cells comprising (e.g., expressing) a polypeptide having aryl sulfotransferase activity, wherein said recombinant host cells have been modified to have an increased uptake of sulfate compared to identical host cells that does not carry said modification. Further provided are processes for the production of aryl sulfates, such as zosteric acid, employing such recombinant host cells.

The present invention generally relates to the field of biotechnology as it applies to the production of aryl sulfates using recombinant host cells. More particularly, the present invention pertains to recombinant host cells comprising (e.g., expressing) a polypeptide having aryl sulfotransferase activity, wherein said recombinant host cells have been modified to have an increased uptake of sulfate compared to identical host cells that does not carry said modification. Further provided are processes for the production of aryl sulfates, such as zosteric acid, employing such recombinant host cells.

The present application relates to the technical field of genetic engineering, and provides a monooxygenase mutant, a preparation method and application thereof. The monooxygenase mutant has any one of the amino acid sequences shown in (I) and (II): (I) an amino acid sequence having at least 80% identity with the amino acid sequence shown in SEQ ID NO. 1; and (II) an amino acid sequence obtained by modifying, substituting, deleting, or adding one or several amino acids to the amino acids at 23 to 508 positions of the amino acid sequence shown in SEQ ID NO. 1, the substituting referring to a substitution of 1 to 34 amino acids, wherein the mutant has the activity of monooxygenase.

The present invention relates to a selective process for preparing sulfones from sulfides by enzymatic catalysis, and to a composition comprising a symmetrical sulfide, an oxidoreductase enzyme catalyzing the oxidation of said symmetrical sulfide to symmetrical sulfone; optionally at least one cofactor C of said enzyme E; and an oxidant, which allows in particular the implementation of said process.

The present invention relates to a selective process for preparing sulfones from sulfides by enzymatic catalysis, and to a composition comprising a symmetrical sulfide, an oxidoreductase enzyme catalyzing the oxidation of said symmetrical sulfide to symmetrical sulfone; optionally at least one cofactor C of said enzyme E; and an oxidant, which allows in particular the implementation of said process.

Among other things, the present disclosure provides biosynthesis polypeptides, methods, and non-naturally occurring microbial organisms for preparing various compounds such as 1,5-pentanediol, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, and 2-keto carboxylic acids.

Among other things, the present disclosure provides biosynthesis polypeptides, methods, and non-naturally occurring microbial organisms for preparing various compounds such as 1,5-pentanediol, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, and 2-keto carboxylic acids.

A vapor viable formula for sanitizing the lungs in order to shield them from a digitally encoded pathogen. The digital code translates into 2 and 3 dimensional proteins capable of self-replicating in the host. Agent(s) can traverse the semipermeable membranes of the host cells in order to specifically target the translated proteins in a 2-dimensional state before they fold into a functional 3-dimensional molecule. The agent(s) must be able to disable the 3-dimensional functional analog state of a pathogen component. 2-Propene-1-sulfinothioic acid S-2-propenyl or an R group derivative thereof is formulated so that it can be put into vapor form and inhaled into the sinuses, throat, bronchi, or lungs with maximum surface bioavailability. Selenium or Selenocysteine exploits of the digital pathogen code are leveraged using vapor formulas. Vapor delivery allows maximum analog or digital exploitation of the pathogen.

A vapor viable formula for sanitizing the lungs in order to shield them from a digitally encoded pathogen. The digital code translates into 2 and 3 dimensional proteins capable of self-replicating in the host. Agent(s) can traverse the semipermeable membranes of the host cells in order to specifically target the translated proteins in a 2-dimensional state before they fold into a functional 3-dimensional molecule. The agent(s) must be able to disable the 3-dimensional functional analog state of a pathogen component. 2-Propene-1-sulfinothioic acid S-2-propenyl or an R group derivative thereof is formulated so that it can be put into vapor form and inhaled into the sinuses, throat, bronchi, or lungs with maximum surface bioavailability. Selenium or Selenocysteine exploits of the digital pathogen code are leveraged using vapor formulas. Vapor delivery allows maximum analog or digital exploitation of the pathogen.