The present disclosure relates to solid forms and salts, crystalline and otherwise, of (E)-2-[[3-(3-methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid and pharmaceutical compositions comprising same. The use of such solid forms, salts, and pharmaceutical compositions, for treating, preventing, or ameliorating diseases or conditions associated with fibrosis, inflammation and/or proliferation are disclosed.

The present disclosure relates to solid forms and salts, crystalline and otherwise, of (E)-2-[[3-(3-methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid and pharmaceutical compositions comprising same. The use of such solid forms, salts, and pharmaceutical compositions, for treating, preventing, or ameliorating diseases or conditions associated with fibrosis, inflammation and/or proliferation are disclosed.

The present disclosure relates to solid forms and salts, crystalline and otherwise, of (E)-2-[[3-(3-methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid and pharmaceutical compositions comprising same. The use of such solid forms, salts, and pharmaceutical compositions, for treating, preventing, or ameliorating diseases or conditions associated with fibrosis, inflammation and/or proliferation are disclosed.

The present disclosure relates to solid forms and salts, crystalline and otherwise, of (E)-2-[[3-(3-methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid and pharmaceutical compositions comprising same. The use of such solid forms, salts, and pharmaceutical compositions, for treating, preventing, or ameliorating diseases or conditions associated with fibrosis, inflammation and/or proliferation are disclosed.

Amine derivatives of benzoylbenzoic acid, benzoylbenzoic acid esters and salts were prepared, which are suitable as photo initiators for UV & LED curable compositions. The derivatives are compounds of Formula I, Ia, and II wherein R.sup.1, R.sup.1a, R.sup.2, R.sup.3, n and r are as defined herein. ##STR00001##

Amine derivatives of benzoylbenzoic acid, benzoylbenzoic acid esters and salts were prepared, which are suitable as photo initiators for UV & LED curable compositions. The derivatives are compounds of Formula I, Ia, and II wherein R.sup.1, R.sup.1a, R.sup.2, R.sup.3, n and r are as defined herein. ##STR00001##

The invention provides a process for the preparation of a compound of Formula 1,

##STR00001##

comprising coupling a carboxylic acid of Formula 2

##STR00002##

with an aniline of Formula 3

##STR00003##

in the presence of a coupling agent.

The invention provides a process for the preparation of a compound of Formula 1, ##STR00001##
comprising coupling a carboxylic acid of Formula 2 ##STR00002##
with an aniline of Formula 3 ##STR00003##
in the presence of a coupling agent.

The invention provides a process for the preparation of a compound of Formula 1, ##STR00001##
comprising coupling a carboxylic acid of Formula 2 ##STR00002##
with an aniline of Formula 3 ##STR00003##
in the presence of a coupling agent.

The invention provides a process for the preparation of a compound of Formula 1,

##STR00001##

comprising coupling a carboxylic acid of Formula 2

##STR00002##

with an aniline of Formula 3

##STR00003##

in the presence of a coupling agent.