Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

The present invention provides novel compounds having the general formula:

##STR00001## wherein A.sub.1 to A.sub.4, L.sub.1, L.sub.2, R.sup.1 and R.sup.2 are as described herein, compositions including the compounds and methods of using the compounds.

The present invention provides novel compounds having the general formula:

##STR00001## wherein A.sub.1 to A.sub.4, L.sub.1, L.sub.2, R.sup.1 and R.sup.2 are as described herein, compositions including the compounds and methods of using the compounds.

Described herein are compounds of Formula I and methods of using said compounds for treating, ameliorating, and/or preventing cancer. The compounds are cyanine dyes, and have increased effects in hypoglycemic environments.

##STR00001##

Described herein are compounds of Formula I and methods of using said compounds for treating, ameliorating, and/or preventing cancer. The compounds are cyanine dyes, and have increased effects in hypoglycemic environments.

##STR00001##

Provided are an organic electroluminescent material and device. The organic electroluminescent material is a novel compound containing a dehydrobenzooxazole, dehydrobenzothiazole, dehydrobenzoselenazole, dehydrobenzimidazole structure or a similar structure. These novel compounds have properties such as a deep LUMO, strong electron acceptability, a strong charge transfer ability and low volatility. Due to unique properties, these novel compounds have the prospect for wide applications in the field of organic semiconductors, especially the potential for use as p-type conductive doping materials, charge transporting layer materials, hole injection layer materials and electrode materials of the organic semiconductors.

Provided are an organic electroluminescent material and device. The organic electroluminescent material is a novel compound containing a dehydrobenzooxazole, dehydrobenzothiazole, dehydrobenzoselenazole, dehydrobenzimidazole structure or a similar structure. These novel compounds have properties such as a deep LUMO, strong electron acceptability, a strong charge transfer ability and low volatility. Due to unique properties, these novel compounds have the prospect for wide applications in the field of organic semiconductors, especially the potential for use as p-type conductive doping materials, charge transporting layer materials, hole injection layer materials and electrode materials of the organic semiconductors.

The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.

The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.