The invention relates to a novel substituted amino acids, agricultural compositions comprising the novel substituted amino acids, and their use for controlling undesired plant growth alone or in combination with crop protection agents such as pesticides or plant growth regulators.

Disclosed are compounds effective against tuberculosis based on substituted 1,2,4-oxadiazoles of general formula I, where Y═S or CH.sub.2 and R=phenyl- or phenyl-substituted in positions 2, 3, 4, and 5 by one or several electron-acceptor groups or electron-donor groups. These compounds can be produced by easy syntheses and are characterized by low toxicity and high efficacy against mycobacteria, including multiresistant strains thereof. Also disclosed are a pharmaceutical preparation containing substituted 1,2,4-oxadiazole of formula I as an active substance as well as the use of this substituted 1,2,4-oxadiazole as an antituberculosis drug.

Disclosed are compounds effective against tuberculosis based on substituted 1,2,4-oxadiazoles of general formula I, where Y═S or CH.sub.2 and R=phenyl- or phenyl-substituted in positions 2, 3, 4, and 5 by one or several electron-acceptor groups or electron-donor groups. These compounds can be produced by easy syntheses and are characterized by low toxicity and high efficacy against mycobacteria, including multiresistant strains thereof. Also disclosed are a pharmaceutical preparation containing substituted 1,2,4-oxadiazole of formula I as an active substance as well as the use of this substituted 1,2,4-oxadiazole as an antituberculosis drug.

Are disclosed oxadiazole derivatives, their use as medicaments and in particular for the treatment of diseases associated with the presence of a nonsense mutation in the gene or a premature stop codon in the mRNA, pharmaceutical formulation comprising said oxadiazole derivatives and prodrug or mixture thereof and the methods for the preparation of said Oxadiazole derivatives.

Are disclosed oxadiazole derivatives, their use as medicaments and in particular for the treatment of diseases associated with the presence of a nonsense mutation in the gene or a premature stop codon in the mRNA, pharmaceutical formulation comprising said oxadiazole derivatives and prodrug or mixture thereof and the methods for the preparation of said Oxadiazole derivatives.

Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with a mutation in a protein.

The present invention discloses a compound of formula (I),

##STR00001##

wherein, R.sup.1, L.sup.1, A, L.sup.2, W.sup.1, R.sup.2f, R.sup.3f, Q, and R.sup.10 are as defined in the detailed description. The present invention also relates to a process for preparing the compound of formula (I).

The present invention discloses a compound of formula (I),

##STR00001##

wherein, R.sup.1, L.sup.1, A, L.sup.2, W.sup.1, R.sup.2f, R.sup.3f, Q, and R.sup.10 are as defined in the detailed description. The present invention also relates to a process for preparing the compound of formula (I).

The present invention relates to the use of compounds of Formula (I) as herbicides, wherein Z, W, X.sup.1-X.sup.4, R.sub.1, F.sub.2, R.sub.3, R.sub.4, m and n are as defined herein. The invention further relates to agrochemical compositions comprising a compound of Formula (I) and to the use of such compositions for controlling weeds at a locus, particularly among useful crops. The invention further relates to select compounds of Formula (I).

The present invention relates to the use of compounds of Formula (I) as herbicides, wherein Z, W, X.sup.1-X.sup.4, R.sub.1, F.sub.2, R.sub.3, R.sub.4, m and n are as defined herein. The invention further relates to agrochemical compositions comprising a compound of Formula (I) and to the use of such compositions for controlling weeds at a locus, particularly among useful crops. The invention further relates to select compounds of Formula (I).