The present invention relates to sedation assessment. In order to facilitate sedation depth monitoring in an autonomous imaging setting, it is proposed to use the imaging modality itself to measure the response to suitable reflexes in order to determine the depth of sedation wherein suitable reflexes include, but are not limited to, the pupil reflex, so-called superficial reflexes and the withdrawal reflexes. In one embodiment, the pupil reflex may be measured in an MRI system by repeated interleaving of dedicated iris MR imaging with the conventional scan protocol. In another embodiment, superficial reflexes in response to stroking of the skin may be measured. This may involve a dedicated actuator that may be closely integrated with the imaging modality, e.g. an MR receive coil applied to the patient. Alternatively, remote haptic systems may be used. The reflex is then acquired with a suitable diagnostic imaging method. In another embodiment, the withdrawal reflex in response to pain may be measured. This may involve an actuator that induces sudden stitching pain or very local temperature-induced pain and that is closely integrated with the imaging modality, e.g. a pinching device integrated with a patient support or an MR receive coil applied to the patient. The reflex is then acquired with a suitable diagnostic imaging method.

Embodiments herein relate to ear-worn devices and, more specifically, ear-worn devices that can measure reaction and/or reflex speeds. An ear-worn device herein can include a control circuit, a clock circuit in electrical communication with the control circuit, a motion sensor in electrical communication with the control circuit, an electroacoustic transducer for generating sound in electrical communication with the control circuit, and a power supply circuit in electrical communication with the control circuit. The ear-worn device can be configured to initiate generation of a stimulus sufficient to generate a response from the ear-worn device wearer. The ear-worn device can be configured to monitor for a qualified response to the stimulus and measure an amount of time between the stimulus and the qualified response. Other embodiments are also included herein.

The method includes excitation during which an internal mechanical stress is generated in an excitation zone, and imaging by acquiring signals during movements generated by the mechanical stress in the visco-elastic medium in response to the internal mechanical stress in an. imaging zone that includes the excitation zone. The method further includes calculating a quantitative index associated with the rheological properties of the visco-elastic medium at least at one point of the imaging zone situated at a given depth outside the excitation zone. The quantitative index is representative of a comparison between signals acquired during the movements generated in response to the mechanical stress at least at one point of the excitation zone situated at the given depth, and signals acquired during the movements generated in response to the mechanical stress at at least the point of the imaging zone situated outside the excitation zone.

The present invention relates generally to a system and method for measuring the structural characteristics of an object. The object is subjected to an energy application processes and provides an objective, quantitative measurement of structural characteristics of an object. The system may include a device, for example, a percussion instrument, capable of being reproducibly placed against the object undergoing such measurement for reproducible positioning. The system does not include an external on/off switch or any remote on/off switching mechanism. The system also includes a disposable feature or assembly for minimizing cross-contamination between tests. The structural characteristics as defined herein may include vibration damping capacities, acoustic damping capacities, structural integrity or structural stability.

The invention comprises a method and apparatus for selecting optical pathways sampling a common tissue layer, such as the dermis, of a person for analysis in a noninvasive analyte property determination systemy, comprising the steps of: probing skin with a range of illumination zone-to-detection zone distances with at least two wavelength ranges, which optionally overlap, and selecting, using a metric, illumination zone-to-detection zone distances having mean optical pathways probing the common tissue layer, such as without the mean optical pathways entering the subcutaneous fat layer of the person. Optionally, the skin tissue layers are modulated and/or treated via tissue displacement before and/or during data collection.

A device for detecting motion of a surface includes a light source for emitting light, a focusing lens configured to focus the light, and a detector configured to receive the focused light reflected off the surface and to detect motion of a distribution pattern of the reflected light. The motion of the distribution pattern of the reflected light is indicative of the motion of the surface. A conic constant of the focusing lens is in the range from □1.5 to □0.5, and a diameter of the focusing lens is at least 60% of the distance from the focusing lens to a beam waist of the focused light. When the conic constant and the diameter are within the above-mentioned ranges, the device is suitable for handheld apparatuses for free-hand measurements of small motions of surfaces. A handheld apparatus can be for example an apparatus for detecting eye pressure.

A system for characterizing tissue includes a probe that delivers a continuous and periodic mechanical vibration to a tissue of a subject; an ultrasound emitter that emits a sequence of ultrasound shots and an ultrasound receiver that receives corresponding echo signals to track how the tissue is moved by the periodic mechanical vibration delivered to the tissue; and a control module programmed to provide homogeneity information to an operator of the system, the homogeneity information being determined from at least some of the echo signals and being representative of the ability of the tissue to transmit elastic waves and of the homogeneity of the tissue with respect to the propagation of elastic waves.

Parametric model based computer implemented methods for determining the stiffness of a bone and systems for estimating the stiffness of a bone in vivo. The computer implemented methods include determining a complex compliance frequency response function Y(f) and an associated complex stiffness frequency response function H(f) and independently fitting a parametric mathematical model to Y(f) and to H(f). The systems include a device for measuring the stiffness of the bone in vivo and a data analyzer to determine a complex compliance frequency response function Y(f) and an associated complex stiffness frequency response function H(f).

Provided is an apparatus for measuring implant osseointegration, and the apparatus for measuring implant osseointegration includes: a vibration generation unit configured to apply multiple vibrations with frequencies in different bands, respectively, to an implant fixture; a vibration sensor configured to measure three-axis vibration information of the implant fixture caused by the vibrations from the vibration generation unit; and a control unit configured to determine the degree of osseointegration based on the measured vibration information.

A light source device includes: light sources; a detector configured to detect light amounts; and a processor configured to: control the light sources to emit light beams by applying a pulse current with a pulse width larger than a predetermined pulse width to the light sources before the processor makes a shift to a strobe observation mode; set a pulse current value at which a ratio of the light amounts of the light beams emitted by the plurality of light sources becomes a predetermined ratio for the plurality of light sources based on a detection result detected by the detector under a state where the pulse current with the pulse width larger than the predetermined pulse width is applied to the plurality of light sources; and make the shift to the strobe observation mode while maintaining the pulse current value for realizing the predetermined ratio.