Augmenting real-time views of a patient with three-dimensional (3D) data. In one embodiment, a method may include identifying 3D data for a patient with the 3D data including an outer layer and multiple inner layers, determining virtual morphometric measurements of the outer layer from the 3D data, registering a real-time position of the outer layer of the patient in a 3D space, determining real-time morphometric measurements of the outer layer of the patient, automatically registering the position of the outer layer from the 3D data to align with the registered real-time position of the outer layer of the patient in the 3D space using the virtual morphometric measurements and using the real-time morphometric measurements, and displaying, in an augmented reality (AR) headset, one of the inner layers from the 3D data projected onto real-time views of the outer layer of the patient.

The invention relates to a computer-implemented method (10) for determining the blood volume flow (I.sub.BI) through a portion (90.sub.i, i=1, 2, 3, . . . ) of a blood vessel (88) in an operating region (36) using a fluorophore. A plurality of images (80.sub.1, 80.sub.2, 80.sub.3, 80.sub.4, . . . ) are provided, which are based on fluorescent light in the form of light having wavelengths lying within a fluorescence spectrum of the fluorophore, and which show the portion (90.sub.i) of the blood vessel (88) at different recording times (t.sub.1, t.sub.2, t.sub.3, t.sub.4, . . . ). By processing at least one of the provided images (80.sub.1, 80.sub.2, 80.sub.3, 80.sub.4, . . . ), a diameter (D) and a length (L) of the portion (90.sub.i) of the blood vessel (88) and also a time interval for a propagation of the fluorophore through the portion (90.sub.i) of the blood vessel (88) are determined, which time interval describes a characteristic transit time (τ) for the fluorophore in the portion (90.sub.i) of the blood vessel (88), in which a blood vessel model (M.sub.B.sup.Q) for the portion (90.sub.i) of the blood vessel (88) is specified, which blood vessel model describes the portion (90.sub.i) of the blood vessel (88) as a flow channel (94) having a length (L), having a wall (95) with a wall thickness (d), and having a free cross section Q. A fluid flow model M.sub.F.sup.Q for the blood vessel model (M.sub.B.sup.Q) is assumed, which fluid flow model describes a local flow velocity (122) at different positions over the free cross section Q of the flow channel (94) in the blood vessel model (M.sub.B.sup.Q), and a fluorescent light model M.sub.L.sup.Q is assumed, which describes a spatial probability density for the intensity of the remitted light at different positions over the free cross section Q of the flow channel (94) in the blood vessel model (M.sub.B.sup.Q), which light is emitted by a fluid, which is mixed with fluorophore and flows through the free cross section Q of the flow channel (94) in the blood vessel model (M.sub.B.sup.Q), when said fluid is irradiated with fluorescence excitation light. The blood volume flow (I.sub.BI) is determined as a fluid flow guided through the flow channel (94) in the blood vessel model (M.sub.B.sup.Q), which fluid flow is calculated from the length (L) and the diameter (D) of the portion (90.sub.i) of the blood vessel (88) and from the characteristic transit time (τ) for the fluorophore in t

A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.

A treatment apparatus and a treatment method capable of minimally invasively specifying a lesion extent and checking progress of treatment while performing the treatment for destroying tumor cells. The treatment apparatus that detects and destroys a tumor cell by irradiating an antibody-photosensitive substance adsorbed on a tumor cell membrane with excitation light includes: an elongated tubular shaft having optical transparency; a light irradiation unit configured to emit the excitation light of the antibody-photosensitive substance from an inside of the shaft in a side direction perpendicular to an axial direction of the shaft; and a side direction fluorescence detection unit configured to detect, from the side direction perpendicular to the axial direction of the shaft, fluorescence emitted by the excited antibody-photosensitive substance, and movable in the axial direction with respect to the shaft.

Systems and methods are disclosed for an optical mapping device. The device emits different wavelengths of light from a plurality of light sources to a cardiac tissue and passes the light through a lens, a first filter cube in the path of the light with a first light filter, a second light filter, and a third light filter. Light passing through the filters is recorded by three cameras that each record an indicator of cardiac physiology, which are mapped simultaneously by the device.

A medical implant includes a sensor that detects electromagnetic waves; and a data transmission unit that can wirelessly transmit data supplied by the sensor to a receiving unit.

The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

A method for determining a disease state prediction, relating to a potential disease or medical condition of a subject, includes accessing a set of subject images, the subject images capturing a part of a subject's body, and accessing a set of clinical factors from the subject. The clinical factors are collected by a device or a medical practitioner substantially contemporaneously with the capture of the subject images. The subject images are inputted into an image model to generate disease metrics for disease prediction for the subject. The disease metrics generated by the image model and the clinical factors are inputted into a classifier to determine the disease state prediction, and the disease state prediction is returned.

A light therapy diagnostic device comprising a shaft, and an optical waveguide disposed in a lumen of the shaft and being movable forward and backward in a longitudinal direction, wherein: the optical waveguide guides a first light and a second light; the shaft has a lateral emission window which allows the first light and the second light to be emitted toward a lateral direction and a distal emission window which allows the first light to be emitted toward a distal direction; a first mirror is provided on a distal end part of the optical waveguide and reflects the first light toward a lateral direction of the shaft; and a second mirror is provided on an inner surface of the shaft, located distal to a distal end of the lateral emission window, and reflects the first light reflected by the first mirror toward a distal direction of the shaft.

The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.