The current invention relates to the use of a neural network to improve the quality of images obtained from light scattered by an intermediate object that scatters light, such as tissue or a frosted screen. The invention relates to a method of imaging a human or animal bode using a nanocrystal array capable of fluorescing upon excitation from light from a near-infrared light source. This invention also relates to detection means and apparatus used in said methods, as well as to quantum dots useful in said use.

A method and apparatus for providing hand-mounted surgical tools is provided. The apparatus includes a housing configured to be mounted to a body of a user. The apparatus also includes an optical source to generate a first optical signal in an absorption spectrum of a biocompatible fluorescing dye (BFD). The apparatus also includes an optical detector to detect a second optical signal in an emission spectrum of the BFD. The apparatus also includes a processor to receive a signal from the optical detector that indicates that the second optical signal was detected by the optical detector. The processor is further configured to cause the apparatus to transmit a signal to a non-visual feedback device to cause the non-visual feedback device to output non-visual feedback to the user that the second optical signal was detected by the optical detector.

A composite device for medical image capturing according to the present invention includes: a head part including a camera unit provided with an image sensor to capture a tooth image, a printed circuit board for operation control of the camera unit and signal transmission therefrom, a light source panel having multiple light sources mounted therein, the light sources emitting light towards a target tooth of which an image is to be captured by the camera unit, an upper housing having the camera unit, the printed circuit board, and the light source panel which are embedded therein, and a lower housing; and a main body part provided with an operation panel for signal input, and supplying electric power to the head part and transmitting a tooth image signal received from the head part to outside.

Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.

A method is provided comprising: positioning a slide that includes a concave region that is formed in a top surface of the slide and that can contain an object, such that a focal point of an objective lens of a fluorescence lifetime imaging microscopy (FLIM) device is within an area of the concave region between a bottom surface of the concave region and the top surface of the slide; and using the FLIM device to capture a sequence of wide field images of a portion of the object within a field of view of the objective lens.

A user-wearable fluorescence based visualization system comprising a multi-light lamp assembly that provides for the selected output of light using multiple light emitting sources, wherein the outputted light may be tailored to generate response wavelength by the interaction of the emitted light and a tissue illuminated by the emitted light, through the process of fluorescence, and a viewing system that allows a practitioner view the fluorescent light generated by the tissue, and distinguish between healthy and diseased tissues.

Methods for quantifying fluorescence and optical properties in a turbid medium such as tissue. Devices and systems suitable for the methods are also disclosed.

Provided herein are systems and methods for simultaneous imaging and stimulation using a microscope system. The microscope system can have a relatively small size compared to an average microscope system. The microscope can comprise in part an imaging light source and a stimulation light source. Light from the imaging light source and the stimulation light source can be spectrally separated to reduce cross talk between the stimulation light and the imaging light.

The invention provides methods and systems for imaging.

A fully integrated miniaturized optical biosensor and methods of making the same are disclosed. The biosensor may include a fluid transport system and an optical system.