A system and method of detecting acoustic waves including directing a continuous-wave source laser beam to an optical resonator that is impinged by acoustic the waves. Optionally, the source laser beam can propagate through the optical resonator, thereby generating a propagated laser beam. Using an interferometer, the acoustic waves can be detected by monitoring transients in an optical phase of the propagated laser beam.

The instant disclosure provides for medical imaging systems that may be used in conjunction with an intraoperative medical device, such as an endoscope. Generally, the disclosed medical imaging systems include an illumination source configured to generate illuminating photons for illuminating a biological sample. An optical signal modulator is configured to separate one or more of the illuminating photons and photons that have interacted with the biological sample into a first optical signal having first multi-passband wavelengths and a second optical signal having second multi-passband wavelengths. At least one detector is configured to detect one or more of the first optical signal and the second optical signal and generate at least one image data set. A processor is configured to analyze the at least one image data set. In some embodiments, the processor is configured to differentiate between structures of the biological sample, such as between an ureter and surrounding tissue.

An imaging device includes an image pixel array and a display pixel array. The image pixel array is configured to capture an infrared image of an interference between an infrared imaging signal and an infrared reference wavefront. The display pixel array is configured to generate an infrared holographic imaging signal according to a holographic pattern driven onto the display pixels. The holographic pattern is derived from the infrared image captured by the image pixel array.

The present invention provides a method which can significantly increase the signal-to-noise ratio of an ultrasound-modulated optical signal by overcoming the shallow depth problem of in vivo optical imaging in existing optical imaging by use of a quantum optical phenomenon based on ultraslow light and nondegenerate phase conjugation and which can be applied directly not only to medical optical imaging, but also to medical photodynamic therapy, through slow light amplification of phase conjugate waves.

The object of the invention is a skeletal method utilizing electromagnetic waves to be utilized at least in one of skeletal actuation, skeletal detection and skeletal therapy. In the method is performed at least one of first and second method steps, where in the first method step is generated by means of electromagnetic waves at least one mechanical wave in at least one generation location into the skeleton through soft tissue. In the second method step is detected by means of electromagnetic waves skeletal vibrations due to at least one mechanical wave, is recorded the detected at least one mechanical wave in at least one recording location to form mechanical wave information, and distance of said at least one recording location from said at least one generation location is known, and further in the second method step is determined skeletal properties based on at least one recorded signal.

The present invention provides imaging devices, systems, and methods of operation for acoustic-enhanced optical coherence tomography. The systems coordinate imaging devices, optical coherence tomography (OCT), and pulsed ultrasound (FUS) and or pulsed ultrasound (PUS) to enhance the contrast of images. Moreover, the systems improve in vivo diagnosis and drug release through the utilization of sonographic enhancers such as microbubbles (MBs).

Systems and methods are provided for performing OCT vibrography based on the synchronization of components of the OCT vibrography system. An A-scan trigger is employed to synchronize the operation of the scanning subsystem that scans the sample beam and an acoustic stimulus source that generates an acoustic stimulus for vibrographic measurements. The acoustic stimulus source is controlled such that when the scanning subsystem dwells on an imaging line selected for vibrography measurements, the acoustic stimulus is generated over a plurality of A-scans and the phase of the acoustic stimulus is locked to the A-scan trigger, such that the phase of the acoustic stimulus is incrementally modified with each A-scan. The accumulation of the acoustic phase is therefore synchronized to the A-scan trigger. The synchronization, providing synchronized acoustic phase evolution during each acoustic phase waveform cycle, permits the use of the OCT vibrography system for simultaneous anatomical and functional imaging.

A light pulse is emitted from a light source for illuminating a medium. Energy level data of the light pulse is measured before the light pulse enters the medium. An image sensor captures an image that includes an interference pattern generated by an exit signal of the light pulse exiting the medium interfering with a reference wavefront. Normalized intensity data is generated by normalizing intensity data exit signal data by the energy level data.

An apparatus for optical detection of ultrasound includes one or more optical resonators (OR200), one or more optical passive-demodulation interferometers (OPDI22), and one or more respective electro-optical readout circuits (EORC24). The one or more optical resonators (OR) are configured to modulate respective carrier frequencies of optical signals indicative of US waves impinging thereon. The one or more OPDI are implemented in one or more photonic integrated circuits (PIC), wherein each OPDI is configured to demodulate the optical signal output by the respective OR, so as to generate a respective intensity-modulated optical signal. Each OPDI includes an interferometer (32) having imbalanced arms (323, 325) that are recombined using an optical hybrid (34). The one or more respective EORC are each configured to measure the intensity demodulated optical signal produced by the respective OPDI, and to output a respective electrical signal.

The present disclosure discloses a method and an apparatus for acquiring motion information. A frequency domain transformation is performed on a detection signal of a vibration propagating in a medium to obtain a frequency domain signal, then a signal that is outside of a defined vibration velocity range is removed from the frequency domain signal, that is, only a vibration signal is retained, and then a position-time diagram is obtained along a defined vibration propagation direction. It is not necessary to perform motion estimation on propagation of the vibration by a complicated calculation, and it is only necessary to determine the presence or absence of the vibration by processing in the frequency domain, and then the position-time diagram is obtained, which is a highly efficient method for acquiring motion information.