The present invention relates to a fusion protein comprising a first peptide and a second peptide linked together with a linker, wherein the first peptide is an allergen and the second peptide is a targeting unit and the targeting unit is a FGL-2 C-terminal peptide according to SEQ ID no 1. Provided herein are also uses of said fusion protein as a vaccine for treating allergy, such as shrimp, peanut or mite allergy, as well as a vaccine composition and methods for producing such fusion proteins.

The present invention relates to a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein, a silica nanoparticle a silica connected to the fusion protein, a fusion protein-silica nanoparticle complex comprising the silica nanoparticle having bioactivity and adhesiveness for cell proliferation and accelerating the differentiation, a surface coating composition including the complex, its use, and a method of coating a surface using the surface coating composition.

Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.

This disclosure describes recombinant hypoallergens and methods of treating allergy that involve administering a recombinant hypoallergen to a subject. Generally, the recombinant hypoallergen includes at least one amino acid modification compared to a corresponding wildtype allergen. As a result, the recombinant hypoallergen binds to IgE that specifically binds to the allergen, but induces release of histamine from basophils to a degree less than the wildtype allergen.

Provided is an antimicrobial peptide Sparamosin from Scylla paramamosain. The Sparamosin mature peptide and its functional domain Sparamosin.sub.26-54 were synthesized by solid-phase synthesis with a purity of over 95%. Both Sparamosin and Sparamosin.sub.26-54 exhibit strong antimicrobial activity. More importantly, Sparamosin.sub.26-54 has strong antifungal activity and could inhibit the growth of a variety of yeasts and filamentous fungi. Based on the potent antimicrobial activities of Sparamosin and Sparamosin.sub.26-54, both peptides could be developed as alternatives for conventional antibiotics, antimicrobial agents, feed additives in aquaculture and livestock, preservatives, and mold inhibitors.

The present invention relates to “a heterodimer which combines a Factor G α-subunit containing an amino acid sequence that is the same as or substantially the same as an amino acid sequence represented by SEQ ID NO: 2 or SEQ ID NO: 4 with a Factor G β-subunit containing an amino acid sequence that is the same as or substantially the same as an amino acid sequence represented by any one of SEQ ID NO: 6, 8, 10, 12, 14, or 16, a method of measuring a β-glucan using the heterodimer, and a kit for measuring a β-glucan containing the heterodimer”.

The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.

The present invention provides methods and compositions for improved diagnosis of shrimp allergies.

The present invention is directed to a peptide, and methods of using the same such as in the delivery of an agent into a cell, or modification of a cell.

Antimicrobial peptides of general formula X.sub.0X.sub.1X.sub.2C X.sub.3X.sub.4X.sub.5CX.sub.6X.sub.7X.sub.8X.sub.9CYX.sub.10X.sub.11CX.sub.12X.sub.13 are provided. Also provided are certain formulations containing these peptides and methods of using these peptides for treating skin infections in an animal in need thereof.