A Magnetic Particle Imaging (MPI) system with a magnet configured to generate a magnetic field with a field free line, the magnet integrated with a flux return designed so that a flux path at approximately the center of the field-free line has a first reluctance and a second flux path distal from the center of the field-free line has a second reluctance, and the second reluctance is lower than the first reluctance to facilitate a high fidelity magnetic field and high fidelity field free line.

This invention relates to methods and systems for removing plaque from arteries and blood vessels in human subjects non-invasively utilizing coated superparamagnetic nanoparticles introduced into the human bloodstream and controlled by external magnetic fields to effect plaque removal. Magnetic nanoparticles are injected into a patient, and magnetic fields are used to move the nanoparticles to the site of an arterial blockage. The nanoparticles are then oscillated by means of an alternating current source and oscillating magnetic field. The nanoparticles impact the plaque deposit, causing it to break up, so that it may be safely disintegrated, dissolved in the bloodstream, digested by enzymes or ions and/or removed with the nanoparticles themselves. The nanoparticles are removed by a unipolar magnetic field directing them to be removed at the point of injection or alternative location in the body. The nanoparticles are also removed by natural bodily functions. The methods and systems are directed to the emergency clearance of arteries in the human body, and the routine annual and quarterly clearance and preventative maintenance of arteries in the human body.

Provided is an electromagnetic device for magnetic particle imaging, including: a return yoke having a gap, which extends in a Y direction and forms a magnetic field space; a gradient magnetic field generating unit, which is provided to the return yoke, and is configured to generate, in the magnetic field space, a gradient magnetic field in an X direction, and to form, in the magnetic field space, a zero-field region extending in the Y direction; an alternating magnetic field generating unit, which is provided to the return yoke, and is configured to generate an alternating magnetic field in the magnetic field space; and a rotation mechanism configured to rotate the gradient magnetic field and the alternating magnetic field relative to a subject with a Z direction being a rotation axis.

Provided is an electromagnetic device for magnetic particle imaging, including: a return yoke having a gap, which extends in a Y direction and forms a magnetic field space; a gradient magnetic field generating unit, which is provided to the return yoke, and is configured to generate, in the magnetic field space, a gradient magnetic field in an X direction, and to form, in the magnetic field space, a zero-field region extending in the Y direction; an alternating magnetic field generating unit, which is provided to the return yoke, and is configured to generate an alternating magnetic field in the magnetic field space; and a rotation mechanism configured to rotate the gradient magnetic field and the alternating magnetic field relative to a subject with a Z direction being a rotation axis.

The invention relates to a method for detecting and/or identifying magnetic supraparticles using magnet particle spectroscopy (MPS) or magnet particle imaging (MPI), wherein magnetic supraparticles are provided, each of which contains a plurality of magnetic nanoparticles and which have a specific composition and/or structure. The magnetic supraparticles are exposed to at least one magnetic field, whereby at least one voltage and/or a voltage curve is induced based on the magnetic moment of the magnetic supraparticles. The at least one voltage and/or the voltage curve is detected as at least one measurement signal, and at least one spectrum is generated from the at least one measurement signal, said spectrum containing harmonics, each of which has an amplitude and a phase. The magnetic supraparticles are (uniquely) detected and/or identified using the at least one generated spectrum.

Methodologies and mechanisms are provided for introducing one or more magnetizable particles introduced non-invasively into one or more body structures containing nervous tissue in a subject, directing, guiding, transporting, focusing and/or concentrating the one or more particles using at least one image-guidance component in proximity to the one or more body structures which can direct the one or more particles within the one or more body structures, and modulating, using at least one activation component, the one or more particles to modulate neuronal function in the one or more body structures of the subject.

The invention relates to a method for carrying out signal detection by means of magnetic particle imaging, in which method magnetic/magnetisable particles (4), arranged in the field-free region of a location-dependent magnetic field, in particular a gradient magnetic field, are magnetised by means of an excitation magnetic field that changes over time, and the harmonics (9, 15), generated by the particles (4), of the frequency of the excitation magnetic field are detected as a signal from the magnetic particles (4) by means of a receiver coil arrangement (1) which in particular surrounds the particles (4), wherein a signal-transmitting arrangement, which has an outer coil (10) and at least one inner coil (11; 16, 17) connected in series to said outer coil, is positioned within the receiver coil arrangement (1) around the particles (4), wherein the signal received from the particles (4) by the at least one inner coil (11; 16, 17) is transmitted to the outer coil (10) by current flow and is re-emitted by said outer coil, in particular as a result of which the signal (S) received directly from the particles (4) and the signal (S) received from the particles (4) indirectly by the outer coil (10) are superimposed at the receiver coil arrangement (1). The invention also relates to a signal-transmitting arrangement for a magnetic-particle-imaging scanner/spectrometer, comprising an outer coil (10) which in particular has a smaller diameter than the sample-receiving channel (2) of the scanner/spectrometer, and comprising at least one inner coil (11; 16, 17) which is arranged in the outer coil (10), preferably arranged coaxially therein, and in particular has greater diameter than a sample to be examined, wherein the outer coil (10) and the inner coil (11; 16, 17) are electrically connected in series. The invention also relates to a system comprising a magnetic-particle-imaging scanner and a signal-transmitting arrangement.

The invention relates to a method for carrying out signal detection by means of magnetic particle imaging, in which method magnetic/magnetisable particles (4), arranged in the field-free region of a location-dependent magnetic field, in particular a gradient magnetic field, are magnetised by means of an excitation magnetic field that changes over time, and the harmonics (9, 15), generated by the particles (4), of the frequency of the excitation magnetic field are detected as a signal from the magnetic particles (4) by means of a receiver coil arrangement (1) which in particular surrounds the particles (4), wherein a signal-transmitting arrangement, which has an outer coil (10) and at least one inner coil (11; 16, 17) connected in series to said outer coil, is positioned within the receiver coil arrangement (1) around the particles (4), wherein the signal received from the particles (4) by the at least one inner coil (11; 16, 17) is transmitted to the outer coil (10) by current flow and is re-emitted by said outer coil, in particular as a result of which the signal (S) received directly from the particles (4) and the signal (S) received from the particles (4) indirectly by the outer coil (10) are superimposed at the receiver coil arrangement (1). The invention also relates to a signal-transmitting arrangement for a magnetic-particle-imaging scanner/spectrometer, comprising an outer coil (10) which in particular has a smaller diameter than the sample-receiving channel (2) of the scanner/spectrometer, and comprising at least one inner coil (11; 16, 17) which is arranged in the outer coil (10), preferably arranged coaxially therein, and in particular has greater diameter than a sample to be examined, wherein the outer coil (10) and the inner coil (11; 16, 17) are electrically connected in series. The invention also relates to a system comprising a magnetic-particle-imaging scanner and a signal-transmitting arrangement.

A system for one-sided measuring a presence of magnetic particles in a probe volume comprises a one-sided coil assembly and a current controller, wherein the one-sided coil assembly is arranged around a central coil assembly axis for generating a rotating magnetic field distribution and comprises at least 3, preferably at least 4, circumferentially distributed coil assembly sectors, wherein the current controller is configured to generate a time varying current in each of said coil assembly sectors, said time varying current comprising a periodic modulation with a rotation frequency and phase shifted between adjacent coil assembly sectors to generate a magnetic field rotating in a plane perpendicular to the coil assembly axis, said magnetic field rotating with a rotation frequency associated with a frequency of said periodic modulation, and wherein the system is configured for measuring said presence of magnetic particles in said probe volume with said one-sided coil assembly.

A system for one-sided measuring a presence of magnetic particles in a probe volume comprises a one-sided coil assembly and a current controller, wherein the one-sided coil assembly is arranged around a central coil assembly axis for generating a rotating magnetic field distribution and comprises at least 3, preferably at least 4, circumferentially distributed coil assembly sectors, wherein the current controller is configured to generate a time varying current in each of said coil assembly sectors, said time varying current comprising a periodic modulation with a rotation frequency and phase shifted between adjacent coil assembly sectors to generate a magnetic field rotating in a plane perpendicular to the coil assembly axis, said magnetic field rotating with a rotation frequency associated with a frequency of said periodic modulation, and wherein the system is configured for measuring said presence of magnetic particles in said probe volume with said one-sided coil assembly.